Simone Sidoli

Simone Sidoli, Ph.D., is an Assistant Professor in both the Department of Biochemistry and the Department of Genetics at Albert Einstein College of Medicine. His research focuses on chromatin dynamics, histone modifications, and their roles in disease development. He employs advanced mass spectrometry techniques and 3D cell culture models to study how epigenetic mechanisms regulate cellular identity and contribute to pathological states.

His work integrates proteomics and chromatin biology to uncover how histone post-translational modifications (PTMs) influence chromatin structure and function. Key areas of investigation include the biological consequences of aberrant chromatin states in cancer, metabolic disorders, and viral infections. Dr. Sidoli's methodological innovations aim to bridge gaps between molecular mechanisms and disease outcomes.

Recent publications highlight his contributions to understanding histone reader interactions, SUMOylation in HIV pathogenesis, and myocardial proteomic changes in heart failure. His interdisciplinary approach combines biochemical assays, computational analysis, and cutting-edge imaging to dissect epigenetic regulation at multiple scales.