جستجوی استاد راهنمای دانشگاهی

Overview Dr. Stephanie Langel is an Assistant Professor in the Department of Pathology at Case Western Reserve University School of Medicine, with a joint appointment in the Center for Global Health and Diseases. Her research focuses on mucosal immune responses, particularly IgA antibodies at maternal-neonatal interfaces and their role in protecting against viral pathogens like influenza, rotavirus, and SARS-CoV-2. She leads a multidisciplinary team using single-cell technologies, animal models, and human clinical samples. Education PhD in Virology/Immunology from The Ohio State University (2018), MS in Immunology from Virginia Tech (2013), BS in Animal Sciences from The Ohio State University (2011). Research Interests Maternal immunization strategies to boost breast milk immunity Mechanisms of maternal antibody interference in vaccine responses Mucosal immunization to block airborne virus transmission IgA immunobiology in the female reproductive tract Publications & Awards Over 20 peer-reviewed publications, including high-impact journals like Cell Host & Microbe and Mucosal Immunology . Recognized with awards including the 2022 Distinguished Alumni Award and Seed Fund Award. Active in professional societies like the Society for Mucosal Immunology. Labs & Collaborations Langel Research Team at the Center for Global Health and Diseases. Collaborates on projects involving mucosal immunity, maternal-neonatal health, and vaccine development for respiratory viruses.

• Mucosal Immunology
• Viral Immunology
• Maternal-Neonatal Health
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Rui Guo is an Assistant Professor at Tufts University School of Medicine, affiliated with the Department of Molecular Biology and Microbiology. Their research focuses on Epstein-Barr Virus (EBV) pathogenesis, particularly its role in cancers like Burkitt lymphoma and mechanisms for developing targeted therapies. Doctor of Philosophy (2018), Kansas State University Master of Science (2013) and Bachelor of Science (2010), Yangzhou University Research interests include EBV-driven metabolic vulnerabilities in B-cells, with a focus on methyl group metabolism, mitochondrial remodeling, and lipid dynamics. Their work aims to improve cancer treatments by targeting viral dependencies. Recent publications highlight discoveries in EBV's manipulation of cardiolipin synthesis , methionine metabolism , and lysosomal iron reduction in Burkitt lymphoma. Techniques include transcriptomics , metabolomics , and CRISPR/Cas9 screening . Scientific recognition includes: National Institutes of Health Grant (2022-2026) for Epstein-Barr Virus epigenetic research

• Epstein-Barr Virus (EBV) Pathogenesis
• Viral Oncology
• Cancer Metabolism
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Yi Li is a Professor at the Lester and Sue Smith Breast Center and the Department of Molecular and Cellular Biology at Baylor College of Medicine . He holds a joint appointment in the Department of Molecular Virology and Microbiology and serves as a member of the Dan L Duncan Comprehensive Cancer Center . Dr. Li earned his BS and MS from Jiangsu Agricultural College (1984, 1987) and PhD in molecular biology from Michigan State University (1996). His postdoctoral training included National Cancer Institute (2000) and Memorial Sloan Kettering Cancer Center (2002). Dr. Li's research focuses on molecular mechanisms of breast cancer initiation, progression, and metastasis , with a particular emphasis on JAK-STAT5/BCL-xL signaling , EGFR-Wnt interactions , and immune surveillance evasion . His lab pioneered immunocompetent rodent models that mirror human ER+ breast cancer, enabling studies on therapy resistance and metastasis. Recent work includes preclinical validation of intermittent anti-JAK treatment (clinical trial TBCRC042) and CRISPR/Cas9-based somatic gene editing for high-fidelity tumor modeling. The lab's 15 most recent publications span topics including RSPO2-LGR4-RANKL signaling in bone metastasis , epigenetic roles of BCL-xL , precision gene editing , and metformin/IGF-1R inhibition in triple-negative breast cancer. These studies intersect with immunology , epigenetics , and signal transduction . Key lab members include Wen Bu (Assistant Professor), Weiyu Jiang (Senior Research Assistant), Ahmed Talab (Postdoctoral Associate), and Amy Ku (Predoctoral Fellow). The lab periodically recruits postdoctoral fellows with molecular biology expertise for projects involving oncogenic driver studies and microenvironment interactions .

• Breast Cancer
• Cancer Stem Cells
• Metastasis
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Nancy Du is an Associate Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College specializing in cancer metastasis mechanisms. She holds the Mildred L. and John F. Rasweiler Research Scholar in Cancer Research title and maintains active collaborations with Northwell Health through professional services. B.S., National Tsing Hua University (Taiwan) Ph.D., State University of New York at Stony Brook Her research focuses on: Bcl-xL's non-apoptotic role in metastasis RHAMM isoform B in pancreatic cancer progression Carbon monoxide-based anti-metastatic therapies MicroRNA regulation of tumor suppressors Epigenetic mechanisms in oncogenesis Tumor microenvironment interactions Publications (2024-2019) highlight advancements in: Murine cancer models Epigenetic metastatic drivers Nanotherapy approaches T cell infiltration in tumors miRNA-dysregulated pathways Bcl-xL mutation analysis Scientific honors include: Mildred L. and John F. Rasweiler Research Scholar in Cancer Research Current grants (2024-2027): DoD: Bcl-xL in breast cancer metastasis Manhasset Women's Coalition: CO-based breast cancer prevention NCI: RHAMM B in pancreatic cancer metastasis

• Cancer Research
• Oncology
• Metastasis
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Dr. Jeffrey M. Rosen is the C.C. Bell Distinguished Service Professor and Vice-Chair of Molecular & Cellular Biology at Baylor College of Medicine. He leads a prominent research laboratory focused on mammary gland development and breast cancer, with particular emphasis on triple negative breast cancer. His work has established him as a leading expert in understanding the molecular mechanisms underlying normal mammary development and their alterations in breast cancer. Dr. Rosen's research centers on defining the mechanisms regulating normal mammary gland development to understand alterations in breast cancer. His lab specifically investigates the interplay of Wnt and Fgf family members in mammary gland development and breast cancer, translational regulation as a therapeutic vulnerability in triple negative breast cancer, and the development of unique preclinical syngeneic mouse models to study tumor response to therapies. A major focus is on understanding tumor initiating cells and the role of the immune microenvironment in treatment response. Analysis of Dr. Rosen's recent publications reveals a strong emphasis on triple negative breast cancer , with particular focus on the tumor immune microenvironment , epigenetic reprogramming , and metastasis . His work increasingly integrates single-cell analysis and spatial pathology to understand tumor heterogeneity. A growing theme is leveraging preclinical models to study metastatic breast cancer and identify novel therapeutic combinations that target both tumor cells and the immune microenvironment. Dr. Rosen has mentored an extensive number of students and postdoctoral fellows throughout his career, many of whom have gone on to become independent investigators, professors, and researchers in academia and industry. His laboratory has been consistently funded through various grants, supporting research on mammary gland development, breast cancer mechanisms, and therapeutic approaches. The lab maintains strong collaborations with other researchers at Baylor College of Medicine and beyond. The Rosen Lab at Baylor College of Medicine comprises a dynamic team of postdoctoral associates, graduate students, and technical staff working collaboratively to advance understanding of breast cancer biology. The lab maintains extensive resources including detailed protocols for mammary gland research and collaborates with other laboratories through regular lab meetings and joint projects. Current research focuses on epigenetic reprogramming of triple negative breast cancer and the tumor immune microenvironment in metastatic disease.

• Mammary gland development
• Breast cancer
• Wnt signaling
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Anastasia Vlasova, DVM, Ph.D., is an Associate Professor at The Ohio State University, primarily affiliated with the Department of Animal Sciences and the College of Food, Agricultural, and Environmental Sciences. Her role is split 90% research and 10% extension. She holds a Ph.D. in Molecular Virology from the Ivanovsky Institute for Virology (Moscow, Russia) and a DVM from the Moscow State Academy of Veterinary Medicine and Biotechnology. Her research focuses on the pathogenesis, epidemiology, and immunity of enteric viruses, particularly rotaviruses (RVs) and coronaviruses (CoVs), with an emphasis on zoonotic potential and mucosal immune responses. Key models include gnotobiotic pigs and intestinal organoids. Her work explores how innate immunity, microbiota, and dietary factors influence viral infections and vaccine efficacy. Notable projects include studying SARS-CoV-2 antibody interactions, probiotic modulation of rotavirus pathogenesis, and the evolutionary dynamics of CoVs. She leads a lab investigating viral-host interactions and public health implications of emerging pathogens.

• Innate Immunity
• Molecular Virology
• Viral Pathogenesis
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Peter Cattini, PhD, is a Professor in the Department of Physiology & Pathophysiology at the Max Rady College of Medicine , University of Manitoba. His research spans neuroendocrinology, reproductive endocrinology, and cardiovascular biology with recent expansion into cancer cell biology. PhD in Biophysics (1983) and BSc Hons in Cell & Molecular Biology (1979) from King's College London Postdoctoral training at University of California San Francisco with John D. Baxter and Norman L. Eberhardt Research foci include: Neuro- and reproductive-endocrinology: pituitary growth hormone and placental lactogen regulation Cardiovascular sciences: fibroblast growth factor family in cardiac protection Cancer biology: targeting telomere maintenance in multiple myeloma Collaborations with Drs. Elissavet Kardami (cardiovascular) and Sabine Mai (cancer) drive translational research. Awards highlight his mentorship excellence and sustained research contributions: Three-time recipient of Health Science Graduate Students' Association Mentorship Award Over a decade as Henry G. Friesen Chair in Metabolic & Endocrine Disorders MRC/CIHR Scientist Award and multiple university-level research honors Currently chairs the Manitoba Medical Service Foundation Board of Directors while maintaining active research in human growth hormone regulation and cancer cell biology.

• Neuroendocrinology
• Reproductive Endocrinology
• Cardiovascular Sciences
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