Michael Matthay

Michael Matthay, MD is a Professor at the University of California, San Francisco (UCSF) School of Medicine, specializing in Critical Care Medicine and Pulmonary Diseases. His work focuses on Acute Respiratory Distress Syndrome (ARDS), Sepsis, and Mesenchymal Stromal Cell (MSC) Therapies.

• Education:
  • MD, University of Pennsylvania (1973)
  • Fellowship, Cardiovascular Research Institute, UCSF (1979)
  • Fellowship, Pulmonary Division, UCSF (1978)

Research Interests encompass ARDS pathogenesis, MSC-based therapies, sepsis heterogeneity, and lung injury biomarkers. His publications analyze inflammatory phenotypes, viral-bacterial interactions in critical illness, and clinical trial designs for personalized ARDS treatment.

Scientific Awards include the Edward Livingston Trudeau Medal (2014), Lifetime Achievement in Mentoring (UCSF, 2013), and Julius Comroe Award (American Physiologic Society, 2009). He has led major trials like the ASTER and ISPY COVID adaptive platform studies.

His lab investigates lung epithelial biology, endothelial dysfunction, and immune-microbiome interactions in ARDS. Current work explores vitamin E acetate toxicity, neutrophil reduction in pneumonia, and elective ventilation strategies for organ donors.