معرفی
Francesco Neri is a Professor at the Department of Life Sciences and Systems Biology (DBIOS) at the University of Turin, Italy. His research focuses on the epigenetic mechanisms underlying aging and cancer development, particularly in intestinal stem cells. He leads the Epigenetics of Aging & Cancer Lab located at the Molecular Biotechnology Center (MBC) "Guido Tarone" in Turin and maintains collaborations with the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) in Jena, Germany.
Professor Neri's research interests span several interconnected areas related to aging and disease:
- Epigenetic drift and DNA methylation changes during aging
- Intestinal stem cell biology and regeneration in aging
- Inflammaging (age-related chronic inflammation)
- Gut microbiome dysbiosis in elderly individuals
- Development of dietary interventions for healthy aging
- Colon cancer development and epigenetic mechanisms
His research group employs cutting-edge technologies including single-cell RNA sequencing, organoid culture systems, and various genome-wide approaches (RNA-seq, ChIP-seq, ATAC-seq, Bisulfite-seq) to investigate the molecular mechanisms connecting aging with intestinal dysfunction and cancer. Recent work has revealed important connections between interferon gamma signaling, intestinal stem cell function, and tissue regeneration in aging.
Professor Neri's publication record demonstrates a strong focus on aging, epigenetics, and intestinal biology, with numerous high-impact publications in journals such as Nature Communications, Cell Reports, and Nature Reviews. His work shows a clear trajectory from fundamental epigenetic mechanisms to translational applications in aging and cancer.
His research has important implications for developing interventions to improve intestinal health in elderly individuals and potentially prevent age-related diseases including cancer.
