معرفی
Bryan E. Welm is an Assistant Professor in the Department of Surgery at the University of Utah and an investigator at the Huntsman Cancer Institute (HCI), where he leads the Welm Labs research group. His work focuses on understanding breast cancer development through the lens of breast stem cell biology and tumor microenvironment interactions.
Dr. Welm's research interests center on breast cancer stem cells, mammary tumor development, and therapeutic approaches for metastatic disease. His laboratory investigates how breast stem cells contribute to cancer initiation and progression, with particular emphasis on understanding the cellular origins of breast cancer and the early transforming events within those cells. His team has developed innovative patient-derived xenograft and organoid models that accurately reflect human breast cancer metastasis and treatment response.
His recent publications demonstrate a strong focus on triple-negative breast cancer, tumor microenvironment interactions, and developing novel therapeutic strategies. His work spans molecular mechanisms of cancer development, translational applications of patient-derived models, and identification of new therapeutic targets for metastatic disease.
Dr. Welm completed his postdoctoral training at the University of California, San Francisco, working in the laboratory of Zena Werb, PhD. He earned his PhD from Baylor College of Medicine and completed undergraduate studies at the University of California, Santa Cruz and Diablo Valley College.
His laboratory conducts research in three major areas: developing innovative models of human breast cancer that accurately reflect metastasis and response to therapy; understanding the biology of tumor-microenvironment interactions during metastasis, particularly the role of resident macrophages; and translating these findings toward development and testing of new therapies.
