جست‌وجوی استاد و پژوهشگر

Mark Milesمشاهده پروفایل

پژوهشگر ارشد

• Biochemistry
• Immunology
• Oncology
• +۷ مورد دیگر

Dr. Mark Miles is a Postdoctoral Research Fellow in the Department of Health and Biomedical Sciences at RMIT University. His research focuses on understanding the molecular mechanisms of inflammation, viral pathogenesis, and cancer biology, with a particular emphasis on respiratory viruses, TLR signaling pathways, and metastatic processes. He investigates how host immune responses to pathogens like influenza and RSV contribute to acute and chronic disease outcomes, including sex-dependent disparities in inflammation. His work also explores the role of endosome-lysosome systems in cancer metastasis and the development of therapeutic strategies targeting these pathways. Key research areas include: Biochemistry and Cell Biology, Oncology, Immunology, Medical Microbiology, and Pharmacology. Recent studies highlight TLR7's dual role in mediating inflammation during influenza infection while preventing long-term airway dysfunction, as well as sporadic BRAF/KRAS mutations' contributions to colorectal cancer progression. He has also examined how early-life respiratory infections influence gut-associated immunity in adulthood and the vascular effects of maternal influenza infection. Dr. Miles' publications span 2022–2025, addressing topics like TLR9-based immunotherapy for prostate cancer, aspirin's protective effects in pregnancy-related influenza complications, and molecular mechanisms of apoptosis regulation via BIRC2 proteins. His research combines experimental models with genomic and proteomic approaches to uncover translational insights into viral diseases and oncology.

Stephen Archerمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Mitochondrial Biology
• Oxygen Sensing Mechanisms
• +۳ مورد دیگر

Dr. Stephen Archer is a Professor and former Head of the Department of Medicine at Queen's University. He holds the C. Franklin and Helene K. Bracken Chair and serves as Director of the Translational Institute of Medicine (TIME) and Scientific Director of the Queen’s CardioPulmonary Unit (QCPU). His expertise spans pulmonary hypertension, mitochondrial biology, and translational cardiovascular research. Dr. Archer has over 300 publications, an H-index of 113, and >50,000 citations. Education: MD from Queen’s University (1981) Bachelor of Arts from Queen’s University (1977) Research Interests: Pulmonary arterial hypertension mechanisms and therapies Oxygen sensing via mitochondrial pathways Right ventricular dysfunction Experimental therapeutics for cancer Key Contributions: Founded the QCPU, an $8M translational research facility Co-founded TIME at Queen’s University Developed mitochondrial fission inhibitors like Drpitor1a Awards: Fellow of the Royal Society of Canada Distinguished Scientist Awards (AHA, ACC) AFMC President’s Award (2023) Grants & Mentorship: CIHR-funded research lab Mentored over 75 trainees Labs/Teams: Leads the Archer Lab at Queen’s University, focusing on mitochondrial dynamics and oxygen-sensing pathways.

Amelia Wilkinsonمشاهده پروفایل

استادیار

• Quality Improvement
• Patient Safety
• Medical Education
• +۷ مورد دیگر

Dr. Amelia Wilkinson is an Assistant Professor in the Division of General Internal Medicine at Queen’s University. She holds an undergraduate degree in Life Sciences from Queen’s University, a medical degree from the University of Ottawa, and a Master of Science in Healthcare Quality from Queen’s University (2022). Her clinical practice focuses on medical clinical teaching units, General Internal Medicine (GIM) inpatient consult services, and outpatient care in GIM, bariatric medicine, and perioperative medicine. Education: Bachelor of Science in Life Sciences, Queen’s University Medical Degree (MD), University of Ottawa Internal Medicine Residency and Subspecialty Training in General Internal Medicine, Queen’s University Master of Science in Healthcare Quality, Queen’s University (2022) Research Interests: Dr. Wilkinson’s work emphasizes quality improvement, patient safety, and medical education. She investigates geriatric patient care, particularly osteoporosis therapy, and collaborates with Kingston Health Sciences Centre to enhance care for elderly populations. Her research also explores mitochondrial and metabolic mechanisms in cardiometabolic diseases, leveraging metabolomics and genetic models. Publications: Her articles focus on metabolomics, mitochondrial dysfunction, and cardiometabolic disease mechanisms, including studies on platelet bioenergetics as liquid biopsy tools and tissue-specific effects of mitochondrial-nuclear DNA mismatches. These span animal models and translational applications. Grants & Awards: No specific grants or awards are listed in the provided text. Advising & Teams: No student advisees or specific lab/team affiliations are mentioned.

Gareth Sullivanمشاهده پروفایل

پژوهشگر ارشد

• Stem Cell Biology
• Organoid Technology
• Mitochondrial Disorders
• +۲ مورد دیگر

Gareth Sullivan is an Industry Principal Research Fellow at the University of St Andrews School of Medicine. His research develops stem cell-derived organoid models for studying mitochondrial disorders and neurodegenerative diseases. Dr. Sullivan's work advances applications of induced pluripotent stem cell (iPSC) technology in disease modeling and drug screening. Research focuses on POLG-related mitochondrial disorders, cerebral organoid development, and hepatobiliary transport mechanisms. His team employs 3D microperfusion systems to enhance organoid functionality and disease modeling accuracy. Sullivan's publications demonstrate extensive work on mitochondrial dysfunction mechanisms and stem cell applications. Recent innovations include NAD+ precursor therapies for mitochondrial defects and cerebral organoid models that recapitulate disease pathology. As Principal Investigator, Dr. Sullivan leads projects on liver organoid testing platforms and neuroprotective therapies. His research contributes to UN Sustainable Development Goals related to health innovation.

David Heidaryمشاهده پروفایل

استاد پژوهشی

• Photodynamic Therapy
• Metal-Based Anticancer Agents
• Enzyme Inhibition (Cytochrome P450)
• +۳ مورد دیگر

David Heidary is a Research Professor at North Carolina State University, specializing in inorganic chemistry with a focus on photoactive metal complexes and their applications in cancer therapy. His work bridges medicinal chemistry, enzymology, and molecular biology, particularly targeting cytochrome P450 enzymes and developing light-activated anticancer agents. Key research areas include: Design of ruthenium-based anticancer drugs with photodynamic properties Structure-activity relationships of metal complexes for targeted therapies Enzyme inhibition strategies for cancer treatment Development of fluorescent probes for cellular imaging Recent studies emphasize dual-action compounds combining enzyme inhibition and DNA/RNA targeting. His work has advanced light-activated drug delivery systems and improved understanding of hypoxic tumor responses. Dr. Heidary collaborates extensively with biochemists and clinicians to translate fundamental discoveries into clinical applications. Publications (2021-2025) highlight advancements in: Photocaged enzyme regulators Mitochondrial dysfunction mechanisms Subcellular localization of molecular rotors CYP1B1/P450 inhibition strategies No specific awards or grants are explicitly mentioned in the provided text.

• Acute Respiratory Distress Syndrome (ARDS)
• Sepsis
• Critical Care Medicine
• +۳ مورد دیگر

Carolyn Calfee, MD, MAS is a Professor in Residence of Medicine and Anesthesia at the University of California, San Francisco (UCSF). She attends at Moffitt-Long Hospital's intensive care units and leads research on ARDS, sepsis, and lung injury mechanisms. Her roles include Principal Investigator for multiple NIH grants and memberships in UCSF’s Center for Tobacco Control Research and Education, the Cardiovascular Research Institute (CVRI), and the UCSF Cancer Center. Education and Training: Carolyn Calfee earned her MD from the University of Pennsylvania School of Medicine and completed residency and chief residency in Internal Medicine at UCSF, followed by a Pulmonary/Critical Care fellowship and a MAS in Clinical Research at UCSF. She has undergone specialized training in Diversity, Equity, and Inclusion (2021). Research Interests: Her work focuses on molecular phenotyping of ARDS and sepsis for precision medicine, cigarette smoke exposure effects, and novel treatments for critical respiratory conditions. She employs multi-omic approaches, machine learning, and clinical trials (e.g., I-SPY COVID, COMET Consortium) to advance diagnostic and therapeutic strategies. Scientific Awards: None explicitly listed in the provided text. However, her leadership roles and research contributions reflect significant recognition in her field. Advising and Grants: As Principal Investigator, she leads grants such as NIH/NHLBI R35177135 (2025–2032) and NIH U01HL168415 (2023–2029). Her research also involves collaborations with institutions like the Cardiovascular Research Institute and teams like the COMET Consortium focused on critical illness subphenotypes. Labs and Teams: She directs the Calfee Lab, which investigates ARDS and sepsis biology. Active collaborations include the UCSF COMET Consortium, IMPACC Network, and I-SPY COVID adaptive platform trial. Her work integrates multi-omic data and clinical informatics for precision medicine applications.

Stephen Wilkieمشاهده پروفایل

پژوهشگر

• Cancer Metabolism
• Leukaemia Research
• Mitochondrial Biology
• +۳ مورد دیگر

Dr. Stephen Wilkie is a Research Associate at the Paul O'Gorman Leukaemia Research Centre, University of Glasgow, where he investigates metabolic vulnerabilities in leukaemic stem cells and mitochondrial biology in cancer models using genetic, pharmaceutical, and dietary interventions. His research centers on cancer metabolism , particularly serine and one-carbon metabolism in leukaemia, mitochondrial dynamics in lung adenocarcinoma, and hydrogen sulfide signaling in ageing and disease. Methodologies include metabolomic analysis, high-resolution respirometry, and single-cell RNA sequencing to identify therapeutic targets for leukaemia and age-related disorders. Recent publications (2020-2024) reveal a cohesive focus on metabolism-ageing-disease interplay, featuring hydrogen sulfide's role in liver function, genetic/dietary impacts on healthspan, and strain-specific metabolic responses in mouse models. This work bridges fundamental molecular mechanisms with translational applications in oncology and gerontology. Wilkie operates within the Paul O'Gorman Leukaemia Research Centre at Glasgow's Wolfson Wohl Building, a specialized facility dedicated to elucidating leukaemia pathogenesis and developing novel therapeutics through interdisciplinary metabolic research.

Fabien Delerueمشاهده پروفایل

پژوهشگر ارشد

• Genome Editing
• Gene Transfer Techniques
• Dementia Research
• +۳ مورد دیگر

Fabien Delerue is an Honorary Senior Research Fellow at the Dementia Research Centre (DRC) at Macquarie University, leading the Genome Editing at Macquarie (GEM) transgenic facility. He holds a MSc from the University of Bordeaux and a PhD from the University of Sydney. His career spans over 20 years in transgenesis, genome editing, and generating animal models of diseases. Affiliations: Macquarie Medical School, Dementia Research Centre (DRC) Roles: Head of GEM Transgenic Facility, Senior Lecturer (prior to 2018 at UNSW) His research focuses on optimizing genome editing techniques for dementia applications and investigating rare genetic disorders like FoxG1 syndrome. Current projects include developing assisted reproductive techniques, engineering endonucleases, and refining gene transfer methods for genetically modified animals. Key collaborations and funding include the FoxG1 Syndrome PhD Scholarship (2021–2025) and projects supported by the OOA_FoxG1 Foundation and NBR grants. His work has led to publications in journals such as Neuron , International Journal of Molecular Sciences , and Computational and Structural Biotechnology Journal .

Amy Si-Ying Leeمشاهده پروفایل

استادیار

• Protein Synthesis Regulation
• Virology
• Cellular Stress Response
• +۳ مورد دیگر

Amy Si-Ying Lee is an Assistant Professor of Cell Biology at Harvard Medical School (HMS) and holds a joint appointment at Dana-Farber Cancer Institute. She completed her Ph.D. in Virology at Harvard University (2012) and postdoctoral research at UC Berkeley. Her lab investigates mechanisms regulating mRNA translation in response to environmental signals, focusing on development, viral infection, and cellular stress. The lab employs an integrative approach combining biochemistry, cell biology, structural biology, and sequencing technologies. Key research interests include specialized mRNA translation pathways, ribosome dynamics, and their roles in disease contexts such as cancer and viral pathogenesis. Lee’s work bridges fundamental biology with translational applications, particularly in understanding how translational control governs cellular responses to stress and infection.

Anita Laytonمشاهده پروفایل

استاد

• Mathematical Biology
• Medicine
• Kidney Physiology
• +۷ مورد دیگر

Anita Layton is the Canada 150 Research Chair in Mathematical Biology and Medicine and a Professor of Applied Mathematics, Computer Science, Pharmacy, and Biology at the University of Waterloo. She holds leadership roles as Associate Dean, Research and International, in the Faculty of Mathematics and chairs the Research Equity, Diversity and Inclusion Council. Her research focuses on computational modeling of physiological systems, particularly kidney function, hypertension, diabetes, and circadian rhythms. Layton's interdisciplinary team collaborates with clinicians and engineers to address questions like drug efficacy differences between sexes and circadian-driven health outcomes. Education: PhD in Mathematics from the University of Toronto. Research interests include kidney physiology, biofluid dynamics, metabolic pathways in aging, and applying AI to medical challenges. Notable projects involve modeling sex differences in drug responses and developing tools for early autism detection via eye-gaze analysis. Awards include Fellow of the Association for Women in Mathematics (2022), Krieger-Nelson Prize (2021), and Royal Society of Canada Fellowship (2022). She edits journals like Hypertension and SIAM Review . Her lab hosts postdocs, graduate students, and undergraduates, with funded positions in computational biology and AI. Ongoing work includes kidney disease modeling, circadian rhythm impacts on health, and water quality analysis using machine learning.

• Cancer Biology
• Cell Signaling
• Genetic Disorders
• +۶ مورد دیگر

Professor Andrew Tee is a leading academic and researcher in Cardiff University's School of Medicine, Division of Cancer and Genetics. He holds a BSc (Hons) and PhD from the University of Dundee. His research focuses on mTOR signaling pathways, genetic disorders like Tuberous Sclerosis Complex (TSC), Birt-Hogg-Dubé (BHD), and Neurofibromatosis, and their implications in cancer biology. His work has led to clinical trials using mTOR inhibitors for TSC patients and explores novel therapies for sporadic cancers. Key research interests include understanding how mutations in tumor suppressor genes like TSC1/TSC2 and FLCN disrupt mTOR signaling, driving tumor formation and metabolic dysregulation. Recent projects investigate ferroptosis resistance in TSC2-deficient cells, transcriptomic/proteomic analysis of BHD syndrome, and biomarkers in Graves' Orbitopathy. Professor Tee's grants and collaborations include funding from the Tuberous Sclerosis Association, Myrovlytis Trust, and pharmaceutical companies like Apexian and GW/JAZZ. His lab includes postdoctoral researchers, PhD students, and technicians. Notable achievements include identifying mTOR's role in HIF-1α and STAT3 signaling and discovering therapeutic synergies with nelfinavir and bortezomib for TSC-related tumors. Scientific accolades include EMBO and BHF Fellowships, and he serves on editorial boards for Cancers and Seminars in Cell and Developmental Biology . His future work aims to translate rare disease insights into broader cancer therapies and predictive biomarker strategies.

Christopher W. Sundbergمشاهده پروفایل

استادیار

• Exercise Physiology
• Muscle Fatigue Mechanisms
• Aging and Neuromuscular Performance
• +۳ مورد دیگر

Christopher W. Sundberg, PhD, is an Assistant Professor of Exercise Science in the Department of Physical Therapy at Marquette University. He holds affiliate faculty status through the Athletic and Human Performance Research Center (AHPRC). His primary research focuses on mechanisms of muscle fatigue and neuromuscular performance limitations across aging and disease, employing integrative approaches from whole-limb to cellular/molecular levels. He investigates exercise adaptations to improve muscle power and fatigability in clinical populations. Education includes a B.S. and M.S. in Kinesiology from the University of Wyoming (2008, 2011), followed by a Ph.D. in Clinical and Translational Rehabilitation Health Science from Marquette University (2018). Postdoctoral training in skeletal muscle physiology with Dr. Robert Fitts preceded his faculty appointment in 2020. Research interests emphasize: Muscle fatigue etiologies (H+ and Pi ion effects, metabolic byproducts) Aging-related neuromuscular decline mechanisms Exercise interventions targeting muscle power Skeletal muscle bioenergetics and mitochondrial function His work has secured grants from NIH, NSF, NASA, and American Heart Association. Recent studies include case analyses of elite aging athletes and translational projects on blood flow restriction training. Laboratory investigations involve advanced techniques like single-fiber proteomics and contractile mechanics analysis. Teaching responsibilities include courses in human physiology, biomechanics, and instrumentation. Professional affiliations include the American Physiological Society and American College of Sports Medicine.

• Proteomics
• Bacterial Pathogenesis
• Cardiovascular Disease
• +۵ مورد دیگر

Professor Stuart Cordwell is a Professor of Analytical Biochemistry at the University of Sydney, co-appointed in the School of Life and Environmental Sciences and the School of Medical Sciences. He is the Academic Director of Sydney Mass Spectrometry and a member of the Charles Perkins Centre. His research focuses on protein post-translational modifications (PTMs) in bacterial and cardiovascular diseases, with significant contributions to proteomics and bacterial pathogenesis. He has published over 140 papers, including foundational work on the 'proteome' term, and holds an h-index of 49. His awards include the Selby Research Award (2006) and the VELUX Professorship (2009). Education: Graduated from the University of Sydney. Research Interests: Utilizing proteomics to study disease mechanisms, particularly bacterial pathogenesis (e.g., Campylobacter jejuni and Pseudomonas aeruginosa ), PTMs in cardiovascular disease, and vaccine targets. Current projects include N-linked glycosylation in pathogens, membrane protein cross-linking, and redox PTMs in biological systems. Recent articles highlight advancements in COPD microbiota modulation, Campylobacter acetylation, and ALS proteomics. He leads a research group with 6 PhD students and an Honours student, focusing on mass spectrometry methods and clinical pathology. Professional roles include Secretary-General of HUPO (2023-2025) and Past-President of the Australasian Proteomics Society.

William Kuang-Yao Panمشاهده پروفایل

استاد

• Environmental Health
• Epidemiology
• Global Health
• +۶ مورد دیگر

William Kuang-Yao Pan is a Professor of Global Environmental Health Research and Population Studies at Duke University, with a joint appointment between the Duke Global Health Institute (DGHI) and the Nicholas School of the Environment. He is also an Adjunct Professor at the Johns Hopkins Bloomberg School of Public Health. His research focuses on the intersection of human-environment dynamics and health in low- and middle-income countries, particularly in Latin America and the Amazon region. Research Interests: Dr. Pan’s work addresses mercury and chemical exposures from artisanal gold mining, vector-borne disease forecasting (e.g., malaria), migration’s role in disease transmission, lead exposure in indigenous communities, and the benefits of nature-based solutions like agroforestry. His methods include spatial analysis, biostatistics, and interdisciplinary collaboration. Grants & Projects: Current initiatives include developing malaria early warning systems, evaluating mercury-free gold supply chains, and assessing climate impacts on disease risk. He leads projects funded by NIH, USAID, and other agencies. Courses: Teaches courses on One Health, environmental epidemiology, and population-environment dynamics at Duke. Examples include One Health: From Philosophy to Practice and Population and Environmental Dynamics Influencing Health . Key Contributions: His team’s research on mercury exposure in Peruvian Amazon communities influenced national policy changes. He collaborates with global partners to build capacity for disease surveillance and environmental health interventions.

David Frielمشاهده پروفایل

دانشیار

• Calcium homeostasis
• Electrophysiology
• Ion channels
• +۷ مورد دیگر

David Friel, PhD is an Associate Professor in the Department of Neurosciences at Case Western Reserve University School of Medicine. His research focuses on calcium homeostasis mechanisms in neurons, ion channel function, and mitochondrial regulation of calcium signals. He has authored over 28 publications in neuroscience and cell biology, with notable work on P/Q-type calcium channel mutations in cerebellar ataxia models and computational modeling of calcium regulatory networks. His research combines experimental and theoretical approaches to understand how cells process information through calcium signaling pathways. Key research areas include: calcium-induced calcium release mechanisms, mitochondrial-calcium interactions, and the role of calcium channels in synaptic transmission. His recent work (2021) explores innovative medical education strategies for teaching diagnostic reasoning to students. He holds an office at Robbins Building 740D and can be reached at David.Friel@case.edu. Publications span topics from cerebellar Purkinje cell physiology (2007-2010) to mitochondrial calcium dynamics in sympathetic neurons (2000). His work has implications for understanding neurological disorders linked to calcium regulatory dysfunction. No awards are explicitly listed, but his extensive publication record indicates sustained academic contribution.