Matthias Feige

Matthias Feige is an Associate Professor of Cellular Protein Biochemistry at the Technical University of Munich (TUM). He leads the Focus Group for Cellular Protein Biochemistry, previously serving as a Rudolf Mößbauer Tenure Track Assistant Professor. His research focuses on understanding cellular proteome integrity, particularly in the secretory pathway, combining protein biochemistry and cell biology. Key interests include protein folding, quality control mechanisms, and their biomedical applications.

Education & Career:

• PhD in Biochemistry (2009), TUM under Johannes Buchner
• Postdoctoral Fellowship at St. Jude Children’s Research Hospital (Memphis, USA) with Linda Hendershot
• Head of the Cellular Protein Biochemistry Lab at TUM since 2015

Research Interests:

Feige’s work explores molecular mechanisms governing protein biogenesis, secretory pathway proteins, and their roles in immunity. His interdisciplinary approach targets fundamental biology and translational applications like protein engineering and therapy development.

Scientific Contributions:

His publications highlight advancements in cytokine assembly, ER quality control, and protein aggregation mechanisms. Notable recent work includes studies on KDELR3 signaling, helminth immune modulation, and engineered cytokines.

Awards & Recognition:

• Leopoldina Fellowship (2011–2014)
• Fellow of the Daimler and Benz Foundation (2016)
• Rainer Rudolph Award (2012)
• Multiple honors from TUM and international institutions

Labs & Teams:

He directs a lab investigating protein biogenesis and proteostasis. Collaborations span biochemistry, immunology, and structural biology, with a focus on translational research.