Alessandro D. Santin

Dr. Alessandro D. Santin is a Professor at the Yale School of Medicine within the Department of Obstetrics, Gynecology & Reproductive Sciences. He serves as Clinical Research Team Leader for Gynecologic Oncology at the Yale Cancer Center and co-chief of the Section of Gynecologic Oncology.

• Graduated magna cum laude from the University of Brescia, Italy
• Completed fellowships at the University of California, Irvine and University of Arkansas for Medical Sciences

Dr. Santin's research bridges tumor immunology and translational oncology, focusing on:

• Immunotherapy for chemotherapy-resistant gynecologic cancers
• Therapeutic HPV vaccines for genital tumors
• Monoclonal antibody development
• Angiogenesis and radiation biology

His recent publications highlight advancements in:

• VEGF/VEGFR2 system targeting for ovarian cancer
• Personalized medicine approaches with biomarkers
• Microsatellite instability in endometrial cancer immunotherapy
• Antibody-drug conjugates for uterine serous carcinoma
• NAC supplementation in post-COVID gynecologic patients

Scientific Awards:

• American Association young investigator award
• Italian Society of Gynecologic Oncologists award for translational science

Dr. Santin's lab (Laboratory for Surgery, Obstetrics & Gynecology) at Yale collaborates extensively, with 50+ postdoctoral fellows mentored. Current grants include NIH funding for Clostridium Perfringens Enterotoxin as a novel ovarian cancer therapy and leadership in multiple Gynecologic Oncology Group trials.