معرفی
Robert P. Hausinger is a University Distinguished Professor at Michigan State University, holding appointments in the Department of Biochemistry & Molecular Biology and the Department of Microbiology, Genetics, & Immunology. He is also a faculty member of the Cell & Molecular Biology Program and the BioMolecular Science Gateway. His research focuses on microbial physiology and enzymology related to transition metals, with major contributions to understanding metalloenzymes and their cofactors.
Education:
- Ph.D. 1982, University of Minnesota
- B.S. 1977, University of Wisconsin
Research Interests:
Dr. Hausinger's laboratory investigates the mechanisms of catalysis by metalloenzymes and the biosynthesis of their protein metallocenters. Key areas include:
- Nickel-pincer nucleotide cofactors: Discovery and characterization of the nickel-pincer nucleotide (NPN) cofactor in lactate racemase and related enzymes.
- Fe(II)/2-oxoglutarate-dependent hydroxylases: Studies on TauD and ethylene-forming enzymes, focusing on substrate binding and reaction mechanisms.
- Bacterial microcompartments: Investigating enzyme confinement effects on iron-dependent 2-aminophenol 1,6-dioxygenase.
Recent Publications:
Dr. Hausinger's recent work (2021-2023) spans structural enzymology, cofactor biosynthesis, and computational studies. His articles delve into nickel-pincer nucleotide cofactor assembly, ethylene-forming enzyme mechanisms, and urease inhibition, reflecting a blend of biochemical, spectroscopic, and structural approaches.
Awards:
- 2009 - Distinguished Faculty Award, MSU
Lab and Mentorship:
Dr. Hausinger leads the Hausinger Lab, mentoring postdocs, graduate students, and undergraduates. His team includes researchers like Santhosh Gatreddi, Shramana Chatterjee, and Yali Wang, who study nickel cofactors, ethylene-forming enzymes, and bacterial microcompartments. The lab has a rich history of alumni now in academia and industry.
Contact:
Location: 6193 Biomed Phys Sci, MSU
Phone: 517-884-5404
Email: hausinge@msu.edu
