Johan Auwerx

Johan Auwerx is a Full Professor at the École Polytechnique Fédérale de Lausanne (EPFL), leading the Laboratory of Integrative and Systemic Physiology (LISP) within the School of Life Sciences (IBI-SV). His research focuses on metabolism, genetics, and aging, with a particular emphasis on mitochondrial function and systemic physiology. He oversees doctoral programs in Life Sciences Engineering and supervises numerous PhD students, contributing significantly to translational research in metabolic disorders and aging-related diseases.

Key research areas include systems biology approaches to metabolic health, genetic determinants of lifespan, and the development of therapeutic strategies targeting mitochondria and cellular stress responses. His lab has pioneered studies on NAD+ metabolism, lysosomal surveillance, and the impact of dietary interventions on healthspan. Collaborative projects involve multi-omics integration and systems genetics to unravel disease mechanisms and identify novel therapeutic targets.

Dr. Auwerx has published extensively on topics such as mitochondrial dysfunction in aging, the role of ceramides in sarcopenia, and the application of natural compounds like urolithins to enhance mitochondrial health. His work bridges fundamental research and clinical translation, aiming to improve treatments for metabolic, neurodegenerative, and age-related conditions. He is actively involved in academic governance at EPFL, contributing to educational programs and research policy.