Jean-Paul Armache

Jean-Paul Armache is an Assistant Professor of Biochemistry and Molecular Biology at the Pennsylvania State University, affiliated with the Eberly College of Science. His research focuses on the structural and functional analysis of ATP-dependent chromatin remodeling complexes, particularly their role in gene regulation and nucleosome dynamics. He is also involved in virology studies related to SARS-CoV-2 and utilizes cryo-electron microscopy (cryo-EM) for high-resolution structural analysis of protein-DNA interactions.

• Key Affiliations: Molecular, Cellular, and Integrative Biosciences, Center for Structural Biology, Center for Infectious Disease Dynamics, Center for RNA Molecular Biology.
• Research Highlights: Mechanisms of chromatin remodeling enzymes, viral protein interactions with host ribosomes, and cryo-EM method development.

His recent work includes seed-funded projects on SARS-CoV-2 nsp1 protein and collaborations on opioid settlement fund analysis. Publications span top journals like Nature, Science, and Molecular Cell, with expertise in structural biology and enzymology.

Scientific Contributions:

• Developed cryo-EM methodologies for studying membrane proteins and nucleosome complexes.
• Elucidated regulatory mechanisms of chromatin remodelers like Chd1 and Dot1L.
• Investigated viral strategies for hijacking host translation machinery.