Peiquing Sun

Peiquing Sun is a Professor at Wake Forest University School of Medicine, leading research on tumor-suppressing defense mechanisms in mammals. Their lab investigates signal transduction pathways, particularly the p38 MAPK pathway, and its role in oncogene-induced senescence using cell culture and animal models.

• Key discoveries include the tumor-suppressing function of p38 MAPK pathway components like PRAK and Tip60
• Identified miR-17-92 cluster as a senescence-disrupting oncogenic microRNA
• Elucidated spatial-temporal separation of p38-PRAK pathway functions during cancer development

Their work reveals a novel signaling circuit in tumor angiogenesis and provides therapeutic targets for cancer treatment. Current research focuses on Tip60-mediated acetylation mechanisms and functional analysis of senescence-disrupting microRNAs.

Publications demonstrate sustained contributions to understanding how inflammation/stress pathways intersect with tumor suppression, with implications for both basic science and clinical applications.