جستجوی استاد راهنمای دانشگاهی

Andrew Holleمشاهده پروفایل

استادیار

• Mechanobiology
• Stem Cell Differentiation
• Cancer Mechanobiology
• +۳ مورد دیگر

Andrew Holle is an Assistant Professor at the Mechanobiology Institute , National University of Singapore , where he leads the Confinement Mechanobiology Lab within the Department of Biomedical Engineering . His work spans mechanobiology, stem cell differentiation, cancer mechanobiology, and microfluidics, with a focus on understanding how physical confinement influences cellular behavior. Education: B.S.E. in Bioengineering (Minor in Statistics), Arizona State University (2008) Ph.D. in Bioengineering, University of California San Diego (2013) Research in the Confinement Mechanobiology Lab centers on the hypothesis that stem cell differentiation is driven by mechanical cues during migration through confined extracellular matrix (ECM) environments. The lab develops microfluidic systems to mimic ECM confinement and studies its impact on osteogenic differentiation , cancer cell migration , and cellular condensates . Recent publications highlight interdisciplinary approaches combining mechanobiology , nanotechnology , and microfluidics to explore nuclear morphological changes, volume regulation, and ligand signaling in confined cellular environments. Laboratory Members: Privita Edwina (Research Fellow) Vaishnavi Rangaraj (Research Assistant) Sriram Muthukumar (Research Fellow) Chang Ye Ji (PhD Student) Gao Xu (PhD Student) Lim Yuan Bin (PhD Student) Shinny Sunny (PhD Student) Lee Jia Wen Nicole (PhD Student) Li Yixuan (PhD Student)

Steven L'Hernaultمشاهده پروفایل

استاد

• Spermatogenesis
• Cell Biology
• Genetics
• +۲ مورد دیگر

Steven L'Hernault is Professor and Chairman of Biology at Emory University, where he leads research on cellular and developmental processes using Caenorhabditis elegans models. His laboratory investigates molecular mechanisms underlying spermatogenesis, focusing on genetic controls of sperm development and function. The L'Hernault Lab studies highly conserved genome protection mechanisms in germ lines using genetic, molecular, and biochemical approaches. Key research areas include secretory vesicle function, membrane protein interactions, and ubiquitin ligase activity during sperm differentiation. Recent publications examine paternal epigenetic inheritance pathways and palmitoyltransferase functions in spermiogenesis. The lab maintains an extensive collection of C. elegans mutants with defective spermatogenesis to study fundamental cellular processes.

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

Clifford P. Brangwynneمشاهده پروفایل

استاد

• Biophysics
• Bioengineering
• Soft Matter Physics
• +۳ مورد دیگر

Clifford P. Brangwynne is the June K. Wu '92 Professor of Chemical and Biological Engineering and Bioengineering at Princeton University, serving as Director of the Omenn-Darling Bioengineering Institute. His research bridges biophysics, bioengineering, and cell biology to investigate the physical principles governing intracellular organization through liquid-liquid phase separation. Education Ph.D. in Applied Physics, Harvard University (2007) B.S. in Materials Science and Engineering (minor in Physics), Carnegie Mellon University (2001) Research Focus Brangwynne's lab pioneers the study of membrane-less organelles (biomolecular condensates) formed via phase separation, exploring their roles in nuclear architecture, genome regulation, and disease mechanisms. His work integrates soft matter physics with advanced cell biology to uncover how these condensates form, function, and contribute to pathological protein aggregation in neurodegenerative disorders, while developing synthetic organelle engineering for biomedical applications. Publication Trends His publications consistently demonstrate how liquid phase condensation governs cellular organization across scales—from nuclear genome restructuring to pathological aggregation. The interdisciplinary approach reveals fundamental physical principles while driving technological innovations in organelle engineering and disease modeling. Major Awards Breakthrough Prize for Life Sciences (2023) Raymond and Beverly Sackler International Prize in Biophysics (2023) Tsuneko & Reiji Okazaki Award (2021) Wiley Prize in Biomedical Sciences (2020) Blavatnik National Award in Life Sciences (2020) Human Frontier Science Program Nakasone Award (2020) Michael and Kate Bárány Award, Biophysical Society (2020) HHMI Transformative Technology Award (2019) MacArthur Fellow (2018) HHMI, Simons Foundation, and Bill & Melinda Gates Foundation Faculty Scholar (2016) SCB Gibco Emerging Leader Prize, American Society of Cell Biology (2015) Sloan Research Fellowship (2014) NSF CAREER Award (2013) NIH New Innovator Award (2012) Searle Scholar Award (2012) Helen Hay Whitney Fellow (2008-2010) Advising and Funding He mentors graduate students including Jordy Botello, Yi-Che (Eje) Chang, Yoonji Kim, Claire Weaver, Lennard Wiesner, and Jessica Zhao. Research is supported by HHMI, Simons Foundation, Bill & Melinda Gates Foundation, NIH, NSF, and the Human Frontier Science Program. Laboratory and Collaborations Leading the Soft Living Matter Group, Brangwynne collaborates with theorists including Mikko Haataja (Princeton Mechanical Engineering), Ned Wingreen (Princeton Molecular Biology), and Rohit Pappu (WUSTL), while contributing to the NIH 4D Nucleome Consortium to advance understanding of nuclear organization.

Pillai Ramesh Shanmughomمشاهده پروفایل

استاد

• Epigenetics
• RNA modifications
• miRNAs
• +۵ مورد دیگر

Ramesh Shanmughom Pillai is a Full Professor at the Department of Molecular Biology, University of Geneva, Switzerland. He holds additional roles as a Visiting Professor at the University of Kumamoto, Japan, and has been a Group Leader at EMBL Grenoble and a postdoctoral fellow at the Friedrich Miescher Institute. His research focuses on RNA modifications, epigenetics, and piRNA pathways in germline biology. Pillai has received prestigious awards including the ERC Consolidator Grant and The RNA Society Scaringe Award. Education: BSc Botany (University of Kerala, India) MSc Biotechnology (IIT Roorkee, India) PhD in Cell Biology (University of Bern, Switzerland) Research Interests: Pillai’s work centers on RNA biology, particularly the role of RNA modifications (e.g., m6A, m6Am) in development and fertility. He investigates piRNA biogenesis, transposon silencing, and the molecular mechanisms of RNA-protein interactions. His studies bridge biochemistry, genetics, and structural biology to elucidate how RNA molecules regulate critical biological processes. Teaching & Service: At the University of Geneva, he teaches Molecular Biology courses (BSc/MSc levels) and advises 5 PhD students and 4 postdocs. He chairs the ERC Consolidator Grant Review Panel and organizes major conferences like the PIWI/piRNAs Meeting and Swiss RNA Workshop. Pillai also serves on editorial boards for Nucleic Acids Research and RNA . Awards: ERC Consolidator Grant (2015) Best PhD Thesis Award (2003) RNA Society Scaringe Award (2005) Grants & Labs: Funded by ERC Starting and Consolidator Grants, his lab explores RNA modification networks in germ cells. Former trainees include Professors Simon Conn (Flinders University) and Hao Wu (CAS, China).

Mirko Trajkovskiمشاهده پروفایل

استاد

• Metabolic Diseases
• Obesity
• Insulin Resistance
• +۵ مورد دیگر

Professor Mirko Trajkovski leads the Laboratory of Metabolic Diseases at the Faculty of Medicine, University of Geneva. He completed his PhD at the International Max Planck School in Dresden (2005), followed by postdoctoral research at ETH Zurich, before establishing his lab at University College London (2012) and moving to Geneva (2013). His work focuses on adipose tissue plasticity , gut microbiota , and their roles in obesity , diabetes , and insulin resistance . Swiss National Science Foundation Professor (2014) ERC Starting Grant (2014) & Consolidator Grant (2019) Dr Walter Seipp Prize & Carl Gustav Carus Prize (2005) His lab investigates fat browning mechanisms , microbiota-host communication , and multi-tissue metabolic regulation using in vivo , in vitro , and human cohort approaches. Recent publications emphasize microbiome-based therapies , temperature effects on metabolism , and gut-bone-adipose crosstalk . Current advisees include PhD student Silas Kieser, with past members like Jing Xue, Salvatore Fabbiano, and Claire Chevalier contributing to immuno-metabolism and microbial engineering projects.

Patrick M. Gillevetمشاهده پروفایل

استاد

• Molecular Ecology
• Bioinformatics
• Genomics
• +۵ مورد دیگر

Patrick M. Gillevet is a Professor and Director of the Microbiome Analysis Center at George Mason University, with a primary appointment in the Biology Department and affiliate faculty status in the School of Systems Biology. His career focuses on integrating genomics, bioinformatics, and molecular ecology to study microbiome interactions in human health and environmental systems, including the development of multitag sequencing for high-throughput microbial analysis. Education: Ph.D., Biochemistry, University of Manitoba (1982) B.S., Microbiology, University of Toronto (1976) His research explores dysbiosis in the human microbiome (gut, mouth, urogenital, respiratory tracts) and its role in diseases, cognitive function, and social behavior. He pioneered the concept of the "metabiome" to describe host-microbiome interactions in systems biology. Key projects include analyzing multitag sequencing for evolutionary studies and microbial community characterization in ecosystems. Recent publications highlight collaborations on gut microbiome trends in cirrhosis, alcohol use disorder, and antibiotic resistance, with a focus on cross-sectional and longitudinal analyses. His work spans clinical trials (e.g., griffithsin gel), dietary interventions, and environmental microbiome studies.

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +۵ مورد دیگر

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

Jianping Fuمشاهده پروفایل

استاد

• Stem Cell Bioengineering
• Developmental Bioengineering
• Mechanobiology
• +۴ مورد دیگر

Jianping Fu is a Professor in the Department of Mechanical Engineering at the University of Michigan , with joint appointments in Biomedical Engineering and Cell and Developmental Biology. His research integrates micro/nanoengineering , mechanobiology , and stem cell biology to model human development and disease. Education: PhD (MIT, 2007), BE (University of Science and Technology of China, 2000) His research interests focus on stem cell bioengineering , developmental bioengineering , and mechanobiology , particularly in modeling early post-implantation human development, neural tube formation, and pluripotent stem cell mechanoregulation. His work combines biomimetic culture systems with microfluidic gradients to study embryogenesis and organogenesis. Recent publications highlight advances in human embryo modeling (2024 Cell, Nature, Cell Stem Cell), neural tube patterning (2024 Nature), and mechanobiology of stem cells (2024 Nature Reviews Physics). These studies emphasize computational methods , single-cell analysis , and standardization of embryo models . Scientific honors include: Friedrich Wilhelm Bessel Research Award (2022) ISSCR Merit Award (2024) Fellow, American Institute for Medical and Biological Engineering (2019) NSF CAREER Award (2012) Life Member, World Association of Chinese Biomedical Engineers (2024) Dr. Fu mentors extensively, with 20+ alumni including PhD students and postdocs now in academic and industry positions. His lab has received $3M NIH funding for immunological diagnostics and MTRAC grants for translational research. Collaborations with institutions like Cincinnati Children's Hospital and Rice University enhance his interdisciplinary approach to regenerative medicine.

Benjamin Simonsمشاهده پروفایل

استاد

• Stem Cell Biology
• Developmental Biology
• Cancer Biology
• +۳ مورد دیگر

Benjamin Simons is the Royal Society EP Abraham Professor and Herchel Smith Professor of Physics at the University of Cambridge. He serves as Director of the Gurdon Institute, Senior Group Leader at the Gurdon Institute, Principal Investigator at the Cambridge Stem Cell Institute, and member of the Theory of Condensed Matter physics group. He is also a Fellow of St. John's College, Cambridge. His research integrates quantitative approaches from physics and mathematics with experimental biology to investigate stem cell fate regulation in tissue development, maintenance, and cancer pathogenesis. Research focuses on: Stochastic cell fate decisions in epithelial tissues Self-organization principles in tissue morphogenesis Single-cell lineage tracing and gene expression analysis Mathematical modeling of stem cell dynamics Cancer initiation through stem cell reprogramming Publication analysis reveals consistent themes: spatial dynamics of stem cell niches, mechanical regulation of cell fate, computational modeling of tissue organization, and evolutionary principles in cancer development. Recent work emphasizes in vivo lineage tracing, single-cell omics, and interdisciplinary approaches bridging physics and biology. Scientific Awards: Fellow of the Royal Society (FRS) Fellow of the Academy of Medical Sciences (FMedSci) Leads an interdisciplinary research group combining wet-lab experiments (lineage tracing, single-cell genomics) with theoretical modeling. Research supported by EPSRC, MRC, Wellcome Trust, Cancer Research UK, and Royal Society grants. Current projects include gliomagenesis mechanisms, spermatogenic wave regulation, and injury response pathways co-opted in cancer.

• Gynecologic Oncology
• Cancer Immunotherapy
• Tumor Immunology
• +۷ مورد دیگر

Dr. Alessandro D. Santin is a Professor at the Yale School of Medicine within the Department of Obstetrics, Gynecology & Reproductive Sciences . He serves as Clinical Research Team Leader for Gynecologic Oncology at the Yale Cancer Center and co-chief of the Section of Gynecologic Oncology. Graduated magna cum laude from the University of Brescia, Italy Completed fellowships at the University of California, Irvine and University of Arkansas for Medical Sciences Dr. Santin's research bridges tumor immunology and translational oncology, focusing on: Immunotherapy for chemotherapy-resistant gynecologic cancers Therapeutic HPV vaccines for genital tumors Monoclonal antibody development Angiogenesis and radiation biology His recent publications highlight advancements in: VEGF/VEGFR2 system targeting for ovarian cancer Personalized medicine approaches with biomarkers Microsatellite instability in endometrial cancer immunotherapy Antibody-drug conjugates for uterine serous carcinoma NAC supplementation in post-COVID gynecologic patients Scientific Awards: American Association young investigator award Italian Society of Gynecologic Oncologists award for translational science Dr. Santin's lab (Laboratory for Surgery, Obstetrics & Gynecology) at Yale collaborates extensively, with 50+ postdoctoral fellows mentored. Current grants include NIH funding for Clostridium Perfringens Enterotoxin as a novel ovarian cancer therapy and leadership in multiple Gynecologic Oncology Group trials.

Jeff De Jongمشاهده پروفایل

دانشیار

• Molecular Biology
• Cell Biology
• Gene Regulation
• +۷ مورد دیگر

Jeff De Jong is an Associate Professor in the Department of Biological Sciences at the School of Natural Sciences and Mathematics, University of Texas at Dallas , where he has been a faculty member since 1995, rising from Assistant to Associate Professor in 2001. His research investigates the molecular mechanisms of gene regulation, particularly in germ cells. Research Interests: Specialized transcription machinery in germ cells vs. somatic cells Function and regulation of the germ cell-specific transcription factor ALF Core promoter dynamics and transcription initiation Interactions between TFIIA, TBP, and TFIID complexes Potential roles of non-coding RNAs, including piRNAs, in germ cell gene expression Developmental transitions in gene expression during gametogenesis and early embryogenesis The published articles show a consistent focus on germ cell-specific transcription , particularly the ALF factor, its promoter regulation, structural properties, and functional compensation for somatic factors. The work spans model organisms like Xenopus and mouse, utilizing biochemical, molecular, and genetic approaches. Research trends emphasize the evolutionary divergence of transcriptional machinery in reproductive tissues and its implications for fertility and development. Scientific Awards: No awards listed in the provided text. Advising and Teaching: Dr. De Jong has mentored multiple Ph.D. students and postdoctoral researchers, including SangHyun Lee, Ashok Upadhyaya, SangYoon Han, MinJung Kim, Dan Li, Dr. Xiao-li Wang, and Dr. Wensheng Xie. He teaches key courses such as Biochemistry II, Genetics, Molecular Genetics, and Modern Biochemistry II, contributing significantly to both undergraduate and graduate education. Labs and Research Teams: His laboratory has been actively engaged in studying the molecular basis of germ cell transcription, maintaining a research team focused on gene regulation mechanisms. The group has produced a body of work published in high-impact journals, indicating a sustained and productive research program.

Jun Wuمشاهده پروفایل

استادیار

• Stem Cell Biology
• Genome Editing
• Interspecies Chimeras
• +۶ مورد دیگر

Dr. Jun Wu is an Assistant Professor in the Department of Molecular Biology at UT Southwestern Medical Center. He holds a PhD in Life Science from the University of Tennessee and completed postdoctoral training at the University of Southern California and the Salk Institute. His research focuses on stem cell biology, genome editing, and interspecies chimeras to advance regenerative medicine and developmental biology. Education: Bachelor of Medicine, Shandong University School of Medicine (China) PhD in Life Science, University of Tennessee (2013) Postdoctoral Fellowships: USC (2013-2015) and Salk Institute (2015-2017) Research Interests: Generation of pluripotent stem cells with distinct molecular/phenotypic features Development of interspecies blastocyst complementation systems Modeling peri-implantation human development using stem cell embryo models Study of species-specific developmental barriers and evolutionary biology Application of chimeras to study cancer resistance and organ size determination Lab Activities: The Wu Lab develops stem cell models to study mammalian development and create regenerative therapies. Key projects include: Creation of interspecies chimeras (human-monkey, rat-mouse) Development of blastoids and peri-gastruloids Analysis of species-specific cell competition mechanisms Engineering cross-species organogenesis systems Grant Activities: Focuses on NIH-funded projects related to stem cell biology, interspecies chimerism, and regenerative medicine applications. Collaborates with institutions like Salk Institute and University of California campuses. Lab Team: Includes postdoctoral researchers like Dr. Yi Ding and a multidisciplinary team of molecular biologists, bioengineers, and computational biologists.

Jeffrey Weissمشاهده پروفایل

استاد پژوهش

• Gonadal Development
• Pituitary
• Gonadotropins
• +۷ مورد دیگر

Jeffrey Weiss is a Research Professor at the Department of Medicine (Endocrinology, Metabolism and Molecular Medicine) within Northwestern University Feinberg School of Medicine. His work bridges genetic research and core facilities management , focusing on reproductive biology and organizational efficiency in academic settings. Education: BS from The Pennsylvania State University (1982), PhD from University of Virginia (1987), and postdoctoral training at Harvard Medical School (1990) and Massachusetts General Hospital (1991). Dr. Weiss's research spans gonadal development , pituitary function , and reproductive genetics , with a focus on hormones like activin, LH, and FSH. He also contributes to core facilities infrastructure , including software solutions for research management. His recent publications highlight trends in bioinformatics systems for core facilities and genetic models for studying reproductive disorders. Key subfields include mouse mutagenesis , gene expression , and research portfolio sustainability . Scientific Awards: Member, Association of Biomolecular Research Facilities (2013 - Present) Dr. Weiss is affiliated with the Center for Genetic Medicine and Center for Reproductive Science at Feinberg. While no current grants are listed, his work emphasizes interdisciplinary collaboration and efficient research infrastructure.