Jose M Silva

Jose M Silva is a Professor in Pathology and Oncological Sciences at Columbia University Medical School. He holds adjunct faculty status and has prior roles including Assistant Professor at Columbia and postdoctoral training at Cold Spring Harbor Laboratory. His research focuses on cancer genomics, functional networks, and translating discoveries into clinical applications. He has pioneered integrative approaches combining genomics and systems biology to identify critical cancer cell regulators, leading to clinical trials.

Education:

• BSc, Complutense University of Madrid
• PhD, Autonoma University of Madrid
• PostDoc & Senior Fellow, Cold Spring Harbor Laboratory

Research Interests: His lab investigates breast cancer development and therapeutics, including molecular characterization of tumor networks, novel drug targets (e.g., RSF1, BIN3), and clinical translation of discoveries. Current efforts target triple-negative breast cancers and aging-cancer intersections.

Grants & Trials: Initiated NCT02066532 clinical trial; ongoing work includes HDAC6/STAT3 inhibition studies and single-cell atlas projects.