Carol Lange

Carol Lange, PhD is a Professor of Medicine and Pharmacology at the University of Minnesota with a joint appointment in the Division of Hematology, Oncology, and Transplantation. Her research bridges molecular endocrinology, cancer biology, and pharmacology, focusing on steroid hormone receptor signaling in hormone-driven cancers.

• Breast Cancer
• Steroid Hormone Receptors
• Cancer Stem Cells
• Signal Transduction
• Endocrine Resistance
• Cancer Metabolism

Recent studies highlight her work on progesterone receptor isoform-specific regulation of super enhancers in breast cancer stem cell expansion, glucocorticoid receptor interactions with TGFβ signaling in triple-negative breast cancer, and clinical trials targeting endocrine resistance. These investigations align with emerging themes in tumor microenvironment dynamics and hormone receptor crosstalk.

Key collaborations include the SMILE Study (Onapristone + Fulvestrant for ER+/HER2- metastatic breast cancer) and the ONAWA (SOLTI-1802) trial evaluating antiprogestin therapy. Her work also explores metabolic reprogramming, PDK4 activation, and epigenetic regulation in therapy-resistant populations.