معرفی
Professor Alexander J. Hartemink holds dual appointments in the Department of Computer Science and Department of Biology at Duke University, Trinity College of Arts & Sciences. He is also a Bass Fellow in Computer Science. His research focuses on computational biology, machine learning, and systems biology, with applications to genomics, epigenomics, and transcriptional regulation. Hartemink leads the Duke Office of University Scholars and Fellows and has directed the Computational Biology and Bioinformatics graduate program. He earned a PhD from MIT (2001), MPhil from the University of Oxford (1996), and BS from Duke (1994).
Research Interests
His work integrates computational methods to study chromatin dynamics, transcriptional networks, and epigenetic mechanisms. Key areas include modeling chromatin accessibility, predicting transcription factor binding, and understanding cell-cycle regulation. Techniques employed include Bayesian networks, dynamic systems modeling, and machine learning algorithms.
Publications & Trends
Recent work emphasizes single-cell multi-omics integration, chromatin occupancy modeling (RoboCOP framework), and transcriptional regulation in response to genetic perturbations. Themes include epigenetic plasticity, disease-associated enhancers, and systems-level analysis of gene expression.
Awards & Grants
Hartemink has received the Sloan Research Fellowship (2005) and NSF CAREER Award (2004). Active grants include NIH funding for chromatin-transcription interplay studies and NSF support for regulatory genome research. He collaborates on projects like the Data+ initiative, promoting interdisciplinary data science.
Affiliations & Labs
Associated with Duke’s Center for Genomic and Computational Biology and Center for Advanced Genomic Technologies. His lab develops computational tools for genomic analysis, including software for chromatin modeling and epigenetic data integration.
