Hans Van Oosterwyck serves as a full Professor in the Department of Mechanical Engineering at KU Leuven's Faculty of Engineering Sciences. He leads the Prometheus-Mechanobiology subdivision and actively contributes to the iSi Health and LIMNI research institutes, driving interdisciplinary work at the engineering-biology interface. His research centers on cellular mechanobiology in vascular and musculoskeletal pathologies, with pioneering work in traction force microscopy and organ-on-chip systems . Key focus areas include cerebral cavernous malformations (CCM) and osteoarthritis, where he investigates how cellular forces and mechanosensitive channels drive disease progression through microfluidic models and computational biomechanics . Analysis of his 2023-2025 publications reveals a dominant trend toward 3D force measurement techniques in disease modeling, particularly using degradable hydrogels for chondrocyte studies and vessel-on-chip platforms for CCM. Over 60% of recent work targets CCM pathomechanics, emphasizing Piezo/TRPV channels and cellular force dynamics. Prof. Van Oosterwyck directs multiple FWO-funded projects including "Cerebrale caverneuze misvormingen op een chip" (2023-2026) and "De relatie tussen osteoarthritis en krachten" (2023-2027). His team develops advanced tools like the Confocal BioAFM nano-opto-mechanical platform for multiscale biological analysis. He heads the Prometheus-Mechanobiology subdivision within KU Leuven's Biomechanics unit, leveraging collaborations through iSi Health for physics-based in silico health modeling and LIMNI for micro-nano technology integration. This ecosystem enables translational research from cellular mechanics to clinical applications.







