Mansoureh Eghbali

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling.

Her research integrates multiomics approaches to explore:

• Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection
• MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis)
• Gut-heart-lung interactions in diet-induced pulmonary hypertension
• Endothelial subpopulations (TM4SF1+) in disease progression

Analysis of her recent publications reveals strong emphasis on:

• Integrative multiomics in vascular diseases
• Sex differences in drug responses
• Novel therapeutic targeting of RNA-binding proteins
• Cross-organ communication in cardiopulmonary pathologies

She directs multiple NIH grants including:

• R01HL159865: Role of Chromosome Y gene, Uty (2021-2025)
• R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023)
• R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021)
• R01HL131182: Epigenetic regulation by X chromosome (2016-2021)