جست‌وجوی استاد و پژوهشگر

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

• Stem Cell Biology
• Genetic Engineering
• Epigenetics
• +۵ مورد دیگر

Konstantinos Anastassiadis is a Professor at the Center for Molecular and Cellular Bioengineering (CMCB) of Dresden University of Technology , leading the Stem Cell Engineering group at the Biotechnology Center (BIOTEC) . His research focuses on unraveling molecular pathways regulating stem cell self-renewal and lineage commitment, with a strong emphasis on genetic engineering tool development and epigenetic mechanisms during cellular reprogramming. The lab utilizes mouse and human embryonic stem cells, neural stem cells, mesenchymal stromal cells, and induced pluripotent stem cells (iPSCs) in their investigations. Core Research Areas: Molecular regulation of stem cell fate Epigenetic mechanisms (e.g., UTX/UTY histone demethylases) Genetic engineering tool development (Flp, Dre, Vika recombinases, CRISPR protocols) Conditional immortalization systems for rare cell expansion Publications highlight his contributions to understanding: Role of histone methyltransferases (MLL1, MLL2, Setd1b) in hematopoiesis and cancer Epigenetic regulation during mouse development and spermatogenesis Genetic tools for protein tagging, transposon-mediated BAC transgenesis Interactions between stem cells and niche microenvironments Transcriptional and mechanical markers during reprogramming Collaborations span immunology , developmental biology , and bioinformatics . The lab actively participates in teaching activities at CMCB and maintains a focus on translational applications of stem cell research.

Hang Luمشاهده پروفایل

دانشیار

• Science Communication
• Health Communication
• Environmental Communication
• +۴ مورد دیگر

Hang Lu is an Associate Professor in the Department of Communication and Media at the University of Michigan's College of Literature, Science, and the Arts. He specializes in science, health, environmental, and risk communication (ComSHER), with a focus on media psychology. His research explores audience responses to media messages about sensitive topics and strategies to enhance message effectiveness. Lu holds a Ph.D. in Communication from Cornell University (2018), along with advanced degrees from Cornell, Marquette University, and Central South University in China. He directs the Media and Risk (MaR) Lab and previously served as a postdoctoral fellow at the Annenberg Public Policy Center. His research spans four main areas: 1) emotion dynamics in media responses, 2) predictors of information behaviors, 3) media effects on stigmatization, and 4) AI applications in sensitive domains. He has published in journals like Journal of Communication , Risk Analysis , and Public Understanding of Science , earning multiple top paper awards. As Vice Chair of the Environmental Communication Division at the International Communication Association, Lu contributes to interdisciplinary dialogue. His work addresses critical societal issues such as climate change communication, vaccination hesitancy, and emerging technology ethics.

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

Maxim Artyomovمشاهده پروفایل

استاد

• Systems Immunology
• Immunometabolism
• Cancer Immunology
• +۲ مورد دیگر

Maxim Artyomov is an Alumni Endowed Professor and Professor of Pathology and Immunology at Washington University School of Medicine , with affiliations to the Institute of Clinical and Translational Sciences (ICTS), Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs), and Siteman Cancer Center. His research spans Systems Immunology , Immunometabolism , and Cancer Immunology , focusing on integrating epigenetic, transcriptional, and metabolic regulation in immune cells. 2018 promoted to Associate Professor with Tenure 2017 awarded LEAP Inventor Challenge 2018 Unanue Prize for Innovative Research in Immunology Key research contributions include: Discovery of itaconate's anti-inflammatory role (2016) Metabolic reprogramming in macrophage polarization (2015) TREM2's function in microglial metabolic fitness (2017) Development of CORESH gene signature search engine (2025) His high-throughput omics pipelines enable cross-disciplinary analysis of immune responses in tuberculosis, Alzheimer's, and cancer. Notable collaborations include work with Schreiber's lab on immune checkpoint therapy (2018) and ITMO University on systems biology workshops (2017-2018). Awards and grants include the Unanue Prize (2018), LEAP Inventor Challenge (2017), and R01 grant from NIAID (2017). He mentors PhD/MSTP students and co-organizes international systems biology workshops.

• Immunology
• Cancer Therapy
• Oncology
• +۳ مورد دیگر

Angelo Porciuncula is an Associate Research Scientist in the Department of Pathology at Yale School of Medicine, affiliated with the Schalper Lab. He holds a PhD from the University of Navarra. His research focuses on immunology, cancer therapy, and stem cell biology, with a particular emphasis on immune microenvironment modulation in oncology and translational drug development. Key projects include studying STING pathway activation via antibody-drug conjugates (e.g., TAK-500) targeting CCR2-expressing myeloid cells, as well as investigating immunotherapeutic biomarkers in lung cancer and glioblastoma. His work spans clinical-stage drug evaluation, tumor immunology, and epigenetic reprogramming of stem cells. Publications highlight contributions to understanding senescence mechanisms in cancer, pancreatic differentiation of iPSCs, and the role of OX40/OX40L pathways in tumor immunity. Porciuncula collaborates widely, including with Kurt Schalper and teams at Takeda Pharmaceuticals. His research bridges basic science and clinical applications, aiming to advance targeted therapies and regenerative medicine strategies.

Torsten Nielsenمشاهده پروفایل

استاد

• Sarcoma
• Breast Cancer
• Molecular Diagnostics
• +۷ مورد دیگر

Professor Torsten Nielsen is a clinician-scientist at the University of British Columbia 's Department of Pathology & Laboratory Medicine (Faculty of Medicine), based at Vancouver General Hospital and BC Cancer . He directs UBC's MD/PhD Program , contributes to cancer clinical trials with the Canadian Cancer Trials Group , and chairs the international Connective Tissue Oncology Society 's Research Committee. Key affiliations: UBC, Vancouver General Hospital, BC Cancer, Molecular and Advanced Pathology Core Academic focus: Translational research in sarcomas and breast cancer His research prioritizes translating genomic discoveries into clinical diagnostics and treatments, particularly for synovial sarcoma , breast cancer subtypes , and tenosynovial giant cell tumors . He develops FDA-cleared molecular assays like the PAM50 (Prosigna) test and leads pan-Canadian precision oncology initiatives . Collaborative efforts include work with Stanford, Leiden, and DKFZ Heidelberg. Recent publications highlight advancements in epigenetic therapies , immune biomarker validation , and synovial sarcoma pathogenesis . His lab's work on CSF1/CSF1R signaling inspired new treatment strategies for joint-destructive tumors. Scientific Awards: Fellow, Canadian Academy of Health Sciences Fellow, Royal Society of Canada As director of UBC's MD/PhD Program, he trains future clinician-scientists. His lab team includes experts in epigenomics , proteomics , and mouse modeling . Current projects focus on precision oncology for sarcomas and Ki67 standardization in breast cancer.

• Biophotonics
• Nanotechnology
• Fluorescence Applications
• +۷ مورد دیگر

Professor Ewa Goldys is a distinguished academic at the University of New South Wales (UNSW), serving as a Professor in the School of Engineering with a focus on Biomedical Engineering. She holds the prestigious position of Deputy Director at the ARC Centre of Excellence for Nanoscale Biophotonics (CNBP), where she leads partnerships, knowledge transfer, and research commercialization efforts. Her work spans interdisciplinary research connecting engineering, medicine, and biology, with significant contributions to biophotonics and nanotechnology applications in healthcare. Professor Goldys' research interests center around advanced imaging techniques, particularly autofluorescence characterization, which provides a non-invasive metabolic 'fingerprint' for distinguishing healthy from diseased cells. Her work has significant applications in cancer, diabetes, and neurodegenerative diseases. She has pioneered research in fluorescent and luminescent nanomaterials for biological applications, developing innovative approaches for high-contrast, background-free imaging using time-gating techniques. Her research portfolio also includes significant contributions to CRISPR-based biosensing, stem cell characterization, and non-invasive diagnostic approaches using multispectral imaging. Her publication record demonstrates a clear trend toward increasingly sophisticated applications of autofluorescence imaging combined with machine learning and molecular techniques. Recent work integrates hyperspectral imaging with transcriptomics, develops CRISPR-based point-of-care diagnostics, and applies autofluorescence techniques to diverse medical challenges from kidney disease diagnosis to immune cell characterization. The interdisciplinary nature of her work spans oncology, immunology, nephrology, and regenerative medicine. Professor Goldys has received notable recognition for her work, including: Eureka award in 2016 for Innovative Use of Technology Her research leadership has secured substantial funding, including directing the $23 million ARC investment in the CNBP (matched by $17 million from partners), establishing the $2 million ARC/NHMRC Network 'Fluorescence Applications in Biotechnology and Life Sciences,' and leading research that leveraged an additional $155 million in external funding. She has founded the Optical Characterisation Facility at Macquarie University and has been instrumental in establishing international research networks in biophotonics. Professor Goldys has made significant contributions to the international biophotonics community through conference organization, having chaired 11 conferences including SPIE 'Biophotonics Australasia' and serving as Track Chair for Nanobiophotonics at BIOS, the world's largest biomedical optics meeting. Her work has established foundational methodologies in autofluorescence characterization that continue to drive innovation in label-free medical diagnostics.

Filippo Vegliaمشاهده پروفایل

استادیار

• Cancer Immunology
• Myeloid Cell Biology
• Tumor Metabolism
• +۴ مورد دیگر

Filippo Veglia, Ph.D., is an Assistant Professor at The Wistar Institute, where he leads research in the Genome Regulation and Cell Signaling Program within the Ellen and Ronald Caplan Cancer Center. He returned to Wistar in December 2023 after serving as an Assistant Member at Moffitt Cancer Center in the Department of Immuno-Oncology and Neuro-Oncology Program from 2020-2023. Dr. Veglia is an expert in myeloid cell biology, cancer immunology, and tumor metabolism. His research focuses on understanding how the tumor microenvironment, particularly in glioblastoma (the deadliest form of brain cancer), reprograms the metabolism and function of myeloid cells to create an immunosuppressive environment that helps tumors evade immune responses. His lab has made significant discoveries regarding histone lactylation and its role in promoting immunosuppressive activity in tumor-associated macrophages. Dr. Veglia earned his Ph.D. in Immunology and Applied Biotechnology from Tor Vergata University in Rome, Italy, and completed his postdoctoral training in the lab of Dr. Dmitry Gabrilovich at The Wistar Institute. His research has been published in high-impact journals including Nature, Immunity, and Cancer Discovery. His recent publications demonstrate how glucose metabolism in tumor-associated macrophages drives histone lactylation, which promotes the expression of immunosuppressive molecules like IL-10. His work has revealed potential therapeutic targets such as PERK that could disrupt this immunosuppressive pathway and enhance immunotherapy effectiveness against brain cancer. Dr. Veglia's laboratory includes Staff Scientist Alessandra De Leo, Ph.D., Postdoctoral Fellows Barbara Peixoto, Ph.D. and Alessio Ugolini, Ph.D., and Predoctoral Trainee Filippo Badii. His research has been supported by grants from The Ben & Catherine Ivy Foundation, The National Institute of Neurological Disorders and Stroke, and the American Cancer Society.

Filipe Pereiraمشاهده پروفایل

استاد

• Cellular Reprogramming
• Hematopoiesis
• Immunology
• +۵ مورد دیگر

Filipe Pereira is a Professor and Senior Lecturer at Lund University's Faculty of Medicine, where he holds a Wallenberg Molecular Medicine Fellowship and leads the Cell Reprogramming in Hematopoiesis and Immunity research team within the Division of Molecular Medicine and Gene Therapy. His work contributes to UN Sustainable Development Goals related to health and well-being. Dr. Pereira's research focuses on understanding the molecular determinants of cell reprogramming and hematopoietic specification. His laboratory investigates how cellular identities are specified during development, with particular emphasis on Hematopoietic Stem Cells (HSCs) for their regenerative potential and Dendritic Cells (DCs) as key orchestrators of immunity. The team explores experimental approaches to cell reprogramming including nuclear transfer, cell fusion, and transcription factor expression to develop new therapies for immune and blood diseases. Analysis of Dr. Pereira's 98 research outputs reveals a strong focus on cellular reprogramming techniques for immunotherapy applications, particularly in cancer treatment. His work spans molecular biology, immunology, and stem cell research, with significant contributions to understanding transcription factor networks that control cell fate decisions. The research has practical applications in regenerative medicine and cancer immunotherapy, with several publications in high-impact journals including Nature Communications and Science Immunology. Scientific Recognition: Imperial College Emerging Alumni Leader Award (2025) ERC Proof of Concept grant (2024) Pfizer-Portugal award in basic research (2024) ERC Proof of Concept Grant (2023) Eric K. Fernströms Prize to young particularly promising researchers (2023) Dr. Pereira actively supervises graduate students and postdoctoral researchers, with 12 PhD students and 8 postdocs under his mentorship. He leads multiple research projects including 'In Vivo Dendritic Cell Reprogramming Immunotherapy' and 'Functional chemical reprogramming of cancer cells to induce antitumor immunity,' funded by organizations including the European Commission and Cancer Research Institute. His laboratory has developed innovative approaches to reprogram somatic cells into desired hematopoietic cell types, with significant implications for therapeutic applications. The Cell Reprogramming in Hematopoiesis and Immunity team collaborates extensively across international boundaries, with research outputs picked up by numerous news outlets and referenced in patents and Wikipedia pages, demonstrating the broad impact of their work in the scientific community and beyond.

• Neuroplasticity
• Visual Systems
• Neural Circuits
• +۵ مورد دیگر

Dr Jennifer Sun is a Lecturer at the UCL Institute of Ophthalmology, leading the Visual Plasticity Lab. Her research investigates how visual cortex integrates sensory and modulatory inputs to regulate neuroplasticity, with applications in vision recovery from aging, injury, and neurological disorders. PhD: University of Southern California (Circuit Computation, Sensory Cortical Development) Postdoc: University of California, San Francisco (Molecular Techniques, Electrophysiology, 2-Photon Imaging) Research interests focus on neuroplasticity mechanisms in visual systems using genetic, physiological, and computational approaches. Key areas include local circuit dynamics, brain region crosstalk, neuron-glial interactions, and translating findings into therapies via collaborations with clinicians at Moorfields Eye Hospital. Teaching roles include supervising PhD students (LiDo, Optical Biology, UCL-Birkbeck MRC DTP) and Master's students (MRes Brain Science, MSc Neuroscience). She organizes UCL's Visual Neuroscience (NEUR0017) and Systems and Circuit Neuroscience (ANAT0020) modules, plus Cold Spring Harbor's international Neural Data Science summer course. Labs/teams: Visual Plasticity Lab (UCL Institute of Ophthalmology), collaborating with Sainsbury Wellcome Centre, UCL bioengineers, and Moorfields Eye Hospital clinicians to explore health-disease plasticity differences.

Guoqiang Yuمشاهده پروفایل

استاد

• Machine Learning
• Pattern Recognition
• Optimization
• +۹ مورد دیگر

Guoqiang Yu is a Professor in the Bradley Department of Electrical and Computer Engineering at Virginia Tech. He holds a joint appointment at the Virginia Tech Research Center - Arlington. His research focuses on integrating machine learning, signal processing, and statistical methods to develop computational tools for analyzing multiplatform biomedical data. Key areas include neuroinformatics, bioinformatics, and systems biology, with applications in understanding human diseases through genomic, proteomic, and imaging data integration. Education: Ph.D. in Electrical Engineering, Virginia Tech (2011) Postdoctoral Fellowship at Stanford University (2012) M.S. Tsinghua University (2004) B.S. Shandong University (2001) Research Interests: Machine learning methodologies for biomedical data analysis, pattern recognition in complex datasets, optimization algorithms for high-dimensional data, stochastic signal processing, and their applications in neurodegenerative diseases (e.g., ALS, Alzheimer's), glial cell biology, and precision medicine. His work emphasizes developing open-source tools like ABDS, CAM3.0, and SynQuant for data normalization, deconvolution, and quantitative imaging analysis. Awards & Service: NSF Career Award (2018) Dean's Award for Excellence in Research (2022) Member of NIH BRAIN Initiative Consortium (2021–present) Associate Editor for BMC Bioinformatics (2017–present) Labs & Teams: Leads the Yu Lab at Virginia Tech, collaborating with multidisciplinary teams in neuroscience, bioengineering, and computational biology. Active in NIH-funded consortia focused on brain data science and large-scale neuroimaging initiatives.

• Immunology
• Infection Immunology
• Respiratory Viral Infections
• +۶ مورد دیگر

Prof. Dunja Bruder is a university professor of infection immunology at the Institute of Medical Microbiology and Hospital Hygiene at Otto von Guericke University (OVGU) and Head of the Immune Regulation Research Group at the Helmholtz Center for Infection Research (HZI). She obtained her PhD in immunology from TU Braunschweig and completed postdoctoral training at Harvard Medical School and Yale University School of Medicine. Her research focuses on immune regulation in respiratory viral infections, chronic inflammatory lung diseases, and mucosal immunity. She leads two research groups and holds leadership roles in the Research Focus on Respiratory Viral Infections (HZI), the CRC 854, and the Otto-von-Guericke Graduate Academy. Her work integrates innate and adaptive immunity, with particular emphasis on T-cell responses, microbiota interactions, and vaccine development. She also contributes to teaching in master's programs and human medicine. Education Bachelor/Master: Biotechnology, Technical University of Braunschweig PhD (1996–1999): Immunodominance and T-cell responses to bacterial toxins, HZI Habilitation (2009): Immunology, Hannover Medical School Research Interests Bruder’s work examines immune responses to respiratory pathogens like influenza and SARS-CoV-2, the role of epithelial-T-cell interactions in asthma, and the modulation of immune defenses by microbiota. She investigates vaccine strategies using defective interfering particles and antigen-targeting approaches. Her studies also address antitumor immune training via viral infections and metabolic control of T-cell function in asthma endotypes. Key Contributions She pioneered the analysis of alveolar macrophage dysfunction in chronic lung diseases and demonstrated the protective role of IL-33 in microbiota-mediated antibacterial defenses. Her team developed predictive models for influenza infection using hematological data and identified CD47 as a critical regulator of antiviral macrophage activity. Labs/Teams Leads the Immune Regulation Group at HZI and collaborates with the Institute of Medical Microbiology at OVGU. Active in the HZI’s Respiratory Viral Infections Research Focus and the CRC 854.

John Iacominiمشاهده پروفایل

استاد

• Adaptive immune responses
• Immunological tolerance
• MicroRNAs in T cell activation
• +۲ مورد دیگر

John Iacomini is a Professor at Tufts University School of Medicine , affiliated with the Department of Immunology and cross-appointed in Genetics, Molecular and Cellular Biology, and other biomedical programs. He has taught courses like Intro to Immunology and Advanced Cellular Immunology since 2011. Doctor of Philosophy , Tufts University (1991) Bachelor of Science , Syracuse University (1986) His research focuses on adaptive immune responses , immunological tolerance , and the role of microRNAs in T cell activation and tissue injury responses . Recent work explores how hyperlipidemia and dietary factors influence organ transplant rejection and immune regulation. His publications since 2015 highlight studies on Treg dysfunction , Th17 cell pathogenicity , microRNA-mRNA interactions in nephrotoxicity, and hormonal modulation of T cells. These studies often intersect transplant immunology and metabolic-immune crosstalk . Scientific Awards NIH Grant: Post-transcriptional regulation of gene expression by microRNAs (2021-2026) NIH Grant: Microbial disruption of dendritic cell function (2018-2023) NIH Grant: Hyperlipidemia effects on immune memory (2018-2020) NIH Grant: Diet-induced transplant rejection (2015-2020) American Heart Association Grant: Hyperlipidemia in cardiac rejection (2014) As a mentor, he has advised graduate students like Christopher Benway and contributed to training programs. His laboratory remains active in uncovering mechanisms of immune tolerance , microRNA regulation , and metabolic influences on transplant outcomes .

• Melanoma Biology
• Cancer Immunology
• Tumor Microenvironment
• +۴ مورد دیگر

Marcus Bosenberg, MD, PhD, is the Anthony N. Brady Professor of Dermatology, Pathology and Immunobiology at Yale School of Medicine. He serves as Director of the Yale SPORE in Skin Cancer, Director of the Yale Center for Immuno-Oncology, Co-Leader of the Cancer Immunology Program at Yale Cancer Center, and Director of the Center for Precision Cancer Modeling. As a practicing dermatopathologist at Yale Medicine, he specializes in diagnosing skin cancers and inflammatory disorders. Education & Training: BA, Cornell University (1986) PhD, Cornell University Medical College (1993) MD, Cornell University Medical College (1994) Residency: Brigham & Women's Hospital Fellowships: Harvard Medical School Dermatopathology, Dana-Farber Cancer Institute Research Focus: Dr. Bosenberg's laboratory investigates melanoma biology, anti-cancer immune responses, metastasis mechanisms, and therapeutic development. His team pioneered mouse models for melanoma progression and therapy testing, with strong emphases on tumor microenvironment interactions, epigenetic regulation of immunity, and precision cancer modeling. Key research areas include BRAF/MEK signaling pathways, DNA methylation in immunotherapy resistance, and nanoparticle-based drug delivery systems. Publication Trends: His recent articles (2023-2025) demonstrate a strong focus on melanoma immunotherapy resistance mechanisms, tumor microenvironment modulation, and diagnostic innovations. Epigenetic regulation (e.g., DNA methylation, Setdb1) emerges as a recurrent theme, alongside novel approaches to enhance T-cell responses and overcome immune evasion. Nanotechnology applications for targeted drug delivery and advanced molecular diagnostics feature prominently in his translational work. Awards: Yale School of Medicine Basic Science Research Prize (2022) Mentoring & Leadership: Dr. Bosenberg mentors undergraduate, graduate, and medical students along with postdoctoral fellows. He directs multiple research centers and leads the Yale SPORE in Skin Cancer, focusing on translational melanoma research. His laboratory develops patient-derived tumor models for renal cell carcinoma and melanoma studies.