Epitranscriptomics Professors and Supervisors in Canada

Julio Fernandesمشاهده پروفایل

استاد

University of MontrealCanada

Julio Fernandes is a Full Professor in the Department of Surgery at the University of Montreal’s Faculty of Medicine and holds the University of Montreal Research Chair in Orthopedics at the Hôpital du Sacré-Cœur de Montréal. He is a globally recognized leader in orthopedic surgery and non-viral gene therapy using polymeric nanoparticles. His research focuses on osteoporosis, bone quality analysis, surgical instrumentation, and advanced therapies for arthritis and fractures. Education: MD, MSc Affiliations: CIUSSS Nord-de-l’Île-de-Montréal, Hôpital du Sacré-Cœur de Montréal International Collaborations: Brazil, China, USA, Europe Research Highlights: Over CAD 13 million in funding since 2000, 68 international invited lectures, and pioneering work on chitosan-based nanoparticles for gene delivery. Key projects include developing resolvin analogues for osteoporosis therapy and investigating 4-hydroxynonenal’s role in osteoarthritis. Advising & Grants: Supervised 16+ graduate students (PhD/MSc), led projects like the CAD 1.3M ‘Science Without Borders’ program. Major grants include IRSC and FQRNT funding for bone metabolism and nanomedicine research. Labs & Teams: Leads the Orthopedic Research Chair and collaborates with global teams on biomaterials, fracture prevention, and gene therapy.

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Masad J. Damhaمشاهده پروفایل

استاد

McGill UniversityCanada

Masad J. Damha is a Distinguished James McGill Professor in the Department of Chemistry at McGill University. He holds a B.Sc. (1983) and Ph.D. (1988) from McGill University and completed postdoctoral training at the California Institute of Technology. His research bridges chemical biology and synthesis/catalysis, focusing on the chemical synthesis, biochemical properties, and molecular behavior of nucleosides, nucleic acids, and their analogues, with applications in biotechnology including siRNA, antisense oligonucleotides, and aptamers. Research Interests: Professor Damha's work explores inter- and intracellular communication between nucleic acids and proteins, particularly investigating how chemically modified nucleic acids (e.g., ANA, 2’F-ANA) can enhance therapeutic efficacy. His research aims to develop novel strategies for genetic regulation and diagnostic tools through engineered nucleic acid systems. Honors and Awards: R.U. Lemieux Award (CIC, 2020) Queen Elizabeth II Diamond Jubilee Medal (2012) Bernard Belleau Award (CSC/CIC, 2007) Merck-Frosst Award for Therapeutic Research (1999) Fellow of the Chemical Institute of Canada (FCIC, 1999) John Charles Polanyi Chemistry Prize (1989) Leo Yaffe Award for Excellence in Teaching (2011-12) David Thomson Award in Graduate & Teaching (2010) Teaching and Leadership: Professor Damha teaches Introductory Organic Chemistry (CHEM 302) and Advanced Nucleic Acid Chemistry (CHEM 542). He has held leadership roles as President of the International Society of Nucleosides, Nucleotides & Nucleic Acids (2019-20) and the Oligonucleotide Therapeutics Society (2013-14).

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Li Chenمشاهده پروفایل

استاد

University of SaskatchewanCanada

Professor Li Chen holds dual appointments in Electrical and Computer Engineering and Biomedical Engineering at the University of Saskatchewan's College of Engineering. His research develops radiation-hardened electronics and reliable computing systems for critical applications. Holds BSc in Electrical Engineering, MEng, and PhD degrees. Professional engineering license (P.Eng.) indicates certified expertise. Research focuses on radiation effects in microelectronics, fault-tolerant circuit design, neural network reliability, silicon device reliability, and biomedical sensors. Current projects include radiation hardening techniques for advanced nodes, single-event effect characterization, and photonic biosensors. Publications demonstrate innovations in radiation-hardened flip-flop designs, SEE characterization methodologies, and applications of machine learning in bioinformatics and reliability engineering. Recent work includes photonic biosensors for virus detection and federated learning for genomic analysis. No scientific awards reported in source materials Leads research at Radiation Effects Research Laboratory, focusing on semiconductor reliability under radiation exposure. Collaborations include industry partners in aerospace and medical device sectors. No specific student advising details available in provided text

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Syam Somasekharanمشاهده پروفایل

استادیار

University of British ColumbiaCanada

Syam Somasekharan is an Assistant Professor in the Department of Urologic Sciences at the University of British Columbia's Faculty of Medicine and serves as a Senior Research Scientist at the Vancouver Prostate Centre, located at Vancouver General Hospital. His academic career spans multiple institutions across continents, reflecting his international research expertise. Dr. Somasekharan's research interests focus on RNA Biology , with particular emphasis on Cell Biology, Molecular Biology, Biomolecular Condensates, Nucleolus function, mRNA Translation mechanisms, and Liquid-liquid Phase Separation. His laboratory investigates the molecular mechanisms of RNA regulation in both health and disease states, with special attention to prostate cancer. Analysis of Dr. Somasekharan's recent publications reveals a strong focus on RNA granule machinery in prostate cancer treatment resistance, epitranscriptomic RNA modifications (particularly m6A), liquid-liquid phase separation mechanisms involving proteins like G3BP1, and multiomics approaches to understanding selective mRNA translation. His work bridges fundamental molecular biology with clinical applications in cancer research. Among his scientific achievements, Dr. Somasekharan was awarded the prestigious Ramanujan Fellow position at the Indian Institute of Technology. His research methodology emphasizes interdisciplinary approaches to understand how RNA regulatory mechanisms contribute to disease pathogenesis, particularly in prostate cancer. Dr. Somasekharan actively collaborates with other researchers and expresses interest in working with undergraduate students on research projects.

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Harinad Babu Magantiمشاهده پروفایل

استاد مدعو

University of OttawaCanada

Dr. Harinad Babu Maganti serves as an Adjunct Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa's Faculty of Medicine and holds dual roles as Research Scientist and Scientific Director of Cellular Therapies Research and Development at Canadian Blood Services in Ottawa, Ontario. His academic credentials include: Master of Science in Microbiology from McMaster University Doctor of Philosophy in Immunology and Stem Cell Biology from the University of Ottawa Postdoctoral training in Neuroscience at the Hospital for Sick Children Postdoctoral training in Hematology and Stem Cell Biology at Canadian Blood Services Dr. Maganti's research centers on hematopoietic stem cell (HSC) biology to develop curative cellular therapies for over 30 illnesses. His laboratory employs systems biology and omics data (RNA-seq, ATAC-seq, ChIP-seq) to construct gene-regulatory networks, validated through CRISPR-Cas9 genome engineering. Key projects investigate epi-transcriptomic regulation of HSPCs and CRISPR-based correction of sickle cell disease mutations in collaboration with the National Research Council of Canada, with emphasis on "off the shelf" immune cell therapies and GMP manufacturing. His publication trends (2022-2025) reveal consistent focus on HSC expansion mechanisms, cryopreservation optimization, transplantation outcomes through systematic reviews/meta-analyses, and translational applications of gene editing. The work bridges basic molecular discovery with clinical implementation across hematology, oncology, and regenerative medicine. Scientific recognition includes: American Society of Hematology Scholar Award (2024) Leading the Maganti Lab at Canadian Blood Services, he cultivates an inclusive research environment uniting biologists, engineers, and clinicians. The team leverages molecular biology, nanotechnology, and bioinformatics to pioneer novel HSC products, with current efforts targeting universal cellular therapies and precision oncology applications.

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Ryan Hiliمشاهده پروفایل

دانشیار

York UniversityCanada

Ryan Hili is an Associate Professor in the Department of Chemistry at York University, holding a York Research Chair (Tier 2). He leads the Hili Group, which focuses on chemical biology, combinatorial chemistry, and organic chemistry at the interface of chemistry and biology. His research integrates synthetic organic chemistry with molecular biology to develop DNA-encoded library technologies for drug discovery, small-molecule catalysts, and biomarker profiling. The group is affiliated with the Centre for Research on Biomolecular Interactions (CRBI). Research interests include molecular evolution, DNA-encoded libraries, and epitranscriptomics. The Hili Group employs enzymatic methods and high-throughput DNA sequencing to screen millions of molecules for functional properties, emphasizing interdisciplinary collaboration. Recent work addresses N2-methylation in RNA and ligase-catalyzed polymerization techniques for aptamer evolution. Awards: York Research Chair (Tier 2) Labs: Hili Lab, CRBI Key Technologies: LOOPER (ligase-catalyzed oligonucleotide polymerization), PhOxi-seq Advising and grants focus on training interdisciplinary researchers. Ongoing projects explore synthetic nucleic acid polymers, RNA modifications, and enzyme-free translation systems.

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Marc Coppolinoمشاهده پروفایل

دانشیار

University of GuelphCanada

Dr. Marc Coppolino is an Associate Professor in the Department of Molecular and Cellular Biology at the University of Guelph. He holds a B.Sc. from the University of Waterloo (1990) and a Ph.D. in Medical Biophysics from the University of Toronto (1998). His postdoctoral training included an MRC Fellowship at the Hospital for Sick Children, Toronto, where he studied host-pathogen interactions involving Salmonella typhimurium . His research focuses on the molecular mechanisms linking cell adhesion, migration, and invasion, particularly in cancer metastasis. Key areas include SNARE protein complexes, MT1-MMP trafficking, and invadopodia formation. His work is supported by NSERC funding. Dr. Coppolino has been recognized with the 2000 John Charles Polanyi Award for Physiology and Medicine. His lab is located in SSC 2203B, and his office is SSC 2245. Current advisees include Evan Perehiniak (Ph.D.).

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Ly Vuمشاهده پروفایل

استادیار

University of British ColumbiaCanada

Dr. Ly Vu serves as an Assistant Professor at the University of British Columbia's Faculty of Pharmaceutical Sciences and as a Scientist at the Terry Fox Laboratory, BC Cancer Research Centre. Her dual appointments position her at the nexus of academic research and clinical translation within British Columbia's premier cancer research infrastructure. Dr. Vu's research program focuses on post-transcriptional and translational regulation in hematopoietic stem cells and leukemogenesis , with particular emphasis on RNA modifications (especially m6A methylation), deadenylation complexes, and RNA-binding proteins. Her laboratory employs integrated approaches spanning Human and murine disease models Global transcriptomic and epitranscriptomic profiling Functional genomics screens Translational control assays to dissect mechanisms driving leukemia stem cell maintenance. Analysis of her 15 most recent publications reveals a dominant research trajectory in RNA-centric regulation of hematopoietic malignancies , with emerging themes in immune evasion mechanisms and therapeutic targeting. Key technical innovations include Nanopore direct RNA sequencing applications and characterization of the CCR4-NOT deadenylation complex in leukemogenesis. Her scientific recognition includes: Terry Fox New Investigator Award (2022) ASH Scholar Award (2020) Leukemia & Lymphoma Society Fellowship (2018) reflecting her rising prominence in hematology research. Dr. Vu currently leads multiple major grants totaling over $2 million CAD, including CIHR Operating Grants and Terry Fox New Investigator funding, supporting her laboratory's mission to develop RNA-targeted leukemia therapies. Her research group collaborates extensively with the Terry Fox Laboratory's core facilities including Strand-seq, Flow Cytometry, and Integrated Mouse Modeling services.

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Peter Moffettمشاهده پروفایل

استاد پژوهشی

University of SherbrookeCanada

Dr. Peter Moffett is a Research Professor specializing in plant innate immunity , viral pathogenesis , and RNA silencing mechanisms . His work utilizes model organisms like Arabidopsis , tobacco, and tomato to investigate plant-pathogen interactions involving viruses, viroids, and bacteria. Research themes include: Decoding phytohormone networks (jasmonic acid, salicylic acid) regulating antiviral defenses Mechanistic studies of Argonaute proteins (AGO2, AGO5) and NLR immune receptors Pathogen strategies to manipulate apoplastic microenvironments for virulence Article trends show strong focus on plant virology , RNA-based defense systems , and genetic variation in immune components. Key collaborations span Ohio State University (David Mackey), Michigan State University (Sheng-Yang He), Université de Strasbourg (Christophe Ritzenthaler), and institutions in China, Spain, and Japan.

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Mohamed Benderdourمشاهده پروفایل

استاد

University of MontrealCanada

Biochemistry of lipid peroxidation aldehydes
Joint diseases
Cellular metabolism alteration
+۷ مورد دیگر

Mohamed Benderdour is a Full Professor in the Department of Surgery at the University of Montreal and a Regular researcher at the Research Center of the Sacré-Coeur Hospital of Montreal, where he contributes to the Trauma – acute care research axis. His academic career spans over two decades with significant contributions to biochemical research related to joint diseases. Dr. Benderdour's research primarily focuses on the biochemistry of lipid peroxidation aldehydes and their implications in joint diseases, particularly osteoarthritis. His work investigates how aldehydes alter cellular metabolism and cause post-translational modifications of proteins, with specific attention to cell signaling mechanisms involving protein kinases and transcription factors. He has extensively studied 4-hydroxynonenal and its role in osteoarthritis pathogenesis, exploring mechanisms of gene regulation and promoter analysis in joint tissue pathology. Analysis of Dr. Benderdour's publication history reveals an evolution from fundamental biochemical mechanisms to increasingly translational research. His recent work shows strong emphasis on RNA modifications in osteoarthritis (epitranscriptomics), nanotechnology approaches for therapeutic delivery (particularly chitosan-based nanovectors for siRNA), and the pathophysiology of immunoporosis. His publications demonstrate a progression toward developing therapeutic applications from basic science discoveries. Dr. Benderdour maintains a productive research career with publications spanning molecular biology, biochemistry, rheumatology, and nanotechnology. His work bridges basic science with potential clinical applications in orthopedics and joint disease treatment, reflecting a commitment to advancing both scientific understanding and potential therapeutic interventions for osteoarthritis and related conditions.

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