Carolyn Calfee

Carolyn Calfee, MD, MAS is a Professor in Residence of Medicine and Anesthesia at the University of California, San Francisco (UCSF). She attends at Moffitt-Long Hospital's intensive care units and leads research on ARDS, sepsis, and lung injury mechanisms. Her roles include Principal Investigator for multiple NIH grants and memberships in UCSF’s Center for Tobacco Control Research and Education, the Cardiovascular Research Institute (CVRI), and the UCSF Cancer Center.

Education and Training: Carolyn Calfee earned her MD from the University of Pennsylvania School of Medicine and completed residency and chief residency in Internal Medicine at UCSF, followed by a Pulmonary/Critical Care fellowship and a MAS in Clinical Research at UCSF. She has undergone specialized training in Diversity, Equity, and Inclusion (2021).

Research Interests: Her work focuses on molecular phenotyping of ARDS and sepsis for precision medicine, cigarette smoke exposure effects, and novel treatments for critical respiratory conditions. She employs multi-omic approaches, machine learning, and clinical trials (e.g., I-SPY COVID, COMET Consortium) to advance diagnostic and therapeutic strategies.

Scientific Awards: None explicitly listed in the provided text. However, her leadership roles and research contributions reflect significant recognition in her field.

Advising and Grants: As Principal Investigator, she leads grants such as NIH/NHLBI R35177135 (2025–2032) and NIH U01HL168415 (2023–2029). Her research also involves collaborations with institutions like the Cardiovascular Research Institute and teams like the COMET Consortium focused on critical illness subphenotypes.

Labs and Teams: She directs the Calfee Lab, which investigates ARDS and sepsis biology. Active collaborations include the UCSF COMET Consortium, IMPACC Network, and I-SPY COVID adaptive platform trial. Her work integrates multi-omic data and clinical informatics for precision medicine applications.