Alfredo Franco-Obregón

Professor Alfredo Franco-Obregón is a Research Associate Professor at the National University of Singapore (NUS), with multiple appointments across the Yong Loo Lin School of Medicine. He holds positions in the Department of Surgery and the Department of Physiology, and is affiliated with the Institute for Health Innovation & Technology, the Healthy Longevity Translational Research Programme, the NUS Centre for Cancer Research, and the Nanomedicine Translational Research Programme. He leads the Biolonic Currents Electromagnetic Pulsing Systems (BICEPS) Laboratory, which focuses on developing non-invasive electromagnetic technologies to enhance muscle function and systemic health, particularly for aging populations and those with mobility limitations.

Dr. Franco-Obregón's research centers on understanding how biophysical forces, particularly mechanical and electromagnetic stimuli, translate into tissue regeneration and survival. His work specifically investigates the role of Transient Receptor Potential (TRP) channels, particularly TRPC1, in skeletal muscle development and how magnetic fields can activate mitochondrial respiration through a process he terms "Magnetic Mitohormesis." This research has significant implications for metabolic health, cancer therapy, and aging interventions. His laboratory has demonstrated that brief (10-minute) weekly exposure to low-energy pulsed electromagnetic fields (PEMFs) can enhance muscle development, improve metabolic efficiency, and even produce anticancer effects through the activation of muscle secretome responses.

His recent publication record demonstrates a strong focus on translating these findings into clinical applications, with numerous randomized controlled trials examining the effects of PEMF therapy on conditions including knee osteoarthritis, Achilles tendinopathy, metabolic disorders, and breast cancer. His research bridges fundamental cellular mechanisms with practical clinical applications, showing how magnetic field exposure can serve as a non-invasive exercise mimetic for populations unable to engage in physical activity.

• 2020: Innovation of the Year Product Winner by the Ageing Asia World Ageing Festival (for QuantumTx)
• 2015: Wong Hock Boon Society Best Mentor Award (NUS)
• 2008: Goldenen Eule (The Golden Owl Excellence in Teaching Award) (ETH)
• 1990: Martin Luther King Mentorship Award (UCSF)

Dr. Franco-Obregón is actively engaged in mentoring students and collaborating on international research projects. He has established the BICEPS Laboratory as a hub for interdisciplinary research, bringing together engineers, clinicians, and basic scientists. His work has led to the founding of QuantumTx Pte. Ltd., a NUS spin-off company developing magnetic therapeutic devices, and he is currently conducting human clinical trials in Singapore, China, Southeast Asia, and the US to evaluate the efficacy of his magnetic therapeutic platforms.

The BICEPS Laboratory operates at the intersection of engineering and clinical medicine, with a mission to develop non-invasive technologies that enhance muscle function and bioenergetics. The lab's research has significant potential to transform clinical practice, particularly in preventative medicine and rehabilitation. Dr. Franco-Obregón is also working to establish international collaborations, including potential student exchange programs between ETH/UZH and NUS, to further advance this field of research.