Yan Jie

Professor Yan Jie is a distinguished academic at the National University of Singapore, holding faculty positions at the Mechanobiology Institute and the Department of Physics. He also maintains an affiliation with the Centre for BioImaging Sciences under the Department of Biological Sciences.

• Professor, Mechanobiology Institute (MBI), NUS
• Professor, Department of Physics, NUS
• Professor, Centre for BioImaging Sciences, NUS

Dr. Yan's research lies at the intersection of biophysics, molecular biology, and mechanobiology. His work focuses on understanding how mechanical constraints influence biomolecular stability, including:

• Force-dependent conformations and interactions of nucleic acids and proteins
• Mechanosensing at cell-ECM adhesion and cell-cell junctions
• Chaperone-mediated protein folding mechanisms
• Chromosome packaging and DNA damage repair dynamics

His recent publications highlight advancements in:

• Mechanical stabilization of biomolecular complexes via energy landscape modeling
• Multi-domain interactions in cytoskeletal proteins
• Force-transducing mechanisms in bacterial membranes
• Calcium signaling in stem cell mechanical properties

Dr. Yan has mentored a diverse team including PhD students Kayo Kumadaki, Lin Yueying, Guo Yanyu, Sun Yuze, Liu Jingzhun, Dasvit Shetty, and former student Pang Si Ming. His lab integrates single-molecule biophysical methods with theoretical modeling to explore mechanical regulation at the molecular and cellular level.