معرفی
Dr. Astrid Kahnt is a Researcher at the Institute of Pharmaceutical Chemistry within the Department 14 - Biochemistry, Chemistry and Pharmacy at Goethe University Frankfurt. Her work focuses on lipid mediators, enzymology, and their roles in inflammation and cancer. She is affiliated with the Biochemistry for Pharmacists unit and contributes to teaching through courses like Drug Analysis and Pharmaceutical/Medicinal Chemistry II.
Research Interests: Dr. Kahnt’s research explores lipoxygenase enzymes (e.g., 5-LO), specialized pro-resolving mediators (SPMs), and their implications in cancer and inflammation. She investigates drug design targeting these pathways, including enzyme inhibitors and dual-modulators of receptors like PPARγ. Her work integrates biochemical assays, cellular models, and structural biology to uncover mechanisms linking lipid signaling to disease.
Recent Trends in Publications: Her recent articles emphasize 5-lipoxygenase’s non-canonical roles in cancer progression, structure-based drug design for enzyme degradation (e.g., PROTACS), and the biosynthesis of pro-resolving mediators. She also explores polypharmacological approaches to modulate multiple targets (e.g., Farnesoid X Receptor/SEH) for therapeutic efficacy.
Teaching and Affiliations: She coordinates courses on drug analysis and medicinal chemistry, reflecting her expertise in pharmaceutical applications. Her lab’s interdisciplinary approach bridges biochemistry, pharmacology, and drug design, contributing to both fundamental and translational research.
