جست‌وجوی استاد و پژوهشگر

Allyson F. O'Donnellمشاهده پروفایل

دانشیار

• Protein Trafficking
• GPCR Signaling
• Molecular Biology
• +۷ مورد دیگر

Dr. Allyson F. O'Donnell is an Associate Professor in the Department of Biological Sciences at the Dietrich School of Arts and Sciences, University of Pittsburgh. She is affiliated with the Center for Protein Conformational Diseases, the Pittsburgh Center for Evolutionary Biology and Medicine, and professional societies including the American Society for Cell Biology. Ph.D., Biochemistry & Molecular Biology, Dalhousie University (Canada) M.S., Biology, University of New Brunswick (Canada) B.S., Biochemistry (Honors), University of New Brunswick (Canada) Her research focuses on the α-arrestin family of protein trafficking adaptors, their role in GPCR signaling, and their unexpected involvement in endosomal recycling and clathrin-independent endocytosis. She employs Saccharomyces cerevisiae as a model organism to define molecular mechanisms before applying findings to mammalian systems. Key areas include ubiquitination, signaling regulators (kinases/phosphatases), and transmembrane cargo recognition. Analysis of her 15 most recent publications reveals trends in yeast protein trafficking, GPCR regulation, and metabolic stress responses. Subfields span ubiquitination motifs, nutrient signaling, and evolutionary conservation between yeast and mammals. Dr. O'Donnell mentors graduate students and participates in science outreach programs. She teaches advanced biology courses and leads a lab with collaborative projects involving yeast genetics, mammalian tissue culture, and computational modeling of protein interactions.

Simone Sidoliمشاهده پروفایل

استادیار

• Chromatin Biology
• Proteomics
• Mass Spectrometry
• +۳ مورد دیگر

Simone Sidoli, Ph.D., is an Assistant Professor in both the Department of Biochemistry and the Department of Genetics at Albert Einstein College of Medicine. His research focuses on chromatin dynamics, histone modifications, and their roles in disease development. He employs advanced mass spectrometry techniques and 3D cell culture models to study how epigenetic mechanisms regulate cellular identity and contribute to pathological states. His work integrates proteomics and chromatin biology to uncover how histone post-translational modifications (PTMs) influence chromatin structure and function. Key areas of investigation include the biological consequences of aberrant chromatin states in cancer, metabolic disorders, and viral infections. Dr. Sidoli's methodological innovations aim to bridge gaps between molecular mechanisms and disease outcomes. Recent publications highlight his contributions to understanding histone reader interactions, SUMOylation in HIV pathogenesis, and myocardial proteomic changes in heart failure. His interdisciplinary approach combines biochemical assays, computational analysis, and cutting-edge imaging to dissect epigenetic regulation at multiple scales.

• Epigenetics
• Cancer Biology
• Histone Variants
• +۴ مورد دیگر

Yasmin Dijkwel is a Research Fellow at the Genome Sciences and Cancer Division of The Australian National University. Her research focuses on epigenetic mechanisms, particularly the role of histone variants like H2A.Z in development, cancer progression, and chromatin regulation. She employs biochemical and genomic approaches to study protein stability, posttranslational modifications, and their impacts on cellular processes. Her work bridges developmental biology and oncology, investigating how histone variants influence genome organization and cell cycle dynamics. Recent studies include exploring 3D genome architecture changes in breast cancer and mechanisms of histone chaperone interactions. She collaborates widely, as evidenced by her multidisciplinary publications spanning biochemistry, structural biology, and plant pathology. Key areas of expertise include chromatin remodeling complexes, protein conformation analysis via isotope labeling, and the functional implications of histone variants in disease contexts. Though no formal awards are listed, her active research profile (h-index 45) reflects significant contributions to epigenetics and cancer biology.

Maxim Nekrasovمشاهده پروفایل

پژوهشگر

• Chromatin Structure
• Epigenetics
• Next Generation Sequencing
• +۵ مورد دیگر

Maxim Nekrasov is a Researcher and Team Leader (Sequencing) at the Biomolecular Resource Facility (BRF) within the John Curtin School of Medical Research at the Australian National University (ANU). He holds a PhD from EMBL-Heidelberg and an MSc from Krasnoyarsk State University. His research focuses on chromatin structure, epigenetics, and next-generation sequencing technologies, with particular emphasis on histone variants and their roles in gene regulation and immune cell biology. Research Interests: The dynamics of histone variants such as H2A.Z, their impact on promoter architecture, and their involvement in immune responses (e.g., B and T cell functions). He also explores genome 3D organization and its dysregulation in diseases like cancer. His work integrates experimental and computational approaches to dissect chromatin regulation in human cells. Collaborations & Projects: Led the ANU project The Special Role of Histone Variants in Regulating the Inheritance and 3D Genome Organization (2016–2020). Collaborates internationally on vaccine immunology and infectious disease research, including studies on atypical B cells in human immunity. Labs & Facilities: Manages the BRF Sequencing Facility, which supports genomic and epigenomic analyses for ANU researchers. His lab contributes to methodological advancements in chromatin profiling and immunology.

• Signal Transduction Pathways
• Tumor Suppression Mechanisms
• p38 MAPK Pathway
• +۳ مورد دیگر

Peiquing Sun is a Professor at Wake Forest University School of Medicine, leading research on tumor-suppressing defense mechanisms in mammals. Their lab investigates signal transduction pathways, particularly the p38 MAPK pathway, and its role in oncogene-induced senescence using cell culture and animal models. Key discoveries include the tumor-suppressing function of p38 MAPK pathway components like PRAK and Tip60 Identified miR-17-92 cluster as a senescence-disrupting oncogenic microRNA Elucidated spatial-temporal separation of p38-PRAK pathway functions during cancer development Their work reveals a novel signaling circuit in tumor angiogenesis and provides therapeutic targets for cancer treatment. Current research focuses on Tip60-mediated acetylation mechanisms and functional analysis of senescence-disrupting microRNAs. Publications demonstrate sustained contributions to understanding how inflammation/stress pathways intersect with tumor suppression, with implications for both basic science and clinical applications.