Embryonic Development Professors and Supervisors | ApplySharif

جست‌وجوی استاد و پژوهشگر

استاد راهنما، استاد دانشگاه یا پژوهشگر مناسب برای مسیر پژوهشی‌تان را پیدا کنید و با او ارتباط بگیرید.

نمایش ۷۳۶-۷۵۰ از ۳٬۳۱۹ استاد راهنما

اطلاعات این پروفایل‌ها از صفحات عمومی دانشگاه‌ها جمع‌آوری شده و ممکن است به‌روز نباشد.

Dilek Colakمشاهده پروفایل

دانشیار

Cornell UniversityUnited States

Dilek Colak is an Associate Professor at the Feil Family Brain & Mind Research Institute of Weill Cornell Medicine. Her research focuses on molecular mechanisms of neurodevelopmental and neuropsychiatric diseases, particularly autism and schizophrenia. Primary appointment: Feil Family Brain & Mind Research Institute Secondary appointment: Pediatrics, Gale and Ira Drukier Institute for Children's Health Research Interests Molecular basis of neurodevelopmental disorders RNA regulation in synaptic plasticity Glial cell contributions to neuropsychiatric disease Use of iPSC-derived cerebral organoids for disease modeling Neurogenetic mechanisms of cognitive dysfunction Publication Trends show expertise in RNA biology, neurodevelopmental modeling with organoids, and synaptic dysfunction in psychiatric disorders. Her work bridges molecular neuroscience with translational approaches for therapeutic target identification. Scientific Awards EMBO Postdoctoral Long-term Fellowship (2009-2011) Druckenmiller Postdoctoral Fellowship (2011-2014) Blavatnik Regional Postdoctoral Finalist (2014) Leon Levy Foundation Postdoc Mentorship (2023) Lab Members include postdoctoral fellows (Michael Notaras, Megan Allen, Estibaliz Barrio Alonso, Pablo Lituma, Nicolle Morey), graduate student Isidora Stankovic, and technician Natalie Wayland. The lab employs multi-omics approaches, electrophysiology, and cross-species transplantation techniques.

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William E Theurkaufمشاهده پروفایل

استاد

University of Massachusetts Chan Medical SchoolUnited States

William E Theurkauf is a Professor in the Program in Molecular Medicine at UMass Chan Medical School's T.H. Chan School of Medicine. He also holds appointments in the RNA Therapeutics Institute, Systems Biology, and multiple graduate programs including the Interdisciplinary Graduate Program and MD/PhD Program. His research focuses on genome maintenance mechanisms during germline development, particularly the piRNA pathway's role in transposon silencing and genome evolution. BA in Biochemistry from Brandeis University (1980) PhD in Biochemistry from Brandeis University (1988) Postdoctoral fellow at UCSF Department of Biochemistry and Biophysics (1988-1993) Faculty at SUNY Stony Brook Department of Biochemistry and Cell Biology (1993-1998) Theurkauf's research centers on the mechanisms that maintain genome integrity during germline development. His laboratory investigates piRNA production and function, particularly how these small RNAs silence transposons to protect the inherited genome. His work has revealed how the piRNA pathway acts as an adaptive immune system against mobile genetic elements, with discoveries showing that transposon invasions trigger structural changes in genome architecture that enhance silencing capacity. His lab also studies how DNA damage checkpoint pathways control key developmental processes like embryonic axis specification and the maternal-to-zygotic transition. Analysis of Theurkauf's recent publications reveals a consistent focus on piRNA biology, transposon control, and genome evolution. His work spans from fundamental mechanisms of piRNA biogenesis to evolutionary adaptations in response to transposon invasions, with recent studies examining retroviral integration in koalas. The publications demonstrate interdisciplinary approaches combining molecular genetics, biochemistry, computational analysis, and evolutionary biology to understand genome defense mechanisms. Theurkauf directs the Program in Cell and Developmental Dynamics and maintains an active laboratory investigating cell cycle control, chromosome segregation, and embryonic patterning using Drosophila as a model system. His lab offers rotation projects for graduate students focusing on cell cycle checkpoint pathways during embryogenesis and mechanisms of cellular asymmetry establishment. The laboratory employs a range of techniques including classical and molecular genetics, high-resolution in vivo imaging, and biochemical approaches to define fundamental biological processes.

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Harald Lukschمشاهده پروفایل

استاد

Technical University of MunichGermany

Prof. Dr. Harald Luksch is a faculty member at the Department of Zoology , Technical University of Munich , and has led the Leonardo da Vinci Center for Bionics since 2018. He previously served as Dean of Biosciences (2016–2018), Vice-Speaker of the Bernstein Center for Computational Neuroscience (2012–2017), and Department Speaker for Animal Sciences (2010–2016) at TU Munich. Education: Diplomarbeit (1989) at University of Bonn , conducted at University of Cologne under Prof. Walkowiak Dissertation (1990–1994) at University of Cologne on auditory midbrain neuroanatomy/physiology of Discoglossus pictus Habilitation (2002) at RWTH Aachen for Zoology Research Interests focus on: Cellular Mechanisms: Understanding information processing in neurons via whole-cell patch clamping, electrostimulation, and in vitro brain slice physiology, primarily in the vertebrate optic tectum of birds. Feedback Loops: Studying tectal-isthmic circuits as winner-takes-all systems, using in vitro analysis to dissect molecular factors like R-Cadherin in embryonic development. Multimodal Interactions: Examining how auditory, somatosensory, and infrared afferents align with visual maps in the optic tectum, with implications for error signaling in sensory calibration. Developmental Neuroscience: Investigating neuronal network formation in precocial species (e.g., chickens) through cell culture techniques , magnetic cell sorting , and biohybrid circuits . Article Trends reveal expertise in neuronal connectivity (tectum, isthmus), sensory integration (visual-auditory, echo-acoustic flow), and developmental neurobiology (R-Cadherin, CARTp localization, multimodal calibration). Techniques span intracellular recording , optical imaging , uncaging experiments , and embryonic manipulations . Scientific Affiliations include memberships in the Society for Neuroscience , International Society for Neuroethology , FENS , and V-BIO . Collaborations span institutions like University of California, San Diego , RWTH Aachen , and University of Bremen . Labs/Teams are embedded in the Chair of Zoology at TU Munich, with methodological focus on neuronal tracing , patch-clamp physiology , and developmental studies . Current projects include in-vivo electrophysiology in behaving animals, optical imaging of isthmic feedback, and uncaging experiments for synaptic analysis.

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Eszter Posfaiمشاهده پروفایل

استادیار

Princeton UniversityUnited States

Eszter Posfai is an Assistant Professor in the Department of Molecular Biology at Princeton University, where she leads the Posfai Lab focused on quantitative approaches to understanding mammalian preimplantation embryo formation. Her research integrates developmental biology, stem cell biology, biophysics, and imaging technologies to dissect the mechanisms of cell fate decisions, embryonic patterning, and totipotency. Research Interests: Quantitative analysis of mammalian embryo development Mechanisms of cell fate specification and symmetry breaking Role of mechanical forces in embryogenesis Molecular basis of totipotency in vivo and in vitro Development of synthetic embryo models from stem cells Live imaging and genome engineering (CRISPR-based tools) The lab employs advanced imaging techniques, including light sheet microscopy, and develops computational tools for image analysis. They have pioneered CRISPR/Cas9-based methods for large DNA fragment insertions in mouse embryos, enabling precise interrogation of gene function. The recent publications reflect a strong focus on developmental dynamics, totipotency evaluation, and innovative genetic tool development. These works span disciplines such as developmental biology, biophysics, and genome engineering, with applications in stem cell modeling and synthetic embryology. Scientific Contributions: Co-development of 2-cell HR-CRISPR for efficient knock-in mouse models Establishment of criteria for evaluating totipotency Live imaging approaches for developmental cell cycles Novel mouse models for planar cell polarity studies Advising & Collaborations: The lab welcomes prospective graduate students and postdoctoral researchers, particularly those with expertise in imaging and data analysis. While no current students are listed, the lab fosters interdisciplinary collaborations involving computational modeling and image analysis. Although specific grants are not mentioned, her technical innovations suggest significant funding support for method development and embryogenesis research. Laboratory: The Posfai Lab at Princeton's Thomas Laboratory emphasizes 'seeing is believing'—prioritizing direct visualization of developmental processes. The lab actively develops live imaging and genome editing tools to probe molecular events in real time and build quantitative models of embryonic development.

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Paul D. Schedlمشاهده پروفایل

استاد

Princeton UniversityUnited States

Paul D. Schedl is a Professor in the Department of Molecular Biology at Princeton University, where he leads the Schedl Lab focused on understanding gene expression and early development in Drosophila melanogaster . His research investigates how genetic and epigenetic mechanisms regulate developmental pathways, including sex determination, chromatin architecture, and embryonic polarity. Position: Professor of Molecular Biology Institution: Princeton University Department: Department of Molecular Biology Lab: Schedl Lab Contact: pschedl@princeton.edu | 609-258-4979 His research centers on three major developmental systems in Drosophila : (1) The Sex-lethal gene in sex determination, examining how pathway choice, commitment, and differentiation are regulated through transcriptional and post-transcriptional mechanisms; (2) Chromatin structure and regulation of the Abd-B gene via cis-regulatory domains, Polycomb/Trithorax group proteins, and boundary elements like Fab-7 and Fab-8; and (3) mRNA localization in oocyte polarity, particularly the role of the orb gene in establishing anterior-posterior and dorsal-ventral axes. The 15 most recent publications reflect a consistent focus on chromatin boundaries, insulator function, gene regulation, and mRNA localization. Key themes include the functional dissection of boundary elements (e.g., Fab-7, Fab-8), the role of CTCF and GAGA factors in chromatin organization, the autoregulatory function of orb in oocyte specification, and the mechanisms of transcriptional quiescence in germ cells. The work spans molecular genetics, developmental biology, and epigenetics, often combining genetic screens with biochemical and imaging approaches. No scientific awards are explicitly listed in the provided texts. Dr. Schedl actively mentors graduate students and postdoctoral researchers, many of whom co-author his publications. His lab investigates fundamental questions in developmental gene regulation, including zygotic genome activation, germline-soma distinction, and chromatin domain organization. Research is supported by ongoing projects exploring the roles of insulator proteins, CPEB family members, and signaling pathways in cell fate determination. The Schedl Lab is a key contributor to understanding how chromatin architecture and RNA regulatory networks orchestrate development in Drosophila , serving as a model for higher eukaryotes.

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Stanislav Y. Shvartsmanمشاهده پروفایل

استاد

Princeton UniversityUnited States

Stanislav Y. Shvartsman is a Professor in the Department of Molecular Biology and a member of the Lewis Sigler Institute for Integrative Genomics at Princeton University. His research integrates experimental, theoretical, and computational approaches to understand the dynamics of living tissues during development. His primary research interests include: Quantitative modeling of signaling networks, particularly the ERK cascade Mechanisms of small cell cluster formation and function in Drosophila Developmental abnormalities arising from deregulated RAS signaling Metabolic control of embryogenesis Epithelial morphogenesis and tissue mechanics The Shvartsman Lab employs Drosophila and zebrafish as model systems, utilizing live imaging, optogenetics, genome editing, and dynamical systems theory. Recent work emphasizes the integration of physical principles with biological complexity to build predictive models of developmental processes. His recent publications reveal a strong trend toward quantitative, systems-level understanding of development, combining high-resolution imaging with mathematical modeling. Key themes include signal transduction dynamics, collective cell behaviors, nuclear organization, metabolic regulation, and mechanical forces in tissue patterning. The work spans molecular, cellular, and tissue scales, reflecting an integrative approach to developmental biology. Scientific contributions include: Development of optogenetic tools for controlling ERK signaling Quantitative models of germline cyst growth and synchronization Insights into the biophysics of intercellular bridges Elucidation of transcriptional repression dynamics by Capicua Analysis of scaling laws in collective cell growth Shvartsman actively mentors students and postdoctoral researchers, as evidenced by extensive collaborations with early-career scientists on publications. His lab receives funding for interdisciplinary research at the interface of biology, physics, and computation, supporting projects in live imaging, quantitative developmental biology, and systems modeling. The lab collaborates widely with groups at Princeton and beyond, including those led by Wieschaus, Toettcher, Fuchs, and others. The Shvartsman Lab is a hub for integrative research, combining wet-lab experiments with theoretical modeling. It focuses on uncovering fundamental principles that govern the self-organization of developing tissues, using Drosophila embryos and egg chambers as primary model systems. The team explores how genetic programs interact with physical constraints to produce robust developmental outcomes.

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Stefan Semrauمشاهده پروفایل

دانشیار

Leiden UniversityNetherlands

Dr. Stefan Semrau is an Associate Professor at the Leiden Institute of Physics (LION) within the Faculty of Science at Leiden University . His research focuses on quantitative single-cell biology, particularly studying cell-fate decision-making using embryonic stem cells as a model system. Develops single-cell RNA-seq and single-molecule FISH methods Applies machine learning and mathematical modeling to decode stem cell differentiation Investigates interplay of epigenetics, cell cycle, and signaling molecules His work addresses both fundamental biological dynamics and applications in regenerative medicine and cancer stem cell eradication . Recent publications emphasize single-cell transcriptomics and gene fusion quantification . The Semrau Lab maintains collaborations across disciplines and develops tools like fuseFISH for cancer research. Scientific Awards FOM-Projectruimte Grant (2016) for stem cell dynamics research Advising & Collaborations Current advisees include PhD students studying retinoic acid-induced differentiation and lineage priming. The lab integrates computational and experimental approaches through partnerships with biotech and physics teams.

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Vasileios Trikalitisمشاهده پروفایل

پژوهشگر

University of TwenteNetherlands

Vasileios Trikalitis is a Researcher at the University of Twente's Advanced Manufacturing, Sustainable Products & Energy Systems department, specializing in cutting-edge bioprinting methodologies for tissue engineering and vascularization. His work bridges advanced manufacturing with regenerative medicine through innovative hydrogel and bioink development. Education: PhD in Tissue Bioprinting (University of Twente, 2024) MSc (institution unspecified) His research focuses on solving fundamental challenges in vascular network formation within engineered tissues, with particular expertise in embedded 3D printing techniques using granular baths and shear-thinning materials. He pioneers approaches like aptamer-based programmable bioinks and Magnetic Nozzle-Free Embedded 3D Printing to achieve precise microvascular morphogenesis. His work integrates principles from hydrogel engineering, growth factor delivery, and microfluidics to create biomimetic tissue constructs. Analysis of his 2023-2025 publications reveals a strategic progression from foundational embedded printing techniques toward increasingly sophisticated vascularization strategies. Key trends include the development of multi-material printing systems, dynamic bioink programming for 4D tissue evolution, and integration of biological cues like vascular endothelial growth factors. His research consistently targets clinical translation barriers in regenerative medicine through engineering-first solutions. Scientific Awards: No awards documented in provided materials While no formal advising relationships or grant awards are specified, his extensive collaborative network—evident in co-authorships with Rouwkema, Misra, and Schwach—demonstrates active participation in large-scale research initiatives. His conference presentations track methodological evolution from basic bioprinting (2018-2019) toward advanced vascularization techniques (2023-2025). Dr. Trikalitis operates within University of Twente's interdisciplinary biomanufacturing ecosystem, contributing to teams focused on sustainable advanced manufacturing applications in medical technology. His work particularly advances the intersection of granular mechanics, hydrogel science, and vascular tissue engineering through experimental innovation.

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Roy Sillitoeمشاهده پروفایل

استاد

Baylor College of MedicineUnited States

Roy Sillitoe, Ph.D. is a Professor in both the Department of Pathology and the Department of Neuroscience at Baylor College of Medicine in Houston, Texas. His research is conducted at the Duncan Neurological Research Institute, where he leads the Sillitoe Lab focused on understanding brain circuit development and neurological disorders. Dr. Sillitoe received his Ph.D. from the University of Calgary in 2003, followed by postdoctoral fellowships at the University of Oxford (2004), New York University School of Medicine (2006), and Memorial Sloan-Kettering Cancer Center (2008). Dr. Sillitoe's research focuses on the developmental origins of neurological diseases, particularly examining how precise neural circuitry is established during brain development and how disruptions lead to conditions like ataxia, dystonia, and autism spectrum disorders. His lab uses the cerebellum as a model system due to its well-organized architecture and established circuit connections. The Sillitoe Lab employs an interdisciplinary approach combining mouse molecular genetics, high-resolution neuroanatomy, and in vivo electrophysiology to study how genes and neural activity interact to establish functional neural circuits that control complex behaviors. Their work has revealed how cerebellar patterning cues control the precise targeting of neural connections required for smooth purposeful movements. Analysis of Dr. Sillitoe's recent publications reveals a strong focus on cerebellar development, neural circuit mapping, and the genetic basis of neurological disorders. His work has made significant contributions to understanding the zonal organization of the cerebellum, the role of specific genes (particularly engrailed homeobox genes) in neural circuit formation, and the relationship between cerebellar dysfunction and motor coordination disorders. The research employs advanced techniques including multicolor neural circuit mapping, whole-mount immunohistochemistry, and analysis of gene expression patterns in mouse models. Dr. Sillitoe is actively involved in research funding, with support from NINDS grant #NS089664 for his project 'Synaptic origins of cerebellar disease.' His lab includes research assistants, associates, and collaborators working on various aspects of cerebellar development and function. The Sillitoe Lab maintains a strong presence in the neuroscience community, with members participating in professional organizations including the Society for Neuroscience, American Physiological Society, and Society for Research on the Cerebellum and Ataxias. The lab has developed numerous protocols for studying cerebellar development and function, including specialized techniques for immunohistochemistry, tissue processing, and neural circuit mapping. Their ultimate goal is to uncover the developmental mechanisms affected by disease-linked genes, with the hope of identifying novel therapeutic targets to improve quality of life for individuals with neurological disorders.

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Katrina Adamsمشاهده پروفایل

استادیار

University of Notre DameUnited States

Katrina Adams is the Gallagher Assistant Professor in the Department of Biological Sciences at the University of Notre Dame, where she leads a research laboratory focused on brain development and regeneration. Her work bridges cellular and molecular neuroscience with regenerative medicine, particularly in the context of demyelinating diseases such as Multiple Sclerosis. Her research interests center on glial cell biology, neural stem cells, and white matter regeneration. She investigates how glial progenitor cells respond to injury and disease, with a focus on oligodendrocyte development and myelination. Her lab uses mouse models of demyelination, human tissue analysis, single-cell transcriptomics, and advanced genetic tools to uncover conserved molecular pathways that could serve as therapeutic targets for brain repair. The recent publications highlight a consistent trajectory in understanding endogenous repair mechanisms in the central nervous system. Her work spans developmental neurobiology, injury response, glial heterogeneity, and regenerative signaling pathways, with strong emphasis on translational relevance for neurodegenerative conditions and perinatal brain injury. Selected Scientific Contributions: Investigated Sirt2 in white matter oligodendrogenesis and neonatal hypoxia Explored Endothelin-1 signaling in postnatal glial progenitor proliferation Examined environmental enrichment effects on white matter recovery Elucidated the complexity of glial scar formation Developed stem cell models of motor neuron differentiation Katrina Adams mentors trainees in her lab and utilizes interdisciplinary approaches combining developmental biology, molecular signaling, and regenerative neuroscience. Her research is supported by institutional and likely federal funding, though specific grants are not listed. She collaborates with experts in neuroscience and stem cell biology, as evidenced by her co-authorships with prominent researchers like Vittorio Gallo and Bennett Novitch. Her laboratory is located in the Galvin Life Science Center (Lab: Galvin 044, Office: Galvin 049), and she is actively contributing to the neuroscience research community through high-impact publications and innovative experimental models.

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John McCarreyمشاهده پروفایل

استاد

University of Texas at San AntonioUnited States

John McCarrey is a Professor and the Kleberg Distinguished University Chair in Cellular and Molecular Biology at The University of Texas at San Antonio (UTSA), where he is also Co-Director of the Institute of Regenerative Medicine. He is affiliated with the Department of Neuroscience, Developmental and Regenerative Biology in the College of Sciences and holds joint appointments with the Department of Cell Systems & Anatomy and the Department of Obstetrics & Gynecology at UT Health San Antonio. He leads the McCarrey Laboratory, which focuses on epigenetic regulation in mammalian germ cells and stem cells. Ph.D. in Genetics, University of California, Davis M.S. in Genetics, University of California, Davis B.S. in Animal Science, University of California, Davis Dr. McCarrey's research centers on epigenetic mechanisms governing germ cell and stem cell function, including epigenomic reprogramming, genomic imprinting, and transgenerational epigenetic inheritance. His lab investigates how assisted reproductive technologies and environmental exposures affect epigenetic programming and genetic integrity. He is pioneering the use of the baboon as a nonhuman primate model for translational stem cell research and regenerative medicine. His work integrates molecular, genomic, and epigenomic approaches across mouse, human, and primate models. The recent publications of Dr. McCarrey reflect a strong focus on epigenetic regulation in spermatogenesis, stem cell biology, and transgenerational inheritance. His research combines cutting-edge techniques such as single-cell RNA-seq, epigenomic profiling, and in vitro reprogramming to understand cell fate decisions, germ cell development, and the impact of environmental exposures. A recurring theme is the comparison of epigenetic states across cell types and species, particularly in the context of pluripotency and germline transmission. Kleberg Distinguished University Chair in Cellular and Molecular Biology Dr. McCarrey mentors graduate students and postdoctoral researchers through UTSA’s Developmental and Regenerative Sciences PhD program, Biology Masters program, and Biotechnology Masters program. His research is supported by collaborations with institutions such as the Southwest National Primate Research Center, Washington State University, UCLA, and international partners. He is actively involved in the National Centers for Translational Research in Reproduction and Infertility (NCTRI), contributing to community education on male reproductive epigenomics. He leads a multidisciplinary team within the McCarrey Laboratory, which includes current and former members engaged in high-impact research. The lab also contributes to seminars and graduate training initiatives at UTSA.

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Holm Zaehresمشاهده پروفایل

مدرس ارشد

Max Planck Institute for Molecular BiomedicineGermany

Holm Zaehres is a Senior Lecturer at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, leading the Stem Cell Engineering Laboratory . His work focuses on reprogramming somatic cells to pluripotency using transcription factors like OCT4, SOX2, and KLF4, with significant contributions to induced pluripotent stem (iPS) cell generation from neural and hematopoietic progenitors. Key Research Areas: Stem cell engineering, iPS cell differentiation, genome editing, and disease modeling (including Frontotemporal Dementia and Duchenne Muscular Dystrophy). Publications: Authored 10+ seminal works in Nature , Cell , and Stem Cells , establishing methods for efficient cellular reprogramming and organoid-based disease studies. Collaborations: Partnered with institutions like University of Bonn, German Cancer Research Center (DKFZ), and academic hospitals in neurology and hematology.

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David Greg Fitzharrisمشاهده پروفایل

استاد

University of MontrealCanada

David Greg Fitzharris is a Full Professor associated with the Université de Montréal and practices at the CRCHUM (Montreal University Hospital Research Center) in the Viger Tower. His research focuses on the mechanisms of conception, specifically the impact of maternal age on egg and embryo quality, and its implications for fertility. Education: Bachelor of Science in Physiology and Pharmacology, University College London (2000) PhD in Physiology, University College London (2004) Postdoctoral Fellow at Ottawa Health Research Institute (2007) His current projects investigate motor protein roles in age-related oocyte aneuploidy, chromosome segregation errors in early embryos, and centriole biogenesis regulation. He utilizes live-cell microscopy to study these processes. Scientific Contributions: Dr. Fitzharris has published extensively on reproductive aging, embryo development, and cellular dynamics in mouse models. His work addresses critical challenges in fertility decline associated with maternal age.

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Emília Santosمشاهده پروفایل

استادیار

University of CambridgeUnited Kingdom

Dr. Emília Santos is an Assistant Professor and NERC Independent Research Fellow in the Department of Zoology at the University of Cambridge. Her research focuses on the genetic and developmental mechanisms underlying morphological diversity in Lake Malawi cichlid fishes, integrating evolutionary biology, genetics, and developmental biology. Research themes include pigmentation pattern evolution, neural crest cell development, and adaptive radiation. Utilizes genome editing tools (CRISPR, Tol2 transgenesis) and comparative genomics to link cellular biology to macroevolutionary patterns. Investigates whether micro- and macroevolutionary processes share common genetic pathways. Her recent work examines transposable element dynamics, visual system adaptation, and neural crest divergence across cichlid species. She leads the Cichlid Eco-evo-devo Group, accepting PhD applications. Scientific Awards: NERC Independent Research Fellowship Contact: es754@cam.ac.uk , Room 2.01, Downing St, Cambridge CB2 3EJ.

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Leo van Grunsvenمشاهده پروفایل

استاد

Vrije Universiteit BrusselBelgium

Leo van Grunsven is a Professor at the Vrije Universiteit Brussel (VUB) where he serves as head of the Liver Cell Biology research group, a position he has held since 2009. His research is situated within the Basic (bio)medical sciences faculty, specifically in the Translational Liver Cell Biology department. With over 239 research outputs and 60 active projects, his work has significantly contributed to the understanding of liver biology and disease mechanisms. Dr. van Grunsven obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996), following postdoctoral training at the NINDS/NIH (Bethesda, USA, '96-'98) and KU Leuven (Belgium, '98-'06). His laboratory specializes in studying molecular mechanisms driving liver homeostasis, fibrosis, and regeneration, with particular expertise in hepatic stellate cells and in vitro disease modeling. His research interests focus on understanding hepatic stellate cell biology and developing innovative in vitro models for chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms in hepatic stellate cell activation during liver fibrogenesis. They also established the first hepatocyte-injury dependent in vitro liver fibrosis model using organoid cultures of human hepatocytes and iPSC-derived hepatic stellate cells. Current research focuses on refining these models and investigating stress pathway regulation in liver cells during acute and chronic injury. Analysis of Dr. van Grunsven's recent publications reveals a strong focus on liver fibrosis mechanisms, with particular emphasis on hepatic stellate cell activation, liver organoid models, and the molecular pathways driving liver disease progression. His work bridges basic science with translational applications, developing novel in vitro models that better recapitulate human liver pathologies. Dr. van Grunsven actively supervises research, with 43 supervised works documented in his profile. He leads multiple significant research projects including B-LIVER 2.0 (Brussels Alliance for Liver Research & Valorization, 2025-2029), CATCH (CAR-T cell immunotherapy against chronic liver disease, 2024-2028), and 3D-CELLMAP (advanced imaging of cell interactions in tissues, 2024-2028). His laboratory, the Liver Cell Biology Laboratory, maintains active collaborations across multiple institutions and continues to advance the field of liver research through innovative approaches to modeling liver disease and identifying potential therapeutic targets.

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