Jeffrey M. Rosen

Dr. Jeffrey M. Rosen is the C.C. Bell Distinguished Service Professor and Vice-Chair of Molecular & Cellular Biology at Baylor College of Medicine. He leads a prominent research laboratory focused on mammary gland development and breast cancer, with particular emphasis on triple negative breast cancer. His work has established him as a leading expert in understanding the molecular mechanisms underlying normal mammary development and their alterations in breast cancer.

Dr. Rosen's research centers on defining the mechanisms regulating normal mammary gland development to understand alterations in breast cancer. His lab specifically investigates the interplay of Wnt and Fgf family members in mammary gland development and breast cancer, translational regulation as a therapeutic vulnerability in triple negative breast cancer, and the development of unique preclinical syngeneic mouse models to study tumor response to therapies. A major focus is on understanding tumor initiating cells and the role of the immune microenvironment in treatment response.

Analysis of Dr. Rosen's recent publications reveals a strong emphasis on triple negative breast cancer, with particular focus on the tumor immune microenvironment, epigenetic reprogramming, and metastasis. His work increasingly integrates single-cell analysis and spatial pathology to understand tumor heterogeneity. A growing theme is leveraging preclinical models to study metastatic breast cancer and identify novel therapeutic combinations that target both tumor cells and the immune microenvironment.

Dr. Rosen has mentored an extensive number of students and postdoctoral fellows throughout his career, many of whom have gone on to become independent investigators, professors, and researchers in academia and industry. His laboratory has been consistently funded through various grants, supporting research on mammary gland development, breast cancer mechanisms, and therapeutic approaches. The lab maintains strong collaborations with other researchers at Baylor College of Medicine and beyond.

The Rosen Lab at Baylor College of Medicine comprises a dynamic team of postdoctoral associates, graduate students, and technical staff working collaboratively to advance understanding of breast cancer biology. The lab maintains extensive resources including detailed protocols for mammary gland research and collaborates with other laboratories through regular lab meetings and joint projects. Current research focuses on epigenetic reprogramming of triple negative breast cancer and the tumor immune microenvironment in metastatic disease.