جست‌وجوی استاد و پژوهشگر

Angela Grittiمشاهده پروفایل

دانشیار

• Regenerative Medicine
• Gene Therapy
• Neural Stem Cells
• +۷ مورد دیگر

Angela Gritti is an Associate Professor of Human Histology at Vita-Salute San Raffaele University and a Group Leader at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) since 2006. Her work focuses on genetic neurodegenerative diseases , particularly Leukodystrophies and GM2 gangliosidosis , using neural stem cells and gene therapy approaches. PhD in Basic Sciences and Veterinary Biotechnology (University of Turin, 2006) Specialty in Toxicology (University of Milan, 1996) Degree in Biological Sciences (University of Milan, 1990) Her research explores regenerative medicine and gene therapy through neural stem cell biology , focusing on: Pathogenesis of lysosomal storage disorders iPSC modeling of human CNS diseases AAV/lentiviral vector safety Epigenetic modulation of oligodendrocytes Preclinical development for metabolic CNS diseases The articles section reveals her contributions to gene therapy safety , iPSC neural modeling , and combined cell/gene strategies for leukodystrophies. Despite extensive grant reviewer roles (ERC, AFM Telethon, EJPRD) and international collaborations with institutions in France, Norway, and the USA, no formal scientific awards are listed in the current text. She has supervised 12 PhD students and 22 master's students while leading funded projects with institutions like the Bespoke Gene Therapy Consortium (NIH), European Leukodystrophy Association , and Italian Telethon Foundation . Her lab also contributes to patient advocacy through educational outreach and clinical translation frameworks.

Suming Huangمشاهده پروفایل

استاد

• Epigenetics
• Gene Regulation
• Leukemia Research
• +۵ مورد دیگر

Suming Huang serves as Professor and Chair of the Four Diamonds Epigenetics and Gene Regulation Research Program in Pediatric Oncology at Penn State University's College of Medicine. Holding dual appointments in the Department of Pediatrics Division of Hematology and Oncology and the Department of Molecular and Precision Medicine, Huang directs research within the Penn State Cancer Institute's Mechanisms of Carcinogenesis program. With an h-index of 36 and over 4,000 citations, Huang maintains an active research profile through the National Cancer Institute. Huang's research centers on epigenetic mechanisms in leukemia development, specializing in transcriptional regulation, non-coding RNA functions, and chromatin organization. Key focus areas include TAL1/SCL regulation in T-cell leukemia, lncRNA-mediated genome organization in AML, and the role of histone modifiers like HDAC1 in tumor suppression. The research integrates hematopoietic stem cell biology with leukemogenesis pathways, particularly examining how non-coding RNAs reprogram chromatin architecture in NUP98-rearranged leukemias and other hematological malignancies. Current publication trends reveal consistent output in high-impact oncology journals, with 2025 publications examining CK2α deletion effects on stem cells, IKAROS/HDAC1 heterochromatin regulation, guanine biosynthesis blockade in MLL leukemias, and HoxBlinc lncRNA functions. These works demonstrate Huang's shift toward therapeutic targeting of epigenetic vulnerabilities while maintaining core investigations into transcriptional dysregulation in pediatric cancers. Huang leads eight major research projects including the active National Cancer Institute grant Role of lncRNA mediated R-loops in CTCF boundary function and AML genome organization (2021-2025). Past projects span leukemogenesis mechanisms, long non-coding RNA functions in hematopoiesis, and TAL1 regulation in T-cell leukemia, securing sustained NCI funding since 2008. The research program maintains strong collaborations across hematology-oncology and molecular medicine departments. The Four Diamonds Epigenetics and Gene Regulation Research Program in Pediatric Oncology serves as Huang's primary research hub, focusing on translating epigenetic discoveries into therapeutic strategies for childhood leukemias. Current work integrates multi-omics approaches to dissect lncRNA-mediated chromatin reorganization in leukemic stem cells.

Edward Hawrotمشاهده پروفایل

استاد

• acetylcholine receptors
• Biochemistry
• drug design
• +۹ مورد دیگر

Edward Hawrot is the Alva O. Way Professor of Molecular Biology, Cell Biology and Biochemistry at Brown University's Division of Biology and Medicine. He has been at Brown since 1990, initially serving as Chair of the Section of Molecular Pharmacology. His research focuses on nicotinic acetylcholine receptors and the neurotoxins that target them, with particular emphasis on structure-function relationships. Hawrot received his Ph.D. in Biochemistry from Harvard University and completed postdoctoral training at Harvard Medical School as a Helen Hay Whitney Postdoctoral Fellow working with Paul Patterson. Prior to joining Brown, he spent ten years on the faculty in the Department of Pharmacology at Yale University School of Medicine. His research spans multiple areas including molecular pharmacology, drug design and discovery, nicotine receptor biology, proteomics, and transgenic mouse models. Hawrot's laboratory pioneered the development of a knock-in mouse model where the alpha3 gene was modified to impart sensitivity to alpha-bungarotoxin, enabling systematic determination of alpha3-containing nAChR roles in behavior and nervous system function. His work combines biochemical, biophysical, and molecular biological approaches to understand drug-receptor interactions at the molecular level. Hawrot has received significant funding from NIH and NSF, including grants for mass spectrometry equipment, training programs, and research on nicotinic receptors in pulmonary hypertension. His publication record spans over 70 articles with consistent output through 2021, demonstrating sustained research productivity in receptor biology and neuropharmacology. Established Investigator of the American Heart Association Upjohn Professor of Pharmacology Fellow of the American Association for the Advancement of Science (2011) Multiple NIH study section appointments (2005-2015) Hawrot has served on multiple NIH study sections and has been an active member of several professional organizations including the American Society for Pharmacology & Experimental Therapeutics, American Society for Biochemistry and Molecular Biology, and Society for Neuroscience. His laboratory has developed innovative techniques including the 'pharmatope' approach for engineering receptor sensitivity to alpha-bungarotoxin, creating valuable tools for neuroscience research.

• Biophysics
• Bioenergetics
• Electrophysiology
• +۳ مورد دیگر

Rikke Birkedal Nielsen is a Senior Research Fellow at Tallinn University of Technology's School of Science, Department of Cybernetics, where she has been employed since 2009. She holds a PhD in biology (zoophysiology) from the University of Aarhus, Denmark, completed in 2004 under the supervision of Hans Gesser. Her educational background includes higher education in biology at the University of Aarhus (1996-2000) followed by doctoral studies there (2000-2004). Prior to her position at Tallinn University of Technology, she conducted postdoctoral research at the University of Manchester (2006-2008) and INSERM U-446 at Université de Paris-Sud (2005). Dr. Birkedal Nielsen's research focuses on biophysics, bioenergetics, electrophysiology, and cardiac physiology, with particular expertise in energy metabolism in cardiomyocytes. Her work investigates compartmentalization in cardiac cells, creatine kinase systems, calcium handling, and the relationship between cellular structure and function in the heart. She has developed several open-source software tools including IOCBIO Gel and IOCBIO Kinetics for analyzing biological data. Her most recent publications reveal consistent focus on cardiac metabolism, particularly examining how energy transfer systems function in cardiomyocytes, the role of creatine kinase in heart function, calcium signaling mechanisms, and sex differences in cardiac physiology. Her research often employs mouse and rat models, including genetically modified organisms with creatine deficiencies. She is currently leading research on energy transfer in compartmentalized cardiac muscle cells (2021-2025), examining how altered energy transfer affects mitochondria, contractility, electromechanical coupling, and overall heart performance. Dr. Birkedal Nielsen collaborates extensively with Martin Vendelin and other researchers at Tallinn University of Technology, contributing to numerous publications in high-impact journals including American Journal of Physiology, FEBS Letters, PLoS ONE, and Journal of Molecular and Cellular Cardiology.

Maja Lind Nyboمشاهده پروفایل

پژوهشگر

• Metabolism
• Obesity
• Laboratory Animal Research
• +۳ مورد دیگر

Maja Lind Nybo serves as a Guest Researcher in the Department of Biomedical Sciences within the Faculty of Health and Medical Sciences at the University of Copenhagen. Her work centers on molecular mechanisms of metabolism, obesity, and lifestyle-related diseases using laboratory animal models. M.Sc in Molecular Biomedicine Her research integrates genetic, biochemical, and pharmacological approaches to investigate reproductive disorders and metabolic dysregulation. Key focus areas include ADGRA3-related reproductive anomalies , N-terminal protein acetylation defects , and GHSR-mediated metabolic pathways , primarily utilizing genetically modified mouse models to uncover disease mechanisms with translational relevance. Recent publications demonstrate consistent investigation into gene-phenotype relationships, particularly regarding ADGRA3 in reproductive tract development (2023-2024) and metabolic regulation (2020). Her collaborative work spans genetics, biochemistry, and pharmacology, revealing novel pathogenic mechanisms in congenital disorders and metabolic conditions through rigorous mouse model phenotyping. Maja Lind Nybo actively contributes to collaborative research within the Molecular and Translational Pharmacology group, co-authoring publications with cross-institutional teams across Denmark. Her work receives consistent peer-reviewed publication in high-impact journals including BMC Biology and FASEB Journal , demonstrating ongoing research productivity without documented grant leadership or student supervision. She maintains laboratory operations within the Department of Biomedical Sciences, utilizing specialized mouse model facilities for metabolic and reproductive phenotyping studies. Her collaborative network spans multiple Danish research institutions as evidenced by co-authorship patterns in recent publications.

Mark Smitsمشاهده پروفایل

پژوهشگر

• Endocrinology
• Metabolism
• Gut Hormone Physiology
• +۵ مورد دیگر

Mark Smits is a postdoctoral researcher at the University of Copenhagen's Faculty of Health and Medical Sciences, Department of Biomedical Sciences, working within Professor Jens Juul Holst's research group focused on endocrinology and metabolism. His academic journey began with medical training in Amsterdam where he earned both Bachelor's and Master's degrees with honors from Vrije Universiteit Amsterdam. Medical Doctor (MD) qualification from Amsterdam PhD in gut-hormone based therapies from Vrije Universiteit Amsterdam (completed with honors) Current endocrinology specialist training Dr. Smits' research centers on gut hormone physiology, particularly mechanisms to enhance glucagon-like peptide-1 (GLP-1) secretion. His work spans molecular mechanisms of hormone secretion, dietary influences on metabolic pathways, and therapeutic applications for diabetes and metabolic disorders. Recent publications demonstrate expertise in incretin biology, gut-brain axis signaling, and translational approaches to metabolic disease. His collaborative research network spans multiple international institutions, with significant contributions to understanding GLP-1 secretion pathways, nutrient-hormone interactions, and metabolic adaptations in disease models. Dr. Smits has published over 65 peer-reviewed articles, with recent work appearing in high-impact journals including Diabetes , American Journal of Physiology , and Diabetes/Metabolism Research and Reviews . As part of Holst's renowned research group, he contributes to cutting-edge investigations into gut hormone-based therapies while advancing his clinical training in endocrinology. His dual expertise in clinical medicine and basic research positions him at the intersection of translational endocrinology and metabolic disease therapeutics.

Jackson Taylorمشاهده پروفایل

استادیار

• Epigenetics
• Aging Research
• Longevity Mechanisms
• +۳ مورد دیگر

Jackson Taylor is an Assistant Professor at Cleveland State University's Center for Gene Regulation in Health and Disease (GRHD), leading research on epigenetic mechanisms of aging using Drosophila melanogaster models. His work focuses on how epigenetic modifications drive age-related dysfunction and disease, with emphasis on lifespan extension strategies. Education: Ph.D. in Neuroscience, Wake Forest University School of Medicine (2013) Postdoctoral Training, Wake Forest Health Sciences (2013-2016) Postdoctoral Training, Brown University (2016-2022) Dr. Taylor's research program investigates epigenome dynamics during aging, particularly how experimental manipulation of epigenetic regulators like Sirt6 extends lifespan and preserves physical function. His lab employs next-generation sequencing, bioinformatics, genetic engineering, and longevity assays to study Alzheimer's disease models and identify novel epigenetic modifiers. Key findings demonstrate that Sirt6 overexpression represses Myc target genes through H3K9ac deacetylation, reducing protein synthesis and extending lifespan in fruit flies. Analysis of his publication record reveals consistent focus on epigenetic aging mechanisms across model systems, with significant contributions to understanding transposable element regulation, DNA methylation patterns in immune aging, and calcium channel dynamics in sarcopenia. His work bridges basic epigenetic discovery with translational applications for age-related diseases. Dr. Taylor advises graduate students in the Taylor Lab (established Fall 2022), mentoring Samira Xhaferi, Roja Sharma, and Prema Singaravel. His research is supported through GRHD center resources and collaborations with the Cleveland Clinic Joint Ph.D. Programs. The Taylor Lab operates within CSU's Science and Research Building (Room 259), utilizing advanced genomic and bioinformatic infrastructure through the GRHD center's facilities. Current projects target tissue-specific Sirt6 mechanisms in Alzheimer's disease models and high-throughput screening of epigenetic longevity modifiers.

Randal J. Westrickمشاهده پروفایل

دانشیار

• Genetics
• Cardiovascular Disease
• Thrombosis
• +۳ مورد دیگر

Randal J. Westrick is an Associate Professor in the Department of Biological Sciences at Oakland University. He joined the university in 2013 with funding from an American Heart Association Scientist Development grant and maintains an active research laboratory focused on cardiovascular genetics. Dr. Westrick holds a Ph.D. and is an internationally recognized researcher in the genetics of thrombosis, hemostasis, and cardiovascular disease whose work has been cited over 4,000 times. His research primarily focuses on the genetics of cardiovascular disease , with particular emphasis on thrombosis and hemostasis. His laboratory employs genome wide mutagenesis approaches in mice with genetically lethal blood clotting disorders to identify and characterize genetic variants that restore survival. His work explores how these variants alter biological activities such as cytoskeletal regulation, lipid biology, and extrinsic blood coagulation, providing innovative therapeutic targets for reducing blood clot risk. A significant portion of his research has centered on identifying genetic loci controlling the expression of platelet plasminogen activator inhibitor-1 (pPAI-1). Dr. Westrick's publication record shows a consistent focus on cardiovascular genetics with increasing emphasis on genomic approaches. His recent work (2021-2023) demonstrates expansion into tumor biology and RNA splicing mechanisms while maintaining his core focus on thrombosis and hemostasis. The integration of genomic techniques with traditional cardiovascular research represents a cutting-edge approach to understanding complex disease mechanisms. Fellow of the American Heart Association (FAHA) Dr. Westrick actively mentors students at various levels, with multiple undergraduate and graduate students contributing to his research publications. His laboratory is supported by multiple grants including: American Heart Association Strategically Focused Research Network Center on Inflammation in Cardiac and Neurovascular Disease, NIH R15 grant investigating Arl6ip5's roles in suppressing thrombosis, NSF grant on data analytics in STEM education, NIH U2C/TL1 Institutional Network Award, and American Heart Association undergraduate research programs. His lab occupies space in Dodge Hall rooms 301, 304, and 307 and includes graduate students, postdoctoral researchers, and undergraduates working collaboratively on projects related to cardiovascular genetics and thrombosis.

Christopher Percivalمشاهده پروفایل

دانشیار

• Genetics
• Developmental Biology
• Craniofacial Development
• +۳ مورد دیگر

Christopher J. Percival is an Associate Professor in the Department of Anthropology at Stony Brook University. He obtained his Ph.D. from Pennsylvania State University in 2013 and specializes in the genetic and developmental basis of craniofacial variation using mouse models. Education: Ph.D. in Anthropology, Pennsylvania State University (2013) Research Interests focus on: Quantifying genetic contributions to skull morphology Developmental biology of craniofacial structures Evolutionary implications of morphological variation Establishing genotype-phenotype associations in mouse models Key Research Approaches: 3D morphometric landmark analysis Diallel genetic studies Mouse Collaborative Cross project Allometric correction techniques Notable Collaborations: University of Calgary, University of Colorado School of Medicine, UCSF School of Medicine, University of North Carolina-Chapel Hill Technical Expertise: Micro-computed tomography (μCT), Procrustes superimposition, MorphoJ software, BayesDiallel modeling

• Autism
• Induced pluripotent stem cells
• Neuroscience
• +۴ مورد دیگر

Samuele Marro is an Assistant Professor in the Nash Family Department of Neuroscience and the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai. His research program focuses on synaptic plasticity and its dysfunction in Fragile X syndrome, which represents the number one genetic cause of autism. Dr. Marro received his PhD in Human Biology from the Molecular Biotechnology Center at the University of Torino in Italy. He completed his postdoctoral training in pluripotent stem cell biology in the laboratory of Marius Wernig, MD PhD, at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University. His laboratory utilizes human neurons directly differentiated from pluripotent stem cells and genetically modified using CRISPR/Cas9 tools to investigate neurodevelopmental disorders. His research spans multiple disciplines including neuroscience, stem cell biology, and genetic engineering, with particular emphasis on autism spectrum disorders and synaptic function. Dr. Marro's team has developed sophisticated protocols for generating precise disease models and investigating cellular mechanisms underlying neurological conditions. Analysis of Dr. Marro's 15 most recent publications reveals a consistent trajectory from foundational stem cell techniques to complex disease modeling. His work demonstrates expertise in CRISPR-based gene editing, single-cell analysis, and advanced imaging techniques applied to neurodevelopmental and neurodegenerative conditions. There is a clear progression toward increasingly sophisticated models of neurological disorders with translational applications. Dr. Marro serves as co-Director of the Stem Cell Engineering Core, which provides critical infrastructure services including derivation of iPSCs from patient blood samples, differentiation into specific cell types, and gene-editing to create or repair disease mutations for the Icahn School of Medicine community. This role positions him at the intersection of basic research and translational applications across multiple disciplines.

Rui Yiمشاهده پروفایل

استاد پژوهشی

• Stem Cell Biology
• Molecular Biology
• Skin Development
• +۵ مورد دیگر

Rui Yi, PhD, is the Paul E. Steiner Research Professor of Pathology and Professor in Pathology (Experimental Pathology) and Dermatology at Northwestern University Feinberg School of Medicine. Their research focuses on stem cell biology, aging, and cancer mechanisms in mammalian skin, using single-cell genomics, computational tools, and mouse models. Education: BS (Peking University, 1999), PhD (Duke University, 2004) Their work explores how transcription factors, epigenetic regulators, and microRNAs govern cell fate specification and stem cell maintenance at single-cell resolution. Recent studies highlight mechanobiology in hair follicle quiescence, computational spatial analysis methods, and miRNA roles in cardiac development. Publications emphasize interdisciplinary approaches spanning stem cell biology, mechanotransduction, and genomic data analysis. Awards include NIH Pathway to Independence (2007), American Cancer Society Research Scholar (2013), and NIH NIAMS STAR Award (2017). Leadership roles include NIH Study Section (DEV2), editorial board membership, and scientific advisory roles. Research at the Laboratory of Stem Cells and Aging advances regenerative medicine and skin disease treatment. NIAMS STAR Award, NIH (2017) American Cancer Society Research Scholar (2013) NIH Pathway to Independence Award (2007) Rui Yi’s team at Northwestern collaborates with institutions like Robert H. Lurie Comprehensive Cancer Center and Skin Biology and Diseases Resource-Based Center. Current work aims to translate molecular insights into therapies for skin aging and diseases.

• Neurodegenerative diseases
• Rett syndrome
• Neurodevelopmental genetics
• +۶ مورد دیگر

Dr. Huda Yahya Zoghbi is a Professor at Baylor College of Medicine , holding appointments in the Departments of Molecular and Human Genetics, Pediatrics - Neurology and Developmental Neuroscience, Neuroscience , and other programs. She serves as an Investigator at the Howard Hughes Medical Institute and as Director of the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital. Her research spans neurogenetics, neurodegenerative diseases, and neurodevelopmental biology. Education: MD, Meharry Medical College (1979) BS, American University of Beirut (1976) Post-Doctoral Fellowship, Baylor College of Medicine (1985) Research Interests: Dr. Zoghbi's work focuses on the pathogenesis of neurodegenerative diseases like spinocerebellar ataxia type 1 (SCA1) and Rett syndrome , using genetic and biochemical approaches to understand disease mechanisms. Her lab investigates Ataxin-1 in polyglutamine diseases, Atoh1 in neurodevelopment, and MECP2 regulation in neurological disorders. She explores therapeutic strategies including antisense oligonucleotides and deep brain stimulation . Notable Awards: Kavli Prize in Neuroscience (2022) Breakthrough Prize in Life Sciences (2017) National Academy of Sciences (2004) Shaw Prize in Life Science and Medicine (2016) Canada Gairdner International Award (2017) Honorary Doctorates from Yale, Meharry, and Middlebury (2007-2014) Laboratory: The Zoghbi Laboratory at Baylor College of Medicine investigates genetic mechanisms in neurological disorders , collaborating with institutions like the Howard Hughes Medical Institute and Texas Children’s Hospital. The lab employs mouse models , CRISPR tools , and single-cell sequencing to study neuronal differentiation and disease vulnerability.

• Stem Cell Research
• Beta Cell Biology
• Pancreas Development
• +۵ مورد دیگر

Dr. Ingo Burtscher serves as Deputy Director and Group Leader of the Stem Cell Research group at the Institute of Diabetes and Regeneration Research (IDR), Helmholtz Munich. His work bridges fundamental developmental biology and translational diabetes research through advanced stem cell engineering. His academic background includes: Diploma in Biology from University of Vienna (1993-1999) PhD from Queen Mary & Westfield College, University of London (2000-2004) Burtscher's research focuses on human pancreatic development and beta cell regeneration using CRISPR/Cas9-engineered iPSC reporter lines. His team investigates endocrine lineage decisions, beta cell maturation mechanisms, and the pancreatic endocrine niche to advance diabetes therapies. Current methodologies emphasize live-cell imaging of fluorescent reporter systems and precise genetic manipulation of stem cells. Publication analysis reveals consistent innovation in genetic reporter systems across species (mouse to human iPSCs), with increasing translational emphasis post-2013. Core themes include endoderm development, pancreatic organogenesis, and CRISPR-based disease modeling, demonstrating evolution from basic embryogenesis studies to diabetes-focused regenerative applications. Burtscher leads active collaborations with EU ISLET, Eli Lilly, and BMBF on diabetes research initiatives. His laboratory (Campus Neuherberg, building 3620, room 302c) specializes in generating genetically modified stem cell models for drug screening and beta cell replacement therapy development.

• Mitochondrial fatty-acid β-oxidation
• Post-translational redox modifications
• Nitric-oxide signalling
• +۶ مورد دیگر

Paschalis-Thomas Doulias is Associate Professor of Organic Chemistry and Biochemistry in the Department of Chemistry at the University of Ioannina, Greece. His laboratory, located in Ioannina Campus building X3-106D, investigates the molecular mechanisms governing mitochondrial fatty-acid β-oxidation and their translational exploitation for rare inherited disorders of long-chain fatty-acid oxidation. Research Interests His research spans two tightly integrated themes: Basic Research: Elucidating post-translational redox modifications—particularly S-nitrosylation, acetylation and succinylation—that regulate key enzymes of mitochondrial fatty-acid oxidation. Work uses genetically modified mouse models (Sirt-3 -/- , Sirt-5 -/- , eNOS -/- and VLCAD Cys238Ala knock-in) complemented by cellular mutagenesis to dissect how energetic demand is coupled to enzymatic flux. Translational Research: Developing nitric-oxide-based therapies for long-chain fatty-acid oxidation disorders (LC-FAODs). The group pioneered the concept that augmenting NO signalling restores catalytic efficiency of mutant VLCAD, and is currently validating FDA-approved NO donors and proprietary hybrid NO-plus-substrate molecules in patient-derived cells and a humanised VLCAD-deficient mouse. Publication Landscape (2020-2025) Over the past five years, Doulias and collaborators have generated 15 high-impact articles that collectively map redox-proteomic landscapes in cardiovascular, neurodegenerative and metabolic disease contexts. Recurring keywords include S-nitrosylation, TCA-cycle compromise, mitochondrial energetics, HFpEF, ALS and Alzheimer’s disease, underscoring a unifying theme of redox-metabolic crosstalk. Scientific Awards & Recognition While specific honours are not enumerated, the consistent citation of his work (H-index 30, 3571 citations) attests to significant peer recognition. Funding & Collaborations Active translational projects include medicinal-chemistry optimisation of NO-donating compounds and in vivo efficacy testing in humanised mouse models of VLCAD deficiency, implying sustained competitive funding and multi-disciplinary partnerships. Laboratory & Team The group operates within the Department of Chemistry core facilities, leveraging state-of-the-art proteomics, metabolomics and transgenic animal resources to advance both basic and pre-clinical goals.

Paolo Mediniمشاهده پروفایل

دانشیار

• Neuroscience
• Neurophysiology
• Neurobiology
• +۵ مورد دیگر

Paolo Medini is an Associate Professor at Umeå University, affiliated with the Department of Medical and Translational Biology and the Center for Transdisciplinary AI. His research focuses on cortical microcircuits, sensory processing, and brain recovery mechanisms. Neuroscience Neurophysiology Cortical Plasticity Optogenetics His lab investigates how sensory information is processed by distinct cell types in cortical circuits and how these circuits adapt after brain lesions or sensory deprivations. Research spans both adaptive and maladaptive plasticity, aiming to differentiate molecular mechanisms for targeted interventions. Recent publications highlight applications of all-optical interrogation strategies and multisensory integration in the neocortex. Paolo Medini's group employs advanced techniques such as in vivo patch clamp recordings, two-photon calcium imaging, and optogenetics. They use genetically modified strains to study cell-type-specific responses and circuit reorganization post-lesion. Their work is critical for developing therapies in neurodegenerative diseases and cortical repair. Environmental enrichment for brain recovery (Nature Neuroscience) Cortical microcircuit organization (Neuron) Post-stroke plasticity (Journal of Physiology)