جستجوی استاد راهنمای دانشگاهی

Lindsey Backmanمشاهده پروفایل

پژوهشگر ارشد

• Microbiology
• Structural Biology
• Biochemistry
• +۴ مورد دیگر

Lindsey Backman is a Valhalla Fellow at Whitehead Institute for Biomedical Research where she leads the Backman Lab, focusing on protein structure and biochemistry in anaerobic bacteria within the human microbiome. She received her PhD in chemistry from MIT in 2022 and a bachelor's degree in chemistry, summa cum laude, from the University of Florida in 2015. Her research interests center on understanding how bacteria in the human microbiome protect enzymes essential for survival. The Backman Lab investigates competitive strategies bacteria employ to outcompete other microbes, with particular focus on glycyl radical enzymes (GREs) in anaerobic conditions. Her work explores how pathogens like Clostridioides difficile utilize specialized enzymes to consume niche nutrients and survive oxidative stress, potentially revealing new antibiotic targets. Dr. Backman's publication record demonstrates expertise spanning both microbiology/biochemistry (focusing on GRE mechanisms and bacterial metabolism) and cancer biology (examining ATM signaling pathways in breast cancer). Her research shows a consistent theme of investigating molecular mechanisms that enable organisms to survive in challenging environments. Scientific Honors: Paul T. Englund Emerging Scholar Award from Johns Hopkins School of Medicine (2023) MIT Hugh Hampton Young Fellowship (2021) Howard Hughes Medical Institute Gilliam Fellowship (2017) MIT Dept. of Chemistry's Award for Excellence in Teaching (2016) National Science Foundation Graduate Research Fellowship (2016) DOW Chemical Graduate Fellowship for Underrepresented Minorities (2015) During her graduate work at MIT under Catherine Drennan, she characterized hydroxyproline dehydratase (HypD), solving its first structures and proposing an enzymatic mechanism. Her undergraduate research included participation in HHMI's Exceptional Research Opportunities Program. At Whitehead Institute, her lab now explores how anaerobic pathogens thrive amidst oxidative stress, investigating bacterial microcompartments and enzyme repair systems as protective mechanisms.

Sarah Bagbyمشاهده پروفایل

استادیار

• Microbiology
• Environmental Science
• Evolutionary Biology
• +۳ مورد دیگر

Sarah Bagby is an Assistant Professor at Case Western Reserve University researching how environmental variables drive microbial and viral evolutionary innovations that reshape Earth's biogeochemical systems. Her primary research domains include: Microbiology Environmental Science Evolutionary Biology Bioinformatics Biogeochemistry Molecular Biology Her lab employs integrated methodologies including fieldwork to characterize in situ microbial communities, experimental ecology/microbiology to identify molecular innovations (e.g., cyanobacterial microcompartments, phage pigment pathways), and ecoinformatics to model ecosystem impacts. This work examines how pressure, temperature, irradiance, and fluid dynamics influence microbial membrane structures, energy harvesting, and genetic diversification mechanisms across temporal and spatial scales. Contact details: Office in Millis 109, phone 216-368-3213, email sarah.bagby@case.edu , and lab website bagby-lab.github.io .

Karin Buschمشاهده پروفایل

استاد

• Mitochondrial Dynamics
• Cellular Bioenergetics
• Oxidative Phosphorylation
• +۴ مورد دیگر

Prof. Karin Busch is a faculty member at the University of Münster, leading the Busch Lab: Cellular Bioenergetics within the Institute of Integrative Cell Biology and Physiology . Her research focuses on mitochondrial dynamics, bioenergetics, and spatiotemporal organization of membrane protein complexes, particularly in oxidative phosphorylation (OXPHOS) systems. She actively participates in interdisciplinary initiatives such as the Cells in Motion Interfaculty Centre and supervises the CiM-IMPRS Graduate Program . Her work combines advanced microscopy techniques (e.g., superresolution imaging, FLIM) to study mitochondrial ultrastructure and function in live mammalian cells. Key research themes include mitochondrial supercomplex assembly, cristae architecture, and their roles in cellular adaptation to metabolic stress and aging. Recent studies highlight the impact of mitochondrial dysfunction on neurodegenerative diseases and cardiac physiology. Prof. Busch collaborates extensively with groups like CALMOS and the Biophysics group/Osnabrück , refining fluorescent reporter systems and quantitative analysis tools. Her lab also explores mitochondrial signaling pathways, such as NF-κB activation via LUBAC platforms, linking mitochondrial biology to immune responses and cellular stress. Her advising and grant activities include mentoring over 20 graduate students and postdocs, many of whom have contributed to high-impact publications. Notable projects include studies on senescent cardiomyocytes, viral myocarditis models, and mitochondrial dynamics in neural cells.

• Nanopore Technology
• Molecular Dynamics Simulation
• DNA Sequencing
• +۳ مورد دیگر

Aleksei Aksimentiev is a Professor of Physics at the University of Illinois Urbana-Champaign, with affiliations in Bioengineering, the National Center for Supercomputing Applications (NCSA), Beckman Institute for Advanced Science and Technology, and the Carl R. Woese Institute for Genomic Biology. His research focuses on computational biophysics, molecular dynamics simulations, and nanopore technologies. Key research interests include: Nanopore-based DNA/RNA analysis and protein sequencing Molecular transport mechanisms in biological systems Biomolecular structure and dynamics using high-performance computing Design of synthetic biological systems and biomaterials Notable achievements include: Development of all-atom molecular dynamics simulation frameworks for biomolecular systems NSF CAREER Award (2010) Contributions to understanding viral capsid structures and membrane protein interactions His work bridges computational modeling with experimental biophysics, addressing challenges in single-molecule analysis, synthetic biology, and biomedical engineering.

Todd O. Yeatesمشاهده پروفایل

استاد پژوهش

• Bacterial Microcompartments
• Protein Engineering
• Structural Biology
• +۵ مورد دیگر

Todd O. Yeates serves as a Research Professor in the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), where he leads an active laboratory at the UCLA-DOE Institute for Genomics and Proteomics. His research program integrates molecular, structural, and computational biology to address fundamental questions in protein architecture and function, with significant implications for nanotechnology and bioenergy applications. Professor Yeates' primary research interests include: Bacterial Microcompartments : Pioneering structural studies of protein-based metabolic organelles in bacteria, providing the first 3D views of shell proteins and mechanistic insights into substrate transport across microcompartments Synthetic Protein Design : Developing innovative strategies for engineering self-assembling protein cages, arrays, and nanomaterials with applications in nanotechnology and biomaterials Computational Genomics : Creating genomic context methods to infer protein function, including the discovery of disulfide bonding as a key stability mechanism in thermophilic archaea Protein Crystallography : Solving theoretical challenges in macromolecular crystallization, including space group preferences and racemic crystallography approaches Analysis of recent publications (2023-2025) reveals a dominant research trajectory toward engineered protein scaffolds for cryo-EM applications, with significant focus on overcoming resolution barriers for small proteins. Concurrently, his group continues advancing bacterial microcompartment research while integrating computational tools like AlphaFold for hybrid structure determination. The work demonstrates a consistent theme of bridging fundamental structural biology with practical nanotechnology applications through rational protein design. No scientific awards were documented in the available source materials. The Yeates laboratory maintains an active research program supported by institutional resources at UCLA, though specific grant details and advisee information are not provided in the source text. The laboratory's extensive publication record and methodological innovations suggest robust research infrastructure and mentorship activities within the department. Based at the UCLA-DOE Institute, the laboratory employs interdisciplinary approaches combining X-ray crystallography, cryo-EM, computational modeling, and synthetic biology. Current priorities include refining imaging scaffolds for structural biology, exploring fundamental principles of protein self-assembly, and applying genomic context methods to discover novel biological mechanisms, with ongoing emphasis on translating basic research into nanotechnology applications.

Millicent Sullivanمشاهده پروفایل

استاد

• Gene Delivery
• siRNA Delivery
• Biomaterials
• +۷ مورد دیگر

Millicent Sullivan is the Alvin B. and Julie O. Stiles Professor of Chemical & Biomolecular Engineering and Professor of Biomedical Engineering at the University of Delaware. She is affiliated with the Allan P. Colburn Laboratory and focuses on developing biomaterials and nanocarriers for nucleic acid and drug delivery in regenerative medicine. Her research addresses challenges in gene therapy, siRNA delivery, and targeted drug delivery for cancers and tissue repair. Dr. Sullivan holds a Ph.D. in Chemical Engineering from Carnegie Mellon University and a B.S. in Chemical Engineering from Princeton University. Her research interests include engineering polymer and peptide-based nanocarriers to target intracellular organelles, exploring stimuli-responsive materials for controlled drug release, and integrating growth factor delivery with wound repair mechanisms. She also investigates bioinspired systems like collagen-mimetic peptides and viral-like particles for therapeutic applications. Recent work highlights advancements in light-responsive nanocarriers, HBV protein particles for targeted delivery, and ECM turnover-stimulated gene transfer. Her lab’s innovations aim to enhance therapeutic efficacy while minimizing side effects in conditions like cancer and chronic wounds. Collaborations focus on interdisciplinary approaches combining chemical engineering, biomaterials science, and cell biology. Her lab’s website provides further details on ongoing projects and clinical translation efforts.

Juan Perillaمشاهده پروفایل

دانشیار

• Molecular Dynamics Simulations
• Structural Biology
• Virology
• +۴ مورد دیگر

Juan Perilla serves as Associate Professor of Chemistry & Biochemistry in the College of Arts & Sciences at the University of Delaware, where he leads computational research integrating biophysical chemistry, structural biology, and virology to investigate viral mechanisms at atomic resolution using advanced simulation methodologies. His educational trajectory includes a Ph.D. in Chemistry from Johns Hopkins University (2011), focusing on transition state theory for protein conformational changes, followed by postdoctoral training at the University of Illinois at Urbana-Champaign under Klaus Schulten, where he pioneered large-scale simulations of viral systems and cellular organelles. Research centers on multi-scale computational approaches spanning quantum mechanics to mesoscale modeling, with primary emphasis on HIV-1 capsid structure, dynamics, and host interactions. His group develops novel frameworks for petascale/exascale computing to simulate billion-atom biomolecular systems, integrating cryo-EM and NMR data for atomic-level insights into viral assembly, nuclear entry, and drug targeting mechanisms. Recent publication analysis reveals sustained focus on HIV capsid mechanics and viral replication cycles, with growing integration of machine learning for simulation analysis and efficient coarse-graining techniques. Key trends include elucidating capsid elasticity in nuclear transport, IP6-mediated assembly mechanisms, and resistance pathways for antiretroviral drugs through structural dynamics. No specific scientific awards or fellowships are documented in available sources. As principal investigator, Dr. Perilla mentors graduate students in computational biophysics while securing computational resources through grants enabling access to national supercomputing facilities including LANL Grizzly and TACC Frontera for billion-atom simulations. The Biophysical Chemistry Laboratory employs high-performance computing to analyze petabyte-scale simulation datasets, developing open-source tools for biomolecular container analysis while maintaining active collaborations with experimental virology groups to validate computational findings and drive therapeutic discovery.

Wade Winklerمشاهده پروفایل

استاد

• Bacterial Genetics
• RNA Biology
• Microbiology
• +۳ مورد دیگر

Wade Winkler is a Professor at the University of Maryland, College of Computer, Mathematical, and Natural Sciences, in the Department of Cell Biology and Molecular Genetics. He leads the Winkler Lab, which focuses on understanding bacterial regulatory RNAs and RNA-binding proteins. His research explores post-transcriptional mechanisms, particularly RNA degradation pathways and their roles in pathogenic microbes and antimicrobial development. Winkler earned his Ph.D. from The Ohio State University in 2002 and completed postdoctoral training at Yale University in 2004. He teaches courses including Principles of Microbiology (BSCI283), Microbial Genetics (BSCI412), and Teaching Science and Professional Development (BISI701). His work integrates structural biology, biochemistry, and genetics to uncover novel regulatory circuits in bacteria. Recent research highlights include studies on diribonucleotide-specific nucleases, RNA degradation bottlenecks, and bacterial microcompartment assembly. His lab’s findings contribute to synthetic biology applications and antimicrobial strategies.

Maria-Eirini Pandeliaمشاهده پروفایل

دانشیار

• Biochemistry
• Enzymology
• Metalloproteins
• +۶ مورد دیگر

Maria-Eirini Pandelia is an Associate Professor of Biochemistry at Brandeis University, affiliated with the Rosenstiel Basic Medical Sciences Research Center. Her research focuses on understanding the mechanisms of metalloproteins involved in critical biological processes, particularly those relevant to human health and environmental science. She employs a combination of spectroscopic methods (e.g., Mössbauer and EPR), structural biology, and bioinformatics to investigate enzyme catalysis and metallocofactor function. Education: B.S. in Physics (University of Patras, Greece), MSc in Applied Physics and Mathematics (National Technical University of Athens), Ph.D. in Biochemistry (Max-Planck Institute for Bioinorganic Chemistry/Technical University Berlin), and postdoctoral research at Pennsylvania State University. Research interests include iron-sulfur clusters, enzyme mechanism diversification within protein superfamilies, and the functional roles of metalloproteins in DNA synthesis/repair. Her lab studies medically relevant enzymes (e.g., hepatitis B virus HBx protein) and industrially relevant catalysts, using transient kinetic and redox techniques to characterize fleeting reaction intermediates. Awards: None explicitly listed. Grants and advising: Not detailed in provided texts, but her lab actively conducts interdisciplinary research with a focus on enzyme mechanisms and metalloprotein structures. Labs/Teams: Director of the Pandelia Lab, specializing in bioinorganic chemistry and enzymology. Collaborations include studies on hydrogenases, ribonucleotide reductases, and organophosphonate-degrading enzymes.

Richard Pickersgillمشاهده پروفایل

استاد

• Structural Biology
• Molecular Biology
• Microbiology
• +۳ مورد دیگر

Prof Richard Pickersgill is a Professor of Structural Biology at Queen Mary University of London's School of Biological and Behavioural Sciences. He leads research in the Centre for Molecular Cell Biology, focusing on structural biology, protein assembly mechanisms, and microbial systems. His work integrates experimental and computational methods to study bacterial microcompartments, type II secretion systems, and enzyme structures. Research interests include understanding protein self-assembly, bacterial metabolic pathways, and the structural basis of enzyme function. Notable projects investigate the architecture of bacterial microcompartments and their roles in encapsulating enzymes, as well as the assembly processes of secretion systems critical for bacterial pathogenesis. Prof Pickersgill has secured significant funding, including grants from the BBSRC and MRC, for projects like 'Structure of the assembly platform of the type II secretion system' and 'Vitamin scavenging in the gut.' He supervises PhD students, such as Minoosadat Tayebinia, and collaborates with researchers in structural biology and microbiology. Key achievements include publications on enzyme-cargo encapsulation, bacterial secretion systems, and structural studies of proteins involved in vitamin B12 biosynthesis. His research bridges fundamental biology with biotechnological applications, such as engineering protein assemblies for industrial use.

• Photon Science
• Structural Biology
• Cryogenic Electron Tomography
• +۵ مورد دیگر

Peter Dahlberg is an Assistant Professor in the Photon Science Directorate and the Department of Structural Biology at Stanford University. He also serves as a Principal Investigator at the Stanford PULSE Institute and is a Member of the Wu Tsai Neurosciences Institute, positioning him at the intersection of advanced photon science and biological discovery. Education: B.S. in Physics from McGill University (2011) Ph.D. in Biophysics from the University of Chicago (2016) Research Focus: Dr. Dahlberg's research centers on developing and applying cutting-edge cryogenic correlative light and electron microscopy (cryo-CLEM) techniques. His work enables unprecedented visualization of cellular structures at near-native states with molecular resolution, bridging the gap between single-molecule fluorescence specificity and electron microscopy detail. He specializes in creating methods to study cellular machinery, microbial communities, and protein organization in their native contexts, with particular emphasis on time-resolved capabilities and environmental biosensing. Publication Trends: Dr. Dahlberg's recent publications (2022-2025) reveal a clear progression from foundational methodology development toward increasingly complex biological applications. His work increasingly integrates time-resolved capabilities, environmental biosensing, and improved fluorescent protein characterization for cryogenic applications. A significant thread connects his research on microbial communities, cellular responses to environmental stimuli, and parasite invasion mechanisms, all studied at unprecedented resolution through advanced correlative microscopy approaches. Scientific Recognition: NSF Graduate Research Fellowship (2012) SLAC Panofsky Fellowship (2021) Mentorship and Collaboration: Dr. Dahlberg maintains an active mentorship role with doctoral students and postdoctoral researchers. He serves as Doctoral Dissertation Reader for Will Dwyer, Doctoral Dissertation Advisor for Gabriel Mintzer and Magda Zaoralova, and Postdoctoral Faculty Sponsor for Arundhati Deshmukh and Kevin Rose. His collaborative work spans multiple departments and institutions, reflecting the interdisciplinary nature of his research. Research Infrastructure: Dr. Dahlberg leads a research group focused on developing correlative microscopy methods with strong connections to SLAC National Accelerator Laboratory. His team works at the intersection of photon science, structural biology, and biophysics, developing innovative approaches for visualizing cellular structures and processes at the nanoscale with applications spanning microbiology, plant biology, and cellular dynamics.

Robert P Hausingerمشاهده پروفایل

استاد

• Metalloenzymology
• Microbial Physiology
• Enzymology
• +۴ مورد دیگر

Robert P. Hausinger is a University Distinguished Professor at Michigan State University , holding appointments in the Department of Biochemistry & Molecular Biology and the Department of Microbiology, Genetics, & Immunology . He is also a faculty member of the Cell & Molecular Biology Program and the BioMolecular Science Gateway . His research focuses on microbial physiology and enzymology related to transition metals, with major contributions to understanding metalloenzymes and their cofactors. Education: Ph.D. 1982, University of Minnesota B.S. 1977, University of Wisconsin Research Interests: Dr. Hausinger's laboratory investigates the mechanisms of catalysis by metalloenzymes and the biosynthesis of their protein metallocenters. Key areas include: Nickel-pincer nucleotide cofactors: Discovery and characterization of the nickel-pincer nucleotide (NPN) cofactor in lactate racemase and related enzymes. Fe(II)/2-oxoglutarate-dependent hydroxylases: Studies on TauD and ethylene-forming enzymes, focusing on substrate binding and reaction mechanisms. Bacterial microcompartments: Investigating enzyme confinement effects on iron-dependent 2-aminophenol 1,6-dioxygenase. Recent Publications: Dr. Hausinger's recent work (2021-2023) spans structural enzymology, cofactor biosynthesis, and computational studies. His articles delve into nickel-pincer nucleotide cofactor assembly, ethylene-forming enzyme mechanisms, and urease inhibition, reflecting a blend of biochemical, spectroscopic, and structural approaches. Awards: 2009 - Distinguished Faculty Award, MSU Lab and Mentorship: Dr. Hausinger leads the Hausinger Lab , mentoring postdocs, graduate students, and undergraduates. His team includes researchers like Santhosh Gatreddi, Shramana Chatterjee, and Yali Wang, who study nickel cofactors, ethylene-forming enzymes, and bacterial microcompartments. The lab has a rich history of alumni now in academia and industry. Contact: Location: 6193 Biomed Phys Sci, MSU Phone: 517-884-5404 Email: hausinge@msu.edu

• Structural Biology
• Cryo-Electron Microscopy (Cryo-EM)
• Virology
• +۵ مورد دیگر

Professor Hong Zhou is a distinguished academic at the University of California Los Angeles (UCLA) , where he serves as a Professor in the Department of Microbiology, Immunology, and Molecular Genetics. His work bridges structural biology, virology, and cryo-electron microscopy (cryo-EM), with a focus on visualizing biological complexes and viral pathogenesis. Education: PhD in Biochemistry (Baylor College of Medicine, 1995), MS in Solid-State Physics (University of Science and Technology of China), BS in Physics (University of Science and Technology of China). Research Interests: Professor Zhou pioneers high-resolution cryo-EM and cryo-electron tomography (cryo-ET) to study viral structures, microbial complexes, and cellular mechanisms. His lab deciphers how viruses like herpesviruses and coronaviruses assemble, enter cells, and interact with host factors, while also advancing computational methods for structural analysis. Scientific Contributions: His recent work includes revealing novel α-synuclein strains linked to neurodegenerative diseases, uncovering species-specific features in herpesvirus tegument and envelope proteins, developing AI-driven cryo-EM techniques to resolve preferred-orientation artifacts. Awards: He is an Elected Fellow of the American Academy of Microbiology (2024), a Pew Scholar in Biomedical Sciences (1999), and has received the Basil O’Connor Scholar Award, Established Investigator Award of the American Heart Association, and the KH Kuo Award for Distinguished Scientist. Labs & Collaborations: As founding Director of the Electron Imaging Center for NanoMachines (EICN) at UCLA’s California Nanosystems Institute (CNSI), he leads a multidisciplinary team advancing structural proteomics and viral pathogenesis research.

Ciaran Kellyمشاهده پروفایل

استادیار

• Synthetic Biology
• Genetic Engineering
• Microbial Metabolism
• +۲ مورد دیگر

Dr. Ciaran Kelly is Assistant Professor in Molecular Biosciences at Northumbria University's Department of Applied Sciences. His research focuses on synthetic biology tools for metabolic engineering. Education: Ph.D. in Molecular Microbiology (University of Dundee, 2013), M.S. Learning and Cognition (Florida State, 2016), B.S. Psychology (Florida State, 2013) Research: Develops genetic tools for cyanobacteria engineering, including rhamnose-inducible systems and transcriptional terminators. Engineers metabolic pathways for biohydrogen production and designs synthetic regulatory circuits using small RNAs. Combines computational and experimental approaches for predictable biological engineering. Awards: ESCMID Research Grant (2020) for innovative microbiology research. Conducted field research in Amazon Basin ecosystems (2004-2005). Expertise: Genetic circuit design, microbial metabolism, cyanobacteria engineering, and enzyme optimization. Published in ACS Synthetic Biology, Nucleic Acids Research, and Microbiology journals.

• Biophysics
• Molecular Biology
• Nanotechnology
• +۳ مورد دیگر

Francois Sicard is an academic researcher with a focus on molecular simulations and biophysical systems. His work integrates computational methods to study complex biological and nanoscale phenomena, including DNA supercoiling, diffusion mechanisms, and nanoparticle interactions. He has published four peer-reviewed articles between 2019 and 2021 in journals such as Journal of Chemical Theory and Computation , Physical Review E , Scientific Reports , and ACS Nano , with a combined citation count of 105. Research interests prominently feature interdisciplinary topics at the intersection of biochemistry, biophysics, and nanotechnology. He explores the dynamics of DNA denaturation, facilitated diffusion in molecular systems, and the structural principles of bacterial organelles like carboxysomes. Additionally, his studies on nanoparticle fragmentation of armored droplets contribute to advances in materials engineering and multiphase flow modeling. Articles Overview : Sicard’s recent publications emphasize theoretical and computational approaches. The 2021 article advances Markov state models in chemical kinetics, while the 2020 studies investigate DNA supercoiling effects and carboxysome protein dynamics. His 2019 work provides insights into nanoparticle-driven droplet fragmentation mechanisms. These studies collectively highlight his expertise in bridging biophysical and nanoscale systems through advanced simulation techniques. No scientific awards are explicitly mentioned in the provided texts. Advising & Grants : Details about academic advising, student mentorship, or research grants are not specified in the available information. Collaborators include researchers such as V. Koskin, N. Destainville, and E. Rosta, reflecting active interdisciplinary partnerships. Labs/Teams : No specific lab or team affiliations are disclosed in the text.