Aleksandra Leligdowicz

Roles and Affiliations: Aleksandra Leligdowicz is an Assistant Professor and Scientist at Western University's Schulich School of Medicine & Dentistry, Department of Medicine, Division of Critical Care Medicine. She is affiliated with Robarts Research Institute, where her lab focuses on immune regulation in critical illness. Her work bridges clinical practice and translational research in sepsis and ARDS.

Education:

• MD: McGill University, Canada
• PhD: University of Oxford, UK (Human HIV Immunology)
• Residencies: Internal Medicine (UBC), Critical Care (UofT)
• Postdoctoral Fellowships: UCSF (Translational Biology), University of Toronto (Translational Biology)

Research Interests: Dr. Leligdowicz investigates immune dysregulation and endothelial injury in sepsis and ARDS. Her lab uses cellular/molecular tools to study patient samples, aiming to develop precision medicine strategies. Key areas include endotoxin tolerance, biomarker discovery, and translational studies leveraging omics technologies. "Immune response heterogeneity in critically ill patients drives her focus on personalized treatment approaches."

Articles Trends: Her recent work emphasizes subphenotyping critical illnesses through machine learning and metagenomics, identifying immune-endothelial interactions in sepsis/ARDS. Collaborations highlight translational applications of biomarkers (e.g., suPAR, IL-6) in clinical decision-making.

Awards:

• CIHR Banting Postdoctoral Fellowship (2015-2018)
• University of Toronto Clinician Scientist Training Program (2015-2020)

Grants/Advising: Leads NIH-funded projects on sepsis heterogeneity and ARDS mechanisms. Advises on clinical trials integrating biomarker-driven therapies. Mentors trainees in translational critical care research.

Labs/Teams: Director of the Leligdowicz Lab at Robarts Research Institute. Collaborates globally on initiatives like the IMPACC study and sepsis phenotyping consortia.