جست‌وجوی استاد و پژوهشگر

Vivek Shenoyمشاهده پروفایل

استاد

• Mechanobiology
• Multiscale Modeling
• Biomaterials
• +۶ مورد دیگر

Vivek Shenoy is the Eduardo D. Glandt President's Distinguished Professor at the University of Pennsylvania, with primary appointments in the Department of Materials Science and Engineering and secondary appointments in Bioengineering and Mechanical Engineering and Applied Mechanics. He leads the Multiscale Mechanobiology and Biomaterials Laboratory, which focuses on developing theoretical frameworks and numerical methods to understand complex biological and engineering systems across multiple length scales. Shenoy's research spans mechanobiology, chromatin organization, cell mechanics, and biomaterials. His work addresses the fundamental challenge of modeling how small-scale cellular phenomena couple with long-range tissue-level interactions across micrometers to centimeters. By integrating insights from soft matter physics, solid mechanics, chemistry, and applied mathematics, his group develops multiphysics continuum and mesoscale theories to elucidate mechanisms controlling both biological and engineering systems. His recent publications demonstrate an increasing focus on nuclear mechanics, chromatin organization, and the interplay between mechanical forces and gene regulation. Analysis of Shenoy's publication record reveals a strong interdisciplinary approach, with high-impact papers spanning biophysics, materials science, and cell biology. His work shows consistent evolution from fundamental mechanics of materials to complex biological systems, with recent emphasis on the mechanical regulation of chromatin architecture, cell migration dynamics in 3D environments, and mechanotransduction in development and disease. His publications appear regularly in top journals including Nature, Science, and their affiliated publications, demonstrating significant influence across multiple fields. Eduardo D. Glandt President's Distinguished Professor Multiple publications in Nature, Science, and PNAS Active research program with publications through 2025 Shenoy actively mentors students and postdocs through his laboratory, with numerous co-authored publications indicating strong mentorship. His research program appears to be well-funded through multiple grants supporting his work in mechanobiology and biomaterials. The Multiscale Mechanobiology and Biomaterials Laboratory maintains active collaborations across disciplines and institutions, reflecting the interdisciplinary nature of his research. The Multiscale Mechanobiology and Biomaterials Laboratory, housed within the Department of Materials Science and Engineering at the University of Pennsylvania, serves as the primary research hub for Shenoy's work. The lab maintains an active presence on social media (Twitter: @ShenoyLab) for updates on activities and publications. Their research approach combines theoretical modeling with experimental validation to address fundamental questions at the interface of mechanics, materials science, and biology.

Holger Knautمشاهده پروفایل

دانشیار

• Collective Cell Migration
• Actin Polymerization
• RhoA Signaling
• +۴ مورد دیگر

Holger Knaut is an Associate Professor in the Department of Cell Biology at NYU Grossman School of Medicine . His research focuses on understanding the molecular and mechanical mechanisms underlying collective cell migration, tissue morphogenesis, and cytoskeletal dynamics using zebrafish models and quantitative imaging techniques. Key research areas: Collective cell migration, RhoA signaling, focal adhesions, actin polymerization Methodologies: Genetics, live-cell imaging, biomechanical analysis Notable findings: Discovery of rear traction forces in tissue migration, integration of adhesion codes in pattern formation His publications in top journals like Nature Cell Biology and Science demonstrate his expertise in developmental biophysics and cell signaling regulation. Contact: Holger.Knaut@nyulangone.org

Yan Jieمشاهده پروفایل

استاد

• Biophysics
• Molecular Biology
• Mechanobiology
• +۳ مورد دیگر

Professor Yan Jie is a distinguished academic at the National University of Singapore, holding faculty positions at the Mechanobiology Institute and the Department of Physics. He also maintains an affiliation with the Centre for BioImaging Sciences under the Department of Biological Sciences. Professor, Mechanobiology Institute (MBI), NUS Professor, Department of Physics, NUS Professor, Centre for BioImaging Sciences, NUS Dr. Yan's research lies at the intersection of biophysics, molecular biology, and mechanobiology. His work focuses on understanding how mechanical constraints influence biomolecular stability, including: Force-dependent conformations and interactions of nucleic acids and proteins Mechanosensing at cell-ECM adhesion and cell-cell junctions Chaperone-mediated protein folding mechanisms Chromosome packaging and DNA damage repair dynamics His recent publications highlight advancements in: Mechanical stabilization of biomolecular complexes via energy landscape modeling Multi-domain interactions in cytoskeletal proteins Force-transducing mechanisms in bacterial membranes Calcium signaling in stem cell mechanical properties Dr. Yan has mentored a diverse team including PhD students Kayo Kumadaki, Lin Yueying, Guo Yanyu, Sun Yuze, Liu Jingzhun, Dasvit Shetty, and former student Pang Si Ming. His lab integrates single-molecule biophysical methods with theoretical modeling to explore mechanical regulation at the molecular and cellular level.

Rachelle Crosbieمشاهده پروفایل

استاد

• Duchenne muscular dystrophy
• Protein biochemistry
• Muscle physiology
• +۵ مورد دیگر

Rachelle Crosbie is a Professor and Department Chair at the University of California, Los Angeles (UCLA), specializing in Integrative Biology and Physiology. Her research focuses on Duchenne muscular dystrophy (DMD), sarcospan, and extracellular matrix interactions in muscle health and disease. She earned her B.S. in Biochemistry from Texas A&M University (1989) and her Ph.D. in Biochemistry from UCLA (1994). Postdoctoral work was conducted at the University of Iowa Carver College of Medicine, supported by the Muscular Dystrophy Association. Her lab investigates sarcospan's role in ameliorating dystrophic muscle by activating compensatory mechanisms. Research includes developing small molecule therapies, in vitro platforms for fibrosis studies, and multi-omics approaches to cytoskeletal remodeling. She leads an NIH T32 training grant for muscle research. Scientific awards include the UCLA Chancellor’s Distinguished Teaching Award, Coalition Duchenne Lotus Award, and National Academies Education Scholar recognition. She developed an online DMD course for UC campuses and contributed to education research on student engagement in asynchronous learning.

• Cell Mechanics
• Tissue Engineering
• Corneal Wound Healing
• +۷ مورد دیگر

Dr. W. Matthew Petroll is a Professor in the Department of Ophthalmology and the Graduate Program in Biomedical Engineering at UT Southwestern Medical Center. He serves as Vice Chair of Research in Ophthalmology and previously directed the Biomedical Engineering Graduate Program from 2012 to 2025. His interdisciplinary work bridges engineering and clinical ophthalmology, focusing on corneal cell mechanics and tissue engineering. Dr. Petroll earned his BS in Biomedical Engineering from Duke University (1984) and PhD from the University of Virginia (1989). He joined UT Southwestern in 1991 after postdoctoral training at Georgetown University. His research centers on cell mechanics , corneal wound healing , and extracellular matrix dynamics , using in vivo confocal microscopy and 3D time-lapse imaging to study fibroblast behavior. His lab investigates how biochemical and biophysical cues regulate keratocyte differentiation, migration, and matrix remodeling in response to injury, surgery, and disease. His recent publications (2023–2025) highlight work on UV cross-linking effects , corneal fibrosis , gene expression in Fuchs’ dystrophy , and biomimetic collagen scaffolds . These studies demonstrate a consistent focus on mechanobiology and regenerative strategies for corneal transparency. Dr. Petroll has trained numerous graduate students, medical students, and postdocs through his active research lab. He has held leadership roles in academic programs and research administration, reflecting his institutional impact. His lab, the Petroll Lab , is embedded within the Department of Ophthalmology and collaborates extensively on corneal imaging, biomechanics, and translational research. The lab develops innovative models for assessing 3D cell-matrix interactions in vitro and in vivo.

Maria Akhmanovaمشاهده پروفایل

پژوهشگر

• Cell Biology
• Biomechanics
• Computational Biology
• +۳ مورد دیگر

Maria Akhmanova is an Assistant Member in the Cell Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC), with affiliations to the Gerstner Sloan Kettering Graduate School of Biomedical Sciences. Her research focuses on understanding how cells invade and migrate through tissues in vivo, integrating live imaging, biomechanical techniques, and computational modeling. Key areas include macrophage infiltration dynamics, tissue resistance mechanisms, and the role of cortactin and actin cytoskeleton regulation. Dr. Akhmanova holds a PhD from Lomonosov Moscow State University and has been recognized with the Austrian Science Fund (FWF) Lise Meitner fellowship (2018-2019). Her lab includes researchers such as Emily Pratt (GSK Graduate Student), Jonah Rosas (Research Scholar), and Xiaoqun Zhang (Senior Research Scientist), with lab alumni including Jayant Asthana. Her work spans disciplines like immunology, biomechanics, and computational biology. Recent studies highlight topics such as mitochondrial bioenergetics in macrophage invasion and Fos signaling in cortical actin regulation. Collaborative projects include work on auxin signaling in plant roots and collagen-based biomaterials for tissue regeneration. Key awards: Lise Meitner Fellowship (2018-2019) Lab members: Emily Pratt (PhD student), Jonah Rosas, Xiaoqun Zhang Collaborations: The lab employs interdisciplinary approaches blending experimental and theoretical frameworks. Her publications emphasize mechanistic insights into tissue-level cell migration, with implications for cancer immunology and regenerative medicine.

Stefano Piccoloمشاهده پروفایل

استاد

• Cancer Biology
• Molecular Biology
• Stem Cell Biology
• +۳ مورد دیگر

Stefano Piccolo is a Full Professor of Molecular Biology at the University of Padua's School of Medicine and a Principal Investigator at IFOM, The FIRC Institute for Molecular Oncology. His research focuses on mechanotransduction, YAP/TAZ signaling, and cancer biology. He holds significant roles including Director of the PhD program in Molecular Medicine and membership in prestigious scientific advisory boards like EMBL and the AIRC Scientific Advisory Board. Education: PhD in Biology and Pathology of the Connective Tissue (University of Padua, 1995), HHMI postdoctoral fellowship under Eddy De Robertis at UC Berkeley (1995–1998). Research interests center on how mechanical forces regulate cell behavior and tissue architecture, particularly through YAP/TAZ. His lab explores applications in cancer, stem cell biology, and regenerative medicine. Awards include the ERC Advanced Grant (2015), Tartufari Award (2012), and the Presidential Venosta Cancer Award (2012). Over 20 patents highlight translational contributions in cancer therapy and stem cell technologies. Grants and roles include ERC Advanced Grant leadership and contributions to scientific policy through roles like Governing Board Member of Human Technopole Milan. Labs/Teams: Leads a multidisciplinary team at IFOM and University of Padua, integrating molecular biology, material science, and omics approaches to study mechanobiology.

Deborah E Leckbandمشاهده پروفایل

استاد

• Cell Adhesion
• Biomaterials
• Tissue Engineering
• +۴ مورد دیگر

Deborah E Leckband is the Reid T. Milner Professor at the University of Illinois at Urbana-Champaign, holding joint appointments in the School of Chemical Sciences, Chemical and Biomolecular Engineering, Bioengineering, and Chemistry. Her research focuses on the biophysics of cell adhesion, biomaterials, and mechanotransduction at biological interfaces. She leads the Biosurfaces Laboratory , exploring how surface chemistry and mechanics influence cell behavior, with applications in drug delivery, tissue engineering, and medical devices. Education: B.S., Humboldt State University, 1982 Ph.D., Cornell University, 1988 Postdoctoral Research: MIT and UC Santa Barbara (1988–1992) Research Interests: Her work integrates surface science, biophysics, and cell biology to study protein interactions (e.g., cadherins), cell adhesion mechanics, and the design of smart biomaterials. Current projects include: Engineering cell microenvironments to control stem cell differentiation Mechano-chemical signaling in cancer metastasis and wound healing Design principles for non-fouling coatings and drug delivery systems Awards: Fellow, American Chemical Society (2009) Fellow, American Association for the Advancement of Science (2005) Langmuir Lectureship Award (2021) Advising & Grants: Leckband has mentored numerous students and secured funding from agencies like the NSF and NIH. Her lab collaborates widely to translate fundamental discoveries into biomedical innovations. Labs/Teams: The Biological Interfaces Group and Cell Adhesion Biophysics Group under her leadership explore interdisciplinary challenges in biomaterials, mechanobiology, and regenerative medicine.

• Computational Biology
• Biophysical Modeling
• Cancer Modeling
• +۱۲ مورد دیگر

João Carlos Lopes de Carvalho is a Full Professor at the Faculty of Science and Technology of the University of Coimbra, Portugal, where he has held academic positions since 1987. He was promoted to Associate Professor in 2003 and attained Full Professor status in 2022. His research spans computational biology, biophysical modeling of cancer, and experimental particle physics, with extensive participation in international collaborations including CERN (CPLEAR, ATLAS) and DESY (HERA-B). PhD in Experimental Particle Physics, University of Liverpool (1994) Aggregate Title (Habilitation), University of Coimbra (2003) Bachelor’s Degree in Physics, University of Coimbra (1987) His research focuses on the computational modeling of biological systems, particularly the bioelectric mechanisms underlying cancer initiation and progression. He develops discrete models such as cellular automata and cellular Potts models to simulate tissue dynamics in 2D and 3D, with applications in bladder and prostate cancer. Earlier in his career, he contributed to particle detector development, data acquisition, and physics analysis in high-energy experiments. The recent trends in his publication record show a strong emphasis on multiscale modeling of tumor growth, angiogenesis, and the role of bioelectricity in carcinogenesis. His work integrates computational simulations with biological insights, targeting early cancer detection and therapeutic strategies. Articles are published in high-impact journals such as Scientific Reports , PLOS Computational Biology , and Bulletin of Mathematical Biology . Supervised or co-supervised 4 PhD theses and 19 master’s dissertations Participated in over 50 research projects, coordinating 9 Principal investigator on grants including FCT projects PTDC/EMD-TLM/7289/2020 and PTDC/BIA-CEL/31743/2017 Involved in major collaborations: CERN (ATLAS, CPLEAR), DESY (HERA-B), SNO+ João Carlos Lopes de Carvalho has been a key figure in advancing computational approaches in oncology and biophysics. His work bridges physics, engineering, and life sciences, contributing to both fundamental understanding and potential clinical applications in cancer research.

• Breast Cancer Metastasis
• Cytoskeletal Dynamics
• Tumor Suppressor Genes
• +۳ مورد دیگر

Michele Vitolo is an Assistant Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. Her research focuses on understanding the molecular mechanisms of breast cancer metastasis, particularly the role of PTEN loss and microtentacle formation in tumor progression. She has developed innovative models and assays to study cytoskeletal dynamics and signaling pathways in cancer cells. University of Maryland Baltimore (PhD, 2004) Franklin and Marshall College (BS, 1995) Dr. Vitolo's research investigates how tumor suppressor gene inactivation affects cancer cell behavior. Key areas include: PTEN loss-induced microtentacle formation Interplay between PI3K and Ras/MAPK pathways Calcium signaling in metastatic processes Epigenetic regulation of cytoskeletal networks Development of novel cell tracking methodologies Identification of therapeutic targets for metastatic disease Her work has been recognized through the NCI Mentored Scientist Research Award. Dr. Vitolo has authored numerous publications examining: Cytoskeletal alterations in detached cancer cells Role of tubulin modifications in metastasis Signaling mechanisms promoting tumor cell reattachment Therapeutic approaches targeting microtentacle formation

Jean E. Schwarzbauerمشاهده پروفایل

استاد

• Extracellular Matrix Biology
• Cell-Matrix Interactions
• Fibronectin Assembly
• +۱۰ مورد دیگر

Jean E. Schwarzbauer is the Eugene Higgins Professor of Molecular Biology at Princeton University, where she leads a research group focused on the extracellular matrix (ECM) and its role in cell function and disease. She is affiliated with the Department of Molecular Biology, the New Jersey Center for Biomaterials, and the Rutgers Cancer Institute of New Jersey. Education: B.S. in Chemistry, University of Wisconsin–Milwaukee Ph.D. in Molecular Biology, University of Wisconsin–Madison Postdoctoral Fellowship, MIT Her research centers on fibronectin and ECM assembly, with implications in tissue development, regeneration, fibrosis, and cancer. She investigates how ECM structure regulates cell behavior, with a focus on fibronectin matrix formation, integrin signaling, and the role of proteoglycans. Her work spans basic molecular mechanisms to translational applications in regenerative medicine. Recent publications highlight her lab's work on fibronectin-binding protein signatures in pulmonary fibrosis, glucose-induced ECM changes in diabetic complications, and the use of engineered ECM-synthetic scaffolds for nerve regeneration. Her studies integrate cell biology, biochemistry, and biomaterials to uncover fundamental principles of matrix biology. Scientific Awards: Peggy Wheelock Award for Excellence in Research, Mentoring, and Promotion of Women in Science Professor Schwarzbauer has served as Director of Graduate Studies in Molecular Biology and Associate Chair of the department. She is actively engaged in service, having led the American Society for Matrix Biology, served on NIH study sections, and held editorial roles at Molecular Biology of the Cell , Matrix Biology , and Journal of Cell Biology . She has organized major scientific conferences and advised national research programs. Her lab trains students and postdocs in cutting-edge techniques in cell and matrix biology. Laboratory and Research Teams: The Schwarzbauer Lab at Princeton uses cell culture models, molecular biology, and imaging to study ECM dynamics. The team collaborates with bioengineers and clinicians to develop biomaterials for tissue repair. Ongoing projects include ECM in skeletal development, fibrosis mechanisms, and synthetic ECM design for regenerative applications.

Pontus Nordenfeltمشاهده پروفایل

دانشیار

• Infectious Medicine
• Immunology
• Cell Biology
• +۸ مورد دیگر

Pontus Nordenfelt is an Associate Professor and Senior Lecturer at the Department of Infection Medicine (BMC), Lund University. He serves as Principal Investigator for multiple active projects, including InfPathMapper (Horizon Europe) and Broad antibody-based protection against SARS-CoV-2 (Swedish Research Council). His research spans infectious medicine, immunology, cell biology, and biophysics , focusing on human cell-environment interactions in infections and cancer. His lab investigates biomechanical forces, antibody-complement systems, and receptor signaling (Fc receptors, integrins), developing technologies like NETQUANT for quantifying neutrophil extracellular traps. Recent projects include Protumoral lipid droplet-loaded macrophages (Science Translational Medicine, 2024) and Targeting Cholesterol Homeostasis (2024). Pontus has received the Schyberg Award (2018) and Anna-Greta Crafoord Prize (2010). He manages advanced infrastructure including the Nikon Ti2 Pathogen Live Microscope and CytoFLEX flow cytometer , and contributes to UN Sustainable Development Goals in health and innovation.

• Molecular Embryology
• Cell Biology
• Focal Adhesion Proteins
• +۵ مورد دیگر

Paris Skourides is a Professor at the Department of Biological Sciences , part of the School of Natural and Applied Sciences at the University of Cyprus . His research focuses on the molecular and cellular mechanisms underlying tissue morphogenesis and neural tube closure in vertebrates, particularly using the Xenopus laevis model organism. He also develops advanced imaging techniques using quantum dot nanocrystals and investigates the role of focal adhesion proteins in embryonic development and disease. Education PhD (1998-2004), The Rockefeller University: Morphogenetic Movements during Xenopus Gastrulation and Development of Biocompatible Quantum Dots BA Biochemistry (1994-1997), Brandeis University: Summa Cum Laude and Highest Honors in Biochemistry Research Interests include: Elucidating molecular mechanisms of vertebrate body plan formation Developing quantum dot-based imaging methods for morphogenesis studies Investigating focal adhesion proteins' roles in ciliogenesis and tissue mechanics Studying mechanotransduction pathways in embryonic development Creating high-throughput mucociliary flow assays for ciliopathy research His scientific contributions include the Marie Skłodowska-Curie Individual Fellowship. The Skourides Lab employs interdisciplinary approaches combining live imaging, 4D cell tracking, optogenetics, and molecular dynamics simulations to study: Ciliary adhesion complex formation Integrin-FAK signaling in spindle orientation Calcium signaling in apical constriction Quantum dot applications in developmental biology

Michael L. Smithمشاهده پروفایل

دانشیار

• Mechanotransduction
• Extracellular Matrix
• Tissue Engineering
• +۱ مورد دیگر

Michael L. Smith is an Associate Professor in the Department of Biomedical Engineering at Boston University, with joint appointments in Materials Science & Engineering and affiliation with the Molecular Biology, Cell Biology & Biochemistry Program. His research focuses on mechanotransduction via the extracellular matrix, particularly fibronectin mechanics, and engineered cell culture platforms. Education includes: PhD in Biomedical Engineering, University of Virginia M.S. in Biomedical Engineering, University of Virginia B.S. in Mechanical Engineering, University of Memphis Research interests include: Quantifying microenvironmental regulation of cell fate Fibronectin tension and cell signaling mechanisms Engineering culture environments for ECM control His publications predominantly explore cell-matrix interactions across biological scales, with recent work focusing on cancer cell mechanics, tensile homeostasis, and extracellular matrix assembly. Awards and honors: NSF CAREER Award (2012–2017) Member of American Society for Matrix Biology Member of Biomedical Engineering Society Member of Materials Research Society Leads the Matrix Mechanotransduction Lab investigating fundamental mechanisms of cellular mechanosensing.

• Cell Biology
• Pharmacology
• Integrin Signaling
• +۵ مورد دیگر

David Calderwood is a Professor of Pharmacology and Cell Biology at Yale School of Medicine, where he also serves as co-Director of Graduate Studies for the Pharmacology Graduate Program. He holds primary appointments in the Department of Pharmacology and secondary appointments in Cell Biology, with additional affiliations across multiple interdisciplinary programs including Cancer Signaling Networks, Vascular Biology and Therapeutics, and Yale Cancer Center. Dr. Calderwood received his PhD from the University of Manchester in 1996. His research program focuses on molecular mechanisms of cell adhesion, particularly integrin receptor signaling and cytoskeletal dynamics. Key research interests include: Integrin activation mechanisms through talin and kindlin interactions Mechanical force transmission in cell-ECM adhesions Cytoskeletal regulation of cell migration and adhesion Structural basis of integrin-mediated signaling complexes His recent publications demonstrate a strong focus on mechanobiology and advanced imaging techniques, with recurring themes of integrin trafficking, cytoskeletal tension sensing, and molecular basis of adhesion complex assembly. The work frequently bridges structural biology with cellular biophysics, employing techniques from molecular modeling to live-cell imaging. Dr. Calderwood has received significant research funding, including a $1,390,200 NIH grant with Titus Boggon (2009) and a $1,356,968 NIGMS grant (2009). As co-Director of Graduate Studies, he oversees doctoral training in pharmacology while maintaining an active research laboratory investigating fundamental cell adhesion mechanisms relevant to cancer, immunology, and vascular biology.