Jose Silva

Jose M. Silva is an Associate Professor of Pathology and Oncological Sciences at the Icahn School of Medicine at Mount Sinai, with a concurrent Adjunct Professor role at Columbia University. His research focuses on uncovering molecular mechanisms underlying breast cancer progression, leveraging functional genomics, systems biology, and translational approaches. Silva holds a PhD in Oncology from Universidad Autónoma de Madrid and completed postdoctoral training at Cold Spring Harbor Laboratory.

Education:

• BS in Biology, Universidad Complutense de Madrid (1990–1995)
• PhD in Oncology, Universidad Autónoma de Madrid (1995–2000)
• Postdoctoral Fellow, Cold Spring Harbor Laboratory (2001–2008)

Research Interests: Silva’s lab investigates cancer-relevant genetic and epigenetic mechanisms, with emphasis on breast cancer. Key areas include:

• Identifying driver genes via integrative genomic approaches
• Developing targeted therapies for aggressive breast cancer subtypes
• Elucidating microRNA networks regulating mammary development and tumorigenesis
• Characterizing HDAC6-dependent survival pathways in inflammatory breast cancer

Article Trends: Silva’s work spans functional genomics (e.g., Helios/ISAR-DEL algorithms), miRNA regulation (miR-424/503 cluster), and translational research (JAK/STAT3 and HDAC6 pathways). Recent studies emphasize drug resistance mechanisms and therapeutic combinations.

Awards:

• NIH/NCI K99/R00 Award (2007)
• Irma T. Hirschl/Monique Weill-Caulier Award (2015)

Grants & Advising: Silva leads projects funded by NIH, Stand Up To Cancer, and private foundations. He mentors students/postdocs in experimental and computational cancer biology, with lab members contributing to seminal studies in breast cancer mechanisms.

Labs/Teams: Coordinates the Silva Lab at Mount Sinai, collaborating with institutions like Columbia University, Cold Spring Harbor, and international cancer centers.