John Iacomini

John Iacomini is a Professor at Tufts University School of Medicine, affiliated with the Department of Immunology and cross-appointed in Genetics, Molecular and Cellular Biology, and other biomedical programs. He has taught courses like Intro to Immunology and Advanced Cellular Immunology since 2011.

• Doctor of Philosophy, Tufts University (1991)
• Bachelor of Science, Syracuse University (1986)

His research focuses on adaptive immune responses, immunological tolerance, and the role of microRNAs in T cell activation and tissue injury responses. Recent work explores how hyperlipidemia and dietary factors influence organ transplant rejection and immune regulation.

His publications since 2015 highlight studies on Treg dysfunction, Th17 cell pathogenicity, microRNA-mRNA interactions in nephrotoxicity, and hormonal modulation of T cells. These studies often intersect transplant immunology and metabolic-immune crosstalk.

Scientific Awards
• NIH Grant: Post-transcriptional regulation of gene expression by microRNAs (2021-2026)
• NIH Grant: Microbial disruption of dendritic cell function (2018-2023)
• NIH Grant: Hyperlipidemia effects on immune memory (2018-2020)
• NIH Grant: Diet-induced transplant rejection (2015-2020)
• American Heart Association Grant: Hyperlipidemia in cardiac rejection (2014)

As a mentor, he has advised graduate students like Christopher Benway and contributed to training programs. His laboratory remains active in uncovering mechanisms of immune tolerance, microRNA regulation, and metabolic influences on transplant outcomes.