جستجوی استاد راهنمای دانشگاهی

Prof. Torsten Ochsenreiter is a Group Leader at the Institute of Cell Biology, University of Bern, and part of the Multidisciplinary Center for Infectious Diseases (MCID). His research focuses on molecular parasitology, particularly on trypanosomes and malaria parasites, utilizing advanced microscopy techniques to study fundamental biological processes. His primary research interests include mitochondrial biogenesis, kinetoplast genome maintenance, RNA editing mechanisms, and cytoskeletal dynamics in Trypanosoma brucei . He investigates how mitochondrial DNA is segregated during cell division and how post-translational modifications regulate parasite transmission. His work bridges cell biology, structural biology, and infectious disease research to understand pathogenic mechanisms in neglected tropical diseases. Analysis of his recent publications reveals a consistent focus on the tripartite attachment complex (TAC), mitochondrial genome inheritance, and expansion microscopy applications. His research demonstrates how structural adaptations in parasite organelles enable survival and transmission, with significant implications for developing novel therapeutic strategies against African sleeping sickness and malaria. No scientific awards were mentioned in the provided text. Prof. Ochsenreiter advises students and leads an active research team at the University of Bern. The Ochsenreiter lab provides opportunities for undergraduate and graduate students to engage in cutting-edge parasitology research, though specific grant funding details were not provided in the text. The Ochsenreiter lab operates within the Institute of Cell Biology and specializes in molecular parasitology techniques including expansion microscopy, cryo-electron tomography, and genetic manipulation of trypanosomes. The team investigates mitochondrial biology and cytoskeletal organization to uncover vulnerabilities in parasite life cycles.

• Molecular Parasitology
• Mitochondrial Biogenesis
• Protozoan Parasites
• +۵ مورد دیگر

Francesco Stellacci is a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL), where he holds the Alcan EP Chair and leads the Supramolecular Nanomaterials and Interfaces Laboratory (SUNMIL). He is affiliated with the School of Engineering (STI) and the Institute of Materials (IMX), with additional appointments in the Institute of Bioengineering (IBI-STI). Stellacci also serves on the EPFL Academic Strategic Committee and the Research Awards Commission, and is a committee member for the Doctoral Program in Materials Science and Engineering. Stellacci's research focuses on the complex interactions between supramolecular assemblies and their molecular surroundings, with particular emphasis on: Nanomaterials and Nanoparticles Soft Materials and Supramolecular Interactions Solid-Liquid Interfaces Nanomedicine and Antiviral Applications His recent work demonstrates a strong trend toward biomedical applications of nanomaterials, particularly in antiviral therapies, drug delivery systems, and diagnostic tools. Stellacci's laboratory has pioneered research on supramolecular interfaces with nanoscale domains, leading to innovative approaches in viral inhibition, protein delivery, and sustainable materials. His publications reveal a consistent focus on the physical and chemical properties of nanomaterials and their interactions with biological systems, with increasing emphasis on practical applications in healthcare and sustainability. Among his notable scientific achievements are: Technology Review TR35 "35 Innovators under 35" award (2005) Popular Science Magazine "Brilliant 10" award (2007) Packard Fellowship (2005) Stellacci has been instrumental in developing novel methodologies for nanoparticle characterization and application, with particular expertise in supramolecular nanostructures. His work bridges fundamental materials science with practical biomedical applications, as evidenced by numerous patents and translational research projects. He has supervised multiple doctoral students whose theses reflect the interdisciplinary nature of his research program, spanning from fundamental nanoscience to applied biomedical engineering. Stellacci's laboratory (SUNMIL) serves as a hub for interdisciplinary research, bringing together expertise from materials science, chemistry, biology, and engineering to address challenges in nanomedicine and sustainable technologies.

• Nanomaterials
• Nanoparticles
• Soft Materials
• +۷ مورد دیگر

Christoph Handschin is a Full Professor in Pharmacology at the Biozentrum, University of Basel, Switzerland , with a research focus on skeletal muscle plasticity, aging, and metabolic diseases since 2015. He leads a research group investigating molecular mechanisms of muscle adaptation to physiological and pathophysiological conditions. Education: PhD in Biochemistry (summa cum laude, 2001), MSc in Molecular Biology (1996), Voluntary training at Novartis (1992) Research Interests span skeletal muscle biology, aging, exercise physiology, neuromuscular diseases, and metabolic disorders. His work emphasizes PGC-1α signaling, mitochondrial dynamics, and chromatin remodeling in muscle adaptation. Recent studies explore exercise-induced chromatin changes, biomarkers of aging, and dysferlinopathy mechanisms. Key Scientific Awards include the ERC Consolidator Grant (2013) , SNSF Professorship (2006) , and MDA Scientist Career Development Award (2004) . He is a member of the American Physiological Society and European Association for the Study of Diabetes. Recent Articles highlight breakthroughs in chromatin accessibility , functional aging biomarkers , dysferlinopathy metabolism , and PGC-1α-driven muscle adaptations . His research bridges molecular mechanisms (e.g., Klf5, PER2) with systemic physiology (e.g., exercise performance, sarcopenia).

• Skeletal Muscle Biology
• Exercise Physiology
• Aging and Age-Related Diseases
• +۴ مورد دیگر

Patricia Boya is a Full Professor in the Department of Medicine at the University of Fribourg, within the Faculty of Mathematics, Natural Sciences and Medicine. She is a leading researcher in autophagy, mitophagy, and lysosomal biology, with a focus on retinal and neurodegenerative diseases. Her research interests center on the molecular mechanisms of autophagy and mitophagy, particularly their roles in retinal health, aging, neurodegeneration, and cell death. She investigates how mitochondrial dynamics, lysosomal function, and autophagic flux contribute to diseases such as retinitis pigmentosa, glaucoma, ALS, and Parkinson’s. Her work combines molecular biology, cell imaging, and preclinical models to uncover therapeutic targets. The analysis of her recent publications reveals a strong focus on mitophagy regulation, neuroinflammation (especially via the cGAS/STING pathway), and the development of neuroprotective compounds. She has contributed to high-impact reviews and guidelines in autophagy research, and her work spans fundamental mechanisms to translational applications. She is actively involved in scientific leadership, including the "Women in Autophagy" initiative to promote gender equity in science and the "DRIVE" international PhD training program in autophagy. Dr. Boya has published over 150 articles in top journals including Nature , Nature Communications , Autophagy , and Cell Death & Disease . Her work is highly collaborative, involving interdisciplinary teams across Europe. She leads a research group focused on cellular recycling mechanisms and their implications for vision and aging, contributing significantly to the understanding of autophagy in health and disease.

• Autophagy
• Mitophagy
• Retinal Degeneration
• +۷ مورد دیگر

Professor Alfredo Franco-Obregón is a Research Associate Professor at the National University of Singapore (NUS), with multiple appointments across the Yong Loo Lin School of Medicine. He holds positions in the Department of Surgery and the Department of Physiology, and is affiliated with the Institute for Health Innovation & Technology, the Healthy Longevity Translational Research Programme, the NUS Centre for Cancer Research, and the Nanomedicine Translational Research Programme. He leads the Biolonic Currents Electromagnetic Pulsing Systems (BICEPS) Laboratory, which focuses on developing non-invasive electromagnetic technologies to enhance muscle function and systemic health, particularly for aging populations and those with mobility limitations. Dr. Franco-Obregón's research centers on understanding how biophysical forces, particularly mechanical and electromagnetic stimuli, translate into tissue regeneration and survival. His work specifically investigates the role of Transient Receptor Potential (TRP) channels, particularly TRPC1, in skeletal muscle development and how magnetic fields can activate mitochondrial respiration through a process he terms "Magnetic Mitohormesis." This research has significant implications for metabolic health, cancer therapy, and aging interventions. His laboratory has demonstrated that brief (10-minute) weekly exposure to low-energy pulsed electromagnetic fields (PEMFs) can enhance muscle development, improve metabolic efficiency, and even produce anticancer effects through the activation of muscle secretome responses. His recent publication record demonstrates a strong focus on translating these findings into clinical applications, with numerous randomized controlled trials examining the effects of PEMF therapy on conditions including knee osteoarthritis, Achilles tendinopathy, metabolic disorders, and breast cancer. His research bridges fundamental cellular mechanisms with practical clinical applications, showing how magnetic field exposure can serve as a non-invasive exercise mimetic for populations unable to engage in physical activity. 2020: Innovation of the Year Product Winner by the Ageing Asia World Ageing Festival (for QuantumTx) 2015: Wong Hock Boon Society Best Mentor Award (NUS) 2008: Goldenen Eule (The Golden Owl Excellence in Teaching Award) (ETH) 1990: Martin Luther King Mentorship Award (UCSF) Dr. Franco-Obregón is actively engaged in mentoring students and collaborating on international research projects. He has established the BICEPS Laboratory as a hub for interdisciplinary research, bringing together engineers, clinicians, and basic scientists. His work has led to the founding of QuantumTx Pte. Ltd., a NUS spin-off company developing magnetic therapeutic devices, and he is currently conducting human clinical trials in Singapore, China, Southeast Asia, and the US to evaluate the efficacy of his magnetic therapeutic platforms. The BICEPS Laboratory operates at the intersection of engineering and clinical medicine, with a mission to develop non-invasive technologies that enhance muscle function and bioenergetics. The lab's research has significant potential to transform clinical practice, particularly in preventative medicine and rehabilitation. Dr. Franco-Obregón is also working to establish international collaborations, including potential student exchange programs between ETH/UZH and NUS, to further advance this field of research.

• Regenerative Medicine
• Mechanobiology
• Electromagnetics
• +۱۱ مورد دیگر

Dr. Dieter Kressler is a Senior Researcher at the Department of Biology , Faculty of Science and Medicine , University of Fribourg. Holding a PhD and serving as head of the proteomics platform , his work focuses on the molecular mechanisms of eukaryotic ribosome biogenesis. Email: dieter.kressler@unifr.ch ORCID: 0000-0003-4855-3563 Contact: +41 26 300 8645 Location: PER 05 building, Fribourg Research Interests include: Dedicated chaperones for ribosomal proteins Co-translational regulation of ribosomal protein expression Ubiquitin signaling in ribosome assembly RNA helicase roles in pre-ribosomal particles Structural dynamics of ribosome maturation Stress response coupling to translational control His 15 most recent publications (2025-2016) reveal a consistent focus on ribosome biogenesis, with key articles in eLife , Nature Communications , and Nucleic Acids Research . Research spans from thermal avoidance circuits in C. elegans to ubiquitin fusion mechanisms in yeast ribosomes , integrating structural biology, genetics, and biochemical approaches.

• Ribosome biogenesis
• Molecular Biology
• Genetics
• +۵ مورد دیگر

Gabriel Neurohr serves as Assistant Professor in the Department of Biology at ETH Zurich, Switzerland, where he leads research on the physiological consequences of cell size dysregulation. His work bridges fundamental cell biology with implications for aging and cancer, investigating how deviations from species-specific cell size norms disrupt cellular homeostasis. Academic training includes a BSc in Biochemistry from ETH Zurich (2003-2006), PhD at Barcelona's Center for Genomic Regulation (2008-2012), and postdoctoral fellowship at MIT's Koch Institute (2013-2020). His research program addresses four core questions: (1) functional size limits of cells, (2) size-senescence relationships, (3) macromolecule-volume coordination, and (4) density-dependent functional impacts, employing genetic, live-imaging, and computational approaches in yeast and mammalian systems. Recent publications reveal a methodological evolution toward quantitative analysis, with machine-learning-enhanced imaging (2023) complementing mechanistic studies linking genome instability to size-induced senescence (2023). His 2024 work establishes cell enlargement as a primary driver of senescence through cytoplasmic dilution and organelle dysfunction, demonstrating conserved principles across eukaryotes. Major recognitions include: SNF Eccellenza Fellowship (2020-2025) EMBO Long Term Fellowship (2013-2014) ETH Medal for Master's excellence (2008) Neurohr's lab develops innovative tools like holotomography-based vacuole quantification while maintaining focus on fundamental size-regulation mechanisms. He teaches advanced courses on biomolecular condensates and cellular matter properties, mentoring through ETH's structured graduate programs. Current work explores therapeutic targeting of size-dependent senescence pathways in age-related diseases.

• Cell Size Regulation
• Cellular Senescence
• Aging Mechanisms
• +۳ مورد دیگر

Johan Auwerx is a Full Professor at the École Polytechnique Fédérale de Lausanne (EPFL), leading the Laboratory of Integrative and Systemic Physiology (LISP) within the School of Life Sciences (IBI-SV). His research focuses on metabolism, genetics, and aging, with a particular emphasis on mitochondrial function and systemic physiology. He oversees doctoral programs in Life Sciences Engineering and supervises numerous PhD students, contributing significantly to translational research in metabolic disorders and aging-related diseases. Key research areas include systems biology approaches to metabolic health, genetic determinants of lifespan, and the development of therapeutic strategies targeting mitochondria and cellular stress responses. His lab has pioneered studies on NAD+ metabolism, lysosomal surveillance, and the impact of dietary interventions on healthspan. Collaborative projects involve multi-omics integration and systems genetics to unravel disease mechanisms and identify novel therapeutic targets. Dr. Auwerx has published extensively on topics such as mitochondrial dysfunction in aging, the role of ceramides in sarcopenia, and the application of natural compounds like urolithins to enhance mitochondrial health. His work bridges fundamental research and clinical translation, aiming to improve treatments for metabolic, neurodegenerative, and age-related conditions. He is actively involved in academic governance at EPFL, contributing to educational programs and research policy.

• Metabolic disorders
• Genetics
• Systems biology
• +۵ مورد دیگر

Dr. Gaëlle Audrey Lentini is a Group Leader at the Institute of Cell Biology , University of Bern, and a member of the Multidisciplinary Center for Infectious Diseases (MCID) . Her research focuses on the molecular mechanisms of host cell exit by the parasite Trypanosoma cruzi , which causes Chagas disease, and her work bridges the fields of Cellular Microbiology , Parasitology , and Host-Pathogen Interactions . Research Interests Dr. Lentini investigates the egress strategies of intracellular pathogens, particularly Trypanosoma cruzi , emphasizing the roles of cytoskeletal dynamics and molecular players in host cell lysis. Her work combines genetic manipulation and mass spectrometry to identify parasite-specific mechanisms critical to disease progression. Publications and Collaborations Her publications span key aspects of apicomplexan parasite biology, including rhoptry discharge, cytokinetic abscission, and lipid kinase functions. Recent studies (2024) highlight her contributions to Toxoplasma gondii invasion and ceramide biosynthesis in intracellular niche formation. Labs and Teams Dr. Lentini leads the Lentini Lab within the Ochsenreiter Lab framework at the University of Bern, focusing on pathogenesis and host cell interactions.

• Molecular Parasitology
• Host-Pathogen Interactions
• Cellular Microbiology
• +۳ مورد دیگر

Pei-Hsuan Wu is an Assistant Professor at the University of Geneva, Faculty of Medicine, within the Department of Genetic Medicine and Development. Her research focuses on germline small non-coding RNAs (piRNAs), mRNA regulation, and RNA-binding proteins in male reproduction and embryonic development. B.Sc. in Biology from Boston University Ph.D. in Molecular Biology from Northwestern University Research spans spermatogenesis , sperm function , and epigenetic paternal contributions to embryos, utilizing mouse models , CRISPR/Cas9, sequencing, and bioinformatics. Key collaborations include networks like iGE3, NCCR RNA & Disease, and ANDRONET Cost Action. Recent publications emphasize piRNA mechanisms, transposon silencing, and evolutionary conservation of small RNA loci. Her work is funded by the PRIMA Grant from the Swiss National Science Foundation. She leads a team including Giulia Perillo, Keigo Shibata, Salman Shehzada, Marcelle Varona Darques, and María Eugenia Gil Diaz, supported by former member Tanya Sedupathy. PRIMA Grant (Swiss National Science Foundation)

• RNA Biology
• Genetics
• Molecular Biology
• +۳ مورد دیگر

Nenad Ban is a Professor at ETH Zurich leading the Ban Lab, which investigates ribosome structure and functional complexes through biochemistry, X-ray crystallography, and electron microscopy. The lab focuses on protein synthesis mechanisms across prokaryotic, eukaryotic, and mitochondrial systems, alongside large cellular assemblies like fatty acid synthases. Research spans four core domains: Prokaryotic Protein Synthesis : Structural analysis of ribosomal subunits with translation factors Eukaryotic Ribosome : Interactions with eukaryotic-specific regulatory factors controlling translation Mitochondrial Ribosome : Evolutionary structural adaptations and functional mechanisms Large Assemblies : Fatty acid synthases as paradigms for complex multi-enzyme systems Techniques include cutting-edge cryo-EM and crystallography to resolve molecular mechanisms at atomic resolution. Recent publications (2021-2023) reveal critical insights into viral translation interference (SARS-CoV-2 frameshifting/Nsp1 shutdown), mitochondrial translation termination, ER protein biogenesis, and ribosome assembly. These studies demonstrate the lab's expertise in linking structural data to functional consequences across diverse biological contexts. Professor Ban mentors PhD students Maša Predin (joined September 2023) and Dominik Schuntermann (joined April 2023). The lab welcomed EMBO Fellow Elena Lavdovskaia as a PostDoc in July 2024, reflecting strong trainee development and competitive grant acquisition. Based at ETH Zurich's Hönggerberg campus, the Ban Lab maintains an active research environment with ongoing projects on co-translational targeting, mitochondrial ribosome maturation, and viral translation mechanisms. The group utilizes 3D animation and conference presentations to disseminate findings and recruits through open positions for PhD and postdoctoral roles.

• Structural Biology
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Florent Waltz is an SNSF Ambizione Project Leader hosted at the University of Basel's Biozentrum within the Engel Lab, leading research on mitochondrial architecture in photosynthetic organisms using cutting-edge cryo-electron tomography. His work bridges structural biology, evolutionary studies, and cellular energy metabolism with a focus on green micro-algae like Chlamydomonas reinhardtii. His research program explores three interconnected themes: (1) visualizing mitochondrial architecture and remodeling using cryo-ET to understand energy production under environmental changes; (2) investigating mitochondrial evolution across eukaryotes with emphasis on photosynthetic organisms; and (3) examining molecular-level interactions between mitochondria and chloroplasts. His March 2025 Science publication on the in-cell architecture of the mitochondrial respiratory chain represents a landmark achievement in visualizing molecular machines within native cellular contexts. Waltz co-developed TomoGuide, an online resource for cryo-ET workflows, and contributed to major datasets like the 1,829-tomogram Chlamydomonas resource enabling community-driven visual proteomics. His technical innovations include MemBrain v2 for membrane analysis in cryo-ET data. SNSF Ambizione Fellowship (major Swiss early-career award) Featured on Science magazine cover (March 2025) Key contributor to open science resources for cryo-ET community As a collaborative researcher, Waltz participates in international consortia studying mitochondrial biology, plant systems, and cryo-ET methodology development. His work has established new standards for in situ structural analysis of energy-producing organelles while advancing open science through public data sharing and software tools.

• Mitochondrial Biology
• Cryo-Electron Tomography
• Photosynthetic Organisms
• +۳ مورد دیگر

Prof. Anne Spang is a Professor at the Biozentrum, University of Basel, where she leads a research group focused on understanding the fundamental mechanisms of intracellular organization. Her laboratory investigates molecular transport processes, RNA localization, and cellular responses to stress. Dr. Spang received her education at several prestigious institutions: Graduate student at the Max Planck Institute for Biochemistry, Genecenter, Martinsried, Germany (1992-1996) Studied Biochemistry at the University Pierre et Marie Curie, Paris VI, Paris, France (1990-1991) Studied Chemical Engineering at the University of Applied Science Darmstadt, Germany (1986-1990) Her research primarily focuses on the laws of organization in the cell, particularly molecular transport processes that ensure proper distribution of proteins and RNA molecules. Dr. Spang's work examines intracellular transport between the Golgi apparatus and the plasma membrane, endosome maturation, mRNA localization and stability, and cellular responses to various stress conditions. Her research has significant implications for developmental biology, stem cell research, and understanding cancer mechanisms related to cell polarity loss. Analysis of Dr. Spang's recent publications reveals a strong focus on endosomal maturation processes, protein folding mechanisms, and the cellular response to stress. Her work bridges fundamental cell biology with potential therapeutic applications, particularly in RNA-based therapies and understanding organelle communication. The research demonstrates sophisticated understanding of membrane trafficking, protein quality control systems, and the organization of cellular compartments. Dr. Spang has received numerous prestigious awards recognizing her contributions to cell biology, including the Lelio Orci Award (2025), election as a Fellow of the American Association for the Advancement of Sciences (2025), membership in the German National Academy of Sciences Leopoldina (2021), and the ASCB Fellow award (2020). As a dedicated researcher and mentor, Dr. Spang serves on editorial boards including Molecular Biology of the Cell and Traffic. Her laboratory actively collaborates with pharmaceutical companies like Roche and engages in cutting-edge research that bridges basic science with potential therapeutic applications, particularly in RNA-based therapies and understanding cellular responses to stress. The Spang Lab maintains active presence on social media platforms including Bluesky and Twitter, sharing their research findings and laboratory activities. The lab also participates in collaborative research initiatives such as the NCCR RNA & Disease, a Swiss National Center of Competence in Research focusing on RNA's role in disease mechanisms.

• Molecular Transport Processes
• Intracellular Transport
• RNA Localization
• +۶ مورد دیگر