جست‌وجوی استاد و پژوهشگر

Maxim Artyomovمشاهده پروفایل

استاد

• Systems Immunology
• Immunometabolism
• Cancer Immunology
• +۲ مورد دیگر

Maxim Artyomov is an Alumni Endowed Professor and Professor of Pathology and Immunology at Washington University School of Medicine , with affiliations to the Institute of Clinical and Translational Sciences (ICTS), Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs), and Siteman Cancer Center. His research spans Systems Immunology , Immunometabolism , and Cancer Immunology , focusing on integrating epigenetic, transcriptional, and metabolic regulation in immune cells. 2018 promoted to Associate Professor with Tenure 2017 awarded LEAP Inventor Challenge 2018 Unanue Prize for Innovative Research in Immunology Key research contributions include: Discovery of itaconate's anti-inflammatory role (2016) Metabolic reprogramming in macrophage polarization (2015) TREM2's function in microglial metabolic fitness (2017) Development of CORESH gene signature search engine (2025) His high-throughput omics pipelines enable cross-disciplinary analysis of immune responses in tuberculosis, Alzheimer's, and cancer. Notable collaborations include work with Schreiber's lab on immune checkpoint therapy (2018) and ITMO University on systems biology workshops (2017-2018). Awards and grants include the Unanue Prize (2018), LEAP Inventor Challenge (2017), and R01 grant from NIAID (2017). He mentors PhD/MSTP students and co-organizes international systems biology workshops.

Eduardo N. Chiniمشاهده پروفایل

استاد

• Metabolism
• NAD Metabolism
• Aging
• +۱۱ مورد دیگر

Eduardo N. Chini, M.D., Ph.D., is a Professor at Mayo Clinic with primary and joint appointments in the Department of Anesthesiology and Perioperative Medicine and the Department of Cancer Biology. He is based in Rochester, Minnesota, and leads a research program focused on NAD metabolism, aging, and their roles in diseases such as cancer, obesity, and kidney disease. Education: BS in Biology, Centro Educacional de Niteroi-RJ MD, Universidade do Rio de Janeiro PhD in Biological Chemistry, Universidade do Rio de Janeiro Fellow, Department of Physiology and Biophysics, Mayo Clinic Resident in Anesthesiology, Mayo Clinic College of Medicine Research Interests: Eduardo N. Chini's research investigates the central role of nicotinamide adenine dinucleotide (NAD) in cellular metabolism, aging, and disease. His lab has made foundational discoveries in NAD catabolism, identifying CD38 as the primary enzyme regulating NAD levels in mammals. His work explores SIRT1 regulation via CD38 and DBC1, NAD metabolism in cancer, and its implications in polycystic kidney disease. He is particularly interested in how NAD signaling influences aging, metabolic syndrome, and organ dysfunction. Recent Research Trends: His recent publications (2023–2025) reveal a strong focus on the role of CD38 in aging, immune function, and tissue metabolism. Key themes include NAD+ depletion triggering inflammatory responses, CD38 inhibition as a therapeutic strategy for cardiotoxicity and metabolic aging, and the interplay between senescence, stem cell function, and mitochondrial health. His work increasingly integrates translational models with molecular mechanisms in aging and cancer. Scientific Awards: Florida Investigator of the Year, Mayo Clinic (2024) Glenn/AFAR Breakthroughs in Gerontology Award (2007) Edward C. Kendall Award, Mayo Clinic Alumni Association (2002) Directors Award for Aging Research, Kogod Center on Aging (2018) Distinguished Scientist Seminar Series, Georgetown Medical School (2022) Grants and Leadership: Dr. Chini is a co-Principal Investigator on multiple NIH-funded grants, including projects on CD38 in scleroderma, CLL, and male reproductive aging. He is Co-Director of the Mayo Clinic Mitochondrial Care Center and Associate Director of the Robert and Arlene Kogod Center on Aging. He has served on numerous national review panels and advisory councils, including the NIH Hepatobiliary Pathophysiology Study Section and AFAR's National Scientific Advisory Council. Labs and Teams: Dr. Chini leads a research laboratory at Mayo Clinic focused on NAD metabolism and aging. His team collaborates extensively with experts in cancer biology, mitochondrial medicine, and aging research. He is affiliated with the Mayo Clinic Comprehensive Cancer Center, the Kogod Center on Aging, and the Robert M. and Billie Kelley Pirnie Translational PKD Center.

Karl-Heinz Wagnerمشاهده پروفایل

استاد

• Oxidative stress and DNA stability
• Molecular nutrition and phytochemicals
• Dietary antioxidants and aging
• +۵ مورد دیگر

Karl-Heinz Wagner is Full Professor of Nutrition and Food Quality at the University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences. He directs an experimental research group investigating how lifestyle factors—diet, specific food components, phytochemicals, physical activity and bioactive non-food compounds—modulate oxidative stress and DNA stability in humans, with emphasis on aging and sarcopenia. He initiated the university-wide “Active Ageing” research platform and coordinates EU projects such as SHIFT2HEALTH. Education & Affiliations: University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences – Professor and Chair of Nutrition and Food Quality Principal investigator of the Emerging Field “Oxidative Stress and DNA Stability” Head of the “Active Ageing” research platform activeageing.univie.ac.at Research Focus: Prof. Wagner’s group applies state-of-the-art biochemical and molecular techniques to quantify antioxidant compounds, ROS-induced DNA and chromosomal damage, DNA repair capacity and transcriptional regulation of antioxidant defenses. Human intervention trials, cross-sectional cohorts and in-vitro models are used to examine: Impact of plant-based vs. animal-based diets on multimorbidity risk Nitrate-rich beetroot juice effects on microbiome, vascular function and oxidative stress Bilirubin biology and metabolic health in Gilbert’s syndrome High-protein nutrition and resistance training on DNA damage and muscle quality in older adults Microbiota-derived metabolites that enhance CD8 T-cell antitumor immunity after exercise Publication Trends 2023-2025: Recent output demonstrates a strategic shift toward multi-omics integration (metabolomics, lipidomics, proteomics) to dissect diet–microbiome–immune crosstalk and to identify predictive biomarkers of healthy ageing. Papers consistently appear in top-tier journals (Cell, Lancet Healthy Longev, Redox Biol, Mol Nutr Food Res) and embrace large multinational cohorts, randomized controlled trials and mechanistic animal/cellular work. Funding & Networks: Research is mainly funded by the Austrian Science Fund (FWF), National Bank, European Commission (Horizon 2020, Horizon Europe), EU Cross-Border Co-operation and the University of Vienna. A dense national and international partner network ensures continuous biomarker development and knowledge transfer. Student Training & Citizen Science: Prof. Wagner actively involves MSc/PhD students and post-docs in externally funded projects and advertises internships via ERASMUS+. Study participant recruitment portals for projects like SHIFT2HEALTH, NUTRIAGING and bilirubin clinical studies are maintained to engage the public and foster translational impact.

Sheng Liمشاهده پروفایل

دانشیار

• Cancer Epigenetics
• Aging
• Clonal Hematopoiesis
• +۳ مورد دیگر

Sheng Li is an Associate Professor of Cancer Biology at the University of Southern California's Keck School of Medicine. She co-leads the Epigenetic Regulation in Cancer Program at the Norris Comprehensive Cancer Center. Her research integrates multi-omics and computational approaches to study epigenetic heterogeneity in blood cancers, aging, and clonal hematopoiesis. Her lab focuses on single-cell spatial multi-omics, 3D epigenomics, and long-read sequencing to map epigenetic drivers of leukemogenesis. Awards include the Leukemia & Lymphoma Society Scholar Award and AACR NextGen Star recognition. She mentors PhD students and postdocs, with her team publishing extensively in high-impact journals. Her publications demonstrate a strong emphasis on computational epigenetics, cancer systems biology, and geroscience. Recent work includes developing tools for spatial transcriptomics interpretation and modeling IDH-mutant AML gene networks.

Khashayarsha Khazaieمشاهده پروفایل

استاد

• Cancer Immunology
• Inflammation
• Regulatory T Cells
• +۱۲ مورد دیگر

Khashayarsha Khazaie, Ph.D., is a Professor of Immunology at Mayo Clinic in Phoenix, Arizona, with a primary appointment as a Consultant in the Department of Immunology and a joint appointment in Cancer Biology, Department of Research. He leads a research laboratory focused on cancer immunology, inflammation, and the tumor-microbiota-immune axis, with emphasis on gastrointestinal and gynecological malignancies. Education: Ph.D. in Genetics/Senescence, MRC, National Institute for Medical Research Doctor of Science, University of Paris V, René Descartes BSc (Hons) in Chemistry, Biology, Physics, University of Surrey Postdoctoral Research, CNRS; EMBL; National Institute for Medical Research Research Interests: Dr. Khazaie’s lab investigates regulatory T cells (Tregs), mast cells, circadian rhythms, fibrosis, and microbial-based cancer vaccines. His work explores how immune suppression and chronic inflammation promote tumor growth, particularly in colorectal and endometrial cancers. Key areas include Treg plasticity, epigenetic reprogramming, microbiota-driven carcinogenesis, and the immunology of metastasis. Recent Research Trends: His most recent publications highlight the role of circadian disruption in colon cancer, the therapeutic potential of biomaterial-enhanced Treg immunotherapy, and the use of single-cell and spatial-omics to dissect immune-related diseases. His studies integrate molecular, cellular, and systems-level approaches to understand immune dysregulation in cancer and chronic inflammation. Scientific Leadership: Director, Federation of Clinical Immunology Societies, Mayo Clinic Center of Excellence (2018–present) Associate Editor, Journal for ImmunoTherapy of Cancer (2013–present) Editorial Board, Cancer Immunology Research (2012–present) Associate Editor, Tumor Immunity, Frontiers in Immunology and Oncology (2011–present) Visiting Professor, University of Regensburg (2016); Université Paris-Est Créteil (2016) Grants and Advising: Dr. Khazaie has led multiple NIH-funded projects, including studies on Parvimonas micra-induced carcinogenesis, β-catenin in Treg expansion, and circadian disruption in colon cancer. He mentors researchers and contributes to the education of future physicians and scientists in immunology and cancer biology. His lab collaborates with Biomed Valley Discoveries and MD Anderson on clinical trials of bacterial vaccines for metastatic cancer. Laboratory and Collaborations: His laboratory operates at the interface of basic and translational science, using mouse models, clinical specimens, and multi-omics technologies. He is deeply involved in collaborative research networks, particularly in cancer immunology and microbiota studies.

Shelley L. Bergerمشاهده پروفایل

استاد

• Epigenetics
• Chromatin structure and function
• Histone modifications
• +۷ مورد دیگر

Shelley L. Berger is the Daniel S. Och University Professor at the University of Pennsylvania, holding a "Penn Integrates Knowledge" Presidential Appointment. She serves as Director of the Epigenetics Institute at the Perelman School of Medicine and is Co-Director of the Tumor Biology Program at the Abramson Cancer Center. Her academic appointments span multiple departments including Cell and Developmental Biology, Biology, and Genetics. Dr. Berger earned her B.S. in Biology from the University of Michigan, Ann Arbor in 1982, followed by a Ph.D. in Cell & Molecular Biology from the same institution in 1987. Her distinguished career has led to her current position as a University Professor, one of the highest academic honors at the University of Pennsylvania. Dr. Berger's research focuses on epigenetics and chromatin structure/function in genomic regulation, with particular interest in post-translational modifications of histones and transcription factors. Her laboratory investigates how DNA-packaging structures are manipulated during genomic processes, with applications to understanding cancer, neurodegeneration, and other diseases. Her work spans multiple biological contexts including: Chromatin regulation of transcription Neuroepigenetics and memory formation Behavioral epigenetics in social insects Chromatin regulation in aging and senescence Cancer epigenetics and tumor suppressor mechanisms Analysis of Dr. Berger's recent publications reveals a strong focus on the intersection of epigenetics with aging, cancer, and neurobiology. Her work demonstrates how histone modifications and chromatin remodeling influence cellular senescence, with implications for age-related diseases including Alzheimer's. She has also pioneered research on epigenetic mechanisms in social behavior using ant models, and in T cell exhaustion relevant to cancer immunotherapy. A unifying theme across her publications is the role of specific histone modifications and chromatin regulators in controlling gene expression programs in diverse biological contexts. Dr. Berger has received numerous honors including her appointment as a Daniel S. Och University Professor and a "Penn Integrates Knowledge" Presidential Appointment, recognizing her exceptional interdisciplinary contributions to science. These prestigious appointments reflect her significant impact on the fields of epigenetics and chromatin biology. Dr. Berger mentors a vibrant research team consisting of multiple postdoctoral researchers, graduate students, and research specialists. Her laboratory, part of the Epigenetics Institute at Penn, investigates fundamental mechanisms of chromatin regulation with implications for human health and disease. Current research directions include exploring how epigenetic mechanisms control aging processes, cancer development, and social behavior in model organisms. Dr. Berger collaborates extensively with other leading researchers, including Carl June (pioneer of CAR T cell therapy) and John Wherry (expert in T cell exhaustion), to translate basic epigenetic discoveries into potential therapeutic applications. The Berger Lab operates within the Smilow Center for Translational Research at the University of Pennsylvania. The lab employs a multidisciplinary approach combining molecular biology, genomics, bioinformatics, and model organism studies to investigate chromatin regulation. Current research foci include epigenetic mechanisms in aging and senescence, cancer epigenetics, neuroepigenetics, and behavioral epigenetics in social insects.

Francesco Neriمشاهده پروفایل

استاد

• Epigenetics
• Aging Research
• Cancer Biology
• +۵ مورد دیگر

Francesco Neri is a Professor at the Department of Life Sciences and Systems Biology (DBIOS) at the University of Turin, Italy. His research focuses on the epigenetic mechanisms underlying aging and cancer development, particularly in intestinal stem cells. He leads the Epigenetics of Aging & Cancer Lab located at the Molecular Biotechnology Center (MBC) "Guido Tarone" in Turin and maintains collaborations with the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) in Jena, Germany. Professor Neri's research interests span several interconnected areas related to aging and disease: Epigenetic drift and DNA methylation changes during aging Intestinal stem cell biology and regeneration in aging Inflammaging (age-related chronic inflammation) Gut microbiome dysbiosis in elderly individuals Development of dietary interventions for healthy aging Colon cancer development and epigenetic mechanisms His research group employs cutting-edge technologies including single-cell RNA sequencing, organoid culture systems, and various genome-wide approaches (RNA-seq, ChIP-seq, ATAC-seq, Bisulfite-seq) to investigate the molecular mechanisms connecting aging with intestinal dysfunction and cancer. Recent work has revealed important connections between interferon gamma signaling, intestinal stem cell function, and tissue regeneration in aging. Professor Neri's publication record demonstrates a strong focus on aging, epigenetics, and intestinal biology, with numerous high-impact publications in journals such as Nature Communications, Cell Reports, and Nature Reviews. His work shows a clear trajectory from fundamental epigenetic mechanisms to translational applications in aging and cancer. His research has important implications for developing interventions to improve intestinal health in elderly individuals and potentially prevent age-related diseases including cancer.

• Non-Alcoholic Fatty Liver Disease
• Intestinal Mucosal Barrier
• Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
• +۳ مورد دیگر

Annette Brandt is a researcher affiliated with the Department of Nutritional Sciences within the Faculty of Life Sciences . Her work focuses on metabolic and liver diseases, with a particular emphasis on non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), and the role of intestinal barrier dysfunction in disease progression. She investigates mechanisms involving microbiota modulation, inflammatory pathways (e.g., TNFα, JNK), and dietary interventions (e.g., choline, beta-glucan, phosphatidylcholine) to mitigate liver damage. Her research also explores the interplay between aging, inflammation ('inflammaging'), and intestinal permeability. Brandt has contributed to over 38 peer-reviewed publications and 47 academic activities, including presentations at conferences. Her studies utilize mouse models to explore therapeutic strategies for liver diseases and metabolic disorders. Key collaborations involve investigating the effects of dietary components (e.g., fructose, soybean oil) and pharmacological agents (e.g., honokiol, 4-methylpyrazole) on liver health. She has also examined the role of toll-like receptors (TLR2/TLR4) in aging-related pathologies and cognitive decline. Her research aligns with UN Sustainable Development Goals related to good health and well-being (SDG 3) and sustainable cities and communities (SDG 11), emphasizing translational approaches to improve public health through dietary and pharmacological interventions.

• Immunology
• Macrophage Biology
• Tumor-associated Macrophages
• +۴ مورد دیگر

Antonio SICA is a Full Professor in the Department of Pharmaceutical Sciences at the University of Eastern Piedmont 'Amedeo Avogadro'. With an extensive research career spanning over three decades, he has published 189 research outputs including articles, reviews, and conference contributions. His ORCID profile (0000-0002-8342-7442) documents his significant contributions to immunology and cancer research. Professor SICA's research primarily focuses on myeloid cells in cancer , particularly tumor-associated macrophages and myeloid-derived suppressor cells . His work explores how these cells contribute to tumor progression, immunosuppression, and response to therapy. Key research areas include immunometabolism, epigenetic regulation of myeloid cells, and the intersection of inflammation with cancer development. Analysis of his recent publications (2021-2024) reveals a strong emphasis on myeloid cell heterogeneity in cancer, immunometabolic pathways , and the role of myeloid cells in age-related diseases . His 2023-2024 work has particularly examined connections between cancer immunology and infectious diseases like COVID-19, demonstrating how immunometabolic interference affects disease outcomes. Advancing the knowledge of human neutrophils displaying polymorphonucler myeloid-derived suppressor cell (PMN-MDSC) functions (2023-2025) BioTher19: Biological bases of immune response in fragile COVID-19 patients Deciphering the molecular and functional heterogeneity of myeloid cells in cancer (2019-2023) Deciphering the epigenetic basis of Myeloid-derived immunosuppression in cancer and therapy (2018-2023) Professor SICA has supervised 5 students throughout his career and maintains active research collaborations across multiple institutions. His work contributes significantly to UN Sustainable Development Goals related to good health and well-being, particularly through advancing cancer immunology and immunotherapy approaches.

Mary Barbeمشاهده پروفایل

استاد

• Musculoskeletal Disorders
• Neural Plasticity
• Work-Related Injuries
• +۷ مورد دیگر

Mary Barbe, PhD, is a Professor at the Lewis Katz School of Medicine at Temple University, with affiliations in multiple research centers: Cardiovascular Sciences, Biomedical Education and Data Science, Neural Sciences, the Center for Substance Abuse Research, and the Comprehensive NeuroAIDS Center. She conducts interdisciplinary research at the intersection of musculoskeletal and neural systems. Her research interests include: Work-related musculoskeletal disorders (WRMDs) and the effects of repetitive and forceful tasks on tissue degeneration and inflammation. Neural plasticity and sensorimotor dysfunction in animal models. Bladder and urethral sphincter reinnervation after spinal cord injury using surgical nerve transfer techniques. Role of fibrosis, inflammation, and aging in bone and connective tissue pathology. Her recent publications show a strong trend in translational research, combining anatomical, physiological, and behavioral assessments in rodent models to understand overuse injuries and neural repair. Her work spans fields such as orthopedics, urology, neuroscience, and rehabilitation science, often involving collaboration with clinical and surgical teams. Her scientific contributions are recognized through consistent publication in high-impact journals, including Journal of Hand Surgery , Neural Plasticity , Life Sciences , and Nature Reviews Urology , with many articles designated as reviews and freely accessible via PMC. Mary Barbe has made significant contributions to mentoring and collaborative research, though specific names of advisees are not listed. She has been continuously funded by major NIH institutes, including NIAMS and NINDS, supporting long-term projects on musculoskeletal injury and neural restoration. She is actively involved in laboratory-based research and collaborates with experts in urology and neuroanatomy. Her lab utilizes advanced techniques such as electrophysiology, neuroanatomical tract tracing, and behavioral assessments to evaluate functional recovery after injury.

Nathan K. LeBrasseurمشاهده پروفایل

استاد

• Aging Biology
• Cellular Senescence
• Skeletal Muscle Aging
• +۷ مورد دیگر

Nathan K. LeBrasseur, Ph.D., M.S. , is a Professor in the Department of Physical Medicine and Rehabilitation and the Department of Physiology at Mayo Clinic in Rochester, Minnesota. He holds key leadership roles including Director of the Robert and Arlene Kogod Center on Aging, Co-Director of the Mayo Clinic Paul F. Glenn Center for Biology of Aging Research, and Scientific Director of the Office of Translation to Practice. His work is central to advancing the science of aging and its clinical translation. Research Interests: Nathan K. LeBrasseur's research is dedicated to understanding the biological mechanisms of aging, with a focus on cellular senescence , skeletal muscle aging , and the development of biomarkers of biological age . His lab investigates how senescent cells contribute to physical decline, metabolic dysfunction, and frailty. A major focus is on how lifestyle factors, particularly exercise, can modulate the accumulation and clearance of senescent cells to promote resilience in older adults. Research Trends: His recent publications (2023–2025) demonstrate a strong trend towards translational and clinical research. The work spans from fundamental discoveries in cell biology (e.g., mtDNA release in senescence) to the characterization of human biomarkers for use in clinical trials. There is a clear emphasis on developing and validating tools to measure biological aging and on understanding the systemic impact of senescent cells on organs like muscle, bone, heart, and brain. His research increasingly leverages large cohort studies and aims to identify individuals who would benefit most from anti-aging interventions. Scientific Awards: Noaber Foundation Professor of Aging Research, Mayo Clinic (2024) Vincent Cristofalo Rising Star Award in Aging Research, American Federation for Aging Research (2019) Advising and Grants: Dr. LeBrasseur is a Principal Investigator (PI) on multiple major research grants, primarily from the National Institute on Aging (NIA). His funded projects include 'The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults (BRIO)' and the 'Biological Analysis Core.' He also serves as PI for the Vincent Cristofalo Rising Star Award and is a Co-PI on the Midwest Murine-Tissue Mapping Center. This extensive grant portfolio reflects his leadership in large-scale, collaborative aging research. Labs and Teams: Dr. LeBrasseur leads a research laboratory focused on the biology of aging at Mayo Clinic. His work is deeply integrated with major institutional centers, including the Robert and Arlene Kogod Center on Aging and the Mayo Clinic Paul F. Glenn Center. He is part of a large, collaborative network of scientists investigating cellular senescence, senolytics, and aging mechanisms, often co-authoring with leading figures in the geroscience field.

• Neutrophils
• Inflammation
• Metainflammation
• +۴ مورد دیگر

Sofia de Oliveira is Assistant Professor in the Departments of Developmental & Molecular Biology and Medicine (Hepatology) at Albert Einstein College of Medicine. Her research investigates neutrophil biology in disease contexts, particularly how metainflammation and inflammaging alter neutrophil responses in liver disease, polytrauma, and aging. The lab employs zebrafish models for live imaging of immune processes. Research examines neutrophil roles in NAFLD-associated liver cancer progression, age-related immune decline, and posttraumatic inflammation. Projects integrate immunology, metabolism, and disease modeling to identify therapeutic targets. Publications establish zebrafish as key model for visualizing neutrophil dynamics and demonstrate metformin's immunomodulatory effects in liver disease. Current work explores neutrophil heterogeneity in aging and metabolic syndrome contexts.

Johann Bauersachsمشاهده پروفایل

استاد

• Acute and chronic heart failure
• Acute coronary syndromes
• Aldosterone and mineralocorticoid receptor-mediated mechanisms
• +۴ مورد دیگر

Professor Johann Bauersachs serves as Full Professor and Director of the Department of Cardiology and Angiology at Hannover Medical School (MHH) since 2010, with a distinguished career in cardiovascular research and clinical cardiology. He is a Fellow of the American Heart Association, European Society of Cardiology, and Heart Failure Association, and holds leadership positions including Chair of the HFA Committee on Peripartum Cardiomyopathies and Spokesperson of the DFG-funded Clinical Research Group KFO 311. His primary research interests focus on acute and chronic heart failure , acute coronary syndromes , left ventricular healing and remodeling , and the pathophysiology and treatment of peripartum cardiomyopathy . His work particularly emphasizes aldosterone and mineralocorticoid receptor-mediated mechanisms and the role of non-coding RNAs in cardiovascular disease. With over 1,133 publications and impressive H-indices (107 in Web of Science, 135 in Google Scholar), his recent research has centered on microRNA-based therapies like the HF-REVERT trial with CDR132L and the DIGIT-HF study investigating digitoxin for advanced heart failure. His most recent publications (2023-2024) demonstrate a clear trajectory toward translational research bridging molecular mechanisms with clinical applications, particularly in heart failure management. Key themes include the synergistic effects of SGLT2 inhibitors with mineralocorticoid receptor antagonists, novel therapeutic approaches for peripartum cardiomyopathy, and innovative diagnostic and treatment strategies for heart failure with preserved ejection fraction. Highly cited researcher in Clinical Medicine (Clarivate, 2023) ScholarGPS Highly Ranked Scholar (2022) Silver Badge of Honour, German Cardiac Society (2021) Paul-Morawitz-Award, German Cardiac Society (2018) Bernard and Joan Marshall Distinguished Investigator Award (2012) Parmley-Award, American College of Cardiology (2006) As Principal Investigator of multiple clinical trials including HF-REVERT and DIGIT-HF, Professor Bauersachs has secured significant funding from organizations including the Deutsche Forschungsgemeinschaft (DFG) and the Federal Ministry of Education and Research. His laboratory at MHH (Building I3) focuses on cardiac wound healing and remodeling after ischemia, with particular emphasis on mineralocorticoid receptor function in myeloid cells. He also serves in editorial capacities including Deputy Editor of the European Heart Journal and Associate Editor of Cardiovascular Research, while maintaining active advisory roles with Cardior Pharmaceuticals and Heartbeat.bio.

Sarah Spencerمشاهده پروفایل

استاد

• Neuroimmunology
• Brain Inflammation
• Alzheimer’s Disease
• +۵ مورد دیگر

Professor Sarah Spencer is an internationally recognized neuroendocrinology researcher at RMIT University’s School of Health and Biomedical Sciences. She holds a BSc (Hons) from Otago University (New Zealand) and a PhD from The University of Queensland (Australia). Her research explores how lifestyle factors like diet influence brain inflammation and associated diseases, with a focus on Alzheimer’s early detection, retinal microglia imaging, glial scarring, and post-SARS-CoV-2 mental health impacts. She has held postdoctoral roles at Calgary University (Canada) and Monash University (Australia) and is currently a top 1% cited scientist (Scopus). Her work integrates neuroimmunological, developmental, and stress physiology approaches to unravel disease mechanisms. Her research portfolio includes over 50 peer-reviewed articles, with projects funded by organizations like AHURI, CSIRO, and the Victorian Government. Teaching interests emphasize translational research in neuroimmune disorders and evidence-based practice. She actively supervises postgraduate research students in areas ranging from brain regeneration to dietary interventions in cognitive decline.

• Autophagy
• Mitophagy
• Retinal Degeneration
• +۷ مورد دیگر

Patricia Boya is a Full Professor in the Department of Medicine at the University of Fribourg, within the Faculty of Mathematics, Natural Sciences and Medicine. She is a leading researcher in autophagy, mitophagy, and lysosomal biology, with a focus on retinal and neurodegenerative diseases. Her research interests center on the molecular mechanisms of autophagy and mitophagy, particularly their roles in retinal health, aging, neurodegeneration, and cell death. She investigates how mitochondrial dynamics, lysosomal function, and autophagic flux contribute to diseases such as retinitis pigmentosa, glaucoma, ALS, and Parkinson’s. Her work combines molecular biology, cell imaging, and preclinical models to uncover therapeutic targets. The analysis of her recent publications reveals a strong focus on mitophagy regulation, neuroinflammation (especially via the cGAS/STING pathway), and the development of neuroprotective compounds. She has contributed to high-impact reviews and guidelines in autophagy research, and her work spans fundamental mechanisms to translational applications. She is actively involved in scientific leadership, including the "Women in Autophagy" initiative to promote gender equity in science and the "DRIVE" international PhD training program in autophagy. Dr. Boya has published over 150 articles in top journals including Nature , Nature Communications , Autophagy , and Cell Death & Disease . Her work is highly collaborative, involving interdisciplinary teams across Europe. She leads a research group focused on cellular recycling mechanisms and their implications for vision and aging, contributing significantly to the understanding of autophagy in health and disease.