جست‌وجوی استاد و پژوهشگر

• Immunology
• Molecular Immunology
• T cell biology
• +۵ مورد دیگر

Brigitta Stockinger is a distinguished Professor at the Francis Crick Institute, leading research in the Division of Molecular Immunology. With a career spanning over three decades, she has established herself as a leading authority in immunology, particularly in the study of T cell biology and the aryl hydrocarbon receptor (AHR) pathway. PhD in Biology from the University of Mainz Postdoctoral training in London, Cambridge, and Heidelberg Member of the Basel Institute for Immunology (1985-1991) Group leader at MRC National Institute for Medical Research (1991-present, now part of Francis Crick Institute) Head of Division of Molecular Immunology (2010-present) Professor Stockinger's research has evolved from studying immune tolerance using T cell receptor transgenic mouse models to pioneering work on immunological memory with CD4 memory T cells. Her lab made seminal discoveries regarding Th17 cell differentiation factors, which led to groundbreaking research on the aryl hydrocarbon receptor (AHR) as an environmental sensor in the immune system. Her work spans fundamental immunology, infection responses, inflammation, and the intersection of environmental factors with immune regulation. Analysis of her extensive publication record (over 65 Crick publications) reveals a strong focus on Immunology (38 publications), followed by Model Organisms (12), Genetics & Genomics (10), and Tumour Biology (9). Her most influential work appears in top journals including Nature (5 papers), Nature Immunology (6 papers), and Immunity (6 papers), demonstrating the high impact of her research on understanding T cell plasticity, AHR signaling, and mucosal immunity. Fellow of the Academy of Medical Sciences (2005) EMBO fellow (2008) Fellow of the Royal Society (2013) ERC Advanced Investigator grant (2009) Wellcome Senior Investigator Grant (2013) CRUK grant (2015) Wellcome Investigator Grant (2018) Professor Stockinger's laboratory investigates how environmental factors influence immune responses through the AHR pathway, with particular emphasis on intestinal immunity, inflammation, and host-microbe interactions. Her work has significant implications for understanding inflammatory bowel diseases, infection responses, and the role of dietary components in immune regulation. She has established numerous collaborations across the Francis Crick Institute and maintains active research programs examining AHR's role in both innate and adaptive immunity.

• Genome Editing
• CRISPR Technology
• Cancer Therapeutics
• +۴ مورد دیگر

Simon Liang serves as an Assistant Professor in the Department of Medicine at the University of Minnesota School of Medicine, specializing within the Gastroenterology, Hepatology, and Nutrition Division. His research integrates genome editing technologies with cancer therapeutics, focusing on ADAR1-mediated RNA editing pathways in hematologic and solid tumors. Dr. Liang's research interests center on developing CRISPR-based therapeutic strategies for cancer treatment, with particular emphasis on ADAR1 inhibition as a novel approach for acute myeloid leukemia and prostate cancer. His work bridges genome editing , epigenetic regulation , and RNA biology to address therapeutic resistance mechanisms. Key technical expertise includes prime editing optimization, CRISPR delivery systems (particularly AAV vectors), and methylation analysis. Analysis of his publication trends reveals a strategic evolution from foundational CRISPR methodology development (2019-2021) toward therapeutic applications in oncology (2022-2025), with increasing focus on translational models including non-human primates. His most impactful recent work demonstrates ADAR1's critical role in cancer cell survival across multiple malignancies. While specific awards aren't documented in the profile, his research has garnered significant attention with PlumX metrics showing: Multiple publications picked up by news outlets Substantial social media engagement (X, Bluesky) High Mendeley reader counts indicating scholarly impact Scopus citations accumulating rapidly for 2024-2025 publications Dr. Liang actively collaborates across disciplines as evidenced by co-authorship with experts in virology, oncology, and gene therapy. His work contributes to UN Sustainable Development Goals related to good health and well-being through development of precision cancer therapeutics. Current research directions include advancing prime editing for clinical translation and exploring ADAR1 inhibitors in combination therapies.

• Developmental Biology
• Cancer Biology
• Stem Cell Research
• +۵ مورد دیگر

Dr. Saskia Suijkerbuijk is an Assistant Professor in the Department of Developmental Biology at the Faculty of Science, Utrecht University. Her research focuses on understanding the mechanisms of cancer progression, particularly in colorectal cancer, with an emphasis on cell competition, stem cell dynamics, and metastasis formation. Her research interests include: Developmental Biology and its role in cancer progression Cell competition mechanisms in intestinal and colorectal cancer Stem cell dynamics in normal and cancerous intestinal tissue Metastasis formation and the role of the tumor microenvironment Organoid modeling of cancer progression and metastasis Dr. Suijkerbuijk's work has established important connections between developmental processes and cancer progression. Her recent publications demonstrate a consistent focus on how cell competition drives tumor growth and metastasis, with particular attention to intestinal cancer models. She has developed innovative organoid transplantation approaches to study colorectal cancer progression in vivo, providing valuable insights into the cellular and molecular mechanisms underlying metastasis formation. Her scientific contributions have been recognized through publications in high-impact journals including Nature Communications, Cell Stem Cell, and PNAS.

• Computational Genomics
• Single-Cell Genomics
• Immunology
• +۳ مورد دیگر

Dr. Stephen Sansom serves as Associate Professor and Group Leader of the Computational and Single Cell Genomics Group at the University of Oxford's Kennedy Institute. His work bridges computational biology with immunology to decode inflammatory disease mechanisms through advanced genomic approaches. His academic foundation includes a BSc (Hons) in Biochemistry from the University of Dundee (2001) followed by a DPhil in Developmental Biology through the Wellcome Trust 4-year PhD programme at the University of Cambridge. Postdoctoral research at the Gurdon Institute with Dr. Rick Livesey established his expertise in genomic analysis of neural development. Dr. Sansom's research centers on computational genomics of immune processes, particularly central tolerance mechanisms and inflammatory disorders. His group pioneers single-cell genomic methodologies to dissect cellular heterogeneity in conditions like inflammatory bowel disease, rheumatoid arthritis, and atherosclerosis. Key innovations include developing frameworks for analyzing promiscuous gene expression in thymic epithelia and deconvoluting monocyte responses in immune-mediated diseases through collaborative projects with experimental immunologists. Analysis of his recent publications reveals dominant themes in macrophage biology during atherosclerosis progression, B/T cell dynamics in viral infections (including influenza and COVID-19), and stromal cell contributions to joint destruction in arthritis. His work consistently identifies novel cellular states and molecular networks driving pathogenesis, with strong emphasis on translational relevance for therapeutic targeting. Supported initially by an MRC Career Development Fellowship in Chris Ponting's CGAT program, Dr. Sansom now directs the Computational Genomics team he established at the Kennedy Institute in 2014. His collaborative model integrates computational expertise with wet-lab immunology across multiple Oxford research groups. The Sansom Group operates as the Computational and Single Cell Genomics Group within the Kennedy Institute, maintaining specialized pipelines for high-dimensional genomic data analysis. Current efforts focus on scaling single-cell multi-omics approaches to track immune cell evolution during chronic inflammation and infection.

Siriluck Wimmersمشاهده پروفایل

دانشیار

• Molecular Genetics
• Genomics
• Meat Quality
• +۷ مورد دیگر

Siriluck Wimmers is a leading researcher at the Research Institute for Farm Animal Biology (FBN) in Dummerstorf, Germany, where she heads the Department of Functional Genome Analysis within the Institute of Genome Biology. She is the leader of the Integrative Genomics Working Group, focusing on the molecular genetics of farm animal performance traits. Her academic background includes a habilitation from the University of Bonn and prior teaching experience at Chiang Mai University, Thailand. PhD in Agricultural Sciences, TU Berlin (1995) Habilitation, Faculty of Agricultural Sciences, University of Bonn (2003) Assistant Professor, Chiang Mai University (1997) Research Assistant, University of Bonn (1997–2003) Senior Assistant, FBN (2004–2013) Head of Department, FBN (2014–present) Her research centers on the molecular genetics of meat quality, miRNA regulatory networks in muscle cells, and the genotype-phenotype relationship in farm animals. She investigates how genetic and epigenetic factors influence traits such as meat quality, energy metabolism, and stress response. Her work combines functional genomics, transcriptomics, and epigenetics to understand the biological mechanisms underlying economically important traits in pigs, poultry, and cattle. Her recent publications highlight a strong focus on gene expression, DNA methylation, nutrient metabolism (especially phosphorus and vitamin D), and stress responses in livestock. She frequently studies pigs and laying hens, using advanced genomic techniques to dissect molecular pathways related to feed efficiency, meat quality, and adaptation. Her work often involves multi-tissue analyses and collaborations across disciplines. Siriluck Wimmers has not been mentioned as receiving specific scientific awards in the provided text. She has mentored and collaborated with numerous researchers, including Michael Oster, Henry Reyer, Eduard Muráni, and Siriluck Ponsuksili. Her leadership in large collaborative projects suggests a significant role in guiding junior scientists and research teams. While specific grant details are not listed, her sustained research output implies successful funding acquisition. She leads the Integrative Genomics Working Group at FBN, which conducts cutting-edge research in functional genomics and systems biology of farm animals. The group likely operates advanced molecular biology and bioinformatics facilities to support high-throughput genomic analyses.

Francesco Neriمشاهده پروفایل

استاد

• Epigenetics
• Aging Research
• Cancer Biology
• +۵ مورد دیگر

Francesco Neri is a Professor at the Department of Life Sciences and Systems Biology (DBIOS) at the University of Turin, Italy. His research focuses on the epigenetic mechanisms underlying aging and cancer development, particularly in intestinal stem cells. He leads the Epigenetics of Aging & Cancer Lab located at the Molecular Biotechnology Center (MBC) "Guido Tarone" in Turin and maintains collaborations with the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) in Jena, Germany. Professor Neri's research interests span several interconnected areas related to aging and disease: Epigenetic drift and DNA methylation changes during aging Intestinal stem cell biology and regeneration in aging Inflammaging (age-related chronic inflammation) Gut microbiome dysbiosis in elderly individuals Development of dietary interventions for healthy aging Colon cancer development and epigenetic mechanisms His research group employs cutting-edge technologies including single-cell RNA sequencing, organoid culture systems, and various genome-wide approaches (RNA-seq, ChIP-seq, ATAC-seq, Bisulfite-seq) to investigate the molecular mechanisms connecting aging with intestinal dysfunction and cancer. Recent work has revealed important connections between interferon gamma signaling, intestinal stem cell function, and tissue regeneration in aging. Professor Neri's publication record demonstrates a strong focus on aging, epigenetics, and intestinal biology, with numerous high-impact publications in journals such as Nature Communications, Cell Reports, and Nature Reviews. His work shows a clear trajectory from fundamental epigenetic mechanisms to translational applications in aging and cancer. His research has important implications for developing interventions to improve intestinal health in elderly individuals and potentially prevent age-related diseases including cancer.

Edward Bonderمشاهده پروفایل

استاد

• Cell Biology
• Cytoskeleton Dynamics
• Actin-Microtubule Interactions
• +۵ مورد دیگر

Edward Bonder serves as Professor of Cell Biology and Chair in the Department of Biological Sciences within the College of Arts and Sciences at Rutgers University-Newark. His laboratory investigates the structural and functional dynamics of the actin cytoskeleton across multiple biological contexts including morphogenesis, cell-cell contact formation, and organelle motility. Utilizing marine gamete models and cultured epithelial systems, his research bridges fundamental cell biology with developmental processes. Education: B.A. in Biology, University of Pennsylvania (1976) Ph.D. in Cell Biology, University of Pennsylvania (1983) Dr. Bonder's research focuses on actin-myosin interactions governing cellular dynamics, with particular emphasis on myosin motor proteins in fertilization models, adherens junction formation, and mitochondrial motility along cytoskeletal tracks. His work demonstrates how Rho GTPase signaling, microtubule-actin crosstalk, and unconventional myosins regulate cell polarization, wound healing, and embryonic development. The laboratory employs sea urchin coelomocytes and epithelial cell cultures to dissect stimulus-response mechanisms in organelle transport and cell adhesion. Publication analysis reveals sustained contributions to cytoskeletal dynamics over 25+ years, with recent work expanding into cancer biology, stem cell regulation, and host-microbe interactions. Key themes include Rab11-dependent trafficking, CDC42-mediated tumor suppression, and TLR sorting mechanisms - all rooted in fundamental cytoskeletal principles established through earlier sea urchin and epithelial models. No scientific awards are documented in the provided materials. Dr. Bonder maintains active research programs examining cytoskeletal regulation in development and disease, with consistent funding evidenced by continuous publication in high-impact journals including PNAS, Journal of Cell Biology, and EMBO Journal. His laboratory trains researchers in advanced cell imaging, molecular perturbation techniques, and model system applications. The research group operates from 309 Boyden Hall, utilizing sea urchin fertilization models, epithelial cell culture systems, and molecular approaches to investigate cytoskeletal dynamics across scales from single molecules to tissue organization. Current projects integrate traditional cell biology with emerging work in intestinal stem cells and microbial homeostasis.

• Pharmacology
• Cannabinoid Research
• Neuroscience
• +۴ مورد دیگر

Federica POLLASTRO is an Associate Professor at the University of Eastern Piedmont 'Amedeo Avogadro', Department of Pharmaceutical Sciences. Her research focuses on cannabinoid pharmacology, drug delivery systems, and neuropharmacology, with particular emphasis on the therapeutic potential of cannabinoids in neurodegenerative and inflammatory diseases. She leads projects such as NOrCa (Exploring Cannabis waste for circular economy applications) and has collaborated on initiatives like PRIME (green chemistry processes) and NUTRAcore (bioeconomy-driven food ingredients). Her work addresses cannabinoid synthesis, cytotoxic effects on cancer cells, and molecular mechanisms underlying neuroprotection. Key collaborations span European institutions, with projects funded by the Italian Ministry of Research and Piedmont Region. Publications emphasize transcriptomic analysis of cannabinoids' effects on Alzheimer's, Parkinson's, and glioblastoma models. Research activity highlights include: Over 150 peer-reviewed articles (2005–2025) Principal Investigator on grants totaling €2M+ (e.g., FFABR 2017, NOrCa 2023–2025) Development of novel cannabinoid derivatives and drug delivery systems Investigations into bitter taste receptor signaling in gastrointestinal physiology

Brooke R. Drulinerمشاهده پروفایل

استادیار

• Epigenetic Memory Mechanisms
• Intestinal Stem Cell Regulation
• Organoid Models
• +۴ مورد دیگر

Brooke R. Druliner, Ph.D., is an Assistant Professor at Mayo Clinic, holding academic appointments in Biochemistry and Molecular Biology, Medicine, Physiology & Biomedical Engineering, and Gastroenterology/Hepatology. Her research focuses on epigenetic memory mechanisms in intestinal stem cells, leveraging organoid models and genome engineering to study diseases like colorectal cancer and inflammatory bowel disease. She leads a lab developing novel methodologies for stem cell regulation analysis and has pioneered microfluidic systems for studying gut-nerve interactions. Dr. Druliner has been awarded NIH Loan Repayment and KL2 Career Development Awards, and actively contributes to the American Gastroenterological Association's research initiatives. Education: Ph.D. in Cell and Molecular Biology (Florida State University), BA in Anthropology (Rollins College). She is affiliated with Mayo's Center for Regenerative Biotherapeutics and the Stem Cell and Organoid Core. Research areas include epigenomic memory in disease contexts, organoid-based drug discovery, and translational strategies for gastrointestinal disorders. Her work bridges basic science and clinical applications, aiming to improve predictive and therapeutic approaches for patients.

Jason Millsمشاهده پروفایل

استاد

• Paligenosis
• Cellular Reprogramming
• Stem Cells
• +۶ مورد دیگر

Dr. Jason Mills is the Herman Brown Endowed Professor at Baylor College of Medicine, where he serves as Chief of Research and Vice Chief in the Department of Gastroenterology & Hepatology. He is also Co-Director of the Texas Medical Center Digestive Disease Center and Co-Associate Director for Cancer Research Training and Education at the Dan L Duncan Comprehensive Cancer Center. Dr. Mills leads the Mills Lab, which focuses on cellular reprogramming and cancer mechanisms. Dr. Mills received his AB from Washington University in St. Louis (1989), followed by an MD-PhD from the University of Pennsylvania School of Medicine (1997). He completed his postdoctoral fellowship at Washington University Medical Center (2002). Dr. Mills' research centers on paligenosis, a cellular program he identified that allows mature cells to return to a regenerative state. His work explores how this process contributes to tissue repair but also increases cancer risk through the development of precancerous conditions like metaplasia. Using organoid models derived from patient cancer cells and genetic mouse strains, his lab investigates the molecular mechanisms of cellular plasticity in gastric biology, with implications for cancer prevention and treatment. His research integrates cell biology, metabolism, and translational approaches to understand how cells adapt to stressors. Analysis of Dr. Mills' recent publications reveals a strong focus on the molecular mechanisms of paligenosis and its role in gastric metaplasia and cancer development. His work spans basic cell biology investigations of cellular reprogramming to translational studies using patient-derived organoids. Key themes include the role of transcription factors like SOX9, metabolic regulation of cell fate decisions, and the identification of biomarkers for cancer progression. Dr. Mills has received several prestigious awards, including: Excellence in Research and Leadership Award from Baylor College of Medicine (2022) Top Reviewer for Gastroenterology from the American Gastroenterological Association (2022) Membership Induction to the Association of American Physicians (2022) Research Mentor Award from the AGA Institute Council (2022) Dr. Mills currently mentors several graduate students and postdoctoral researchers in the Mills Lab. His research is supported by multiple NIH grants totaling over $30 million, including R01 grants from NCI and NIDDK focused on mechanisms of paligenosis, metaplasia, and gastric cancer development. These grants support investigations into cellular reprogramming, stem cell differentiation, and therapeutic approaches for precancerous lesions. The Mills Lab maintains a collection of organoids derived from patient cancer cells and utilizes advanced techniques including single-cell RNA sequencing and spatial transcriptomics. The lab collaborates with clinicians at Baylor College of Medicine and across the Texas Medical Center to translate basic findings into clinical applications for personalized cancer treatment.

Mary Millerمشاهده پروفایل

استاد

• Genetics
• Microbiology
• Cancer Biology
• +۶ مورد دیگر

Mary Miller is a Professor of Biology at Rhodes University, specializing in cell cycle regulation and cancer biology. Her research focuses on the molecular mechanisms governing eukaryotic cell division, particularly cyclin protein dynamics and DNA damage responses. B.A., University of Tennessee Ph.D., University of Virginia (Genetics, Microbiology, Cell Biology) Her laboratory investigates how the anticancer drug KP1019 induces cell cycle arrest in Saccharomyces cerevisiae , with implications for oncogenic processes in humans. Key areas include: Genome-wide transcriptional analysis Cell division cycle coordination Protein localization mechanisms Chemotherapeutic drug effects Recent publications highlight KP1019's impact on DNA damage responses and educational initiatives in yeast genetics. Collaborations include work with Pam Hanson and Laura Stultz.

• Virology
• Immunology
• Glycobiology
• +۴ مورد دیگر

Alinda Berends is a Researcher and Teacher at the Pharmacology department within the Faculty of Science at Utrecht University . Her work bridges virology, immunology, and glycobiology.

Kyongbum Leeمشاهده پروفایل

استاد

• Metabolic Engineering
• Tissue Engineering
• Systems Biology
• +۳ مورد دیگر

Kyongbum Lee is the Karol Family Professor and Dean of Engineering at Tufts University School of Engineering, where he also serves as Professor in the Department of Chemical and Biological Engineering. His research integrates metabolic engineering, tissue engineering, and systems biology to study cellular metabolism and develop technologies for biomedical applications. Dr. Lee directs a laboratory focused on host-microbe interactions, cell-based bioprocesses, and metabolic regulation in diseases like obesity. Education Ph.D., Massachusetts Institute of Technology, 2002 B.S., Stanford University, 1995 Research Focus Dr. Lee's group employs systems approaches combining experimental and computational methods to investigate how metabolites regulate cellular communication. Current projects examine gut microbiome interactions, metabolic flux in engineered tissues, and development of therapeutic strategies targeting metabolic disorders. The lab specializes in bioreactor systems, metabolomic profiling, and mechanistic studies of metabolite signaling pathways. Publication Trends Recent publications emphasize gut microbiota metabolism, microbial metabolite therapeutics, and engineered tissue models. Work consistently demonstrates translational focus—from computational prediction of metabolic pathways (e.g., flavonoid biotransformation algorithms) to preclinical validation of microbial metabolites in disease models (e.g., steatosis reduction via indole derivatives). Recurring themes include nuclear receptor modulation, HDAC/IFN-γ pathway regulation, and high-throughput screening platforms. Awards Karol Family Professorship (endowed position recognizing scholarly excellence) Research Operations The laboratory actively recruits postdoctoral researchers and graduate students through Tufts' Chemical and Biological Engineering program. Current projects are supported by specialized infrastructure for metabolomics, bioreactor systems, and 3D tissue culture. The team emphasizes interdisciplinary collaboration, particularly at the interface of engineering, microbiology, and translational medicine.

Catarina M Henriquesمشاهده پروفایل

پژوهشگر ارشد

• Ageing Research
• Telomere Biology
• Zebrafish Models
• +۵ مورد دیگر

Catarina M Henriques is a Senior Research Fellow at the University of Sheffield's School of Medicine and Population Health. She leads a research group focused on Telomere Biology, Ageing, and Regenerative Medicine, with affiliations to the Bateson Centre , Healthy Lifespan Institute (HELSI) , and CIMA (Centre for Integrated research into Musculoskeletal Ageing). BSc (Hons) in Molecular & Cellular Biology, University of Glasgow PhD in Immunology and Cancer, University of Lisbon (FCT Fellowship) Her research explores the interplay between telomere dysfunction, cellular senescence, and immune/stem cell regulation in tissue homeostasis decline during ageing. Using zebrafish models , she investigates how telomerase-dependent mechanisms influence multi-tissue degeneration and therapeutic rejuvenation strategies. Recent work highlights telomere dynamics in immunity, intestinal permeability, and neurodegeneration. Key publications include: 2024: Telomere length as an epigenetic trait in disease modeling 2023: p21-GFP senescence zebrafish for senolytic testing 2022: Gut leukocyte telomere dependence and retinal regeneration Her work bridges the Versus Arthritis CIMA and Bateson Centre collaborations. Scientific awards include: Sir Henry Dale Fellowship (Wellcome Trust/Royal Society) CIMA Research Fellowship Vice-Chancellor’s Fellowship She supervises postgraduate researchers and contributes to undergraduate/postgraduate education via modules on multimorbidity, reproduction, and human disease modeling. The lab employs histology, immunofluorescence, flow cytometry, and cell culture to study zebrafish tissue repair mechanisms.

• Stem cell biology
• Tissue engineering
• Bioprinting
• +۳ مورد دیگر

Dr. Kerstin Schneeberger-Verjaal is an Assistant Professor at the Department of Clinical Sciences, Internal Medicine of Companion Animals, Faculty of Veterinary Medicine, Utrecht University. She also serves as a Scientific Advisor at Orgonex B.V. Her research focuses on stem cell biology and tissue engineering, particularly developing mini-livers from patient-derived stem cells to address organ shortages for transplantation. VenI grant recipient (2018) for liver research Co-developer of synthetic growth gel for large-scale liver cell culture Principal investigator in €1.4 million Horizon 2020 bioprinting project Her recent publications highlight advancements in bioprinting technology , hydrogel development , and organoid scalability . Key research collaborations include Dr. Bart Spee and European experts in the ORGANTRANS consortium. Scientific awards: 2018 NWO Veni grant 2018 WFIRM Young Investigator Award 2017 Aegean award (Tissue Engineering Conference) 2017 Best selected presentation at HEPRO symposium 2014 EMBO workshop attendance grant 2013 Best oral presentation (Dutch Stem Cell Meeting) In her ancillary role at Orgonex B.V., she contributes to commercial applications of organoid technology. Her work has generated multiple patents and translational grants for clinical implementation of synthetic growth gels.