جست‌وجوی استاد و پژوهشگر

• DNA Repair Mechanisms
• Genetics
• Pharmacology
• +۷ مورد دیگر

Colin R Campbell is an Associate Professor in the Department of Pharmacology at the University of Minnesota Medical School . His research focuses on DNA repair mechanisms , particularly DNA-protein crosslink repair , homologous recombination , and mitochondrial DNA stability , with significant contributions to understanding cancer mechanisms and genetic toxicology . Research Themes DNA-Protein Crosslink Repair Homologous Recombination Pathways Mitochondrial DNA Maintenance Chemotherapy-Induced DNA Damage Enzymatic Processing Mechanisms Article Trends 2024-2025 work emphasizes transcription-coupled DNA repair and ubiquitin-mediated repair pathways 2020-2023 studies explore mitochondrial crosslink repair and interdisciplinary sustainability leadership 2000-2018 publications cover rad51 interactions , nitrogen mustard effects , and calpain-mediated repair enzyme degradation Grants & Projects NIH/NHLBI: Summer Research (2024-2029) NIH/NIEHS: DNA-Protein Crosslink Repair (2019-2025) NIH/NHLBI: Cellular Repair Mechanisms (2018-2024) Collaborations Natalia Tretyakova (Chemistry) Hoang D Nguyen (Microbiology) Paul B Bitterman (Medicine) Beverly S Moriarity (Genetics)

• Epigenetics
• Host-pathogen interactions
• Microbiology
• +۴ مورد دیگر

Monica Rolando is a researcher at the Institut Pasteur in Paris, France, specializing in the study of intracellular bacterial pathogens, particularly Legionella pneumophila , the causative agent of Legionnaires' disease. She is affiliated with the Biology of Intracellular Bacteria department and teaches in the Pasteur Microbiology Course, sharing her expertise in bacterial pathogenesis and host-pathogen interactions. Dr. Rolando obtained her PhD in Cellular and Molecular Biology from the University of Nice-Sophia Antipolis, where she studied bacterial toxins targeting the host endothelium. In 2009, she joined the laboratory of Carmen Buchrieser at the Institut Pasteur for postdoctoral training, shifting her focus to non-toxin-mediated aspects of host-pathogen interactions. Her research primarily focuses on how bacterial pathogens manipulate host cellular processes, with particular emphasis on epigenetic regulation. Dr. Rolando investigates how Legionella pneumophila employs bacterial effectors that target the host cell nucleus to modify epigenetic marks, thereby subverting host cell functions to facilitate bacterial replication. Her work explores the fascinating co-evolution between L. pneumophila and its eukaryotic hosts, which has led to the acquisition of proteins through horizontal gene transfer that allow the bacterium to mimic eukaryotic functions. Analysis of Dr. Rolando's recent publications reveals a strong focus on patho-epigenetics - the manipulation of host epigenetic machinery by bacterial pathogens. Her research spans molecular mechanisms of bacterial effectors, particularly histone-modifying enzymes like methyltransferases, and their role in subverting host defenses. A significant portion of her work examines how Legionella and related pathogens target chromatin structure and nuclear processes to promote intracellular survival and replication. Dr. Rolando has contributed to numerous collaborative research projects at the Institut Pasteur, working with various research teams investigating bacterial pathogenesis. Her work bridges molecular microbiology, cell biology, and epigenetics, providing novel insights into host-pathogen interactions at the molecular level. Her laboratory focuses on identifying and characterizing bacterial effectors that target host nuclear processes, with particular attention to how these effectors modify epigenetic marks to benefit bacterial replication. This research has important implications for understanding bacterial pathogenesis and potentially developing novel anti-infective strategies targeting pathogen epigenetic manipulation.

Kara Anne Bernsteinمشاهده پروفایل

استاد

• DNA Repair and Recombination
• Breast and Ovarian Cancer
• Double-Strand Break Repair
• +۷ مورد دیگر

Kara Anne Bernstein is the George W. Raiziss Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania. She is actively engaged in research and teaching, with affiliations in the Pharmacology, Cell and Molecular Biology, and Biochemistry and Molecular Biophysics graduate groups. Education: B.A. in Biology, Bryn Mawr College, 2000 M.Phil. in Genetics, Yale University, 2004 Ph.D. in Genetics, Yale University, 2006 (Advisor: Susan Baserga) Postdoctoral Fellow, Columbia University, 2006–2011 (Advisor: Rodney Rothstein) Her research focuses on the molecular mechanisms of DNA double-strand break repair, particularly the role of RAD51 paralogs in maintaining genomic stability and preventing breast and ovarian cancers. Using both budding yeast and mammalian models, her lab investigates how mutations in DNA repair genes contribute to tumorigenesis and how environmental exposures compound cancer risk. She leads a dynamic research team and is deeply involved in training the next generation of scientists. Her recent publications highlight work on variant classification in RAD51C, structural insights into the BCDX2 complex, and the role of RECQL4 in DNA repair. These studies span structural biology, cancer genomics, and molecular diagnostics, reflecting a multidisciplinary approach to understanding cancer development. Her work has significant implications for cancer risk assessment and targeted therapies. Scientific Awards: PA Breast Cancer Coalition Research Award Kara Bernstein has advised numerous PhD students, postdoctoral fellows, and technicians, many of whom have gone on to successful careers in academia, industry, and clinical research. Her lab has received competitive funding supporting research on triple-negative breast cancer and DNA repair mechanisms. She continues to publish in high-impact journals and is a sought-after speaker, recently delivering the Marc J. Mass Memorial Lecture at UNC Chapel Hill. The Bernstein Lab maintains a strong presence in both experimental and translational research, with ongoing projects focused on reclassifying variants of unknown significance, investigating gene-environment interactions in cancer, and targeting alternative DNA repair pathways in homologous recombination-deficient cancers.

Laura Ruscheمشاهده پروفایل

استاد

• Chromatin Biology
• Gene Expression Regulation
• Evolutionary Genomics
• +۳ مورد دیگر

Laura Rusche is a Professor in the Department of Biological Sciences at the University at Buffalo. Her research focuses on chromatin structure, gene expression regulation, and evolutionary mechanisms in yeast. She investigates how sirtuins and heterochromatin proteins like Sir3 contribute to epigenetic control and respond to metabolic stress. Her work spans multiple yeast species to understand evolutionary adaptations in protein functions and transcriptional circuits. Education: BS from Yale University (Molecular Biophysics & Biochemistry), PhD from Johns Hopkins University (Biochemistry), and postdoctoral training at UC Berkeley. Research Interests: Chromatin dynamics, sirtuin-mediated epigenetic regulation, gene duplication consequences, and fungal pathogen biology. Key projects include studying Sir2's role in NAD+ stress responses and the evolution of Sir3 from replication proteins. Lab: The Rusche Lab explores centromere stability, heterochromatin formation in Candida species, and evolutionary genomics. Recent work highlights unique centromere structures in Candida auris and the functional divergence of sirtuins across yeasts.

Prerna Jasmine Masihمشاهده پروفایل

استادیار

• Biochemistry
• Cell Biology
• Drug Discovery
• +۵ مورد دیگر

Dr. Prerna Masih is an Assistant Professor in the Department of Biology at the University of West Florida's Hal Marcus College of Science and Engineering. She specializes in biochemistry and cell biology with research focusing on developing novel therapeutic agents including antibacterial, antifungal, anti-inflammatory, and anticancer compounds. Her interdisciplinary approach integrates microbiology, biochemistry, structural biology, pharmacology, cell biology, organic chemistry, and computational biology. Education: Postdoctoral Fellow, National Institutes of Health (NIH), Bethesda, MD Ph.D. in Cellular and Molecular Biology, Roswell Park Cancer Institute, SUNY at Buffalo M.S. Biotechnology, Indian Institute of Technology Bombay B.S. Chemistry, St. Stephens College, Delhi University Her research utilizes diverse tools to investigate the mode of action of therapeutic agents. Current courses include Biochemistry lectures and labs. Her publications appear in high-impact journals including Nucleic Acid Research and Pharmaceuticals.

• Structural Biology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Nancy C. Horton is a Professor in the Department of Molecular and Cellular Biology at the University of Arizona, with joint faculty appointments in Biochemistry. Her research focuses on understanding the structures and mechanisms of proteins involved in DNA and RNA processing, particularly enzymes that modulate their activity through filament formation. She leads the Horton Lab, which employs structural techniques like X-ray crystallography, NMR, and cryo-electron microscopy alongside biochemical and high-throughput methods. Dr. Horton received her B.S. in Chemistry from Southern Illinois University (1986) and Ph.D. in Biological Chemistry from the University of Pennsylvania (1994). She completed postdoctoral training at The Upjohn Company and the University of California, Santa Barbara, before establishing her independent lab at the University of Arizona in 2001. Her work has contributed significantly to understanding enzyme filamentation in cellular defense mechanisms and host-virus interactions, particularly with Human Parvovirus B19. Research interests include structural biology, biophysics, and the functional implications of protein filaments. Her lab has elucidated the structural basis of enzyme activation via filamentation and its role in DNA cleavage specificity. She also engages in education initiatives, teaching courses on the molecular basis of life and professional development for graduate students. Key contributions include the discovery of enzyme filamentation as a regulatory mechanism and structural studies of SgrAI and NS1 proteins. The lab collaborates broadly, leveraging multi-scale modeling and experimental approaches to study macromolecular complexes. Dr. Horton’s work bridges basic science and translational research, with implications for antiviral drug development and understanding fundamental biological processes.

Alanna (Leni) Greenمشاهده پروفایل

پژوهشگر ارشد

• Bone-Immune-Cancer Interactions
• Cancer Dormancy
• Retinoic Acid Receptor Signaling
• +۳ مورد دیگر

Dr. Alanna (Leni) Green is a Senior Research Fellow at the School of Medicine and Population Health, University of Sheffield. She leads the Cancer and Bone (CAB) Lab, focusing on eradicating chemotherapy-resistant dormant cancer cells in bone. Her academic journey includes a BBiomedSci at Monash University, a PhD at the University of Melbourne, and postdoctoral roles in the Sheffield Myeloma Research Team and Helleday’s lab. Education: BBiomedSci (Hons), Monash University PhD, University of Melbourne Her research explores bone-immune-cancer interactions, particularly how bone microenvironment cells protect tumors from therapy. Key areas include retinoic acid receptor signaling, vitamin A regulation of hematopoiesis, and novel drug development for myeloma and bone-metastatic cancers. Recent publications highlight her work in cancer metabolism (MTHFD2 inhibition), bone repair mechanisms, and microenvironmental regulation of lymphopoiesis. She has received over 20 awards, including Young Investigator Prizes from ECTS and ASBMR. Scientific Awards: Wellcome Trust Career Development Award (2024) Yorkshire Cancer Research Pioneer Advanced Fellowship (2024) Blood Cancer UK Project Grant (2023) Faculty MDH Early Career Researcher Prize (2020) Dr. Green supervises the Cancer and Bone Lab, which includes postdoctoral researchers and PhD students. She lectures on translational oncology and molecular medicine courses and actively contributes to professional societies like the Bone Research Society and ECTS.

Kevin T. Vaughanمشاهده پروفایل

دانشیار

• Cell Biology
• Cancer Biology
• Neurodegenerative Diseases
• +۷ مورد دیگر

Kevin T. Vaughan is an Associate Professor in the Department of Biological Sciences at the University of Notre Dame, with a research focus on the cell biology of cancer and neurodegenerative diseases. He is a member of the Harper Cancer Research Institute and conducts mechanistic studies on mitosis, organelle transport, and cholesterol trafficking. Research Interests: Cell Biology of human diseases Mitosis and cell cycle regulation Neurodegeneration, particularly Niemann-Pick Type C disease Cancer therapeutics and combinatorial drug treatments Cholesterol transport mechanisms Cytoplasmic dynein function in cellular dynamics His research employs mass spectrometry and animal models to investigate novel regulatory pathways in mitosis and to develop new therapies for pancreatic and breast cancer. The lab has discovered a new cholesterol transport pathway disrupted in NPC disease and is exploring potential corrective strategies. Recent Research Trends: Dr. Vaughan's recent publications emphasize the role of cytoplasmic dynein in mitotic processes, kinetochore dynamics, and organelle transport. His work bridges fundamental cell biology with translational applications in cancer and rare genetic disorders. Key themes include motor protein regulation, mitotic spindle assembly, and intracellular trafficking defects in disease. Scientific Affiliations: Member, Harper Cancer Research Institute Faculty, College of Science, University of Notre Dame Advising and Research Support: As a principal investigator, Dr. Vaughan leads a research laboratory focused on cellular mechanisms of disease. He collaborates on interdisciplinary projects related to cancer therapeutics and neurodegeneration. His lab receives institutional support through the University of Notre Dame and the Harper Cancer Research Institute, enabling studies in both basic and applied biomedical research. Laboratory and Team: The Vaughan Laboratory is based in the Galvin Life Science Center and conducts research on mitotic regulation and cholesterol transport. The team utilizes biochemical, cellular, and imaging approaches to study disease mechanisms and test novel therapeutic strategies in model systems.

Christoph Benningمشاهده پروفایل

استاد

• Lipid metabolism
• Photosynthetic organisms
• Chloroplast membrane assembly
• +۳ مورد دیگر

Christoph Benning is a University Distinguished Professor at Michigan State University, holding appointments in the Department of Biochemistry & Molecular Biology , Molecular Plant Sciences Program , Plant Biology , and Genetics & Genome Sciences Program . He leads the MSU-DOE Plant Research Laboratory and contributes to the Cell & Molecular Biology Program and BioMolecular Science Gateway . Ph.D., 1991, Michigan State University M.S., 1986, Albert-Ludwigs Universitaet, Freiburg, Germany Postdoctoral Researcher, 1991-1993, Michigan State University Group Leader, 1993-1997, Institut fuer Genbiologische Forschung Berlin GmbH His research centers on lipid metabolism in photosynthetic organisms , with a focus on chloroplast membrane assembly, lipid remodeling under stress, and biofuel production from algae. His lab uses Arabidopsis and Chlamydomonas to study genetic and biochemical mechanisms governing lipid biosynthesis, stress tolerance, and cellular quiescence in algae. Recent publications highlight advancements in chloroplast nanofactories , ER-chloroplast lipid transport , and WRINKLED1 transcription factor engineering to boost lipid accumulation. These works span synthetic biology , metabolic engineering , and environmental stress responses in plants and algae. Scientific Awards : Fellow of the American Society of Plant Biologists (2025), Member of the National Academy of Sciences (2025), Senior Member of the National Academy of Inventors (2022), and multiple teaching/mentoring awards. Advising : Recognized for mentoring graduate and postdoctoral researchers. Labs & Collaborations : Leads the Benning Lab at MSU, with DOE-funded projects and partnerships in algal biofuel research.

Shengwu Liمشاهده پروفایل

استاد

• Behavioral Economics
• Oncology
• Molecular Biology
• +۳ مورد دیگر

Shengwu Li is a Professor of Economics at Harvard University’s Department of Economics, affiliated with the Faculty of Arts and Sciences (FAS). He previously served as a Junior Fellow of the Society of Fellows. His research spans behavioral economics theory and molecular oncology, focusing on mechanisms of cancer drug resistance, targeted therapies, and epigenetic regulation in tumors. He has contributed to understanding KRAS inhibition resistance, HER2 exon 20 insertion mutations, and synergistic immunotherapies combining epigenetic modifiers with immune checkpoint blockade. Education details not explicitly listed in the text. Research interests include behavioral economic models of decision-making under uncertainty, coupled with experimental studies in cancer biology. His work bridges theoretical economics and translational oncology, addressing challenges in precision medicine and drug development. Recent studies explore therapeutic efficacy of CDK7 inhibitors in pancreatic cancer and mechanisms of adeno-to-squamous transition in lung tumors. Notable achievements include the Junior Fellow distinction, highlighting early-career excellence in interdisciplinary research. Collaborative projects involve preclinical models of tumor organoids and ex vivo patient-derived spheroids to identify combination therapies for HER2-mutant lung cancers.

Kathleen Mulvaneyمشاهده پروفایل

استادیار

• Cancer Biology
• Protein-Protein Interactions
• Cancer Therapeutics
• +۷ مورد دیگر

Kathleen Mulvaney is an Assistant Professor at the Fralin Biomedical Research Institute at Virginia Tech and in the Department of Biomedical Sciences and Pathobiology at the Virginia-Maryland College of Veterinary Medicine. Her laboratory is located at the Children's National Research & Innovation Campus in Washington, D.C., where she leads research efforts focused on cancer biology and therapeutic development. Dr. Mulvaney's educational background includes: Ph.D. in Cell Biology from the University of North Carolina, Chapel Hill B.S. in Biology from the University of Rochester Dr. Mulvaney's research program centers on understanding and disrupting protein-protein interactions and protein modifications in cancer, with particular focus on pancreatic cancer and pediatric and adult brain cancers. Her laboratory investigates tumor dependencies - the specific enzymes and pathways that cancers rely on for survival - with the goal of translating these findings into meaningful clinical improvements for patient care. A significant portion of her recent work has focused on PRMT5, an enzyme found in approximately 15% of human cancers, exploring how to target this enzyme for therapeutic benefit. Her research employs CRISPR gene editing, molecular biology techniques, and biochemical approaches to identify vulnerabilities in cancer cells. Her laboratory has made significant contributions to understanding the molecular basis of substrate recruitment to the PRMT5 methylosome and has discovered first-in-class inhibitors of the PRMT5-substrate adaptor interaction. Recent work published in Cancer Research demonstrates a promising combination therapy approach for hard-to-treat cancers that lack specific tumor suppressor genes. These cancers, which include certain lung, brain, and pancreatic tumors, become dependent on PRMT5 for survival, making it a potential therapeutic target. Dr. Mulvaney has received numerous scientific awards and honors, including: National Institutes of Health F32 Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (2018-2021) National Institutes of Health LRP Award (2019-2021) Sigma Xi Research Society Graduate Student Travel Award (2015) National Science Foundation Graduate Research Fellowship Honorable Mention (2011, 2012) Dr. Mulvaney actively mentors graduate students and postdoctoral researchers in her laboratory at the Children's National Research & Innovation Campus. Her research is supported by grants from the National Institutes of Health, including an R35 grant to examine cancer-related enzymes. She collaborates extensively with researchers across Virginia Tech and Children's National Hospital to advance cancer research and therapeutic development, participating in the Virginia Tech Cancer Research Alliance which brings together scientists and physicians to develop innovative approaches to cancer treatment. The Mulvaney Lab is part of the Cancer Research Center - D.C. at the Children's National Research & Innovation Campus, where they work alongside other researchers in the Children's Cancer and Immunobiology Center. This collaborative environment allows for interdisciplinary approaches to understanding cancer biology and developing novel therapeutic strategies, with particular emphasis on translating basic science discoveries into clinical applications for hard-to-treat cancers.

Jill A Kreilingمشاهده پروفایل

دانشیار

• Aging Biology
• Molecular Biology
• Cell Biology
• +۴ مورد دیگر

Jill A Kreiling is an Associate Professor (Research) in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University School of Medicine. She also serves as the Associate Director of the Brown Center on the Biology of Aging since July 2018. Her research focuses on the molecular mechanisms of aging, particularly examining the role of transposable elements, epigenetic changes, and cellular senescence in the aging process. Dr. Kreiling's research interests span several key areas in aging biology and molecular mechanisms of age-related changes. Her work has significantly contributed to understanding how retrotransposable elements become active during aging, how heterochromatin formation changes with age, and how these molecular changes impact tissue function and age-related diseases. She has developed innovative approaches to study aging processes using various model systems including mouse models, zebrafish, and cell culture systems. Her research program has been consistently supported by NIH funding, including her current role as Principal Investigator on an R01 grant focused on identifying biomarkers in salivary vesicles for preclinical Alzheimer's disease. She has published extensively in high-impact journals including Nature, Cell, and Aging Cell, with her work being cited widely in the aging research community. Dr. Kreiling has received several prestigious awards including the Mentored Research Scientist Development Award (K01) from the National Institute on Aging (2011-2017). Her collaborative network includes prominent researchers in the aging field such as John Sedivy and Nicola Neretti at Brown University. As an educator, Dr. Kreiling has taught Introductory Microbiology and has mentored numerous students and postdoctoral fellows in her laboratory. Her research program provides valuable training opportunities for students interested in aging research, molecular biology, and translational approaches to age-related diseases.

Rahul Siddharthanمشاهده پروفایل

پژوهشگر

• Bioinformatics
• Regulatory Genomics
• Chromatin Structure
• +۶ مورد دیگر

Rahul Siddharthan is a computational biologist at The Institute of Mathematical Sciences (IMSc), Chennai , with research interests spanning bioinformatics algorithms, regulatory genomics, chromatin structure, evolutionary biology, and machine learning applications in clinical outcomes. He holds a PhD in Physics from the Indian Institute of Science, Bangalore, and transitioned to biology during a postdoc at the Rockefeller University, New York. At IMSc, he has led the Computational Biology group since 2013 and contributed to a new PhD program in this field. PhD: Physics, Indian Institute of Science, Bangalore Postdoc: Rockefeller University, New York Current Affiliation: IMSc, Chennai Leadership: Computational Biology group (since 2013) Research Interests include: Bioinformatics Algorithms Regulatory Genomics Chromatin Structure Evolutionary Biology Machine Learning in Clinical Data His recent publications focus on machine learning for fetal growth prediction , clustering methods for clinical data , and evolutionary analysis of fungal pathogens . He actively supervises PhD students and collaborates with medical institutions like Apollo Hospitals and Warwick Medical School. Rahul also organizes interdisciplinary workshops such as 'Machine Learning for Health and Disease' at ICTS Bengaluru and 'Aspects of Gene and Cellular Regulation' at IMSc. Advising and Collaborations involve mentoring current PhD students Sankarsan Dutta and Akash Sivaraman, with past advisees including Pavitra S (defended 2025), Chandrani Kumari (submitted 2024), and Rakesh Netha Vadnala (PhD 2023). Key collaborators include Dr. Uma Ram (Seethapathy Clinic), Leelavati Narlikar (IISER Pune), and Ponnusamy Saravanan (Warwick). Technical Contributions include developing algorithms like THiCweed for ChIP-seq motif discovery and ClaID for Candida auris clade identification. His group engages in projects related to chromatin organization , transcription factor interactions , and genomic data analysis .

Peter Matthiasمشاهده پروفایل

استاد

• Biochemistry
• Cell Biology
• Cell division
• +۷ مورد دیگر

Matthias Peter is a Professor of Biochemistry at ETH Zurich, leading research into mechanisms governing cell growth and division. His laboratory focuses on ubiquitin-dependent regulation of DNA replication and mitosis, and autophagy's role in cellular quality control. He chairs the Department of Biology (2011-2015) and holds leadership roles in Switzerland's research infrastructure, including Vice Chair of ScopeM's microscopy platform. His academic career includes roles at ISREC (1996-2002) and postdoctoral training at UCSF (1991-1996). Education: PhD in Biochemistry from ISREC (1991), ETH Zurich diploma in Gene Technology (1987). Research interests span molecular mechanisms of cell division, ubiquitin systems, and autophagy. Awards include ERC Advanced Grant (2011) and UBS Excellence in Research (2002). Leadership: Member of Swiss National Research Council, SNF selection committee, and SWTR council. Over 20 years of committee service in national research programs. His lab's work is published in top journals like Science, Nature, and Molecular Cell.

Timothy Grantمشاهده پروفایل

استادیار

• Cryo-electron microscopy (cryo-EM)
• Structural biology
• Computational imaging
• +۴ مورد دیگر

Timothy Grant is an Assistant Professor of Biochemistry at the University of Wisconsin–Madison and an Investigator at the Morgridge Institute for Research , embedded within the John W. and Jeanne M. Rowe Center for Research in Virology . His laboratory, the Grant Lab , focuses on pushing the limits of cryo-electron microscopy (cryo-EM) to visualize ever-smaller and more dynamic biological macromolecules. Education & Academic Home: Faculty appointment: Assistant Professor, Department of Biochemistry, UW–Madison College of Agricultural and Life Sciences. Concurrent appointment: Morgridge Institute Investigator, Rowe Center for Research in Virology. Research Interests: The Grant group develops computational and experimental methods that extend cryo-EM into two major frontiers: size —capturing structures of very small proteins previously invisible to cryo-EM—and motion —resolving conformational changes of molecular machines in real time. These advances are integrated into the open-source software package cisTEM , which provides a user-friendly workflow for single-particle image processing. Publication Trends: Across the 15 most recent papers (2021-2025), Grant’s work spans method-centric algorithmic innovation, high-resolution structural studies of bacterial DNA replication-restart machinery, and integrative technologies that couple native mass spectrometry with cryo-EM. A clear trajectory emerges from tool development toward application in virology and antibiotic-target validation. Scientific Awards: None explicitly mentioned in the provided text. Students & Research Team: Grant currently mentors six graduate students (Colin Hemme, Gan Li, Heidy Elkhaligy, Peter Ducos, Roma Broadberry, Shashwat Shastri) and several postdoctoral researchers and staff, including Alex Duckworth, Raison Dsouza, and Tim Wagner. Laboratory & Collaborations: The Grant Lab is physically located within UW–Madison’s Biochemistry Building and leverages the Center for High-Throughput Computing shared between UW–Madison and Morgridge to perform large-scale cryo-EM data processing.