Andrew R. Buller

Andrew R. Buller is an Associate Professor in the Department of Chemistry at the University of Wisconsin-Madison. His research focuses on protein engineering, biocatalysis, enzymology, and chemical biology, aiming to expand biological chemical space through enzyme engineering.

• B.S/B.A., University of Iowa (2008)
• Ph.D., Johns Hopkins University (2013)
• Postdoctoral Fellow, California Institute of Technology (2013-2017)

The Buller Lab employs directed evolution and mechanistic studies to develop enzymes that functionalize non-natural precursors, advancing green chemistry and sustainable biosynthesis of pharmaceutical analogs. The lab trains 12 graduate students, 1 postdoctoral researcher, and multiple undergraduates.

Research areas include:

• Engineering C-C and C-X bond-forming enzymes
• PLP (vitamin B6) chemistry and cofactor engineering
• Sequence-activity relationship modeling
• Directed evolution methodology development
• Metabolic pathway expansion with non-canonical residues