جست‌وجوی استاد و پژوهشگر

Nancy C. Reich Marshallمشاهده پروفایل

استاد

• Immunology
• Cancer Biology
• Cytokine Signaling
• +۳ مورد دیگر

Nancy C. Reich Marshall is a Professor in the Department of Microbiology and Immunology at Stony Brook University. She also serves as Past President of the International Cytokine & Interferon Society (ICIS) and is a Fellow of the American Association for the Advancement of Science (AAAS). Her laboratory investigates cytokine signaling pathways, particularly JAK-STAT mechanisms, and their roles in immune defense, viral infections, and cancer biology. Her research focuses on: Molecular mechanisms of cytokine signaling in cancer (especially pancreatic cancer) and viral pathogenesis KRAS-driven tumorigenesis and immune evasion strategies Interferon responses in SARS-CoV-2 and other viral infections STAT transcription factor dynamics in cellular identity and disease Analysis of her 15 most recent publications reveals strong emphasis on: KRAS/STAT3 interactions in pancreatic cancer progression Interferon-mediated immune defenses against viruses including SARS-CoV-2 Novel mechanisms of oncogene dependency and therapeutic resistance Sex-specific pathology in viral infections Her scientific awards include: Fellow of the American Association for the Advancement of Science (AAAS) Past President of the International Cytokine & Interferon Society (ICIS) She has advised over 30 graduate students and postdoctoral researchers, including Stephen D'Amico, Alexei Petrenko, and Hui-Chen Foreman. Her lab employs murine models and molecular techniques to study KRAS signaling in pancreatic cancer and interferon responses to pathogens.

• Coronavirus Immunology
• Viral Immunology
• Veterinary Pathology
• +۷ مورد دیگر

Rudra Channappanavar, DVM, PhD is an Associate Professor in Viral Immunology and Veterinary Pathology at the College of Veterinary Medicine, Oklahoma State University. He also serves as faculty for the Oklahoma Center for Respiratory and Infectious Diseases (OCRID). His research focuses on coronavirus-host interactions, mechanisms of protective and pathogenic immunity, and development of antiviral therapeutics. Dr. Channappanavar earned his DVM from Veterinary College, KVAFSU, India, his MVSc in Veterinary Pathology from Indian Veterinary Research Institute, and his PhD in Biology with a focus on Immunology and Infectious Diseases from Oakland University. He completed postdoctoral training at the University of Iowa in Coronavirus Immunobiology and Virology. His research program has three primary focuses: (1) Understanding coronavirus-host interactions and mechanisms of protective and pathogenic immunity, using in vitro and in vivo approaches including knockout and transgenic mouse models; (2) Improving immune responses to human coronavirus infections and vaccinations in the elderly, investigating the role of interferons and monocytes-macrophages in age-related susceptibility; and (3) Identifying and evaluating antiviral and anti-inflammatory agents to reduce coronavirus disease severity, with work on compounds like Camostat Mesylate and amniotic fluid-derived extracellular vesicles. Analysis of his recent publications (2021-2025) reveals a strong focus on SARS-CoV-2 pathogenesis, particularly investigating TLR-mediated immune responses, macrodomain functions in viral replication, and therapeutic approaches including nanoliposome drug delivery systems. His work spans basic molecular virology to translational therapeutic development, with a consistent emphasis on understanding dysregulated immunity in severe coronavirus disease. Dr. Channappanavar has secured significant funding for his research, including multiple NIH grants such as 'Role of ERK1/2 signaling in SARS-CoV-2-induced dysregulated immunity and lung pathology' (2024-2029) and 'Myeloid cell TRAF6 signaling in SARS-CoV-2-induced dysregulated lung immunity' (2024-2026). He also contributes to the Oklahoma Center for Respiratory and Infectious Diseases (OCRID), a NIH-funded Center of Biomedical Research Excellence (CoBRE). As an educator, he teaches PhD Research and Dissertation courses and Undergraduate Research Problems, mentoring the next generation of veterinary and biomedical researchers. His laboratory serves as an important training ground for students interested in viral immunology and respiratory infectious diseases.

Lindsay Broadbentمشاهده پروفایل

مدرس

• Virology
• Respiratory Viruses
• SARS-CoV-2
• +۷ مورد دیگر

Dr. Lindsay Broadbent is a Lecturer in Virology at the University of Surrey, affiliated with the Section of Virology within the School of Biosciences, Faculty of Health and Medical Sciences. She joined the institution in July 2022 after serving as a Wellcome Trust ISSF Fellow at Queen’s University Belfast. Her research focuses on respiratory virus-host interactions, particularly SARS-CoV-2 and respiratory syncytial virus (RSV), using well-differentiated primary airway epithelial cell models to study infection mechanisms and immune responses. University: University of Surrey School: School of Biosciences Department: Section of Virology Role: Lecturer in Virology Programme Director: Microbiology Dr. Broadbent's research interests center on understanding how respiratory viruses interact with host cells and trigger innate immune responses. She specializes in using physiologically relevant models such as well-differentiated human primary airway epithelial cell cultures (WD-PAEC) to investigate viral pathogenesis, antiviral states, and the development of chronic lung disease following infection. Her work has significant implications for antiviral therapeutics and vaccine development. The analysis of her recent publications reveals a consistent focus on respiratory viruses, particularly RSV and SARS-CoV-2. Her studies explore viral evolution in pediatric cells, interferon-mediated antiviral responses, antibody therapies, and the role of epithelial immunity. A recurring theme is the use of advanced in vitro models that closely mimic human airway physiology, enabling more accurate investigation of viral behavior and host defense mechanisms. Dr. Broadbent is also deeply engaged in science communication, having participated in hundreds of media appearances and public outreach initiatives. She contributes expert commentary on virology, pandemics, and public health through platforms like The Conversation and podcast interviews. Respiratory virus-host interactions Innate immune responses SARS-CoV-2 and RSV pathogenesis Primary airway epithelial cell models Antiviral therapeutics Viral evolution and immune evasion She supervises research but no named students are listed in the provided materials. Her email for professional contact is l.broadbent@surrey.ac.uk.

Ian Humphreysمشاهده پروفایل

استاد

• Viral Pathogenesis
• Immunology
• Cytokine Regulation
• +۳ مورد دیگر

Professor Ian Humphreys is a Professor of Viral Pathogenesis at the Cardiff University School of Medicine , where he leads the Systems Immunity Research Institute as Lead Co-Director . He holds a Wellcome Trust Senior Research Fellowship and focuses on immune response regulation during viral infections, particularly cytomegalovirus (CMV) and SARS-CoV-2. His work bridges basic research and clinical applications, involving collaborations with institutions like the Wellcome Trust Sanger Institute. Education: PhD in Biochemistry (Imperial College London, 2004), BSc in Biological Sciences with Virology (University of Warwick, 2000) Career: Cardiff University (2007–Present), La Jolla Institute (2000–2004), Imperial College London (2004) Research Interests span viral pathogenesis, cytokine regulation, mucosal immunity, and vaccine development. His lab investigates mechanisms of immune suppression during chronic viral infections, including IL-10 and CD200 receptor pathways, and explores how early cytokine signals influence antiviral responses. Recent work connects IFITM3 function to personalized antiviral therapy. Scientific Contributions include seminal studies on CMV immune evasion, influenza T-cell memory decay, and SARS-CoV-2 immunopathology. Key awards: Wellcome Trust Senior Fellowship (2012, 2017) Top 10 most-read paper recognition (2019) Appointments to Wellcome Trust and British Society of Immunology committees Teaching Roles include courses on Microbial Pathogenesis (ME3030) and Advanced Immunology (ME3045), alongside student supervision. He actively engages in public outreach, delivering immunology workshops in primary schools and coordinating Science in Health Live! events.

Helen Lazearمشاهده پروفایل

دانشیار

• Flavivirus pathogenesis
• Herpes simplex virus pathogenesis
• Interferon lambda mediated immunity
• +۳ مورد دیگر

Helen Lazear, PhD is an Associate Professor in the Department of Microbiology and Immunology at the University of North Carolina at Chapel Hill School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. Her research program focuses on viral pathogenesis with particular expertise in flaviviruses (including West Nile virus and Zika virus) and herpes simplex virus. Dr. Lazear's research interests center on understanding viral pathogenesis mechanisms, with special emphasis on interferon lambda (IFN-λ) mediated antiviral immunity. Her work investigates how type III interferons regulate viral infections at barrier surfaces and during pregnancy, examining both protective and pathogenic effects of interferon signaling. Her laboratory has made significant contributions to understanding flavivirus envelope protein glycosylation, Zika virus pathogenesis, and herpes simplex virus immunopathology. Analysis of her recent publications reveals a strong focus on interferon lambda signaling in viral pathogenesis, particularly examining its role in pregnancy contexts, skin viral infections, and neuroinvasive diseases. Her work spans structural virology, animal models of infection, and host immune responses, with significant contributions to understanding flavivirus and herpesvirus pathogenesis. Dr. Lazear maintains an active research laboratory with numerous students and postdoctoral fellows, as evidenced by the lab photos showing team members at conferences and research activities. The lab has established multiple animal models for studying viral pathogenesis, including specialized models for herpes simplex virus reactivation and Zika virus infection during pregnancy.

Timothy J. Niceمشاهده پروفایل

دانشیار

• Host-Microbe Interactions
• Virology
• Immunology
• +۳ مورد دیگر

Timothy J. Nice is an Associate Professor in the Department of Molecular Microbiology and Immunology at Oregon Health & Science University (OHSU). His research focuses on host-microbe interactions in the intestine, particularly how viruses and bacteria interact with host genes and immune responses to influence infection outcomes. The Nice Lab investigates viral and bacterial genes critical for pathogen survival, as well as how microbiota composition modulates anti-microbial immunity. Education: Ph.D. in Molecular and Cellular Biology, University of California, Berkeley (2009) B.S. in Genetics, Cell Biology, and Development, University of Minnesota-Twin Cities (2003) Research Interests: Host-microbe interactions in the gut Viral and bacterial gene determinants of infection outcomes Microbiota-epithelial cell cross-talk in immunity Interferon lambda signaling in intestinal defense Recent Research Trends: Recent work emphasizes norovirus pathogenesis, interferon lambda-mediated antiviral protection, and the role of protists in modulating immune responses. Studies frequently integrate organoid models and genetically engineered mice to explore mechanisms at the host-microbe interface. Laboratory: The Nice Lab operates within OHSU's Molecular Microbiology and Immunology department, focusing on translational studies linking basic immunology to infectious disease outcomes.

• Virology
• Innate Immunity
• HIV Pathogenesis
• +۷ مورد دیگر

Dr. Wenzhe Ho, MD, MPH, is a leading researcher in virology and immunology, focusing on the interplay between viral infections such as HIV and HCV and the host's innate immune system. His laboratory employs multidisciplinary approaches to study how viruses interact with human immune, hepatic, and neuronal cells, with particular emphasis on interferon-mediated antiviral mechanisms and cellular factors like miRNAs that regulate viral replication. His research spans three major areas: (1) Innate Immunity and Viral Infections , where his team investigates how HIV and HCV evade host defenses and how interferons (including IFN-lambda) activate intracellular antiviral pathways; (2) Drugs of Abuse and HIV/HCV Infection , exploring how opioids and methamphetamine suppress immune function and accelerate disease progression in injection drug users, in collaboration with researchers from the University of Pennsylvania and Wuhan CDC; and (3) Innate Immunity and CNS Protection , studying how neurons and glial cells recognize pathogens via toll-like receptors and how interferon signaling can protect the central nervous system from viral damage, particularly from HIV and HSV-1. The body of work from Dr. Ho’s laboratory contributes significantly to understanding the molecular basis of viral persistence and immune evasion. His studies have revealed key roles for IFN-lambda and anti-HIV miRNAs in protecting monocytes and macrophages, and current projects are probing whether drugs of abuse and viral proteins impair innate immune pathways in neurons, potentially compromising antiretroviral therapy (HAART) efficacy. Scientific Awards: No specific awards mentioned in the provided text. Advising and Grants: While specific students or grant funding are not listed, Dr. Ho leads an active research laboratory conducting in vitro, ex vivo, and in vivo studies. His collaborative work with institutions such as the University of Pennsylvania suggests involvement in externally funded research projects. He likely mentors graduate students, postdoctoral fellows, and research staff, though no names are provided. Labs and Research Teams: Dr. Ho directs a research laboratory that utilizes molecular, cellular, immunological, and virological techniques to study virus-host interactions. The lab works closely with clinical populations in Philadelphia and China and collaborates with scientists at the University of Pennsylvania and Wuhan Center for Disease Control and Prevention. Research focuses on innate immune sensing (e.g., TLR pathways), interferon responses, and the impact of substance use on viral disease progression across multiple organ systems, including the liver and central nervous system.

Hannah Atkinsمشاهده پروفایل

استادیار

• Veterinary Pathology
• Digital Pathology
• Comparative Medicine
• +۵ مورد دیگر

Hannah Atkins, DVM, PhD, DACVP is an Assistant Professor in the Division of Pathology and Laboratory Medicine at the University of North Carolina at Chapel Hill School of Medicine. She is an ACVP-boarded veterinary pathologist with expertise in digital pathology image analysis, science communication, and models of human disease. Dr. Atkins directs veterinary residents in comparative anatomic pathology through UNC and NC State-based training programs. Dr. Atkins' research spans multiple areas of pathology and disease modeling. Her primary research interests include: Veterinary and comparative pathology Digital pathology and AI-driven image analysis Endometriosis and reproductive disorders using non-human primate models Papillomavirus-induced cervical cancer Tobacco smoke carcinogenesis Artificial organ pre-clinical testing Post-professional education in veterinary pathology Analysis of her recent publications (2021-2025) reveals a strong focus on infectious disease pathology, cancer biology, and toxicology. Her work frequently employs non-human primate and murine models to study disease mechanisms. Notable research themes include: Investigating host-pathogen interactions in fungal, bacterial, and viral infections Developing novel cancer therapies, particularly for triple-negative breast cancer Studying the effects of environmental toxins on pulmonary and systemic health Advancing veterinary pathology through international nomenclature harmonization Dr. Atkins serves as the chief audio editor for "A Conversation in Veterinary Pathology – The A.C.V.P. Podcast," the official podcast of the American College of Veterinary Pathologists, demonstrating her commitment to science communication and professional development in her field.

Carsten B. Schmidt-Weberمشاهده پروفایل

استاد

• Allergology
• Immunology
• Environmental Health
• +۳ مورد دیگر

Prof. Carsten B. Schmidt-Weber is a full professor of Molecular Allergology at TUM, leading the Center for Allergy and Environment (ZAUM) since 2010. His work bridges basic and applied research, focusing on immunological mechanisms underlying allergies, asthma, and environmentally induced diseases. ZAUM collaborates with Helmholtz Zentrum München and leads EU consortia, generating significant third-party funding and patents. Education: Studied Biochemistry/Immunology in Darmstadt/Erlangen. Postdoctoral training at Harvard Medical School and Swiss Institute of Allergy and Asthma. Habilitation in Davos, followed by roles at Imperial College London before joining TUM. Research Interests: Mucosal host defense mechanisms Type 2 immunity regulation Allergen-specific immunotherapy Epithelial interface biology Environmental triggers (pollen, pollutants) SARS-CoV-2 pathogenesis Awards: EAACI Allergopharma Prize (2007), Curt Dehner Prize (2004). Spin-off companies established to commercialize diagnostic tools and therapies. Grants/Advising: Over €40M in third-party funding. Advises healthcare institutions, governments (pollen risk assessments), and pharmaceutical companies. Trained numerous academic and industry professionals. Labs/Teams: ZAUM integrates immunology, molecular biology, and environmental science. Collaborates with German Center for Lung Research (DZL) and European research networks.

• Microbiology
• Immunology
• Infectious Diseases
• +۴ مورد دیگر

Nicholas H. Carbonetti, PhD, is a Professor in the Department of Microbiology and Immunology at the University of Maryland School of Medicine, where he has held a faculty position since 1991. His research focuses on Bordetella pertussis pathogenesis using murine models, with emphasis on host immune responses and age-dependent disease mechanisms. His educational background includes: B.Sc. in Biological Sciences from the University of Birmingham, UK (1981) Ph.D. in Genetics/Microbiology from the University of Leicester, UK (1985) Postdoctoral training at UNC Chapel Hill under Dr. P. Frederick Sparling (1985-1989) European Community Senior Postdoctoral Fellowship at Sclavo Research Center, Italy (1989-1991) Dr. Carbonetti's research investigates interferon-mediated lung inflammation in adult mice and neonatal susceptibility to lethal pertussis infection. His work reveals critical roles for type I/III interferons in disease pathogenesis and explores therapeutic interventions targeting sphingosine-1-phosphate receptors and pendrin. Current projects examine PTX-mediated pulmonary hypertension , interferon lambda in infant protection , and NK cell immunity using advanced mouse models. Analysis of his publication record shows consistent focus on molecular mechanisms of pertussis toxin , age-specific host responses , and translational therapeutic approaches . His work bridges fundamental microbiology with clinical manifestations, particularly investigating why infants experience severe disease and how host pathways can be modulated for treatment. Dr. Carbonetti has served as PI on multiple NIH grants including R01 AI141372 ( Age-dependent role of type I interferon ) and R21 AI156042 ( NK cell and interferon gamma deficiency ). He directed the Molecular Microbiology and Immunology graduate program (2005-2015) and mentored numerous trainees through his research group. His laboratory maintains active research on pertussis pathogenesis with emphasis on toxin-host interactions and age-dependent immunity . Dr. Carbonetti organized the 9th and 12th International Bordetella Symposia and served on editorial boards for Infection & Immunity and Pathogens & Disease , establishing himself as a leading authority in the field.

Christopher Norburyمشاهده پروفایل

استاد

• Immunology
• Microbiology
• Viral Diseases
• +۵ مورد دیگر

Christopher Norbury is a Professor in the Department of Cell and Biological Systems at the Penn State Cancer Institute. His research spans immunology, virology, and wound healing, with a focus on viral immune evasion and antiviral signaling pathways. Academic Rank: Professor Institution: Penn State Cancer Institute Department: Cell and Biological Systems Research Interests include: Cytomegalovirus and Herpes Simplex Virus pathogenesis Interferon signaling (Type III IFNs) Dendritic cell and T-cell biology Wound healing mechanisms Antiviral immunity and immune evasion Recent Publications highlight work on: Mechanisms of HCMV cytoplasmic envelopment Virus-induced lipid peroxidation γδ T-cell roles in poxvirus wound healing Grants & Projects include NIH-funded studies on: Cytomegalovirus spread via IFN-λ PTP1B in HSV-1 cell-to-cell transmission STAT1-mediated antiviral immunity HCMV tegument formation and maturation Virus impact on cutaneous wound healing Scientific Awards : Dean's Award for Excellence in Teaching (2019)