جست‌وجوی استاد و پژوهشگر

Catarina M Henriquesمشاهده پروفایل

پژوهشگر ارشد

• Ageing Research
• Telomere Biology
• Zebrafish Models
• +۵ مورد دیگر

Catarina M Henriques is a Senior Research Fellow at the University of Sheffield's School of Medicine and Population Health. She leads a research group focused on Telomere Biology, Ageing, and Regenerative Medicine, with affiliations to the Bateson Centre , Healthy Lifespan Institute (HELSI) , and CIMA (Centre for Integrated research into Musculoskeletal Ageing). BSc (Hons) in Molecular & Cellular Biology, University of Glasgow PhD in Immunology and Cancer, University of Lisbon (FCT Fellowship) Her research explores the interplay between telomere dysfunction, cellular senescence, and immune/stem cell regulation in tissue homeostasis decline during ageing. Using zebrafish models , she investigates how telomerase-dependent mechanisms influence multi-tissue degeneration and therapeutic rejuvenation strategies. Recent work highlights telomere dynamics in immunity, intestinal permeability, and neurodegeneration. Key publications include: 2024: Telomere length as an epigenetic trait in disease modeling 2023: p21-GFP senescence zebrafish for senolytic testing 2022: Gut leukocyte telomere dependence and retinal regeneration Her work bridges the Versus Arthritis CIMA and Bateson Centre collaborations. Scientific awards include: Sir Henry Dale Fellowship (Wellcome Trust/Royal Society) CIMA Research Fellowship Vice-Chancellor’s Fellowship She supervises postgraduate researchers and contributes to undergraduate/postgraduate education via modules on multimorbidity, reproduction, and human disease modeling. The lab employs histology, immunofluorescence, flow cytometry, and cell culture to study zebrafish tissue repair mechanisms.

• Mechanisms of diarrheal diseases
• CFTR chloride channel regulation
• Genetic and non-genetic intestinal diseases
• +۳ مورد دیگر

Dr. Nadia Ameen is a Professor of Pediatrics (Gastroenterology) and Cellular and Molecular Physiology at Yale University School of Medicine. As an NIH-funded physician-scientist with over two decades of laboratory leadership, she investigates mechanisms of diarrheal diseases with focus on CFTR chloride channel regulation in genetic and non-genetic intestinal disorders including Cystic Fibrosis. Her research spans trafficking mechanisms, kinase signaling pathways, and translational applications for drug therapies like Linaclotide and Lubiprostone. MBBS from University of West Indies (1985) Her research program combines: CFTR trafficking regulation Microvillus Inclusion Disease (MVID) pathogenesis SGK1 kinase signaling effects Neuropod cell biology Translational organoid models Pediatric gut health promotion Key contributions include: Discovery of CFTR trafficking mechanisms Identification of BEST4+ neuropod cells Development of humanized mouse models Elucidation of stress-induced signaling pathways Advancement of nutritional interventions for children Scientific recognition includes the 2020 NASPGHAN Award for Study of Disorders Associated with Carbohydrate Malabsorption. She leads the Ameen Lab at The Anlyan Center (300 Cedar Street, New Haven) and participates in the Discovery to Cure Internship program.

Thomas B Bartnikasمشاهده پروفایل

دانشیار

• Metal Homeostasis
• Iron Metabolism
• Manganese Metabolism
• +۳ مورد دیگر

Thomas B Bartnikas is an Associate Professor of Pathology and Laboratory Medicine at Brown University and Director of the MD/PhD Program. His research focuses on metal homeostasis in human biology, particularly iron and manganese regulation in health and disease. Education: PhD in Molecular Cell Biology (Washington University in St. Louis, 2004) MD (Washington University in St. Louis, 2004) BA (Cornell University, 1996) Dr. Bartnikas investigates molecular mechanisms of metal absorption, distribution, and elimination using mouse and cell culture models. His work connects genetic mutations, dietary imbalances, and environmental exposures to metal-related disorders like hemochromatosis. Recent publications emphasize hepcidin regulation, divalent metal transport, and metal toxicity pathways. Scientific contributions include: NIH-funded research on iron and manganese homeostasis Development of novel animal models for metal disorders Key discoveries in transferrin and BMP signaling interactions He received the NIDDK K99/R00 DK084122 award and collaborates with international BioIron researchers. Dr. Bartnikas teaches BIOL 2860 - Molecular Mechanisms of Disease and contributes to biomedical science education through the MD/PhD program.

Zuri Sullivanمشاهده پروفایل

پژوهشگر ارشد

• Immunology
• Neuroscience
• Neuroimmunology
• +۵ مورد دیگر

Zuri Sullivan is a postdoctoral researcher at Harvard University, affiliated with the Catherine Dulac Lab. Her work focuses on the intersection of immunology and neuroscience, particularly how inflammatory signals influence social behavior in mice through hypothalamic circuits. Education: PhD in Immunobiology from Yale University AB in Molecular and Cellular Biology (MCB) from Harvard College Research interests span neuroimmunology, inflammation, and genetic screening. Key projects include studying mast cell-leukotriene signaling in anaphylaxis, hypothalamic circuitry in social homeostasis, and the role of γδ T cells in nutrient sensing. Her work often integrates immunobiology with behavioral neuroscience. Recent publications highlight her contributions to understanding immune-gut-brain axis interactions, genetic tools for tissue mapping, and disease mechanisms in obesity-related cancer and tuberculosis. She also develops innovative multimodal screening platforms for in vivo gene function analysis. Scientific Awards: HHMI Hanna H. Gray Postdoctoral Fellowship Zuri actively promotes science communication, diversity in STEM, and education outreach. She previously studied intestinal immune adaptation to diet during her PhD at Yale under Ruslan Medzhitov. Collaborations with William Bishai and Ruslan Medzhitov feature prominently in her research portfolio.

Randy J. Seeleyمشاهده پروفایل

استاد

• Neuroscience
• Endocrinology
• Nutritional Sciences
• +۴ مورد دیگر

Randy J. Seeley is the Henry K. Ransom Endowed Professor of Surgery at the University of Michigan School of Medicine, with adjunct appointments in Internal Medicine and Nutritional Sciences. His research focuses on central nervous system regulation of energy balance, obesity, diabetes, and metabolic disease interventions. His scientific work explores how peripheral hormones interact with the CNS to control food intake, body weight, and fuel metabolism. Recent studies highlight innovative approaches including GLP-1 receptor agonists, bariatric surgery mechanisms, and gut-liver-brain axis interactions. Publications span top journals like Nature , Science , and Cell Metabolism , emphasizing translational research from animal models to human metabolic outcomes. Key themes include hormonal signaling, weight-loss maintenance, and metabolic inflammation. 2009 Outstanding Scientific Achievement Award (American Diabetes Association) 2022 AAAS Fellow Dr. Seeley has served on NIH review panels and the Science editorial board, advancing obesity and diabetes research through interdisciplinary collaborations.

• Obesity Research
• Nutrition Science
• Endocrinology
• +۳ مورد دیگر

Mireille Serlie, MD, PhD, is a Professor of Internal Medicine (Endocrinology) at Yale School of Medicine, joining in 2023. Her research focuses on obesity, nutrition, and brain function, particularly neural mechanisms regulating food intake and insulin resistance pathways. She is also the Medical Director of the Amsterdam University Medical Center’s Expert Center for Intestinal Failure and Parenteral Nutrition. Her work bridges clinical practice and translational research, with collaborations on topics like exercise timing, sleep’s metabolic effects, and genetic determinants of bariatric surgery outcomes. Key contributions include systematic reviews on patient-reported outcomes, glycaemic control, and consensus statements on sarcopenic obesity and micronutrient management. Education: PhD (2007), MD (1995), University of Amsterdam; Residency and Fellowship at Academic Medical Center Amsterdam. Research interests emphasize interdisciplinary approaches to metabolic disorders, leveraging clinical and molecular insights. Her recent articles address topics such as dopamine’s role in glucose metabolism, tissue-specific inflammation in obesity, and the impact of physical activity timing on glycaemia.

• Peptide Chemistry
• Bioorganic Chemistry
• Enzyme Inhibition
• +۳ مورد دیگر

Dr. Agata Gitlin-Domagalska serves as an Adjunct Professor at the Faculty of Chemistry, University of Gdańsk, where she leads research in the Department of Molecular Biochemistry and Laboratory of Bioorganic Chemistry. Her work bridges peptide chemistry and bioorganic drug design, focusing on innovative synthetic strategies and therapeutic applications. Academic Affiliation: Faculty of Chemistry, University of Gdańsk Department: Department of Molecular Biochemistry Laboratory: Laboratory of Bioorganic Chemistry Specializing in peptide synthesis and prodrug development , Dr. Gitlin-Domagalska investigates strategies to enhance oral bioavailability of charged peptides through lipophilic charge masking and non-covalent inhibition of serine proteases like matriptase and furin . Her research extends to antimicrobial peptide conjugates with dual therapeutic functions and Zika virus suppression via protease inhibition. Recent publications highlight her expertise in peptide splicing mechanisms , solid-phase synthesis optimization , and nanoparticle-based delivery . She has developed cyclic RGD prodrugs for targeted intestinal permeability and bicyclic furin inhibitors using combinatorial chemistry approaches. Her work contributes to antibiotic conjugates with leukemia-selective antifungal activity , neuroprotective humanin analogs , and vasopressin derivatives with expanded therapeutic potential. Current trends emphasize matriptase-selective inhibitors and earthworm-derived antimicrobial nanoparticles . Dr. Gitlin-Domagalska employs model membrane biosensing for drug-membrane interaction studies and has pioneered high-shear mixing techniques to improve amide bond formation efficiency in peptide synthesis processes.

Timothy C. Meredithمشاهده پروفایل

دانشیار

• Bacterial Cell Envelope Biosynthesis
• Lipoprotein Biosynthesis
• Functional Genomics
• +۹ مورد دیگر

Timothy C. Meredith is an Associate Professor in the Department of Biochemistry and Molecular Biology at Pennsylvania State University. His career spans academic research and industry roles at Merck Research Laboratories and Novartis Institutes for Research, with a postdoctoral fellowship at Harvard Medical School and a return to Harvard as an instructor.

Ning Chengمشاهده پروفایل

استادیار

• Neurodevelopmental Disorders
• Autism Spectrum Disorder
• Fragile X Syndrome
• +۵ مورد دیگر

Ning Cheng is an Assistant Professor (Teaching & Research) at the University of Calgary's Faculty of Veterinary Medicine, with affiliations to the Alberta Children's Hospital Research Institute (ACHRI) and Hotchkiss Brain Institute (HBI). Their research focuses on neurodevelopmental disorders, particularly autism and Fragile X Syndrome, using rodent models to investigate mechanisms and develop experimental therapeutics. PhD in neuroscience from Johns Hopkins School of Medicine Postdoctoral work on neurological disorders at NIH Research spans molecular mechanisms, neural circuitry, and translational approaches to address social, communication, and behavioral challenges in autism spectrum disorders. The lab utilizes in vivo recording/modulation of brain activity, biochemical analyses, and multidisciplinary collaborations. Recent publications highlight expertise in EEG biomarker discovery, auditory processing abnormalities, ketogenic diet interventions, and ERK pathway modulation in mouse models of neurodevelopmental conditions. Key technologies developed include wireless cortical hemodynamic monitoring systems (TinyIOMS) and open-source electrophysiology tools (OSERR). As part of ACHRI's Precision Medicine & Disease Mechanisms program and HBI's Neurodevelopment/SCNIP strategic initiatives, Cheng contributes to university-wide efforts in Brain and Mental Health (2015-2021) and Child Health and Wellness (2020-2025).

Wen Luمشاهده پروفایل

استادیار

• Cytoskeleton
• Developmental Biology
• Neurobiology
• +۴ مورد دیگر

Wen Lu, PhD is a Research Assistant Professor in the Department of Cell and Developmental Biology at Northwestern University's Feinberg School of Medicine. Her primary research focuses on cytoskeletal regulation and molecular motor coordination in super-large cells including oocytes and neurons, utilizing Drosophila melanogaster as a model organism. She employs high-resolution live microscopy, genetic engineering, optogenetics, and pharmacological manipulations to investigate microtubule and F-actin dynamics in cellular development and regeneration. Her educational background includes a BS from Peking University (2004) and a PhD from The University of Chicago (2010), followed by postdoctoral training at Northwestern University Feinberg School of Medicine. Dr. Lu maintains active affiliations with the American Society for Cell Biology (2019-2024) and the Genetics Society of America (2022-2023), and serves on the FlyBase Community Advisory Group since 2014. Research interests center on cytoskeletal dynamics in cellular polarization, with particular emphasis on oocyte specification, growth mechanisms, and neuronal regeneration after injury. Her work bridges developmental biology and neurobiology through innovative imaging techniques that reveal molecular transport mechanisms in cellular systems. Current investigations explore microtubule movement regulation and the interplay between cytoskeletal elements during critical developmental processes. Publication trends demonstrate strong interdisciplinary focus spanning cell biology, neurobiology, and imaging sciences, with recent work increasingly incorporating translational elements in ophthalmology and oncology. Her articles reveal consistent methodological innovation in live-cell imaging and genetic manipulation techniques applied to fundamental biological questions. Winner 2025 Drosophila Art Contest, The FlyStuff / Genesee Scientific Team Winner of CDB Graphic Design Contest, CDB Special Events Committee (2024) Winner in Category 2, Microscopy Image Competition 2024, ProteinTech Group 2nd Prize in Published Category, Microscopy Today Micrograph Awards (2024) BINA 2022 Image Contest- People's Choice Award, BioImaging North America Dr. Lu serves on the FlyBase Community Advisory Group and maintains industry relationships including ownership in Quantum Music LLC. Her laboratory work integrates advanced microscopy with genetic models to address fundamental questions in cellular organization, with potential implications for understanding developmental disorders and neurodegenerative conditions.

Stuart Rushworthمشاهده پروفایل

استاد

• Molecular Haematology
• Cancer Metabolism
• Tumour Microenvironment
• +۱۲ مورد دیگر

Professor Stuart Rushworth is a faculty member at Norwich Medical School, University of East Anglia, where he serves as the scientific group leader for molecular haematology research. His work focuses on the tumour microenvironment in haematological malignancies, particularly Acute Myeloid Leukaemia and Multiple Myeloma, and the impact of infection and ageing on haematopoietic stem cells. Education: Bachelor's Degree – University of Sunderland PhD in Immunology – University of Cambridge Post-doctoral Training – University of Cambridge and University of East Anglia His research explores metabolic reprogramming, mitochondrial transfer, and stromal interactions in cancer. He has made significant contributions to understanding how leukaemia cells exploit the bone marrow microenvironment for survival and proliferation. His studies have identified key mechanisms such as fatty acid release from adipocytes and intercellular mitochondrial transfer via tunnelling nanotubes. His work bridges basic science and clinical translation, with implications for drug resistance and novel therapeutic strategies. The most recent articles highlight trends in immunometabolism, infection-induced haematopoietic stress responses, and metabolic crosstalk in cancer. Key themes include mitochondrial dynamics, metabolic adaptation, and innate immune signaling pathways like STING. His publications appear in high-impact journals such as Cell Reports , Nature Communications , and Blood . He is actively funded by major research bodies including the British Heart Foundation, The Big C Appeal, Academy of Medical Sciences, and BBSRC. While no formal scientific awards are listed in the provided text, his research has led to clinical trials involving BTK inhibitors in myeloma patients. Professor Rushworth mentors several PhD researchers, including Dominic Fowler-Shorten, E. E. Wojtowicz, A. Jibril, J. A. Moore, and J. Mistry. He leads the Rushworth Group, which is part of the Metabolic Health Research Centre at UEA, focusing on metabolic processes in the tumour microenvironment.

Todd R. Evansمشاهده پروفایل

استاد

• Developmental Biology
• Stem Cell Research
• Cardiac Development
• +۵ مورد دیگر

Todd R. Evans is a Professor at Weill Cornell Medicine with appointments in the Department of Cell and Developmental Biology. His research program bridges developmental biology, stem cell science, and disease modeling, with particular focus on cardiac development, diabetes research, and organoid systems. Dr. Evans maintains active collaborations across multiple institutions and serves as Principal Investigator on several NIH-funded research projects. Dr. Evans' research focuses on the molecular mechanisms governing embryonic development, particularly in cardiac and pancreatic systems. His laboratory investigates transcription factor networks (especially GATA factors), signaling pathways (WNT, BMP, NODAL), and epigenetic regulation during organ formation. Developmental mechanisms of heart formation Stem cell differentiation into functional organ systems Organoid models for disease research Transcriptional and epigenetic regulation during development Diabetes pathogenesis and beta cell biology Analysis of Dr. Evans' recent publications reveals a strong emphasis on using human pluripotent stem cells and organoid models to investigate developmental processes and disease mechanisms. His work increasingly integrates CRISPR-based screening, chemical biology approaches, and advanced imaging techniques to dissect molecular pathways in cardiac and pancreatic development. A notable trend is the application of these models to study viral pathogenesis (particularly SARS-CoV-2) and immune-mediated tissue damage. Dr. Evans' research has been recognized through substantial federal funding and high-impact publications, with several papers receiving over 100 citations. Notable work includes foundational studies on GATA transcription factors in development and innovative organoid models for studying diabetes and viral infections. Dr. Evans serves as Principal Investigator on multiple NIH grants, including projects funded by the National Heart, Lung, & Blood Institute and the National Institute of Child Health & Human Development. His laboratory has trained numerous graduate students and postdoctoral fellows who have gone on to successful careers in academia and industry. Current research directions include the development of novel organoid systems and the application of chemical biology approaches to manipulate stem cell differentiation. Dr. Evans leads a multidisciplinary research team that includes developmental biologists, stem cell experts, and computational biologists. His laboratory maintains state-of-the-art facilities for stem cell culture, organoid development, and advanced microscopy, supporting collaborative projects across Weill Cornell Medicine and with external partners.

Alison Wardمشاهده پروفایل

دانشیار

• Nutritional Epigenetics
• Developmental Programming
• Livestock Production
• +۶ مورد دیگر

Alison Ward is an Associate Professor in the Department of Animal and Poultry Science at the University of Saskatchewan, Canada. Her research focuses on nutritional epigenetics, developmental programming, and molecular genetics in livestock, particularly examining how maternal nutrition affects fetal development and long-term health outcomes in beef cattle. She integrates multi-omics approaches, including transcriptomics and metabolomics, to study nutrient-gene interactions and improve precision agriculture practices. PhD (Animal Science), University of Saskatchewan MSc (Animal Science), University of Saskatchewan BSc (Animal Science), University of Saskatchewan Ward’s work bridges molecular biology, physiology, and genomics to address how maternal micronutrient and one-carbon metabolite supplementation during critical gestational periods alter fetal organ development, placental function, and epigenetic gene regulation. Her recent publications emphasize fetal liver programming, mitochondrial function, and transgenerational effects of maternal nutrition, with a strong focus on sustainable livestock production. Her research has been supported by grants from the USDA National Institute of Food and Agriculture, North Dakota Beef Commission, and other agricultural research bodies. She teaches ANSC 313 – Animal Breeding and Genetics, and has received teaching excellence awards from the University of Saskatchewan Students Union. 2024 Open Resources Initiative Award USSU Teaching Excellence Award

Pawan Kumarمشاهده پروفایل

دانشیار

• Mucosal Immunology
• IL-17A and mucosal host defense
• Th17 cell differentiation
• +۳ مورد دیگر

Pawan Kumar, BVSc, PhD is an Associate Professor in the Department of Microbiology and Immunology at Stony Brook University. His research focuses on mucosal immunology, particularly the intricate crosstalk between immune cells, microbiota, and epithelial cells that influences intestinal and extra-intestinal host defense mechanisms. Dr. Kumar's research interests include: IL-17A and mucosal host defense Th17 cell differentiation pathways IL-22 and mucosal host defense Intestinal immunity and microbiota interactions His laboratory investigates how IL-17A derived from Th17 cells plays dual roles in gastrointestinal homeostasis versus systemic autoimmunity, using intestinal epithelial cell-specific IL-17 receptor knockout mouse strains. His work on IL-22 examines its protective and inflammatory roles in inflammatory bowel disease and systemic metabolic disorders. Recent research trends show an expanding focus on how mucosal immunity interfaces with metabolic disorders, obesity, and gut-liver axis communication, demonstrating the profound connections between immune regulation and metabolic health. Dr. Kumar received his PhD from the University of Southampton, UK in 2009. His laboratory team includes postdoctoral fellows Ankita Singh and Cody Kempen, as well as undergraduate student Ruhee Damie.

• Gut microbiota
• Mucosal barrier function
• Dietary impact on health
• +۵ مورد دیگر

Björn Schröder is an Associate Professor at Umeå University, affiliated with the Department of Molecular Biology and the Laboratory for Molecular Infection Medicine Sweden (MIMS). His research examines how diet, gut microbiota, and mucosal barrier function interact to influence intestinal health, with a focus on Western-style diets, antimicrobial peptides, and protection against infections and inflammation. Current projects include analyzing dietary fiber's role in mucus integrity and linking specific bacteria to barrier function. Primary Affiliation: Department of Molecular Biology, Umeå University Secondary Affiliation: MIMS (Molecular Infection Medicine Sweden) Research interests span gut microbiota, mucosal immunity, antimicrobial peptides, and diet-related pathologies like inflammatory bowel disease and metabolic syndromes. His work combines microbiome analysis with physiological studies in murine models to dissect mechanisms of barrier protection. Recent publications highlight the impact of dietary fiber and probiotics on mucus health, antibiotic effects on barrier integrity, and microbial networks in diseases like colorectal cancer. Themes include diet-microbiota crosstalk, redox regulation of antimicrobial peptides, and microbiota-independent versus dependent mechanisms of mucus damage. Scientific recognition: Fernström Research Prize (2025) Grants: Persson Millions for intestinal research His lab maintains a website at www.mucubacter.org and collaborates with international teams on topics ranging from enteric pathogens to metabolic disease models.