معرفی
Michael Feig serves as Professor in the Department of Biochemistry & Molecular Biology at Michigan State University, leading the Feig Lab within the BioMolecular Science Gateway initiative. His research bridges computational modeling and molecular biology to investigate protein behavior in cellular contexts, with particular emphasis on molecular dynamics simulations and machine learning applications.
His academic background includes:
- Ph.D. (1999) from the University of Houston
- M.S. (1994) from Technical University of Berlin
Feig's research program focuses on computational biophysics of protein systems, specializing in molecular dynamics simulations of crowded cellular environments, bacterial microcompartments, and intrinsically disordered proteins. His lab develops advanced modeling techniques including coarse-grained approaches (COCOMO2) and machine learning frameworks to predict protein properties and conformational landscapes. Current work explores temperature-dependent structural ensembles, enzyme cargo loading mechanisms in engineered microcompartments, and biomolecular condensate physics under shear flow.
Analysis of his 15 most recent publications (2024-2025) reveals three dominant research thrusts: (1) integration of deep learning with molecular dynamics for protein structure prediction, (2) engineering of bacterial microcompartments for synthetic biology applications, and (3) fundamental studies of macromolecular crowding effects on diffusion and phase separation. His work consistently emphasizes methodological innovation with biological relevance, notably through enhancements to the CHARMM simulation platform.
His scientific recognition includes:
- Alfred P. Sloan Fellowship (2005)
As principal investigator of the Feig Lab, he directs research teams in computational biophysics projects supported by active funding mechanisms. While specific grant details aren't provided, his continuous publication pipeline and lab infrastructure indicate sustained research support. His mentorship spans graduate students in the Cell & Molecular Biology Program, with recent work involving multi-institutional collaborations on bacterial microcompartment engineering and protein phase separation.
The Feig Lab operates at the intersection of high-performance computing and molecular biology, maintaining strong connections with experimental groups for method validation. Current initiatives include developing generative models for temperature-dependent protein conformations and investigating cytoplasmic protein capture mechanisms in microcompartments, with potential applications in metabolic engineering and nanobiotechnology.
