جست‌وجوی استاد و پژوهشگر

Dieter Braunمشاهده پروفایل

استاد

• Origins of Life
• Prebiotic Chemistry
• Molecular Evolution
• +۵ مورد دیگر

Dieter Braun is a Professor in the Faculty of Physics at Ludwig Maximilian University of Munich (LMU), leading the Functional NanoSystems research group. He serves as speaker of the CRC 235 Emergence of Life and coordinates the Molecular Origins component of the Origins Cluster. Dr. Braun holds an ERC Synergy Grant (starting April 2025), leads the CRC 392 Molecular Evolution (starting April 2024), and is a Fellow in the Max Planck School Matter to Life (since October 2023). His research focuses on understanding the physical mechanisms that could have led to the emergence of Darwinian evolution from prebiotic molecules on early Earth. Braun's laboratory investigates non-equilibrium settings, particularly asymmetrically heated open cracks in rocks, which create intricate wet-dry cycles, temperature gradients, and fluidic effects that could drive molecular evolution. His work bridges physics, chemistry, and biology to explore how dead molecules might combine through physical forces into autonomous mechanisms of evolution. Analysis of Braun's recent publications reveals a strong focus on thermal gradients and non-equilibrium physics in prebiotic environments. His research demonstrates how heat flows can concentrate molecules, drive polymerization, create pH gradients, and enable non-enzymatic replication of nucleic acids. The publications span high-impact journals including Nature, Nature Physics, and Nature Chemistry, showing interdisciplinary work connecting physics, chemistry, geology, and biology in the context of life's origins. Klung-Wilhelmy Weberbank Price (2011) Technology Transfer Price of the DPG (with LMU and NanoTemper) Deutscher Innovationspreis (2012) Step Award (2012) Dr. Braun has successfully mentored numerous PhD students, including Stefan Duhr and Philipp Baaske who founded the award-winning startup NanoTemper Technologies. His research is supported by multiple prestigious grants including ERC Starting, Advanced, and Synergy Grants, as well as funding from the Simons Collaboration on the Origins of Life. His laboratory collaborates extensively with other researchers across disciplines and institutions, particularly with Hannes Mutschler in the new ERC Synergy project. The Braun laboratory operates within the CRC 235 Emergence of Life and the Origins Cluster at LMU Munich, with strong connections to the Max Planck Society through the Max Planck School Matter to Life. The research group maintains active collaborations with geochemists, biophysicists, and molecular biologists to create comprehensive experimental models of prebiotic environments.

Jacques Archambaultمشاهده پروفایل

استاد

• Human Papillomavirus (HPV)
• Polyomavirus
• Viral DNA Replication
• +۴ مورد دیگر

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

Kumar Somyajitمشاهده پروفایل

دانشیار

• DNA Repair Mechanisms
• Genome Stability
• Replication Stress
• +۴ مورد دیگر

Kumar Somyajit is Associate Professor at the University of Southern Denmark's Department of Biochemistry and Molecular Biology. He leads research on DNA replication and genome surveillance mechanisms using mammalian cell models. Research focuses on: Metabolic regulation of DNA replication Replisome plasticity under stress Homology-directed repair mechanisms Chromatin dynamics in cancer Recipient of Lundbeck Foundation Fellowship (2021). Current projects investigate metabolic coupling to genome surveillance in cancer and development. Supervises PhD students in DNA repair and replication studies.

Alexander J. Harteminkمشاهده پروفایل

استاد

• Computational Biology
• Machine Learning
• Genomics
• +۵ مورد دیگر

Professor Alexander J. Hartemink holds dual appointments in the Department of Computer Science and Department of Biology at Duke University, Trinity College of Arts & Sciences. He is also a Bass Fellow in Computer Science. His research focuses on computational biology, machine learning, and systems biology, with applications to genomics, epigenomics, and transcriptional regulation. Hartemink leads the Duke Office of University Scholars and Fellows and has directed the Computational Biology and Bioinformatics graduate program. He earned a PhD from MIT (2001), MPhil from the University of Oxford (1996), and BS from Duke (1994). Research Interests His work integrates computational methods to study chromatin dynamics, transcriptional networks, and epigenetic mechanisms. Key areas include modeling chromatin accessibility, predicting transcription factor binding, and understanding cell-cycle regulation. Techniques employed include Bayesian networks, dynamic systems modeling, and machine learning algorithms. Publications & Trends Recent work emphasizes single-cell multi-omics integration, chromatin occupancy modeling (RoboCOP framework), and transcriptional regulation in response to genetic perturbations. Themes include epigenetic plasticity, disease-associated enhancers, and systems-level analysis of gene expression. Awards & Grants Hartemink has received the Sloan Research Fellowship (2005) and NSF CAREER Award (2004). Active grants include NIH funding for chromatin-transcription interplay studies and NSF support for regulatory genome research. He collaborates on projects like the Data+ initiative, promoting interdisciplinary data science. Affiliations & Labs Associated with Duke’s Center for Genomic and Computational Biology and Center for Advanced Genomic Technologies. His lab develops computational tools for genomic analysis, including software for chromatin modeling and epigenetic data integration.

• Biomolecular Systems
• Synthetic Biology
• Stochastic Thermodynamics
• +۷ مورد دیگر

Thomas Ouldridge is a Royal Society University Research Fellow and Reader in Biomolecular Systems at the Department of Bioengineering, Faculty of Engineering, Imperial College London. He leads the 'Principles of Biomolecular Systems' group, which focuses on theoretical and computational modeling of complex biochemical systems, particularly exploring the interplay between molecular details and emergent behaviors like sensing, replication, and self-assembly. His work integrates natural systems analysis with synthetic biology applications, aiming to engineer artificial analogs of biological processes. His research spans interdisciplinary areas including stochastic thermodynamics, DNA-based computation, and molecular reaction networks. Key affiliations include the Physics of Life, Synthetic Biology Hub, and the Leverhulme Centre for Cellular Bionics. He has contributed to over 60 peer-reviewed articles since 2009, with recent work emphasizing energy-efficient molecular information processing and thermodynamic limits of biochemical systems. Awards: Royal Society University Research Fellowship (current). Labs/Teams: Principles of Biomolecular Systems Group, collaborating with multiple centers including the Centre for Synthetic Biology and Institute of Chemical Biology. Grants/Positions: Maintains research funding through the Royal Society and UKRI grants, focusing on non-equilibrium biomolecular systems and synthetic biology tools. Recent publications highlight advances in DNA templating networks, stochastic thermodynamic modeling of computation, and optimal protocols for molecular copying systems. His work bridges foundational physics with applied biotechnology, aiming to push the boundaries of synthetic biological engineering.

• Genomic Instability
• DNA Replication and Repair
• Computational Biology
• +۵ مورد دیگر

Dr Michael Boemo is an Assistant Professor at the University of Cambridge, holding dual appointments in the Department of Pathology and Department of Genetics. He leads research at the intersection of computational biology, DNA replication, and cancer genomics, developing machine learning tools to analyze replication stress and genomic instability. Academic Background: BA in Mathematics (Rutgers University), PhD in Physics (University of Oxford) Research Focus: Genomic instability in cancer, DNA replication/repair defects, computational modeling using machine learning and high-performance simulations Teaching: Lectures in Natural Sciences Tripos (mathematical biology, genetics, systems biology), module organizer for cancer biology and biological modeling His research group leverages nanopore sequencing and AI to map replication fork dynamics, revealing how stalled forks generate mutations in cancer cells and pathogens. Recent work examines extrachromosomal DNA replication vulnerabilities and transcription-replication conflicts. Dr Boemo collaborates across computational biology and cancer research domains, with publications spanning journals like Nature Methods, Cell, and PLoS Computational Biology. His lab develops tools such as DNAscent for replication fork analysis and explores therapeutic targeting of replication stress.

Andrew Murrayمشاهده پروفایل

استاد

• Evolutionary Biology
• Genetics
• Synthetic Biology
• +۹ مورد دیگر

Andrew Murray is a Professor at Harvard University, affiliated with the Rowland Institute and Department of Molecular and Cellular Biology. His research focuses on evolutionary biology, genetics, and synthetic biology using budding yeast as a model organism. Primary Affiliation: Harvard University Lab: Murray Lab Collaboration: with David Nelson (Physics/MBI) Research interests include: Evolution of biological novelty through experimental evolution Cellular mechanisms for environmental adaptation Quantitative analysis of evolutionary trajectories Engineering yeast strains to test biological principles Publications span evolutionary genetics, cell biology, and biophysics with recent work on ABC transporters and yeast colony dynamics. Collaborative clinical publications also exist in cardiology and surgical outcomes. Scientific recognition includes the John Harvard Distinguished Science Fellowship .

Nynke Dekkerمشاهده پروفایل

استاد

• DNA replication
• RNA replication
• Single-molecule biophysics
• +۷ مورد دیگر

Professor Nynke Dekker leads the Nynke Dekker Lab at the Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology. Her research focuses on unraveling the dynamics of DNA and RNA replication through single-molecule biophysics and advanced biochemical approaches. The lab will relocate to the University of Oxford in summer 2024. BSc (Physics & Applied Mathematics) - Yale University MSc (Physics) - Leiden University PhD (Physics) - Harvard University Using state-of-the-art single-molecule fluorescence and force spectroscopy techniques, her lab investigates: Real-time tracking of replication machinery Interactions in eukaryotic, bacterial, and viral systems Chromatin and epigenetic replication dynamics Biomedical applications of replication studies Drug-induced mutation mechanisms Physiological condition monitoring The lab's publications highlight technological innovations (e.g., integrated force-fluorescence microscopy) and mechanistic studies of replication processes, with applications in both fundamental biology and biomedical research.

• Genetics
• Molecular Biology
• Microbiology
• +۵ مورد دیگر

Robert G. Fowler is a Lecturer in the Department of Biological Sciences at San José State University (SJSU). He holds a Doctor of Philosophy from Iowa State University, awarded in 1972. His academic focus spans genetics, molecular biology, and microbiology, with a particular emphasis on DNA repair mechanisms, mutagenesis pathways in Escherichia coli , and science education for non-science majors. His research has explored interactions among DNA repair pathways, spontaneous mutagenesis, and the impact of genetic fidelity on bacterial systems. Education: Doctor of Philosophy, Iowa State University, 1972 Dr. Fowler’s research interests include understanding how bacteria maintain genetic stability through enzymatic pathways like MutT, MutM, and MutY, as well as investigating the educational strategies for integrating genetics into introductory biology courses. His publications reflect a balance between experimental molecular genetics and pedagogical advancements in science education. His articles highlight contributions to the study of DNA damage prevention, postreplication repair mechanisms, and the role of specific alleles in mutagenesis. While no scientific awards are explicitly listed, his work demonstrates sustained engagement with fundamental biological processes and undergraduate education. No advising roles or grant information are documented in the provided materials, and no affiliated labs or research teams are mentioned.

• Structural Biology
• Cryo-Electron Microscopy
• Epigenetic Regulation
• +۵ مورد دیگر

Wanqiu Li is an Assistant Professor and doctoral supervisor in the Department of Pharmacology at the School of Medicine, Southern University of Science and Technology (SUSTech). She specializes in structural biology with a focus on cryo-electron microscopy to investigate disease-related protein complexes and epigenetic regulation mechanisms. Education: B.Sc. in Horticulture, College of Agriculture and Biotechnology, China Agricultural University (2008-2012) Ph.D. in Biophysics & Structural Biology, School of Life Sciences, Tsinghua University (2012-2017) Dr. Li's research focuses on understanding molecular mechanisms of chromatin regulation and disease-related protein complexes using cryo-EM combined with biochemical, molecular, and cellular approaches. Her work particularly emphasizes epigenetic regulation through histone methylation processes, NSD family proteins, and nucleosome-level gene regulation. Her structural insights provide foundations for developing therapeutic interventions for related diseases. The laboratory actively investigates molecular mechanisms related to epigenetic regulation using state-of-the-art cryo-EM technology. Her publication record demonstrates consistent high-impact contributions to structural biology, with multiple papers in Nature , Cell Discovery , and PNAS . The research spans from fundamental structural insights into Piezo1 channels and MCM complexes to more recent work on epigenetic regulation mechanisms involving histone methylation. A notable trend shows increasing focus on nucleosome-level epigenetic regulation in her most recent publications, particularly in H3K36 and H4K20 methylation pathways. Scientific Awards: 2023 Shenzhen Youth Science and Technology Award Shenzhen National Leading Talent for High-Level Talents 2022 Shenzhen Excellent Youth 2023 Guangdong Province Young Talents SUSTech President's Outstanding Postdoctoral Fellow (2017) Dr. Li serves as a doctoral supervisor and has secured competitive research funding including the National Natural Science Foundation of China, Shenzhen Excellent Young Scientists program, and Shenzhen Higher Education Stable Support Program. Her laboratory actively recruits PhD students and research staff to advance structural investigations of disease-related molecular mechanisms. She has led projects including the National Natural Science Foundation of China and Shenzhen Higher Education Stable Support Program. Her research is conducted through the Cryo-Electron Microscopy Center at SUSTech, leveraging state-of-the-art instrumentation for high-resolution structural analysis of macromolecular complexes. The lab maintains collaborations with international institutions including Peter MacCallum Cancer Centre in Australia, where she previously served as an Honorary Visiting Scientist. Her work bridges structural biology with disease mechanisms to provide new insights for drug development.

Alexandra Berroyerمشاهده پروفایل

استادیار

• DNA Structure
• DNA Repair
• Genomic Instability
• +۲ مورد دیگر

Alexandra Berroyer serves as an Assistant Professor in the Department of Biological Sciences at St. Mary's University, San Antonio, Texas. Her research program investigates the biological roles of non-canonical DNA structures, particularly G-quadruplexes (G4s), and their implications for genomic instability and cancer pathogenesis using human cell cultures and yeast models. Her academic credentials include: Ph.D. in Microbiology and Molecular Genetics from The University of Texas M.D. Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston M.S. in Biotechnology from Illinois State University B.S. in Biology from Millikin University Following her doctoral work, she completed a postdoctoral fellowship at the Harvard T.H. Chan School of Public Health. Dr. Berroyer's research centers on G-quadruplex DNA structures—four-stranded configurations formed in guanine-rich genomic regions. She examines how regulated G4 formation controls gene expression versus dysregulated G4s that cause DNA replication stress and genomic instability, ultimately driving carcinogenesis. Her laboratory employs molecular, genetic, and biochemical approaches to dissect interactions between G4 structures and DNA repair machinery, with particular focus on topoisomerases, nucleolin, and AP endonucleases. Analysis of her 2015-2022 publications reveals dominant themes in G-quadruplex biology across molecular genetics and cancer research. Key trends include structural characterization of G4-forming genomic regions, mechanistic studies of repair enzyme dysfunction at G4 sites, and exploration of metabolic influences on DNA repair. Her work bridges fundamental genome maintenance mechanisms with disease pathogenesis, featuring one interdisciplinary study in entomological behavior. Dr. Berroyer actively mentors undergraduate researchers, as evidenced by co-authorship patterns in her publications. Her laboratory operations are supported by institutional resources at St. Mary's University, with collaborative networks extending to Harvard and University of Texas researchers. Current projects investigate how DNA repair factors regulate cellular G4 homeostasis and the consequences of G4 dysregulation for genome integrity. Her research laboratory specializes in DNA structure-function analysis, utilizing yeast genetics and human cell models to probe G-quadruplex dynamics. The team employs chromatin immunoprecipitation, fluorescence microscopy, and in vitro reconstitution assays to characterize protein-G4 interactions and their impact on replication fidelity. Future work aims to translate mechanistic insights into therapeutic strategies for G4-associated cancers.

Xiaojiang Chenمشاهده پروفایل

استاد

• Cancer Biology
• Immunology
• Virology
• +۸ مورد دیگر

Dr. Xiaojiang Chen is a Professor at the University of Southern California, holding appointments in the Departments of Biological Sciences and Chemistry. He is also the Director of the Center of Excellence in NanoBiophysics and a member of the Norris Cancer Center. Dr. Chen earned his Ph.D. in Biochemistry and Molecular Biology from the University of California, Davis, and completed postdoctoral training at Harvard University. His research spans cancer biology, immunology, virology, and structural biology, focusing on DNA replication/repair enzymes, APOBEC deaminases, and viral oncoproteins. Cancer Biology: Investigates DNA-modifying enzymes in genomic instability and tumor suppression. Immunology: Studies APOBEC3G and CR2-C3d interactions in antiviral defense. Virology: Analyzes HIV, HPV, and SARS-CoV-2 protein structures for therapeutic targets. Nanobiophysics: Develops protein nanoparticles for gene delivery. His recent publications highlight structural insights into APOBEC3G/3H and Polθ, with implications for cancer therapy and HIV restriction. He has received prestigious awards including AAAS Fellowship and Howard Hughes Medical Institute support. Scientific Awards: AAAS Fellow (2017) American Cancer Society Young Investigator (2003) Howard Hughes Medical Institute Junior Faculty Award (2000) Grants: NIH R01 grants on DNA repair and APOBEC3G structure-function.

Alan Waldmanمشاهده پروفایل

استاد

• Cancer Biology
• Biology of Cellular Stress
• Homologous Recombination
• +۲ مورد دیگر

Alan Waldman is a Professor in the Department of Biological Sciences at the University of South Carolina's College of Arts and Sciences. His research focuses on homologous recombination, DNA repair mechanisms, and their implications in cancer biology and genomic instability. He has pioneered experimental systems to study double-strand break repair and sequence divergence tolerance in mammalian chromosomes. Cancer Biology Biology of Cellular Stress Homologous Recombination DNA Repair Genome Stability Dr. Waldman's work explores how mammalian cells maintain genetic fidelity through stringent homology requirements, yet allow recombination under pathological conditions like cancer or aging. His recent studies investigate the role of proteins such as progerin and Bloom helicase in modulating repair pathways. Analysis of his 15 most recent articles reveals trends in understanding DNA repair under stress, mismatch tolerance, and the interplay between aging proteins and genomic instability. Key themes include double-strand break dynamics, chemotherapeutic responses, and recombination errors in disease contexts.

• Genome Stability
• Chromosomal Instability
• Cancer Biology
• +۵ مورد دیگر

Rui Cui is a Guest Researcher at the University of Copenhagen's Faculty of Health and Medical Sciences, Department of Cellular and Molecular Medicine, and Molecular Aging Program, based in Copenhagen, Denmark. Contactable via phone (+4535324771) and email (cuirui@sund.ku.dk), Cui investigates chromosomal instability mechanisms and their impact on human diseases including cancer, neurodegeneration, and infertility. Research centers on genome maintenance pathways, with emphasis on common fragile sites as models for difficult-to-replicate genomic regions and the characterization of ultra-fine anaphase bridges (UFBs)—DNA structures connecting sister chromatids during mitosis. UFBs are coated with proteins like PICH and BLM helicase (mutated in Bloom's syndrome), studied through protein biochemistry, molecular/cell biology, high-resolution imaging, and microfluidics-based single-molecule techniques for in vitro DNA metabolism reconstitution. Recent work trends show a focus on mitotic regulation, exemplified by the 2025 EMBO Journal article on anaphase bridge signaling to the abscission checkpoint, revealing how UFBs influence cell division fidelity and disease pathogenesis. This aligns with broader efforts to link defective genome maintenance to cancer predisposition. Cui operates within the Hickson Group, a research team dedicated to understanding disease-causing mutations in genome maintenance genes. Collaborative efforts span country-level networks in molecular aging research, leveraging advanced biophysical tools to dissect DNA metabolism pathways.

• Genetics
• Cancer Mechanisms
• DNA Replication
• +۴ مورد دیگر

Ryan M Baxley is a Researcher at the University of Minnesota, affiliated with the Genetics Mechanisms of Cancer program within the Office of Academic Clinical Affairs. His work focuses on understanding the molecular mechanisms underlying genome stability and DNA replication processes, with direct implications for cancer biology and therapeutics development. Dr. Baxley's research program centers on critical genome maintenance pathways, with particular emphasis on: Minichromosome Maintenance (MCM) proteins and their regulation in DNA replication Proliferating Cell Nuclear Antigen (PCNA) post-translational modifications Ubiquitin-mediated regulation of DNA repair pathways Mechanisms of replication stress response Genomic instability in specialized cell types including natural killer cells Interplay between DNA replication and repair machineries Analysis of Dr. Baxley's recent publications (2023-2025) reveals a sophisticated research program examining how ubiquitin modifications of key replication proteins regulate genome maintenance. His work demonstrates how proteins like RAD18, RNF4, and USP7 coordinate to prevent hyper-recombination and maintain replication fidelity, with several studies investigating these mechanisms in differentiated cell types. This research has significant implications for understanding cancer development and identifying potential therapeutic targets in DNA repair pathways. Dr. Baxley maintains an active collaborative network within the University of Minnesota's cancer research community, consistently working with principal investigator Anja Bielinsky and colleagues including Liang Wang, Mark Schmit, and Jeffrey Miller. His research group appears well-integrated within the university's cancer research infrastructure, contributing to UN Sustainable Development Goal 3 (Good Health and Well-being) through fundamental discoveries in cancer mechanisms.