جست‌وجوی استاد و پژوهشگر

Emily Spauldingمشاهده پروفایل

استادیار

• Neurobiology
• Biomolecular Condensates
• Neurodegenerative Diseases
• +۷ مورد دیگر

Emily Spaulding is an Assistant Professor affiliated with the Graduate School of Biomedical Science and Engineering at the University of Maine. Her research focuses on understanding the role of biomolecular condensates in neuronal organization and their implications in neurodegenerative diseases. Research Interests: Dr. Spaulding's work centers on biomolecular condensates (BMCs) in neurons, particularly using the nematode C. elegans as a model system. She investigates how BMCs contribute to cellular organization and how their dysfunction may lead to diseases like Alzheimer’s, Parkinson’s, and ALS. Her lab combines CRISPR/Cas9 genome editing with super-resolution imaging to study endogenous gene function in live animals. Publication Trends: Her recent publications highlight a strong focus on neurodegenerative and peripheral neuropathies, especially Charcot-Marie-Tooth disease and tRNA synthetase-related disorders. The research integrates molecular genetics, neurobiology, and translational approaches, often involving collaborations across multiple institutions. Key themes include biomarker discovery, stress response pathways, and therapeutic interventions such as RNA interference and tRNA overexpression. Scientific Awards: No awards mentioned in the provided text. Advising and Grants: While specific students and grants are not listed, Dr. Spaulding leads an active research lab and mentors trainees through the Graduate School of Biomedical Science and Engineering. Her publications indicate extensive collaboration with leading researchers in neurogenetics and peripheral nerve biology, suggesting involvement in major research initiatives and funding projects. Labs and Teams: The Spaulding Lab at the University of Maine utilizes C. elegans and mouse models to explore fundamental mechanisms of neuronal organization and disease. The team collaborates widely, including with researchers at MDI Biological Laboratory and other institutions, contributing to high-impact studies in journals such as Science and Nature Communications .

Farah Quyyumiمشاهده پروفایل

استادیار بالینی

• Breast Cancer
• Medical Oncology
• Hematology
• +۳ مورد دیگر

Dr. Farah Quyyumi serves as an Assistant Clinical Professor in the Department of Medical Oncology & Therapeutics Research at City of Hope, where she works as a Medical Oncologist and Hematologist specializing in breast cancer. She is board certified in Hematology (2019), Medical Oncology (2018), and Internal Medicine (2015), and speaks Spanish, Hindi, and Urdu to better serve her diverse patient population. Dr. Quyyumi's research focuses primarily on breast cancer, with particular attention to multidisciplinary care coordination and follow-up medical care for women with early-stage breast cancer. Her work examines factors influencing patient access to comprehensive cancer care and adherence to recommended treatment protocols. She emphasizes patient trust, honesty, and overall well-being in her clinical practice while maintaining expertise in the latest targeted cancer therapies. Analysis of Dr. Quyyumi's publication history reveals a consistent focus on improving breast cancer care delivery systems, with significant contributions to understanding care coordination patterns and patient follow-up behaviors. Her earlier work included research in hematology, immunology, and cardiology, demonstrating a broad scientific foundation before specializing in oncology. Dr. Quyyumi maintains active clinical responsibilities at City of Hope in Glendale, California, where she provides direct patient care while contributing to the academic mission of the institution. Her professional experience includes previous work at The Oncology Institute of Hope and Innovation in Burbank and research fellowships at Columbia University Medical Center.

Wojciech Pokrzywaمشاهده پروفایل

استاد

• Protein Metabolism
• Proteostasis
• Ubiquitin-Proteasome System
• +۱۵ مورد دیگر

Wojciech Pokrzywa is a Principal Investigator at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), where he leads the Laboratory of Protein Metabolism. He holds a Ph.D. and D.Sc. and has established himself as a leading researcher in proteostasis, focusing on protein metabolism regulation using C. elegans and mammalian cell models. His lab investigates the ubiquitin-proteasome system, chaperone networks, translation regulation, and the role of muscle-derived exophers in reproductive fitness. Dr. Pokrzywa obtained his Ph.D. at the Catholic University of Louvain, Belgium, studying ubiquitin-mediated membrane protein regulation in yeast. He then joined Prof. Thorsten Hoppe’s lab at the University of Cologne, Germany, to study proteostasis in C. elegans before founding his independent research group in Warsaw in mid-2017. His work bridges fundamental molecular mechanisms with implications for aging, neurodegenerative diseases, and therapeutic development. His research interests include: Mechanisms of protein degradation and ubiquitination Regulation of E3 ligase complexes (e.g., CHIP/CHN-1, UFD-2) Non-canonical ubiquitination and lysine-deficient proteomes Cellular adaptation to cold stress Exophergenesis and intercellular communication via extracellular vesicles Development of bioinformatics tools like DEGRONOPEDIA for degron prediction His recent publications reveal trends in integrating wet-lab experimentation with computational modeling, particularly in degron discovery, stress response mechanisms, and the development of educational tools. He has contributed to high-impact journals such as Nature Communications , Nucleic Acids Research , and Journal of Biological Chemistry , often as corresponding author, indicating leadership in collaborative science. Scientific Awards: Distinction from the Polish Academy of Sciences (PAS), Division II (2024) for 'Discovery of new proteostasis mechanisms important in the functioning of organisms and development of new therapies' Dr. Pokrzywa actively mentors students and researchers, including Ph.D. candidates Natalia Szulc and Pankaj Thapa, and M.Sc. graduate Gabriela. He has secured competitive funding from the National Science Centre (NCN), including OPUS and SONATA BIS grants, and leads projects on cold adaptation and protein degradation evasion. His lab also innovates in science outreach through DEGRADATOR , an educational game on protein degradation, which has been published in the Journal of Chemical Education and integrated into LabXchange. The lab maintains advanced facilities for C. elegans and protein analysis, supporting a multidisciplinary research environment.

Carlo Brugnaraمشاهده پروفایل

استاد

• Hematology
• Red Blood Cell Physiology
• Sickle Cell Disease
• +۱۲ مورد دیگر

Dr. Carlo Brugnara is a Professor in the Department of Laboratory Medicine at Boston Children's Hospital and Harvard Medical School. He serves as Director of the Hematology Laboratory and is Editor-in-Chief of the American Journal of Hematology. His research spans red blood cell physiology, sickle cell disease, thalassemia, and iron metabolism. Research Interests: Dr. Brugnara's work focuses on ion transport in erythrocytes, particularly the role of transport proteins in sickle cell dehydration and novel therapeutic strategies. His research integrates molecular mechanisms, genetic determinants of red cell hydration, and clinical applications in pediatric hematology. He has pioneered the use of reticulocyte parameters for diagnosing iron deficiency and monitoring erythropoiesis. Recent Research Trends: His recent publications highlight therapeutic innovations in hemoglobinopathies, including mitapivat for thalassemia and spherocytosis, omega-3 fatty acids for sickle cell vasculopathy, and resolvins for inflammatory cardiomyopathy. His work also extends to healthcare economics, digital hematology, and genetic modifiers of disease severity. Scientific Awards and Recognition: Fellow, American Society of Clinical Investigation Fellow, Association of American Physicians Fellow, Academy of Clinical Laboratory Physicians and Scientists Editor-in-Chief, American Journal of Hematology (since 2007) Advising and Grants: While specific students and grants are not listed, Dr. Brugnara has led extensive research programs funded by NIH and other agencies, mentoring numerous trainees in hematology and laboratory medicine. His editorial leadership has significantly shaped the field of hematology publishing. Labs and Research Units: He leads research in the Hematology and Oncology Research Unit at Boston Children's Hospital, focusing on translational studies in red cell disorders and diagnostic innovation.

• Molecular Biology of Plants
• Population Genetics
• Genetic Engineering
• +۴ مورد دیگر

Justyna Nowakowska is a Professor at the Faculty of Biology and Environmental Sciences at the Pontifical University of John Paul II in Kraków (UKSW). She holds a doctoral degree from the University of Louis Pasteur in Strasbourg, France, specializing in gene expression analysis in genetically modified plants. Her professional career includes managing the DNA Analysis and Molecular Biology Laboratories at Poland's Forest Research Institute from 2000 to 2017. Her research focuses on molecular biology of plants, population genetics, genetic engineering, and molecular diagnostics of plant pathogens, with notable contributions to understanding Phytophthora infections, ash dieback, and fungal pathogen interactions. She has authored/co-authored 105 scientific papers, 5 monographs, and 52 popular science publications, alongside producing educational films promoting scientific activities. She has held board roles in 9 EU COST Actions since 2008, fostering international collaboration in forest health and biotechnology. Her work emphasizes applied research, including the use of silicon supplements for tree seedlings and electronic nose technology for pathogen detection. She has explored genetic diversity in forest tree populations, linking ecological resilience to climate change impacts. Her outreach includes public education on biotechnology and GMO awareness, addressing societal perceptions through sociological studies. Dr. Nowakowska's research has been recognized through Scopus and Web of Science h-indexes of 15, with over 3,490 total ministerial scores. She actively engages in forest conservation initiatives, including protective forestry practices and sustainable management protocols.

• Parkinson's Disease
• Neuroscience
• Antisense Oligonucleotides
• +۵ مورد دیگر

Dunhui Li serves as an Adjunct Lecturer at the UWA Medical School, The University of Western Australia, working within the Centre for Neuromuscular and Neurological Disorders at the Perron Institute. With a research focus spanning Parkinson's disease, neurodegenerative disorders, and molecular therapeutic approaches, Dr. Li contributes to advancing our understanding of neurological conditions through innovative research methodologies. Dr. Li's research interests center on Parkinson's disease, neuroscience, antisense oligonucleotides, alternative splicing, and neurodegenerative disorders. Their work explores molecular mechanisms underlying neurological conditions, particularly focusing on alpha-synuclein pathology in Parkinson's disease, PTBP1-related astrocyte-neuron transdifferentiation, and exon skipping strategies for therapeutic development. This research has significant implications for developing targeted treatments for neurodegenerative conditions and rare neurological diseases. Analysis of Dr. Li's recent publications reveals a strong emphasis on translational neuroscience, with particular focus on Parkinson's disease mechanisms and therapeutic approaches. The research spans molecular biology, genetics, and clinical applications, demonstrating a comprehensive approach to understanding and treating neurodegenerative disorders. Key themes include antisense oligonucleotide therapies, alternative splicing mechanisms, protein isoform regulation, and novel strategies for neuronal regeneration. Dr. Li actively collaborates with researchers including Wilton S., Mastaglia F., McDowall S., and Aung-Htut M. on projects related to neurological disorders and therapeutic development. Their research has been cited in Scopus, with publications appearing in high-impact journals such as Npj Parkinsons Disease, Frontiers in Neuroscience, and Translational Neurodegeneration. The work contributes to Sustainable Development Goals related to health and well-being, particularly in advancing treatments for neurological conditions. Based at the Centre for Neuromuscular and Neurological Disorders (Perron Institute), Dr. Li works within a specialized research environment focused on understanding and treating neuromuscular and neurological conditions. The center provides a collaborative platform for interdisciplinary research, bringing together clinicians, scientists, and students to address complex challenges in neurological disease research and treatment development.

Paraskevi Goggolidouمشاهده پروفایل

مدرس ارشد

• Molecular Genetics
• Ciliopathies
• Autosomal Recessive Polycystic Kidney Disease (ARPKD)
• +۳ مورد دیگر

Dr. Paraskevi Goggolidou is a Senior Lecturer in Molecular Genetics at the University of Wolverhampton, Faculty of Science and Engineering. She focuses on Autosomal Recessive Polycystic Kidney Disease (ARPKD) , Ciliopathies , and Wnt Signaling mechanisms, with projects funded by PKD Charity UK and the Institute of Biomedical Science . Education: BSc in Genetics from King's College London (2001), DPhil in Developmental Genetics from University of Oxford (2006). Grants: Current projects include Lungs in ARPKD , Liver Genomics in ARPKD , and Rnd3 in Kidney . Professional Activities: Peer reviewer for journals like BMC Developmental Biology and Journal of Inflammation , and grant assessor for multiple funding bodies. Her work combines genetic and transcriptomic approaches to understand disease severity, with recent publications in Biochimica et Biophysica Acta , F1000Research , and Genes . She leads the Biomedical Sciences BSc program and supervises research projects on miRNA in stem cell commitment and genetic modifiers in ARPKD . Scientific Awards : Royal Society Week in Westminster (2020) Research Trends: Recent articles highlight the interplay between Wnt signaling and Ciliopathies in kidney disease, alongside work on COVID-19 vaccine efficacy in chronic kidney disease patients.

Carol Langeمشاهده پروفایل

استاد

• Breast Cancer
• Steroid Hormone Receptors
• Cancer Stem Cells
• +۵ مورد دیگر

Carol Lange, PhD is a Professor of Medicine and Pharmacology at the University of Minnesota with a joint appointment in the Division of Hematology, Oncology, and Transplantation. Her research bridges molecular endocrinology, cancer biology, and pharmacology, focusing on steroid hormone receptor signaling in hormone-driven cancers. Breast Cancer Steroid Hormone Receptors Cancer Stem Cells Signal Transduction Endocrine Resistance Cancer Metabolism Recent studies highlight her work on progesterone receptor isoform-specific regulation of super enhancers in breast cancer stem cell expansion, glucocorticoid receptor interactions with TGFβ signaling in triple-negative breast cancer, and clinical trials targeting endocrine resistance. These investigations align with emerging themes in tumor microenvironment dynamics and hormone receptor crosstalk. Key collaborations include the SMILE Study (Onapristone + Fulvestrant for ER+/HER2- metastatic breast cancer) and the ONAWA (SOLTI-1802) trial evaluating antiprogestin therapy. Her work also explores metabolic reprogramming, PDK4 activation, and epigenetic regulation in therapy-resistant populations.

• Pediatric Dentistry
• Osteoclast Biology
• Periodontal Disease
• +۴ مورد دیگر

Ping Zhang is a Professor of Pediatric Dentistry at the University of Alabama at Birmingham (UAB) School of Dentistry since 2004, with additional appointments as Senior Scientist in UAB's School of Medicine departments including Neurodegeneration and Experimental Therapeutics, and Center for Clinical and Translational Science. Their research bridges dental science and systemic health through immunological mechanisms, focusing on osteoclast biology , periodontal disease , and innovative vaccine adjuvants . Zhang holds concurrent roles in the Civitan International Research Center and Comprehensive Arthritis Center. Ph.D. in Oral Biology (1997) and DDS (1992) from Hubei University of Medicine Board-certified pediatric dentist with NIH-funded research Research highlights include: Defining RANK/IVVY motif's role in Porphyromonas gingivalis -induced bone loss Developing structurally-defined saponin adjuvants from Momordica cochinchinensis Elucidating age-related immunological changes in bone metabolism Discovering oral-gut translocation of periodontal pathogens in metabolic disorders Recent publications emphasize calcium silicate cements for pulp therapy, chromatin regulation in osteoclasts, and microRNA-based therapies for dental inflammation. Ping Zhang serves on multiple graduate committees and teaches courses on oral microbiology and pediatric dentistry research . They have received extramural funding from NIH (NIDCR, NIAID, NIGMS) and industry partners for vaccine adjuvant development and periodontal disease mechanisms.

Katri Pauliina Kantojärviمشاهده پروفایل

مدرس ارشد

• Biomedicine
• Psychiatric Genetics
• Sleep Disorders
• +۷ مورد دیگر

Katri Pauliina Kantojärvi is a Docent at the Faculty of Medicine, University of Helsinki, actively contributing to biomedical and psychiatric research. Her work spans sleep disorders, schizophrenia, genetic risk factors, and neurodegenerative diseases, with extensive collaborations across Finnish population cohorts. Research Interests: Her research focuses on the intersection of sleep, mental health, and genetic predispositions. She investigates how polygenic risk scores for schizophrenia influence both clinical outcomes and broader social impacts, such as labor market performance. Her work also explores the role of sleep disturbances, including nightmares, as markers of psychiatric and neurodegenerative risk. Using large-scale genomic and epidemiological data, she contributes to understanding how genetic variants modulate brain and liver function. Recent Research Trends: Her recent publications (2024–2025) highlight a strong emphasis on psychiatric genetics, sleep phenotypes, and their overlap with neurodegeneration and metabolic health. There is a clear trend toward integrative studies combining genetic, epigenetic, and clinical data to predict disease outcomes and understand modifiable risk factors. Scientific Awards: No awards listed in the provided text. Advising and Grants: While specific students are not listed, Dr. Kantojärvi is an active participant in a major Academy of Finland-funded project titled Sleep as a key to understand the symptoms and course of Schizophrenia (2023–2027), indicating her role in mentoring and collaborative research. This project underscores her leadership in translational psychiatric research. Labs and Teams: She is part of a multidisciplinary research team led by Professor Tiina Paunio, involving experts in psychiatry, genetics, and sleep medicine. The group leverages biobank data and population registries to explore the biological underpinnings of mental illness.

Stewart Thompsonمشاهده پروفایل

دانشیار

• Cognitive Psychology
• Neuroscience
• Cybersecurity
• +۳ مورد دیگر

Stewart Thompson is an Associate Professor in Psychology & Education at New Mexico Tech. His research spans two major areas: (1) the environmental regulation of physiology and behavior (particularly light's effects on alertness and sleep), and (2) the intersection of psychology and cybersecurity, focusing on cognitive vulnerabilities in online systems. Research Focus 1: Non-image-forming visual functions and retinal degeneration mechanisms using animal models. Research Focus 2: Human factors in cybersecurity, including phishing susceptibility and stress management in cyberdefense roles. Key Contributions: Pioneering work on circadian photoreception, pupillometry as a diagnostic tool, and psychological strategies to enhance cybersecurity protocols. His publications highlight interdisciplinary approaches bridging neuroscience and behavioral science. Contact: Email at stewart.thompson@nmt.edu.

Christine M Chinمشاهده پروفایل

استاد

• Black and White Photography
• Digital Photography
• Video
• +۷ مورد دیگر

Christine M Chin is a Professor of Art and Architecture at Hobart and William Smith Colleges, where she has been a faculty member since 2008. She holds a B.A. from Princeton University and an M.F.A. from the University of New Mexico. Her work bridges art and technology, with a focus on photography and new media. B.A. : Princeton University M.F.A. : University of New Mexico Her research and artistic practice center on Black and White Photography, Digital Photography, Video, and New Media technologies . She explores the intersection of biology and technology through imaginative visual narratives. Notable projects include Alternative Alternative Energy , which creatively proposes futuristic energy sources like the Moth Generator and Energy Ice Worm Fuel, and her earlier work on genetically modified foods through the lens of Vegetable Human Hybrids. She has also conducted fieldwork in China, investigating both historical and contemporary energy technologies. Christine Chin is actively engaged in academic and artistic communities, with affiliations including the College Art Association and the Society for Photographic Education . She teaches courses such as: Introductory Photography Intermediate Photography Special Topics in Photography (Digital Photography and Video) There is no public information indicating any scientific awards, publications, or advisees in the provided text. She advises and mentors students in photography and new media, though specific names are not listed. There is no mention of grants or formal advising roles beyond course instruction. She works from the Goldstein Family Carriage House and is an active member of the Art and Architecture faculty, contributing to both curriculum development and creative scholarship.

Julia G MaKinsterمشاهده پروفایل

استاد

• Science Education
• Educational Technology
• Geospatial Technologies in Education
• +۷ مورد دیگر

Julia G MaKinster is a Professor of Educational Studies and the Vice Provost for Assessment, Accreditation and Institutional Effectiveness at Hobart and William Smith Colleges, where she has been a faculty member since 2002. Her work bridges scholarship, teaching, and leadership in science and environmental education. Ph.D. from Indiana University M.S. from Louisiana B.S. from Indiana University of Pennsylvania Her research focuses on integrating geospatial technologies into science education through teacher professional development and curriculum design. She emphasizes reflective, collaborative, and personally relevant learning experiences that empower students as lifelong learners. Her scholarship is driven by questions about how to effectively implement technology-enhanced teaching in science, particularly in addressing biodiversity and environmental issues. Her recent publications reveal a strong trend in using geospatial tools (GIS, web-based maps, multimedia) to support scientific inquiry, environmental awareness, and teacher development. These works span science education, environmental studies, and technology integration, often involving collaborative, interdisciplinary projects with institutions like the Cornell Lab of Ornithology. She has led two major National Science Foundation-funded projects: Crossing Boundaries Project ($1.5M): Focused on biodiversity conservation using ICT. GIS Ahead Project ($899,500): Aimed at creating career pathways through geospatial technology education. She mentors teachers and students through sustained professional development and innovative curriculum design. Her teaching includes courses such as Teaching Secondary Science, Technology in Education, and Citizen Science. She is affiliated with the following initiatives: Director and Principal Investigator, Crossing Boundaries Project Director and Principal Investigator, GIT Ahead Project Faculty member in Science and Environmental Education Coordinator of ESSYI (Environmental Studies Summer Youth Institute)

Steven Poelzingمشاهده پروفایل

استاد

• Cardiac Electrophysiology
• Sudden Cardiac Death
• Arrhythmias
• +۱۰ مورد دیگر

Steven Poelzing, Ph.D., is the James and Deborah Petrine Professor at the Fralin Biomedical Research Institute at VTC, where he also serves as Associate Director for Faculty Affairs. He holds professorial appointments in the Department of Biomedical Engineering and Mechanics (College of Engineering) and the Department of Internal Medicine (School of Medicine) at Virginia Tech. Dr. Poelzing’s research centers on the fundamental mechanisms of cardiac conduction and arrhythmogenesis, with a focus on connexin43, ephaptic coupling, and the impact of extracellular environment on heart electrical activity. His lab investigates how inflammation, edema, and ion imbalances contribute to sudden cardiac death, particularly in young individuals and those with genetic disorders such as Long QT syndrome. His recent publications reveal a trend toward understanding structural microdomains like the perinexus, intercellular sodium dynamics, and novel therapeutic strategies for ischemia-reperfusion injury. His work bridges molecular biology, biophysics, and translational medicine, often employing genetically modified mouse models and advanced electrophysiological techniques. Dr. Poelzing has received numerous honors, including: Fellow, Heart Rhythm Society (2015) Fellow, American Heart Association (2014) Michael Bilitch Fellowship in Cardiac Pacing and Electrophysiology (2004) Multiple Top Instructor awards at the University of Utah (2008–2011) Editorial Board Member, Frontiers in Cardiac Electrophysiology (2010–present) He mentors graduate students such as Grace Blair, Tristan Raisch, and Carissa James, several of whom have secured prestigious NIH fellowships. His lab has received federal funding, including a $2.1 million grant to study gap junctions and fluid therapy impacts on cardiac recovery. He leads the Center for Vascular and Heart Research and the Poelzing Lab at the Riverside 2 facility (R-2115).

Christoph Kleinschnitzمشاهده پروفایل

استاد

• Neurology
• Clinical Neuroimmunology
• Experimental Stroke Research
• +۶ مورد دیگر

Professor Christoph Kleinschnitz is the Director of the Clinic for Neurology at the University Hospital Essen, part of the University of Duisburg-Essen’s Medical Faculty. His clinical and research leadership spans stroke, multiple sclerosis, neuroimmunology, and neuro-oncology. He directs a department recognized nationally and internationally for excellence in neurological care, holding certifications from the German Stroke Society, European Stroke Organisation, and German Multiple Sclerosis Society. His research interests focus on the intersection of immunology and neurology, particularly thrombo-inflammation, ischemia-reperfusion injury, and immune mechanisms in stroke and neurodegenerative diseases. He leads major research initiatives such as the DFG-funded FOR 2879 “ImmunoStroke” consortium, aiming to develop novel stroke therapies by understanding immune cell roles in regeneration. His work integrates clinical observation with experimental models, advancing translational neuroscience. The analysis of his recent publications reveals a strong trend in neuroimmunology and stroke research, with significant contributions to understanding the role of coagulation factors in inflammation, astrocyte dysfunction in motor neuron disease, and the evaluation of new therapies for multiple sclerosis and spinal muscular atrophy. His work frequently employs advanced techniques including machine learning for neuroimaging and detailed molecular and cellular analyses. Certified MS Specialist (Multiple Sclerosis Competence Network) DGKN-recognized training center for neurology DSG and ESO-certified Stroke Unit Multiple awards for national leadership in MS, Stroke, and Parkinson’s care (2025) Director of a DIN EN ISO 9001:2015 certified clinic As a leading academic neurologist, Prof. Kleinschnitz oversees a major clinical department, secures substantial research funding, and mentors future neurologists and researchers. His work is supported by grants from the DFG and BMBF, including the FERROPath consortium targeting ischemia-reperfusion injury. His department functions as a hub for interdisciplinary neurological care, housing specialized centers for epilepsy, myasthenia, neuro-oncology, and neuromuscular diseases, ensuring a comprehensive, research-driven approach to patient treatment.