معرفی
Scott Vande Pol is an Associate Professor in the Department of Pathology at the University of Virginia School of Medicine. His research focuses on the molecular mechanisms by which papillomavirus E6 oncoproteins manipulate cellular signaling pathways to drive cancer progression.
- M.D. and Ph.D. from University of California, San Diego (1985)
- Residency in Pathology at National Cancer Institute (1985-1989)
- Postdoctoral Fellowship at National Cancer Institute (1989-1993)
Dr. Vande Pol's work reveals that E6 proteins interact with key cellular regulators like paxillin and TIP60 to disrupt tumor suppression and integrin signaling. His team identified novel E6 targets including PTPN3, a tyrosine phosphatase, and demonstrated the role of paxillin in focal adhesion kinase activation. These findings highlight how viral oncoproteins hijack cellular machinery to promote oncogenesis.
His publications from 2006-2014 emphasize E6's role in ubiquitin-mediated degradation of tumor suppressors, PDZ domain interactions, and integrin signaling manipulation. Key disciplines include virology, cancer biology, and molecular signaling.
Current research aims to elucidate paxillin's role in oncogenic transformation and characterize E6's interaction motifs that drive ubiquitin ligase activity. This work has implications for understanding viral and non-viral cancer mechanisms.
