Avi Srivastava

Avi Srivastava, Ph.D. is an Assistant Professor in the Genome Regulation and Cell Signaling Program at The Wistar Institute's Ellen and Ronald Caplan Cancer Center. A computational biologist with expertise spanning computer science and biology, Dr. Srivastava leads research focused on understanding how epigenomic regulation influences cellular fate determination, particularly in the context of hematopoiesis and leukemia development.

Dr. Srivastava's research interests center on computational approaches to single-cell genomics, epigenomics, and transcriptomics. His work integrates epigenetic, computational, and cancer biology analysis with state-of-the-art multimodal single-cell technologies and sophisticated uncertainty-aware computational models. His lab specifically investigates chromatin dynamics during cell differentiation, with special emphasis on dysregulation in leukemia.

Analysis of Dr. Srivastava's publication record reveals a strong focus on developing computational methods for RNA-seq and single-cell analysis. His work spans transcript quantification algorithms, uncertainty-aware Bayesian models for single-cell data, and integrated analyses of epigenomic data to understand hematopoietic malignancies. His contributions address critical challenges in handling gene-ambiguous reads and improving accuracy in gene abundance estimation.

Dr. Srivastava's laboratory currently includes Postdoctoral Fellow Rajeev Ramisetti, Ph.D. and Research Assistant Calen Nichols, working together to advance understanding of the molecular mechanisms underlying blood cell development and malignancy.