معرفی
Dr. Harinad Babu Maganti serves as an Adjunct Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa's Faculty of Medicine and holds dual roles as Research Scientist and Scientific Director of Cellular Therapies Research and Development at Canadian Blood Services in Ottawa, Ontario.
His academic credentials include:
- Master of Science in Microbiology from McMaster University
- Doctor of Philosophy in Immunology and Stem Cell Biology from the University of Ottawa
- Postdoctoral training in Neuroscience at the Hospital for Sick Children
- Postdoctoral training in Hematology and Stem Cell Biology at Canadian Blood Services
Dr. Maganti's research centers on hematopoietic stem cell (HSC) biology to develop curative cellular therapies for over 30 illnesses. His laboratory employs systems biology and omics data (RNA-seq, ATAC-seq, ChIP-seq) to construct gene-regulatory networks, validated through CRISPR-Cas9 genome engineering. Key projects investigate epi-transcriptomic regulation of HSPCs and CRISPR-based correction of sickle cell disease mutations in collaboration with the National Research Council of Canada, with emphasis on "off the shelf" immune cell therapies and GMP manufacturing.
His publication trends (2022-2025) reveal consistent focus on HSC expansion mechanisms, cryopreservation optimization, transplantation outcomes through systematic reviews/meta-analyses, and translational applications of gene editing. The work bridges basic molecular discovery with clinical implementation across hematology, oncology, and regenerative medicine.
Scientific recognition includes:
- American Society of Hematology Scholar Award (2024)
Leading the Maganti Lab at Canadian Blood Services, he cultivates an inclusive research environment uniting biologists, engineers, and clinicians. The team leverages molecular biology, nanotechnology, and bioinformatics to pioneer novel HSC products, with current efforts targeting universal cellular therapies and precision oncology applications.
