جست‌وجوی استاد و پژوهشگر

Reilly T. Enosمشاهده پروفایل

استادیار

• Obesity
• Metabolic Disease
• Sex Differences in Metabolism
• +۹ مورد دیگر

Reilly T. Enos, PhD, is an Assistant Professor in the Department of Pathology, Microbiology & Immunology at the University of South Carolina School of Medicine. His research focuses on the molecular mechanisms of sex differences in obesity, particularly metabolic and inflammatory processes influenced by sex steroids. The Enos Lab employs rodent models and advanced metabolic phenotyping to investigate menopause-related metabolic dysfunction and complementary therapies. PhD, Exercise Science (Applied Physiology), University of South Carolina, 2013 Post-Doctoral, Complementary and Alternative Medicine in Cancer and Obesity, University of South Carolina School of Medicine, 2017 MS, Exercise Physiology, Baylor University, 2009 BS, Dietetics, University of Northern Colorado, 2010 BA, Spanish & Physical Education, College of Wooster, 2007 Dr. Enos’s research spans immunometabolism, obesity, cancer cachexia, and gut microbiota. His work explores how dietary components (e.g., quercetin, emodin), hormonal status (especially estrogen), and immune modulation (e.g., miR-155, macrophages) influence metabolic and oncological outcomes. He investigates sex-specific responses to high-fat diets, inflammation, and therapeutic interventions using transgenic and diet-induced mouse models. His recent publications highlight trends in metabolic physiology, inflammation, and cancer, often examining the interplay between adipose tissue, immune cells, and hormonal regulation. Key themes include the impact of vivarium conditions on reproducibility, the role of microRNAs in tumorigenesis, and the safety and efficacy of natural compounds. Dr. Enos has not been awarded any listed scientific prizes or fellowships in the provided texts. He advises a research team focused on metabolic and inflammatory disease models, frequently collaborating with researchers such as Erin A. Murphy and Kandy T. Velázquez. His lab receives funding for studies on obesity, cancer, and complementary medicine, though specific grants are not detailed. The lab is equipped for metabolic phenotyping and rodent model studies. The Enos Lab is dedicated to understanding sex-specific metabolic regulation and developing targeted therapies for obesity and cancer-related metabolic disorders, with a focus on translational relevance and experimental rigor.

Christopher J. Cooperمشاهده پروفایل

استاد

• Cardiovascular Medicine
• Interventional Cardiology
• Renovascular Hypertension
• +۴ مورد دیگر

Christopher J. Cooper, M.D., is Distinguished University Professor of Medicine at the University of Toledo, Ohio, where he also served as Dean of the College of Medicine (2014-2024), CEO of University of Toledo Physicians, and Executive Vice-President for Clinical Affairs. Triple-board-certified in Internal Medicine, Cardiovascular Disease, and Interventional Cardiology, he directs the UT Clinical Coordinating Center and has led national randomized trials on renal-artery stenosis. Education & Training: B.A. magna cum laude in Biology (Philosophy minor), Wittenberg University, 1985 M.D., University of Cincinnati College of Medicine, 1988 — Valedictorian, Alpha Omega Alpha Internship & Residency, Brigham and Women’s Hospital / Harvard Medical School, 1988-1991 Cardiology Fellowship, Brigham and Women’s Hospital, 1991-1994 Harvard School of Public Health, Clinical Effectiveness Program, 1992 Research Focus: Cooper’s group investigates renovascular hypertension, renal-artery stenosis, and cell-based therapies for vascular disease. As PI of the NIH-funded CORAL trial and multiple industry grants, he has published pivotal papers defining when renal stenting benefits patients and elucidating inflammatory and signaling pathways that couple renal artery narrowing to hypertension and renal failure. Recent work integrates large-scale clinical outcomes databases with mechanistic studies on Na/K-ATPase signaling, microRNA regulation of cardiac fibrosis, and biomarkers such as CD40-ligand in renovascular disease. Honors & Awards: Best Doctors in America — multiple years (2002-2014) America’s Top Doctors, Castle Connolly — consecutive listings (2006-2015) College of Medicine Award for Excellence in Clinical Research, UT (2008) Elected Fellow, American Heart Association Council on High Blood Pressure Research (2004) Valedictorian & Alpha Omega Alpha, Univ. of Cincinnati (1988) Leadership & Grants: Cooper has held continuous NIH and industry funding for multicenter trials; he founded and directs the UT Clinical Coordinating Center, overseeing regulatory, data, and biostatistical cores for national studies. His administrative leadership spans Department Chair, Heart & Vascular Center Director, and Dean of the College of Medicine, while maintaining an active interventional cardiology practice. Laboratory & Teams: He leads the Cooper Renal & Vascular Research Group within the UT Cardiovascular Research Institute, mentoring faculty, fellows, and graduate students in translational protocols that bridge molecular cardiology, interventional imaging, and large pragmatic trials.

Pabitra Sahooمشاهده پروفایل

استادیار

• Molecular & Cellular Neuroscience
• Localized Protein Synthesis
• Stress Granules
• +۸ مورد دیگر

Pabitra Sahoo is an Assistant Professor in the Department of Biological Sciences at Rutgers University, leading a research group focused on axonal mRNA dynamics and stress granule biology. His work bridges molecular neuroscience and regenerative medicine with direct implications for neural repair mechanisms. His educational background includes: B.S. from Utkal University, India (2005) M.S. from University of Hyderabad, India (2007) Ph.D. from National Centre for Cell Science, University of Pune (2013) Postdoctoral fellowship at Twiss Lab, University of South Carolina (2023) Dr. Sahoo's research centers on stress granules in axons and their dual role in physiological mRNA storage and pathological inhibition of nerve regeneration. His lab investigates how localized protein synthesis mechanisms govern neural repair, neurodevelopment, and neurodegenerative processes through cutting-edge approaches in spatial transcriptomics and axonal biology. Key discoveries include the identification of G3BP1 as a critical regulator of axonal mRNA translation and the demonstration that stress granules exist under normal physiological conditions in neurons. Analysis of his 2021-2025 publications reveals a dominant focus on stress granule disassembly mechanisms (particularly involving G3BP1), RNA-binding protein functions in axonal mRNA stability, and therapeutic targeting of these pathways for nerve regeneration. His work consistently connects fundamental molecular mechanisms to applications in spinal cord injury, peripheral nerve repair, and neurodegenerative conditions like ALS. The Sahoo Lab operates as a collaborative team of "curiosity driven, fun, and coffee loving scientists" investigating how mRNA storage granules respond to neuronal signals. Current projects specifically examine stress granule dynamics in neuronal development models and their dysfunction in neurodevelopmental disorders (e.g., Down syndrome) and neurodegenerative diseases, with therapeutic strategies emerging from multiple patent filings.

• Immunology
• Cancer Therapy
• Oncology
• +۳ مورد دیگر

Angelo Porciuncula is an Associate Research Scientist in the Department of Pathology at Yale School of Medicine, affiliated with the Schalper Lab. He holds a PhD from the University of Navarra. His research focuses on immunology, cancer therapy, and stem cell biology, with a particular emphasis on immune microenvironment modulation in oncology and translational drug development. Key projects include studying STING pathway activation via antibody-drug conjugates (e.g., TAK-500) targeting CCR2-expressing myeloid cells, as well as investigating immunotherapeutic biomarkers in lung cancer and glioblastoma. His work spans clinical-stage drug evaluation, tumor immunology, and epigenetic reprogramming of stem cells. Publications highlight contributions to understanding senescence mechanisms in cancer, pancreatic differentiation of iPSCs, and the role of OX40/OX40L pathways in tumor immunity. Porciuncula collaborates widely, including with Kurt Schalper and teams at Takeda Pharmaceuticals. His research bridges basic science and clinical applications, aiming to advance targeted therapies and regenerative medicine strategies.

Mansoureh Eghbaliمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +۳ مورد دیگر

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)

Dean Bryantمشاهده پروفایل

مدرس

• Computational Cancer Biology
• Hematology
• Genomics
• +۳ مورد دیگر

Dean Bryant is a Lecturer in Computational Cancer Biology at the University of Southampton. He holds a BSc (Hons) and PhD, and is a Fellow of the Higher Education Academy (FHEA). His research focuses on computational approaches to understanding cancer biology, particularly in hematological malignancies such as leukemia and lymphoma. He is affiliated with the Institute for Life Sciences and the Bioinformatics and Genomics research groups. Current research projects include the Early Cancer Research Initiative Network (ECRIN-M3) funded by Cancer Research UK and studies on SDH-deficient gastrointestinal stromal tumors. Dean supervises PhD students in Cancer Sciences and Biomedicine, and actively contributes to research on tumor immunoglobulin sequencing, genomic landscapes, and metabolic alterations in cancer. His academic background includes roles in bioinformatics and cancer genomics, with a strong emphasis on integrating computational methods with experimental biology. Dean collaborates with institutions such as Wessex Medical Research and maintains active research partnerships within Southampton’s academic community.

ANDREA KASINSKIمشاهده پروفایل

استاد

• Non-coding RNA biology
• MicroRNA therapeutics
• Cancer epigenetics
• +۳ مورد دیگر

Andrea Kasinski is a Professor of Biological Sciences and Deputy Director of the Purdue Institute for Cancer Research at Purdue University. Her research focuses on non-coding RNAs (microRNAs, lncRNAs, circRNAs) in cancer development and their therapeutic applications. She leads a multidisciplinary team investigating RNA delivery systems, extracellular vesicle biology, and epigenetic regulation in cancer. Key projects include ligand-mediated delivery of miRNAs, exosome-based therapies, and high-throughput screens for miRNA inhibitors. Education: PhD in Molecular & Systems Pharmacology (Emory University, 2009), Postdoctoral Fellowship in Genetics (Yale University, 2013). Awards include NIH Pathway to Independence Award (2013), American Cancer Society Research Scholar (2017), and multiple grants from NIH/NCI (R01 CA205420, R01 CA226259). Her lab has pioneered 'FolamiRs' – folate-targeted miRNA therapeutics – and developed novel strategies for endosomal escape of RNA payloads. Major contributions include identifying miRNA drivers of drug resistance, demonstrating exosome-mediated tumor progression, and advancing miR-34a as a clinical candidate. The lab maintains active collaborations with institutions including Harvard Medical School, MD Anderson Cancer Center, and the National Cancer Institute. Current initiatives focus on KMT5C-mediated epigenetic regulation in EGFR-resistant lung cancers and translational development of fully modified miR-34a (FM-miR-34a).

Laura Fonkenمشاهده پروفایل

دانشیار

• Neuroimmunology
• Circadian Rhythms
• Aging and Neurodegeneration
• +۵ مورد دیگر

Laura Fonken, Ph.D. is an Associate Professor of Pharmacology & Toxicology at the University of Texas at Austin's College of Pharmacy. She holds the prestigious Lonnie F. Hollingsworth, Sr. Centennial Fellowship in Pharmacy and leads an active research laboratory focused on neuroimmunology. Dr. Fonken's research broadly investigates how interactions among the immune, nervous, and endocrine systems regulate complex behavioral processes such as cognitive and mood-related behaviors. Her lab particularly focuses on two main research directions: (1) Targeting neuroinflammatory responses in the aged brain to improve cognitive function, and (2) Understanding the mechanisms by which the circadian system regulates neuroimmune function across the lifespan. Her work centers on microglia, the brain's resident immune cells, and how they shape behavior across the lifespan through endogenous factors like circadian rhythms and aging, as well as exogenous factors such as environmental pollutants, infection, and injury. Her research has identified that microglia become more reactive or 'primed' over an animal's lifespan, worsening outcomes when immune challenges are encountered. Her lab is investigating mechanisms by which Mycobacterium vaccae vaccination prevents exacerbated neuroinflammatory and behavioral deficits in aging, supported by NIH R01 AG062716. She is also examining how circadian rhythms in immune cell trafficking become disrupted with age and Alzheimer's Disease-like pathology, supported by NIH R01 AG078758. Dr. Fonken's publications reveal a strong focus on neuroimmunology, circadian biology, and aging. Her work demonstrates significant contributions to understanding sex differences in microglial function, the impact of hormonal changes on neuroinflammation, and the therapeutic potential of immunomodulation for age-related cognitive decline. Lonnie F. Hollingsworth, Sr. Centennial Fellowship in Pharmacy NIH R01 AG062716 grant NIH R01 AG078758 grant Dr. Fonken actively mentors graduate students across multiple programs, including Pharmaceutical Sciences (Division of Pharmacology & Toxicology) and Neuroscience (Institute for Neuroscience). Her lab has successfully graduated two PhD students (Dr. Kevin Sanchez and Dr. Rachel Chen in 2023) and currently mentors several graduate students including Kate Davis, Brandy Routh, Kiersten Bell, Drew Hynes, and Kate Callahan. She has successfully guided her students to win numerous prestigious awards including the CCST Science & Technology Policy Fellowship, NIH predoctoral fellowships, and national competition wins. The Fonken Lab maintains an active research presence with collaborations across disciplines and participation in major conferences including the Society for Neuroscience and the International Behavioral Neuroscience Society.

• Cellular quiescence
• Metabolic regulation
• Cancer metabolism
• +۴ مورد دیگر

Professor Hilary Coller holds joint appointments in Molecular, Cell and Developmental Biology and Biological Chemistry at UCLA. Her NIH-funded research explores cellular quiescence mechanisms, metabolic adaptations in dormant states, and stromal contributions to cancer progression. She currently serves as Editor-in-Chief of Physiological Genomics. Research domains: Metabolic regulation of quiescent stem cells Epigenetic control of cell cycle transitions MicroRNA networks in proliferation arrest Cancer-associated fibroblast biology Her laboratory developed novel biosensing technologies for in vivo metabolomics and contributed fundamental insights into mitochondrial regulation of cell cycle checkpoints. Educational leadership includes directing undergraduate genomics research programs.

Hilary Ann Collerمشاهده پروفایل

استاد

• Cellular Quiescence
• Cancer Biology
• Metabolism
• +۴ مورد دیگر

Hilary Ann Coller is a Professor at the University of California, Los Angeles (UCLA), jointly appointed in the Department of Molecular, Cell and Developmental Biology and the Department of Biological Chemistry within the College of Letters and Science. She leads a research laboratory focusing on cellular quiescence, metabolism, and their implications in cancer and disease progression. Her research integrates molecular biology, epigenetics, and systems approaches to study: Transcriptional and epigenetic control of quiescence Metabolic adaptations in tumor microenvironments RNA biology and gene regulation networks Development of biomedical technologies (e.g., biosensors) Recent publications (2022–2025) highlight trends in: Cellular quiescence mechanisms and transcription factor dynamics Cancer epigenetics and metabolic reprogramming Innovative tools for metabolomics and drug monitoring Educational research on remote STEM training programs She directs multiple NIH-funded projects, including R01CA221296 (stromal autophagy in melanoma) and R01GM086465 (microRNA mechanisms). Her lab mentors graduate students and postdocs, and she co-leads UCLA’s Bruins-in-Genomics summer initiative for undergraduate computational biology training.

Jose M Silvaمشاهده پروفایل

استاد

• Cancer Biology
• Cancer Genetics
• Tumorigenesis
• +۵ مورد دیگر

Jose M Silva is a Professor in Pathology and Oncological Sciences at Columbia University Medical School. He holds adjunct faculty status and has prior roles including Assistant Professor at Columbia and postdoctoral training at Cold Spring Harbor Laboratory. His research focuses on cancer genomics, functional networks, and translating discoveries into clinical applications. He has pioneered integrative approaches combining genomics and systems biology to identify critical cancer cell regulators, leading to clinical trials. Education: BSc, Complutense University of Madrid PhD, Autonoma University of Madrid PostDoc & Senior Fellow, Cold Spring Harbor Laboratory Research Interests: His lab investigates breast cancer development and therapeutics, including molecular characterization of tumor networks, novel drug targets (e.g., RSF1, BIN3), and clinical translation of discoveries. Current efforts target triple-negative breast cancers and aging-cancer intersections. Grants & Trials: Initiated NCT02066532 clinical trial; ongoing work includes HDAC6/STAT3 inhibition studies and single-cell atlas projects.

Melissa Carasمشاهده پروفایل

استادیار

• Auditory Neuroscience
• Perceptual Learning
• Neuroplasticity
• +۳ مورد دیگر

Melissa Caras is an Assistant Professor in the Department of Biology at the University of Maryland, with an affiliation in the Department of Hearing and Speech Sciences. She holds a B.S. in Neuroscience and Biology from Brandeis University and a Ph.D. in Neurobiology and Behavior from the University of Washington. Her postdoctoral training at New York University focused on auditory development and perceptual learning. Her research explores neural mechanisms of auditory learning and plasticity, employing techniques like electrophysiology, optogenetics, and telemetry. Research interests include auditory neuroscience, perceptual learning, neuroplasticity, and cognitive neuroscience. Her work emphasizes top-down modulation of sensory processing and the impact of non-sensory factors on auditory learning. Recent studies investigate orbitofrontal-auditory pathways in gerbils and neural correlates of perceptual plasticity in auditory circuits. Current students include Ying, Rose and Marissa, Renee. The CarasLab website (caraslab.org) highlights her lab’s focus on sensory plasticity mechanisms. No scientific awards are explicitly mentioned, but her research has contributed to understanding developmental hearing loss and neural variability in adolescents.

• Genetics
• Bioinformatics
• Immunology
• +۳ مورد دیگر

Overview Francesc Lopez-Giraldez is a Research Scientist in Genetics at the Yale School of Medicine, with affiliations in the Yale Center for Genome Analysis (YCGA) and the Center for Biomedical Data Science. His research focuses on integrating genomics, bioinformatics, and molecular biology to address complex biological and clinical questions in areas such as cancer, neurodevelopmental disorders, and immune-related diseases. Education PhD in Evolutionary Genetics, Autonomous University of Barcelona (2006) MSc in Health and Life Sciences, Pompeu Fabra University (2004) BS in Biology, University of Girona (2000) Research Interests Lopez-Giraldez’s work spans genetics, immunology, and computational biology. Key areas include: Genetic mechanisms underlying congenital heart diseases and neurodevelopmental disorders Bioinformatic analysis of cancer genomics and immune checkpoint resistance Role of mTOR signaling in vascular and neurological pathologies Spatial transcriptomics to study tumor microenvironments and autoimmune diseases Key Contributions Recent publications highlight his interdisciplinary approach, such as: Identifying genetic contributions to congenital heart diseases Elucidating mTOR dysregulation in lissencephaly Exploring immune checkpoint inhibitors’ resistance mechanisms in lung cancer Awards & Recognition Recipient of the National Cancer Institute Research Specialist Award (R50) in 2023, recognizing his innovative contributions to biomedical data science and translational research. Collaborations Lopez-Giraldez collaborates with leading researchers, including Jeffrey Townsend (Yale), Murat Gunel (Neurology), and Kasia Politi (Oncology), to advance team science in precision medicine and genomics. Labs & Teams He contributes to the Yale Center for Genome Analysis (YCGA) and the Yale Cancer Center, focusing on genomic data integration and bioinformatics pipelines for clinical research.

Ulrike Kutayمشاهده پروفایل

استاد

• Nuclear envelope structure and biogenesis
• Nucleo-cytoplasmic transport
• Metazoan ribosome biogenesis
• +۳ مورد دیگر

Ulrike Kutay is a Full Professor of Biochemistry at ETH Zurich, Switzerland, with a research focus on nuclear biology and dynamics. Her work investigates nuclear envelope structure/function, ribosome biogenesis, and nucleo-cytoplasmic transport. Diploma in Biochemistry (Free University Berlin, 1992) PhD in Natural Sciences (Humboldt University Berlin, 1996) Research interests center on nuclear compartmentalization, including mitotic nuclear envelope breakdown and reassembly, ribosome assembly pathways, and the molecular mechanisms governing nuclear transport. Her lab explores how nuclear dysfunction contributes to diseases like ribosomopathies and cancer. Recent publications highlight her work on SUN/KASH proteins in nuclear envelope dynamics, ribosome biogenesis steps, and nuclear pore complex regulation. Collaborations with groups like the Spahn lab in Berlin underscore her interdisciplinary approach. EMBO Member (2010) Leopoldina Member (2012) ERC Advanced Grant (2012) As a mentor, she has supervised PhD students including Chiara and Roja. She actively participates in editorial boards, grant review panels (e.g., ERC, DFG), and institutional leadership roles at ETH Zurich and the Biochemistry Center Heidelberg. The Kutay Group at ETH Zurich combines proteomics, functional analyses, and structural studies to unravel nuclear processes, fostering a collaborative environment with recent achievements in mitotic nuclear disassembly and ribosome maturation research.

Lukas Edward Dowمشاهده پروفایل

استاد

• Cancer Biology
• Genetics
• Molecular Biology
• +۵ مورد دیگر

Lukas Edward Dow is a Professor of Biochemistry and Biophysics at Weill Cornell Medical College (2025-present) and holds a secondary appointment in Medicine. His research spans genetic and non-genetic resistance mechanisms in KRAS-driven cancers, WNT signaling, and CRISPR-based cancer modeling. Ph.D. and B.Sc. from University of Melbourne Focus on CRC, pancreatic, breast, and prostate cancers Research interests include genetic resistance mechanisms , CRISPR applications , WNT pathway dependencies , and tumor microenvironment dynamics . Key publications reveal trends in mutant-specific therapies , epithelial plasticity , and precision genome editing . Current research projects funded by National Cancer Institute and Department of Defense investigate KRAS allelic imbalance, R-Spondin sensitization, and WNT pathway alterations. External collaborations include scientific advisory roles at Mirimus, Inc. and consulting at Revolution Medicines, Inc. His lab develops genetically engineered mouse models and organoid systems for studying cancer progression, with emphasis on metastasis , drug resistance , and epigenetic adaptations . The work has significant implications for improving cancer therapies through context-dependent targeting .