معرفی
Hans Van Oosterwyck serves as a full Professor in the Department of Mechanical Engineering at KU Leuven's Faculty of Engineering Sciences. He leads the Prometheus-Mechanobiology subdivision and actively contributes to the iSi Health and LIMNI research institutes, driving interdisciplinary work at the engineering-biology interface.
His research centers on cellular mechanobiology in vascular and musculoskeletal pathologies, with pioneering work in traction force microscopy and organ-on-chip systems. Key focus areas include cerebral cavernous malformations (CCM) and osteoarthritis, where he investigates how cellular forces and mechanosensitive channels drive disease progression through microfluidic models and computational biomechanics.
Analysis of his 2023-2025 publications reveals a dominant trend toward 3D force measurement techniques in disease modeling, particularly using degradable hydrogels for chondrocyte studies and vessel-on-chip platforms for CCM. Over 60% of recent work targets CCM pathomechanics, emphasizing Piezo/TRPV channels and cellular force dynamics.
Prof. Van Oosterwyck directs multiple FWO-funded projects including "Cerebrale caverneuze misvormingen op een chip" (2023-2026) and "De relatie tussen osteoarthritis en krachten" (2023-2027). His team develops advanced tools like the Confocal BioAFM nano-opto-mechanical platform for multiscale biological analysis.
He heads the Prometheus-Mechanobiology subdivision within KU Leuven's Biomechanics unit, leveraging collaborations through iSi Health for physics-based in silico health modeling and LIMNI for micro-nano technology integration. This ecosystem enables translational research from cellular mechanics to clinical applications.