جست‌وجوی استاد و پژوهشگر

Kirsten Jungمشاهده پروفایل

استاد

• Bacterial Signal Transduction
• Stress Response Mechanisms
• Membrane Protein Structure-Function Analysis
• +۳ مورد دیگر

Prof. Dr. Kirsten Jung is a faculty member at the Department of Microbiology , Faculty of Biology , Ludwig Maximilian University of Munich . Her research focuses on bacterial signal transduction, stress response mechanisms, and systems biology approaches to understand microbial regulatory networks. Key research areas include stress-dependent gene expression in bacterial populations Structural and functional analysis of membrane-integrated receptors Metabolism-based chemical communication in bacteria Integration of experimental and computational systems biology Recent publications highlight her lab's work on Escherichia coli epitranscriptomic modifications under heat stress, m 5 C rRNA dynamics, and the role of RNA methylation in host-pathogen interactions. Collaborative studies address bacterial acid stress responses and their implications for antibiotic tolerance. Her interdisciplinary work bridges microbiology with ecological studies, as evidenced by research on biodiversity conservation in forest and urban ecosystems. Publications also demonstrate expertise in advanced imaging techniques (e.g., arterial spin labeling for glioma analysis) and bioinformatics approaches. Current advisees include Gloria Gessinger and Tania P. Gonzalez-Terrazas . She can be contacted at jung@lmu.de .

Michael Grabeمشاهده پروفایل

استاد

• Ion Channel Function
• Membrane Biology
• Computational Biology
• +۳ مورد دیگر

Michael Grabe is a Professor in the Cardiovascular Research Institute (CVRI) at the University of California San Francisco (UCSF). He holds a joint appointment in the Department of Pharmaceutical Chemistry. His work focuses on computational methods to study biological phenomena, particularly ion transport across membranes and the molecular mechanisms of ion channels/transporters. He has pioneered theoretical approaches to understand membrane protein function and organelle acidity regulation. Education: PhD in Physics, University of California, Berkeley (2002) ScB in Mathematics-Physics, Brown University (1996) Research Interests: Dr. Grabe’s lab investigates ion channel function, membrane remodeling by TMEM16 proteins, lysosomal pH regulation, and computational modeling of membrane-associated processes. Key themes include: Mechanics of ion transport and lipid flipping Protein-induced membrane deformations Simulations of organelle microphysiology Development of computational tools for membrane protein analysis Recent Research Trends: Recent work emphasizes dynamic protein design using AI (e.g., Science 2025), structural studies of K2P channels, and functional insights into TMEM16 scramblases. His team also explores SARS-CoV-2 protein interactions and mitochondrial uncoupling mechanisms. Awards: NSF CAREER Award (2009-2014) Alfred P. Sloan Research Fellowship (2009-2011) Shining Star Community Service Award (2012) Grants & Advising: Principal Investigator of NIH grants studying TMEM16 proteins (R01GM137109) and lysosomal physiology (R21GM100224). His lab trains graduate students and postdocs in computational biophysics and membrane biology. Labs/Teams: Leads the Grabe Lab at UCSF, which collaborates with experimental groups to bridge theory and experiment in membrane systems. Active in developing open-source tools like APBSmem for electrostatic calculations.

• Molecular Biology
• Biochemistry
• Cell Biology
• +۵ مورد دیگر

Dr. Maruf Ali is an Associate Professor in Molecular and Structural Biology at Imperial College London's Department of Life Sciences, part of the Faculty of Natural Sciences. He holds affiliations with the Centre for Structural Biology, Electron Microscopy Centre, and Membrane Biology. His research focuses on understanding molecular mechanisms of protein quality control during cellular stress, particularly in cancer and neurodegenerative diseases. Research interests include the Unfolded Protein Response (UPR), ER stress signaling pathways, and therapeutic interventions targeting these mechanisms. His multidisciplinary approach combines structural biology, biochemistry, and cellular techniques to study proteins and complexes involved in ER stress responses. Notable affiliations include the Membrane Biology and Molecular Mechanisms of Disease groups. His work explores how the UPR is activated and propagated, with implications for developing novel treatments for diseases linked to protein misfolding. Recent studies emphasize drug repurposing strategies targeting RSK4 to combat chemoresistance in cancers like lung and bladder cancer, as well as identifying key regulators of ER stress pathways such as IRE1 and PERK. Laboratory activities are centered at the Ali Lab (http://www.imperial.ac.uk/ali-lab), where research integrates structural insights with functional studies to advance understanding of cellular stress responses and their therapeutic applications.

Omar Rifaie Grahamمشاهده پروفایل

مدرس

• Artificial Cells
• Polymersome Nanoreactors
• Polymer Chemistry
• +۵ مورد دیگر

Dr. Omar Rifaie Graham is a Lecturer (Assistant Professor) in Chemistry at Queen Mary University of London's School of Physical and Chemical Sciences, joining in September 2023. He leads a research group focused on polymer-based artificial cells to study physicochemical parameters underlying biological phenomena and develop technologies at the Living/Non-Living Interface. Previously, he held postdoctoral positions at Imperial College London and the University of Fribourg, Switzerland. Education: Licenciado in Pharmacy (BSc+MSc), Universidad Complutense de Madrid, Spain (2008–2014) PhD in Chemistry, Adolphe Merkle Institute – University of Fribourg, Switzerland (2014–2018) Research Interests: Development of artificial cells using polymer nanocontainers, stimuli-responsive materials (light, hydromechanical stress), and applications in biotechnology, therapy, and diagnostics. His work includes creating polymersomes with novel functionalities for drug delivery, diagnostics, and synthetic biology. Key Achievements: ACS PMSE Future Faculty Award (2023) Swiss Nanoscience Institute 'Best paper in nanoscience' (2021) Best PhD thesis in Experimental Sciences, University of Fribourg (2019) Co-founded a diagnostics company spun from his PhD research (1M+ USD funding) Grants & Collaborations: Royal Society Grant: £29,907 (2025–2026) National Institute for Health Research Grant: £315,942 (2020–2025) RSC Grant for 'Mimicking colour perception with artificial cells' (2024) Lab/Team: Directs a research group at Queen Mary's Department of Chemistry, collaborating with institutions like Imperial College London and the University of Fribourg. Active in synthetic biology, nanomedicine, and biomimetic materials.

Greta Binfordمشاهده پروفایل

استاد

• Arachnology
• Spider Venoms
• Evolutionary Biology
• +۴ مورد دیگر

Greta Binford is a Professor of Biology at Lewis & Clark College, where she conducts pioneering research on spider biodiversity and venom evolution. Her work focuses on the biochemical and evolutionary mechanisms underlying spider venoms, particularly in brown recluse spiders (Loxosceles) and their relatives (Sicarius), with significant contributions to understanding dermonecrotic toxin distribution. She teaches specialized courses including Arachnology/Biodiversity, Invertebrate Zoology, and Evolution, integrating biodiversity themes across her curriculum and public outreach initiatives. Binford's research program employs integrative approaches spanning field collection, protein biochemistry, and molecular genetics to investigate venom evolution. She has demonstrated the shared evolutionary origin of sphingomyelinase D toxins in Loxosceles and Sicarius spiders, providing critical insights for medical applications. Her work bridges biodiversity science with toxinology, emphasizing how ecological pressures shape venom complexity and function across spider lineages. Analysis of her recent publications (2020-2023) reveals concentrated research on Caribbean spider biogeography and molecular mechanisms of phospholipase D toxins. Key themes include enzyme specificity determinants, structural stabilization of venom proteins, and evolutionary patterns of island endemism. Her work frequently combines taxonomic discovery with biochemical analysis, exemplified by studies on Micrathena orb-weavers and Antillattus jumping spiders. Binford actively mentors undergraduate researchers through hands-on laboratory and fieldwork, securing substantial funding including an NSF CAREER award (2006) for 'Venom Evolution in Sicariid Spiders', a collaborative Caribbean biogeography grant (2011), and a recent HDR DSC grant (2021) building data science capacity through biodiversity research. Her grants consistently emphasize undergraduate training and interdisciplinary collaboration. She leads a dynamic research laboratory at Lewis & Clark College where students participate in all stages of venom research, from specimen collection to molecular analysis. Her team maintains international collaborations focused on Caribbean arachnid biodiversity and contributes to public education about spider biology, emphasizing their ecological importance and dispelling common misconceptions.

Jonathan Weissmanمشاهده پروفایل

استاد

• Protein Folding
• Systems Biology
• Genomics
• +۶ مورد دیگر

Jonathan Weissman is a Professor of Biology at the Massachusetts Institute of Technology (MIT) and a Member of the Whitehead Institute. He is also an Investigator of the Howard Hughes Medical Institute and the Landon T. Clay Professor of Biology. His research spans protein folding mechanisms, ribosome profiling, CRISPR-based tools (CRISPRi/a), and genetic interaction mapping. Whitehead Institute Member MIT Professor HHMI Investigator Co-founder, Maze Therapeutics & KSQ Therapeutics Research Interests focus on: Protein folding in cellular contexts Endoplasmic reticulum (ER) function and stress responses Genome-wide CRISPR screening for gene regulation High-density genetic interaction maps in mammals Mitochondrial protein targeting and quality control Epigenomic engineering with synthetic tools Scientific Awards include: Protein Society Irving Sigal Young Investigator Award (2004) Raymond & Beverly Sackler Prize (2008) National Academy of Sciences election (2009) NAS Award for Scientific Discovery (2015) Genetics Society of America Ira Herskowitz Award (2020) Labs & Collaborations : Leads the Weissman Lab at MIT/Whitehead Institute, co-leads the Laboratory for Genomic Research with GlaxoSmithKline, and chairs the Stowers Institute Scientific Advisory Board.

• Membrane Biology
• Cellular Stress Response
• Lysosomal Function
• +۲ مورد دیگر

Dr. Phyllis I. Hanson is the Minor J. Coon Professor and Chair of Biological Chemistry at the University of Michigan Medical School. She also holds secondary appointments in Neurology and Cell and Developmental Biology, with affiliations to the Rogel Cancer Center and Precision Health Initiative. Research Interests: Her lab investigates mechanisms of cellular membrane stress sensing and repair, focusing on lysosomes and the ESCRT pathway. Her work integrates biochemical, cell biological, and advanced imaging techniques to study organelle membrane dynamics in health and disease. Recent Publications highlight her contributions to understanding ESCRT function in endolysosomal trafficking, membrane resilience under osmotic stress, and protein degradation pathways. These studies intersect with neurodegeneration, cancer biology, and infectious disease. Scientific Awards: AAAS Fellow Keck Scholar Searle Scholar Sloan Scholar McKnight Scholar Grants from NIH and disease-focused foundations since 2018 support her work on ESCRT pathway analysis, HSC70 AMPylation, and signal relay during cell migration. Leadership: She co-chairs Michigan Medicine’s Endowment for the Basic Sciences and chaired the 2024 Gordon Research Conference on Lysosomes & Endocytosis. She serves as Associate Editor of the Journal of Biological Chemistry .

Jian Huمشاهده پروفایل

استاد

• Structural Biology
• Biochemistry
• Metal Homeostasis
• +۷ مورد دیگر

Jian Hu is a Professor at Michigan State University (MSU) in the Department of Biochemistry & Molecular Biology, with joint appointments in the Department of Chemistry and the BioMolecular Science Gateway. His research integrates structural biology, biochemistry, and biophysics to investigate macromolecular mechanisms in biology and biomedicine, focusing on bio-metal utilization and homeostasis. Ph.D., Peking University, 2004 B.S., Beijing Medical University, 1999 Associate Research Scientist, Yale University (2008–2013) Postdoctoral Research Associate, Florida State University (2005–2007) The Hu lab targets three major projects: (1) ZIP metal transporters, exploring alternating access mechanisms and substrate specificity; (2) Lar proteins, analyzing Ni-pincer cofactor biosynthesis and catalytic mechanisms; and (3) PIPK lipid kinases, studying membrane sensing and inhibitor development. Collaborations with Dr. Robert P. Hausinger and Dr. Xuefei Huang advance drug discovery and structural elucidation. Recent publications highlight interdisciplinary work, blending plant biology (phenylalanine metabolism, peroxisome dynamics) with computational methods (watermarking algorithms, signal processing). His collaborations extend to engineering and medicine, emphasizing functional characterization of proteins and drug target validation. Scientific Awards: Invited State-of-the-Art Review, FEBS Journal 2021 Current courses include BMB 829: Special Problems in Macromolecular Analysis & Synthesis and CEM 999: Doctoral Dissertation Research . The lab employs X-ray crystallography, cryo-EM, NMR, and biochemistry to resolve atomic-level structures and functions of critical macromolecules, including ZIP4 and PIP5Kγ.

Jingyi Chenمشاهده پروفایل

استاد

• Physical Chemistry
• Nanoscience
• Materials Chemistry
• +۵ مورد دیگر

Jingyi Chen is a Professor in the Department of Chemistry and Biochemistry at the University of Arkansas. She serves as Vice Chair in the College of Arts & Sciences and leads the Chen Research Group focused on rational design and synthesis of functional nanomaterials for energy conversion and human-health applications. PhD, Chemistry & Nanotechnology – University of Washington (2006) MA, Chemistry – State University of New York College at Buffalo (2002) BS, Chemistry – Sun Yat-sen University (1997) Her research spans three major projects: Project I: Developing cost-effective catalysts for fuel cell applications through precise synthesis of copper-based bimetallic nanocrystals. Project II: Surface modification of nanoparticles with polydopamine for bio-related applications like low-friction coatings. Project III: Creating nanoplatforms for targeted drug delivery against antibiotic-resistant infections and cancer. Recent publications focus on nickel phosphide nanoparticles (2024), perovskite oxide oxygen evolution catalysts (2023-2024), and silver nanoparticle antimicrobial mechanisms (2020-2023). Her group has produced 15+ recent publications in journals like ACS Nano , J. Phys. Chem. C , and ACS Infectious Diseases . Award highlights include: Thomson Reuters Top 1% Highly Cited Researcher (2015-2018) Arkansas Research Alliance Fellow (2018) Women’s Giving Circle Award (2014) Ralph E. Powe Junior Faculty Enhancement Award (2011) She has mentored over 20 graduate and undergraduate students , including Ryan Manso (PhD 2022), Isabelle Niyonshuti (PhD 2021), and David Thompson (DOE SCGSR awardee 2022). Her lab (CHBC 304/306/309) employs advanced tools like synthesis setups , electrochemical stations , and laser irradiation systems .

Fabrizio Marinelliمشاهده پروفایل

دانشیار

• Biophysics
• Molecular Simulation
• Membrane Transport
• +۳ مورد دیگر

Fabrizio Marinelli is an Associate Professor of Biophysics and Data Science at the Medical College of Wisconsin (MCW), effective July 2025, and holds an adjunct senior investigator position at the Versiti Blood Research Institute. He previously served as a staff scientist at the National Heart, Lung, and Blood Institute (NHLBI/NIH) and conducted postdoctoral research at the Max Planck Institute of Biophysics and NIH. Educational background includes a PhD in Statistical and Biological Physics from the International School for Advanced Studies (Trieste, Italy), an MS in Chemistry from La Sapienza University (Rome), and postdoctoral training in molecular biophysics. His research focuses on computational modeling of molecular mechanisms in membrane transport, signaling, and morphological changes, integrating advanced simulation techniques with experimental data (e.g., EPR/DEER, HDX-MS, cryo-EM). Key methodologies include enhanced sampling methods, free-energy calculations, and machine learning. Research highlights include elucidating mechanisms of Na+/Ca2+ exchangers, ion selectivity in lysosomal K+ channels, and structural interpretation of DEER and HDX data. He leads the Biophysics Graduate Program’s recruitment efforts and actively collaborates with experimental labs to bridge theory and experiment. Lab members include postdocs William Brown and Sandra Byju, and graduate student Tyler Trask. Publications emphasize computational tools (e.g., PLUMED, Colvars library) and reproducibility in molecular simulations. His work aims to advance therapies for infectious diseases, drug resistance, and cancer through mechanistic insights into proteins and membranes.

Karin Schumacherمشاهده پروفایل

استاد

• Cell Biology
• Plant Developmental Biology
• Plant Cell Biology
• +۳ مورد دیگر

Prof. Dr. Karin Schumacher is a Professor of Plant Developmental Biology at Heidelberg University and currently serves as Vice-Rector for Quality Development and Sustainability. Her research focuses on plant cell biology, particularly vacuole dynamics, ion homeostasis, and membrane trafficking in Arabidopsis. She leads the Cell Biology Research Group at the Centre for Organismal Studies (COS) and has held leadership roles such as Dean of the Faculty of Biosciences. Her work integrates computational modeling with experimental approaches to study plant growth and stress responses. Dr. Schumacher's academic career includes a Doctorate from the University of Cologne and a Habilitation from the University of Tübingen. She has held professorial positions since 2007 and contributed to advancements in understanding plant membrane systems, including V-ATPase function and calcium signaling. Her research publications emphasize vacuolar ion transport, autophagy mechanisms, and plant stress physiology. Her administrative roles include enhancing early career researcher support and promoting sustainability in university operations. She is an active member of scientific societies like the German Botanical Society and serves on editorial boards such as Plant Cell . Her interdisciplinary work bridges cell biology, molecular genetics, and systems-level plant physiology.

Matthias Feigeمشاهده پروفایل

دانشیار

• Protein Biochemistry
• Cell Biology
• Immunology
• +۳ مورد دیگر

Matthias Feige is an Associate Professor of Cellular Protein Biochemistry at the Technical University of Munich (TUM). He leads the Focus Group for Cellular Protein Biochemistry, previously serving as a Rudolf Mößbauer Tenure Track Assistant Professor. His research focuses on understanding cellular proteome integrity, particularly in the secretory pathway, combining protein biochemistry and cell biology. Key interests include protein folding, quality control mechanisms, and their biomedical applications. Education & Career: PhD in Biochemistry (2009), TUM under Johannes Buchner Postdoctoral Fellowship at St. Jude Children’s Research Hospital (Memphis, USA) with Linda Hendershot Head of the Cellular Protein Biochemistry Lab at TUM since 2015 Research Interests: Feige’s work explores molecular mechanisms governing protein biogenesis, secretory pathway proteins, and their roles in immunity. His interdisciplinary approach targets fundamental biology and translational applications like protein engineering and therapy development. Scientific Contributions: His publications highlight advancements in cytokine assembly, ER quality control, and protein aggregation mechanisms. Notable recent work includes studies on KDELR3 signaling, helminth immune modulation, and engineered cytokines. Awards & Recognition: Leopoldina Fellowship (2011–2014) Fellow of the Daimler and Benz Foundation (2016) Rainer Rudolph Award (2012) Multiple honors from TUM and international institutions Labs & Teams: He directs a lab investigating protein biogenesis and proteostasis. Collaborations span biochemistry, immunology, and structural biology, with a focus on translational research.

• Bioethics
• Clinical Ethics
• Health Care Ethics
• +۳ مورد دیگر

Catherine Bert is a Researcher affiliated with the University of Namur (UNamur), based in the Center for Vulnerabilities and Societies Transitions within the Philosophical Space of Namur. She holds a Doctorate in Philosophy (UNamur) and multiple diplomas in Sociology, International Relations, and Comparative Politics from Université catholique de Louvain (UCL). Her academic roles include being a Professor of Philosophy, Ethics, Anthropology, and Sociology at the IES Parnasse-Deux-Alice in Brussels, a member of the ethics committee at CHR de la Haute Senne, and an editorial board member of the journal Les politiques sociales . Research Interests: Dr. Bert specializes in clinical ethics, bioethics, and pandemic-related healthcare ethics. Her work intersects with sociological and anthropological perspectives, focusing on solidarity practices, care ethics, and gender-based violence in medical contexts. She actively contributes to the United Nations Sustainable Development Goals, particularly in eradicating poverty and promoting health equity. Projects & Activities: She has led or collaborated on projects like the 'Universality of Values in Bioethics' and 'Virtue Ethics in Care Practices Analysis'. Her research spans ethical dilemmas in healthcare, including reproductive rights and pandemic response. She frequently participates in workshops, conferences, and colloquia on ethics and healthcare, such as the 'Certificat interUniversitaire en Éthique des Soins de Santé (CUESS)'. Publications: Her recent work addresses solidarity initiatives, crisis care ethics, and gender violence in reproductive healthcare. She also explores molecular mechanisms in skin diseases, including fungal infections and epidermal barrier dysfunction. Affiliations & Roles: Beyond academia, she advises on ethical committees and editorial boards, emphasizing translational ethics into policy and practice.

Linda Sandbladمشاهده پروفایل

دانشیار

• Cytoskeleton
• Electron Microscopy
• Bacterial Model Organisms
• +۲ مورد دیگر

Linda Sandblad is Associate Professor at the Department of Chemistry, Umeå University, and Research Fellow at Molecular Infection Medicine Sweden (MIMS). She directs the Umeå Centre for Electron Microscopy and leads research into cytoskeletal organization using advanced imaging techniques. Her research investigates: FilP protein dynamics in Streptomyces coelicolor bacterial model Keratin filament assembly in epithelial tissues Microtubule dynamics and associated protein functions Advanced electron microscopy method development Recent publications demonstrate applications of cryoelectron tomography, fluorescence imaging, and structural analysis across bacterial and eukaryotic systems, with particular focus on membrane proteins, cellular division mechanisms, and host-pathogen interactions. She received the Bo and Barbro Hammarström Prize for outstanding contributions to research infrastructure development.

• Autophagy
• Cell Biology
• Membrane Biology
• +۳ مورد دیگر

Thomas Melia is a Professor of Cell Biology at the Yale School of Medicine, part of Yale University. He leads the Melia Lab, focusing on autophagosome biogenesis and membrane dynamics during autophagy. His research integrates cell-based assays with advanced imaging techniques like electron cryo-microscopy. Key areas include understanding membrane sources for autophagosomes, lipid transport mechanisms, and organelle formation under cellular stress. Education: PhD in Biochemistry from Baylor College of Medicine (1999), BS in Biological Sciences from Carnegie Mellon University (1992) Research Interests: Autophagy, lysosomal biology, membrane trafficking, and protein aggregate clearance Lab Affiliations: Collaborates with departments like Biochemistry, Quantitative Biology, and Molecular Cell Biology Melia's work bridges molecular mechanisms with cellular function, particularly in how cells respond to starvation or pathogen invasion by degrading cytosolic components. Recent studies highlight roles for dynamin-like proteins in nuclear autophagy and lipid transfer proteins in organelle biogenesis.