جستجوی استاد راهنمای دانشگاهی

Stacey L. Hanlonمشاهده پروفایل

استادیار

• Meiosis
• Selfish Genetic Elements
• B Chromosomes
• +۴ مورد دیگر

Stacey L. Hanlon serves as an Assistant Professor in the Department of Molecular and Cell Biology / Genetics and Genomics at the University of Connecticut. Her research program focuses on the fundamental mechanisms ensuring fair chromosome transmission during meiosis, with particular emphasis on selfish genetic elements. Education: B.S. in Biology from Texas A&M University Ph.D. in Molecular Biology and Biochemistry from the University of California, San Francisco Postdoctoral training at the Stowers Institute for Medical Research Dr. Hanlon's research investigates how cells counteract "genetic renegades" that attempt to subvert fair meiotic transmission. Her laboratory employs Drosophila melanogaster as a model system to study B chromosomes and female meiotic drive mechanisms using classical genetics combined with modern cell biology approaches. Current work examines the dynamics of selfish genetic elements during female gametogenesis and the cellular systems evolved to suppress their transmission advantage. Analysis of her publication record reveals consistent focus on chromosome biology and non-Mendelian inheritance systems. Her work spans molecular characterization of satellite DNA, structural analysis of supernumerary chromosomes, and mechanistic studies of meiotic drive suppression systems. Recent publications demonstrate increasing sophistication in genomic and cytological approaches to understanding chromosome transmission fidelity. Scientific Recognition: GENETICS December 2018 Highlight for research on B chromosome structure Co-editor of Special Issue on "Non-Mendelian Inheritance and Meiotic Drive" in Chromosome Research (2022) Dr. Hanlon maintains an active research program through the Hanlon Lab, where her team investigates the evolutionary arms race between selfish genetic elements and host suppression mechanisms. Her work bridges classical genetics with modern genomic approaches to address fundamental questions about chromosome transmission and genome evolution. The laboratory employs a multidisciplinary approach combining cytology, molecular biology, and evolutionary analysis to dissect the mechanisms ensuring fair meiosis.

Thomas Gloverمشاهده پروفایل

استاد

• Genomics
• Human Genetics
• Cancer Genetics
• +۴ مورد دیگر

Thomas Glover is a Professor in the Department of Human Genetics at the University of Michigan, specializing in genomic structural variation, replication stress, and fragile sites in cancer. His research explores mechanisms of DNA damage, structural variant formation, and their implications in genetic disorders and oncogenesis. His publications highlight recurring themes in Common Fragile Sites (CFSs) Replication Stress Copy Number Variants (CNVs) Structural Variation in Cancer Genomic Instability Molecular Mechanisms of Mutation . Collaborative work with Thomas Wilson and Martin Arlt underscores interdisciplinary approaches to understanding DNA repair pathways. Recent collaborations include studies on POLQ-mediated structural variants in mitosis (2024), advanced technologies for CNV detection (2023), and foundational work on CFSs in cancer (2017). While no formal scientific awards are explicitly listed, his contributions are memorialized through co-authorship in tributes to Stephen T. Warren, a pioneer in human genetics.

Arul Chinnaiyanمشاهده پروفایل

دانشگاهی

• Cancer Biology
• Genomics
• Molecular Pathology
• +۷ مورد دیگر

Dr. Arul M. Chinnaiyan is a distinguished Professor of Pathology and Urology at the University of Michigan Medical School , where he serves as Director of the Michigan Center for Translational Pathology (MCTP) and an Investigator at the Howard Hughes Medical Institute . His work bridges translational cancer research and precision oncology , with a focus on prostate cancer biomarkers and gene fusion discovery . He has pioneered clinical tools like the MiPS test (combining TMPRSS2-ERG and PCA3) and the bioinformatics platform Oncomine . Education : M.D. and Ph.D. in Pathology Awards : Paul Marks Prize, NCI Outstanding Investigator Award, Sjöberg Prize (2022), AACR Academy Induction (2020) His research spans genomics , epigenetics , and non-coding RNA biology , particularly in prostate cancer and solid tumors . His lab’s 2024–2025 publications highlight advances in FOXA1 mutations , CDK12/13 targeting , and neo-enhanceosome mechanisms . He mentors students like Yihan Liu and has trained notable alumni such as Benjamin Chandler and Jae Eun Choi .

Kathleen Collinsمشاهده پروفایل

استاد

• Virology
• HIV Research
• Immunology
• +۳ مورد دیگر

Kathleen Collins is a Professor in the Department of Internal Medicine - Infectious Diseases at the University of Michigan. Her research focuses on HIV pathogenesis, immune evasion mechanisms, and latent infection dynamics. She has published extensively on viral protein interactions with host immune systems, particularly Nef, Vpr, and Tat proteins. University of Michigan - Internal Medicine - Infectious Diseases Research Interests: HIV immune evasion via Nef/Vpr/Tat proteins Latency mechanisms in T cells and macrophages Major histocompatibility complex (MHC-I) trafficking Epigenetic regulation of viral reservoirs Antiviral drug development targeting immune clearance Scientific Trends: Recent work emphasizes multi-omic approaches to HIV latency, viral protein adaptation in macrophages, and lysosomal acidification pathways. Older publications cover hematopoietic stem cell infection, DNA replication mechanisms, and interleukin-1 gene regulation.

• Biochemistry
• Molecular Biology
• Genetics
• +۳ مورد دیگر

Dr Gerhard May is a Lecturer in Medicine at the School of Medicine, Dentistry & Nursing, University of Glasgow. He works at the Queen Elizabeth University Hospital campus and focuses on both molecular bioscience research and innovative educational practices. Institution: University of Glasgow School: School of Medicine, Dentistry & Nursing Position: Lecturer (Medicine) Contact: Gerhard.May@glasgow.ac.uk | 0141 354 9434 His research spans two primary areas: (1) molecular biology and genetics, particularly DNA-protein interactions, genetic regulation in bacteria, and oncogene mechanisms; and (2) medical education innovations including digital learning tools, curriculum development, and feedback methodologies. Recent publications emphasize educational strategies, while earlier works focus on molecular pathways and bacterial genetics. Selected trends from his 15 most recent publications show a shift toward educational technology and curriculum development since 2012, complementing his foundational work in molecular biology spanning over three decades. Key subfields include synthetic biology, JNK signaling pathways, osmoregulation, and transgenic cancer models. Dr May's professional profile includes ORCID identifier 0000-0002-2532-6758 and affiliation with the Laboratory Medicine Building at Queen Elizabeth University Hospital.

Jean-Paul Armacheمشاهده پروفایل

استادیار

• ATP-dependent Chromatin Remodeling
• Gene Regulation
• Cryo-Electron Microscopy (cryo-EM)
• +۵ مورد دیگر

Jean-Paul Armache is an Assistant Professor of Biochemistry and Molecular Biology at the Pennsylvania State University, affiliated with the Eberly College of Science. His research focuses on the structural and functional analysis of ATP-dependent chromatin remodeling complexes, particularly their role in gene regulation and nucleosome dynamics. He is also involved in virology studies related to SARS-CoV-2 and utilizes cryo-electron microscopy (cryo-EM) for high-resolution structural analysis of protein-DNA interactions. Key Affiliations: Molecular, Cellular, and Integrative Biosciences, Center for Structural Biology, Center for Infectious Disease Dynamics, Center for RNA Molecular Biology. Research Highlights: Mechanisms of chromatin remodeling enzymes, viral protein interactions with host ribosomes, and cryo-EM method development. His recent work includes seed-funded projects on SARS-CoV-2 nsp1 protein and collaborations on opioid settlement fund analysis. Publications span top journals like Nature , Science , and Molecular Cell , with expertise in structural biology and enzymology. Scientific Contributions: Developed cryo-EM methodologies for studying membrane proteins and nucleosome complexes. Elucidated regulatory mechanisms of chromatin remodelers like Chd1 and Dot1L. Investigated viral strategies for hijacking host translation machinery.

George-Lucian Moldovanمشاهده پروفایل

استاد

• DNA Damage Tolerance
• Genomic Instability
• DNA Repair
• +۳ مورد دیگر

George-Lucian Moldovan is a Professor at the Department of Molecular and Precision Medicine, Penn State College of Medicine, and a member of the Penn State Cancer Institute. His research focuses on elucidating the molecular mechanisms of DNA lesion replication in human cells, particularly in the context of genomic stability and cancer prevention. Affiliation: Penn State College of Medicine, Hershey, PA Academic Rank: Professor Research Interests include: Genomic Instability DNA Damage and Repair Replication Stress Translesion Synthesis Role of PARP Proteins in Radioresistance Bisphenol A (BPA) Environmental Impacts Scientific Awards : Outstanding Early-Stage Investigator (2015) Outstanding Research Publication (2021) Dean's Award for Excellence in Teaching (2019, 2022) Outstanding Collaborative Research Team (2020) His grants and projects include studies on DNA damage tolerance pathways (NIGMS, 2015-2026), PCNA-PARI pathway in cancer (U.S. Army and CDMRP), and PARP14/RAD18-mediated repair mechanisms (NIEHS). His work contributes to UN Sustainable Development Goals related to health and well-being.

Mateo Sokačمشاهده پروفایل

استادیار

• Cancer Genomics
• Personalized Medicine
• Bioinformatics
• +۳ مورد دیگر

Mateo Sokač, PhD, serves as Assistant Professor at Algebra University, bringing expertise from his Health Science doctorate at Aarhus University Hospital and multidisciplinary background spanning bioinformatics, genomics, and information technology. His academic foundation includes a Master's in Bioinformatics and Bachelor's in Information Technology from RIT Croatia, complemented by internationally recognized certifications in AI, machine learning, and genomic engineering. His educational qualifications: PhD in Health Science, Aarhus University Hospital, Aarhus, Denmark Master's in Bioinformatics, Aarhus University Hospital, Aarhus, Denmark Bachelor's in Information Technology, RIT Croatia, Zagreb Dr. Sokač's research pioneers the integration of cancer evolution analysis with personalized medicine development, employing cutting-edge computational approaches to transform public health standards. His work uniquely bridges genomic engineering, artificial intelligence, and clinical oncology to address complex challenges in tumor heterogeneity and therapeutic resistance. This multidisciplinary focus has generated significant publications in high-impact journals, particularly in cancer vaccine development and genomic biomarker discovery. Analysis of his 2023-2025 publications reveals dominant themes in computational oncology (73% of works), with strong emphasis on AI-driven cancer vaccine development, multi-omics integration for personalized therapy, and environmental health applications. His research consistently employs advanced techniques like graph neural networks, non-negative matrix factorization, and foundation models across diverse domains from marine microbiology to lung adenocarcinoma grading. Professional development highlights: Dozen+ international certifications in AI, machine learning, and genomic engineering Specialized training in DNA sequencing and genomic engineering Certifications acquired from domestic and foreign institutions While specific advising details remain undisclosed, his publication record indicates extensive collaboration on large-scale cancer genomics projects including TRACERx and international consortia. His work on ctDNA analysis and immune cell profiling suggests involvement in major grants related to cancer evolution and immunotherapy response prediction. Current research trajectories point toward developing integrated platforms for real-time cancer monitoring and personalized treatment adaptation. Dr. Sokač leads innovative projects at the intersection of computational biology and clinical oncology, notably developing frameworks like ANORAK for histopathological analysis and BRAINS for neuroimaging applications. His environmental monitoring initiatives using solar gliders and drone technology demonstrate commitment to cross-domain applications of data science, contributing to Algebra University's research ecosystem through interdisciplinary collaboration.

Velpandi Ayyavooمشاهده پروفایل

استاد

• HIV-1 virology
• Neuropathogenesis
• Neurodegenerative diseases
• +۳ مورد دیگر

Dr. Velpandi Ayyavoo is a Professor and Vice Chair for Education at the University of Pittsburgh School of Public Health, where she also serves as the Graduate Programs Director for Infectious Diseases and Microbiology. With over three decades of expertise in HIV-1 virology, her research focuses on understanding HIV neuropathogenesis and developing innovative models to study viral mechanisms in the central nervous system. Her educational background includes a PhD from Madurai Kamaraj University in India (1991), followed by postdoctoral training at The Wistar Institute (1991-1993) and a research associate position at The University of Pennsylvania (1994-1998). She teaches courses including Molecular Biology of Microbial Pathogens, Laboratory Methods, Seminar Series & Journal Club, Pathogen Biology, and Functional Genomics. Dr. Ayyavoo's research centers on HIV-associated neurocognitive disorder (HAND), where she pioneered the development of brain organoid models with microglia to study HIV neuropathogenesis. Her laboratory was the first to develop brain organoids with microglia, providing groundbreaking platforms for investigating the cellular and molecular mechanisms of HIV in the central nervous system. She also investigates HIV latency in CNS reservoirs and potential therapeutic targets to activate the virus, addressing the critical challenge of viral persistence despite antiretroviral therapy. Her recent publications reveal a strong focus on advancing 3D brain organoid technology to model HIV neuropathogenesis, with increasing emphasis on immunocompetent models containing HIV-infected microglia. Her work bridges virology, neuroscience, and tissue engineering, creating innovative platforms that overcome previous limitations in studying the complex neural-glial interactions affected by HIV. Dr. Ayyavoo has made significant contributions to understanding HIV-1's impact on the central nervous system, particularly in how the virus causes neuroinflammation, dysregulates neurogranin, and induces synaptodendritic injury. Her research has evolved from studying viral proteins like Vpr to developing sophisticated organoid models that better represent human brain complexity. She actively mentors graduate students through the Infectious Diseases and Microbiology program and collaborates with researchers across disciplines to address the persistent challenges of HIV persistence in sanctuary sites like the brain. Her laboratory work has direct implications for developing therapeutic strategies to eliminate viral reservoirs and prevent neurocognitive complications in people living with HIV.

Ramsay Mcfarlaneمشاهده پروفایل

مدرس ارشد

• Cancer Genetics
• Genome Stability
• Stem Cell Biology
• +۵ مورد دیگر

Dr. Ramsay Mcfarlane serves as Senior Lecturer in Biomedical Sciences (Medical & Molecular Genetics) at Bangor University's North Wales Medical School, where he concurrently holds positions as Research Group Leader and Deputy Head of School for Research. His work focuses on elucidating how cancer cells exploit germline and stem cell genes to manipulate cell proliferation and genome dynamics, with the ultimate goal of developing novel diagnostic tools and therapeutic interventions for cancer patients through the identification of druggable targets and biomarkers. Education: Ph.D. in Medical Genetics, Liverpool University, UK (Supervised by Prof. John Saunders) Dr. McFarlane's research program centers on cancer genetics and genome stability mechanisms, specifically investigating germ line genes, cancer testis antigens, meiosis, and telomere biology in human cancer cells, model organisms, and pluripotent stem cells. His group has demonstrated non-uniform DNA replication failure across the genome and identified conserved protein complexes governing telomere maintenance in cancer progression. This work has yielded significant discoveries in cancer-specific biomarker genes with direct applications for patient stratification, early diagnosis, and development of both conventional and immunotherapeutic drug targets. Analysis of his recent publications (2017-2022) reveals a cohesive research trajectory focused on molecular mechanisms of genome instability, with particular emphasis on Translin/Trax complexes, Brachyury signaling, and germ cell-specific gene networks like TEX19. These studies consistently bridge fundamental molecular biology with translational oncology, highlighting novel vulnerabilities in cancer cell regulation that inform therapeutic development. Scientific Awards: NIH Postdoctoral Fellowship at Fred Hutchinson Cancer Research Center, Seattle, USA Dr. McFarlane has supervised 30 research students and projects while securing major funding from the MRC, Wellcome Trust, Royal Society, BBSRC, North West Cancer Research, Cancer Research Wales, NHS, and the Saudi Arabian Government. Current initiatives include the Wales Cancer Research Centre (2020-2025) and the application of cancer-testis genes to address unmet clinical needs in oncology (2023-2027), demonstrating sustained impact in translational cancer research. He established the North West Cancer Research Institute at Bangor University in partnership with the regional cancer charity, creating a dedicated research ecosystem focused on genome dynamics in cancer. His laboratory features state-of-the-art facilities including human cancer/embryonic stem cell culture suites, confocal microscopy, fluorescence-activated cell sorting, and advanced molecular biology technologies, enabling comprehensive investigation of cancer stem cell mechanisms and therapeutic targeting.

Donald Mark Coenمشاهده پروفایل

استاد

• Herpesvirus Replication
• Viral Latency
• MicroRNA Biology
• +۵ مورد دیگر

Donald Mark Coen, Ph.D. is a Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School . His research focuses on molecular mechanisms of herpesvirus replication and latency , with a particular emphasis on herpes simplex virus (HSV) and human cytomegalovirus (HCMV). Investigates viral microRNAs and their role in latency maintenance Studies structural biology of herpesvirus DNA replication proteins Develops antiviral therapies targeting nuclear egress mechanisms The lab has recently transitioned to a closed status while continuing manuscript preparation and reagent support. Collaborations with the Hogle, Abraham, and Arthanari labs have been instrumental in structural studies and drug mechanism analyses. Recent publications highlight advancements in: Small molecule targeting of HCMV nuclear egress MiR-9 mediated HSV-1 latency mechanisms DNA polymerase structural insights for drug resistance Nuclear egress complex phosphorylation studies Chemical genetic approaches to drug development Research foci include post-transcriptional regulation , replication protein functional dissection , and novel antiviral targets through chemical genetics and biophysical approaches. Despite no current positions available, the lab maintains its legacy through ongoing manuscript work and resource sharing.

• Micro and Nano Systems
• Biophysics
• Bacterial Dynamics
• +۳ مورد دیگر

A. Japaridze is a researcher at Delft University of Technology's Department of Mechanical Engineering, specializing in the Dynamics of Micro and Nano Systems . Their work bridges nanotechnology with microbiology, focusing on bacterial behavior and chromosome mechanics. Research Outputs: 19 publications including patents and peer-reviewed articles Key Collaborations: Working with C. Dekker, F. Alijani, and P.G. Steeneken Research interests include: Micro/nano-scale bacterial dynamics Chromosome structural analysis Graphene-based biosensing systems Microfluidic device applications Recent publications examine: Graphene drum sensors for bacterial detection Chromosome morphology in expanded Bacillus cells Microwell-enhanced optical detection systems Datasets contributed include: Single-bacteria nanomotion tracking Replisome movement patterns Microwell optical detection frameworks

Frederic D. Bushmanمشاهده پروفایل

استاد

• Microbiology
• Human Microbiome
• Human Virome
• +۷ مورد دیگر

Frederic D. Bushman is the William Maul Measey Professor in Microbiology at the University of Pennsylvania's Perelman School of Medicine, where he serves as Chair of the Department of Microbiology and Co-Director of the PennCHOP Microbiome Program. His research focuses on the complex interactions between humans and their microbial communities, with particular emphasis on developing new technologies for research and biotechnology applications. Dr. Bushman's educational background includes: B.A. in Biology and English from Amherst College (1980) Ph.D. in Cellular and Developmental Biology from Harvard University (1988) His primary research interests span the human microbiome , the human virome , SARS-CoV-2 , human gene therapy , and HIV . Dr. Bushman's laboratory investigates the gigantic community of microbes that live in association with humans, specific viruses like SARS-CoV-2 and HIV, and methods for understanding and improving human gene therapy approaches, particularly focusing on integration by viral vectors. Analysis of Dr. Bushman's recent publications reveals a strong focus on the human microbiome and virome, with significant contributions to understanding how microbial communities influence human health and disease. His work spans multiple disciplines including microbiology, virology, genomics, and computational biology, often employing cutting-edge sequencing technologies to explore host-microbe interactions at unprecedented resolution. Dr. Bushman has received numerous prestigious honors and awards: Fellow of the American Association for the Advancement of Science (2014) Pioneer Award from the Journal of Human Gene Therapy (2014) Fellow of the American Academy of Microbiology (2009) Master of Arts, Honoris Causa from the University of Pennsylvania (2004) Stohlman Scholar from the Leukemia and Lymphoma Society of America (2001) Multiple fellowships and scholarships from the Leukemia Society of America (1989-2001) Dr. Bushman serves as a mentor for graduate students through the Genomics and Computational Biology and Cell and Molecular Biology graduate groups. His laboratory supports the Viral/Molecular High Density Sequencing Core, which provides genomic analysis for human gene therapy research with particular focus on the consequences of gene modification for the human genome. He has secured significant grant funding from organizations including the Leukemia and Lymphoma Society and the National Institutes of Health. The Bushman Lab operates as a dynamic research environment dedicated to understanding human-microbe interactions. The lab maintains strong collaborations with researchers across the University of Pennsylvania and Children's Hospital of Philadelphia (CHOP), particularly through the PennCHOP Microbiome Program which Dr. Bushman co-directs. The lab's work combines experimental and computational approaches to address fundamental questions in microbiome and virome research.

• Genome Evolution
• Genome Rearrangement
• Molecular Evolution
• +۳ مورد دیگر

Laura Landweber is a Professor at Columbia University, affiliated with the Departments of Biochemistry and Molecular Biophysics, Biological Sciences, and Systems Biology in the Colleges of Physicians & Surgeons and Arts & Sciences. She previously served as faculty at Princeton University (1994-2016) and was a Junior Fellow at Harvard University (1993). Her research focuses on microbial eukaryotes with complex genome architectures, particularly the ciliate Oxytricha, investigating RNA-mediated epigenetic inheritance, genome rearrangement, and the co-evolution of transposons with genomic systems. Her work has been recognized through prestigious awards such as the Guggenheim Fellowship (2012), Blavatnik Award (2008), and fellowship in the American Association for the Advancement of Science (AAAS, 2005). She served as President of the Society for Molecular Biology and Evolution (2017) and contributed to advisory panels for the NSF, NIH, and NASA. Recent publications emphasize genome evolution, RNA-guided DNA reorganization, and computational tools for analyzing complex genomes. Her lab employs functional and comparative genomic experiments to study RNA’s role in programming genome architecture across generations, leveraging Oxytricha’s dual-nucleus system to dissect mechanisms of DNA rearrangement and epigenetic memory. Guggenheim Fellowship (2012) Blavatnik Award for Young Scientists (2008) AAAS Fellow (2005) President, Society for Molecular Biology and Evolution (2017) Her educational background includes an AB in Molecular Biology from Princeton University (1989) and a PhD from Harvard University (1993). She has edited three books and authored over 150 publications spanning genetics, evolution, and biological computation.

• Lung Transplantation
• Immunology
• Pulmonary Medicine
• +۳ مورد دیگر

John Greenland, MD, PhD is a Professor of Medicine at the University of California, San Francisco (UCSF) School of Medicine and a Staff Physician at the San Francisco VA Health Care System. His clinical work focuses on pulmonary medicine and critical care, with specialization in lung transplantation. As an Associate Editor for the American Journal of Transplantation and former member of the programming committee for the International Society for Heart and Lung Transplantation, Dr. Greenland has established himself as a leading expert in transplant medicine. Dr. Greenland earned his BS in Chemistry with minors in Computer Science and History from Stanford University in 2000, followed by a PhD in Virology and MD from Harvard Medical School, completing his MD through the Harvard-MIT Division of Health Science and Technology program in 2008. His research program centers on improving outcomes following lung transplantation, with groundbreaking work demonstrating that airway brush gene expression patterns can identify patients at risk for graft failure. His laboratory investigates novel rejection patterns including epithelial cell reprogramming, dysbiosis, and activation of immune cells in transplant recipients. This work leverages comprehensive bio-repositories for cellular immunology, genomic, epigenetic, and single-cell transcriptomic analyses, complemented by mouse models to understand airway infections and rejection mechanisms. Analysis of his recent publications reveals a clear trajectory toward molecular diagnostics for chronic lung allograft dysfunction (CLAD), with increasing emphasis on single-cell technologies and immune profiling to identify early markers of graft failure. His work demonstrates how understanding immune mechanisms can lead to personalized therapies that preserve transplanted lungs. NIH U01P0555037 Principal Investigator (2022-2027) CFF Airway Brush in CLAD Study Principal Investigator (2022-2027) NIH R01HL161048 Principal Investigator (2021-2026) NIH I01CX002011 Principal Investigator (2020-2024) NIH R01HL151552 Principal Investigator (2020-2025) As a clinician-scientist, Dr. Greenland maintains an active clinical practice serving as an attending physician in the intensive care unit, pulmonary consult service, and outpatient clinic at the SF VAHCS. His research program includes a multidisciplinary team working across immunology, genomics, and pulmonary medicine, with strong translational focus bridging laboratory discoveries to clinical applications in lung transplantation.